assoc_id FEATURE Drug id Drug name Drug Target N_FEATURE_pos N_FEATURE_neg log max.Conc.tested log max.Conc.tested2 FEATUREpos_logIC50_MEAN FEATUREneg_logIC50_MEAN FEATURE_deltaMEAN_IC50 FEATUREpos_IC50_sd FEATUREneg_IC50_sd FEATURE_IC50_effect_size FEATUREpos_Glass_delta FEATUREneg_Glass_delta FEATURE_ANOVA_pval Tissue_ANOVA_pval MEDIA_ANOVA_pval MSI_ANOVA_pval FEATURE_IC50_T_pval ANOVA FEATURE FDR % a1 TP53_mut 1047 Nutlin-3a MDM2 19 13 2.07944154167984 1.38629436111989 3.29504609337469 1.39503602973351 1.90001006364118 0.790770933680293 0.557269293100526 2.68860451874777 2.40273128755306 3.40950073360392 7.5960893080954e-08 NA NA 0.00417602615609596 6.8185866774739e-09 0.0141134139147444 a2 PTEN_mut 87 GW843682X PLK1 4 21 -1.36257783450257 NA -0.524633314705329 -3.22042214608829 2.69578883138296 1.34516875782304 1.01056458796914 2.54268284065861 2.00405251438168 2.66760666609196 0.000370362058860889 NA NA 0.00683160611597096 0.022160523970579 34.4063426785279 a3 EP300_mut 1259 BMN-673 PARP1 6 24 2.30258509299405 NA 4.19450571684518 2.13930598519902 2.05519973164615 0.538374400062722 1.32559372140635 1.68077086709252 3.81741726836699 1.55039941609391 0.00151162963939294 NA NA 0.437915823164415 7.34667673457441e-06 54.7067311493516 a4 PTEN_mut 86 A-443654 AKT1, AKT2, AKT3 4 21 0.0237165266173161 NA 0.529871185715663 -1.66322902338025 2.19310020909591 1.9446146800401 0.753866230079996 2.20701639871384 1.12778137057501 2.90913708770745 0.00165543494982605 NA NA 0.0139151256523202 0.107737799516856 54.7067311493516 a5 PTEN_mut 53 CGP-60474 CDK1,CDK2,CDK5,CDK7,CDK9 4 21 -1.36257783450257 NA -1.15292554822435 -3.08423406436622 1.93130851614187 1.86660020536553 0.652404409894815 2.12684891255879 1.03466640075916 2.96029347265333 0.00193024668850494 NA NA 0.10162228821295 0.129214355617331 54.7067311493516 a6 PTEN_mut 30 Sorafenib PDGFRA, PDGFRB, KDR, KIT, FLT3 4 24 1.38629436111989 NA 2.99612820663472 1.41529660266577 1.58083160396894 1.13055150911956 0.670514786281591 2.14096992598641 1.39828357329783 2.35763869240768 0.00195363863785909 NA NA 0.0114306175465657 0.0641726076615127 54.7067311493516 a7 PTEN_mut 60 BI-2536 PLK1, PLK2, PLK3 4 21 -1.36257783450257 NA -0.508990817446079 -2.63862869637323 2.12963787892715 1.61789034997196 0.906761958205761 2.07201494946367 1.31630544614105 2.34861846557958 0.00299884819927414 NA NA 0.0124927767594346 0.0743595584675821 54.7067311493516 a8 PTEN_mut 45 Z-LLNle-CHO g-secretase 4 21 0.940007258491471 NA 1.13183062854107 -0.0877903577455783 1.21962098628665 1.07705680460146 0.485240841692544 2.04392372705295 1.13236458938481 2.51343432270159 0.00312473309132358 NA NA 0.0474760114919869 0.106304157612689 54.7067311493516 a9 loss_cnaDLBC2 344 THZ-2-49 CDK9 4 25 2.99573227355399 NA 2.62919219799881 0.132491514593352 2.49670068340546 3.09659830459819 0.99014046438765 1.79396843257648 0.806272056565447 2.52156211487583 0.00323890329127998 NA NA 0.678006252426427 0.205128297755661 54.7067311493516 a10 EP300_mut 136 Mitomycin C DNA crosslinker 5 24 2.77258872223978 NA 0.125420595690933 -1.60992073601197 1.7353413317029 1.16332374128108 1.02140815085855 1.66276005990777 1.49170971942162 1.6989695355811 0.00389053960664504 NA NA 0.310923456328126 0.0245735764467751 54.7067311493516 a11 PTEN_mut 104 Bortezomib Proteasome 4 24 -3.91202300542815 NA -4.54593348389757 -6.35985022336411 1.81391673946654 1.42519588583644 0.843514199724283 1.95170599992814 1.27274907084226 2.15042822048455 0.00403659693155402 NA NA 0.0459559796223071 0.0806678721793857 54.7067311493516 a12 TP53_mut 1259 BMN-673 PARP1 18 12 2.30258509299405 NA 3.17047356369041 1.62015448328503 1.55031908040538 1.05732785644169 1.5323519046973 1.22516807060176 1.46626145425015 1.01172522816267 0.00408536887311365 NA NA 0.453339825933315 0.00686548490673411 54.7067311493516 a13 PTEN_mut 41 S-Trityl-L-cysteine KIF11 4 21 1.63315443905142 NA 2.26651776069564 0.197345239142243 2.06917252155339 1.92509611065141 0.834902031496441 1.98233434445003 1.07484115214031 2.47834170177392 0.00444914098050785 NA NA 0.0094958899299862 0.118949324436827 54.7067311493516 a14 TP53_mut 1003 Camptothecin TOP1 17 13 -2.30258509299405 NA -4.34297701266746 -6.00857868032379 1.66560166765633 1.36423210734635 1.26853647725427 1.2579437773394 1.22090783429529 1.31301046325565 0.00464394351946141 NA NA 0.0885912383071359 0.00187296147082864 54.7067311493516 a15 loss_cnaDLBC4_(CDKN2A) 1047 Nutlin-3a MDM2 8 24 2.07944154167984 1.38629436111989 1.49864404138275 2.86467465956637 -1.36603061818361 0.52049667712677 1.13740077593273 1.32992412891157 2.62447519497019 1.20101080207493 0.00464839905716581 NA NA 0.0394435213486514 8.97845743179014e-05 54.7067311493516 a16 EP300_mut 1494 SN-38 TOP1 6 25 -2.99573227355399 NA -3.04820028845886 -5.03353267398914 1.98533238553028 1.14506634599508 1.41963367668506 1.44261051578876 1.73381428287896 1.3984821705316 0.00471106104390863 NA NA 0.586428429757387 0.00537599227232743 54.7067311493516 a17 loss_cnaDLBC2 1375 Temozolomide DNA akylating agent 3 27 3.40119738166216 NA 3.4191764408083 4.73278841706047 -1.31361197625217 0.435530495252343 0.7718132446933 1.74498777740681 3.01611940052803 1.70198164553935 0.00514672310175713 NA NA 0.240312693276162 0.0137224944899657 56.2501776696061 a18 EP300_mut 1005 Cisplatin DNA crosslinker 5 25 1.79175946922805 2.30258509299405 3.89469549043872 2.50481837276803 1.38987711767069 0.824763306274564 0.879980977228669 1.59333525211954 1.68518301808156 1.57943995794982 0.00723237328910016 NA NA 0.0737550034912659 0.0145662868517345 66.1208627532402 a19 TP53_mut 1378 Bleomycin (50 uM) DNA damage 19 12 3.91202300542815 NA 3.9168612712759 2.54311545257857 1.37374581869733 1.36164646099592 1.55675424448671 0.954805183810975 1.0088858290665 0.88244231455446 0.00747448159455697 NA NA 0.391527061229281 0.0202575788254767 66.1208627532402 a20 loss_cnaDLBC4_(CDKN2A) 190 Bleomycin DNA damage 8 21 4.15888308335967 NA -0.0700209317935492 1.8842118473143 -1.95423277910785 1.5879921500798 1.52609033926513 1.26702622546085 1.23063125910896 1.28054855523749 0.0076149719630447 NA NA 0.382591394914484 0.0109632533133151 66.1208627532402 a21 ARID1A_mut 224 AS605240 PI3Kgamma 3 26 2.99573227355399 2.32630161961136 0.423344826257404 2.47003048011224 -2.04668565385483 2.24023267188673 0.976869000656225 1.82671545876002 0.91360405530159 2.09514853320143 0.00765271253226221 NA NA 0.204026212421971 0.252812702982645 66.1208627532402 a22 EP300_mut 228 KIN001-102 AKT1 6 23 2.32630161961136 NA 0.420186445823889 1.45371300502413 -1.03352655920024 1.25975665773421 0.700308252288217 1.24107839502153 0.820417620224471 1.47581662192791 0.00782923224387175 NA NA 0.590736846986746 0.102803409851187 66.1208627532402 a23 loss_cnaDLBC2 204 Tipifarnib Farnesyl-transferase (FNTA) 4 25 2.77258872223978 NA -0.802335901814009 1.33849911364864 -2.14083501546265 1.270511106578 1.47549394941751 1.47222868067191 1.68501873331023 1.45092768174874 0.00959885835088787 NA NA 0.588181979296097 0.0332565312770344 74.7064624800949 a24 TP53_mut 1248 FK866 NAMPT 17 11 0 NA -3.34337352929305 -5.90107057289411 2.55769704360106 3.58622584374603 0.904990111942031 0.891585635541798 0.713200215223867 2.82621545788214 0.00965000186606018 NA NA 0.183302877330137 0.0112771512611976 74.7064624800949 a25 loss_cnaDLBC2 1011 ABT-263 BCL2, BCL2L1, BCL2L2 3 29 0.693147180559945 NA 2.49510709004335 0.179979081616786 2.31512800842656 0.843916569025293 1.60627761909002 1.47739385979104 2.74331384570454 1.44130004733436 0.0112812479137252 NA NA 0.0896366628107756 0.0176355654565013 82.1467555147258 a26 EP300_mut 156 AZD6482 PI3Kbeta 6 24 1.63315443905142 NA 0.0958811356415964 2.04158574986827 -1.94570461422667 2.55827361957954 1.32382009899553 1.20476231480015 0.760553757555633 1.46976512571686 0.0114953380314414 NA NA 0.846771130590875 0.124064445114296 82.1467555147258 a27 EP300_mut 1243 piperlongumine Increases ROS levels 6 24 2.30258509299405 NA 2.62335505675148 1.49332139252515 1.13003366422633 1.40296907786374 0.937093485581751 1.09100862462228 0.805458710427888 1.20589213521723 0.0123530323656246 NA NA 0.354678203812073 0.109193445216218 84.1098491120705 a28 TP53_mut 1494 SN-38 TOP1 19 12 -2.99573227355399 NA -4.0885921191696 -5.53702235968828 1.44843024051868 1.25210943356073 1.66095317744626 1.0192300662461 1.15679205163374 0.872047605065943 0.0126763527512872 NA NA 0.598289912706476 0.0179943994100002 84.1098491120705 a29 MLL2_mut 1006 Cytarabine DNA synthesis 8 22 0.693147180559945 NA -1.54157284927471 0.303204352458134 -1.84477720173284 2.00775618157692 1.66705438258224 1.04910507129995 0.918825312884319 1.10660889111207 0.0132774171320477 NA NA 0.617906464308431 0.0408649537865374 84.1098491120705 a30 TP53_mut 1005 Cisplatin DNA crosslinker 17 13 1.79175946922805 2.30258509299405 3.16048035914772 2.18198235891408 0.978498000233638 0.896573603873797 0.886939674216488 1.09640849888661 1.09137498138008 1.10322948524998 0.0135808230964922 NA NA 0.0796374086874948 0.00615602101142571 84.1098491120705 a31 MLL2_mut 151 QS11 ARFGAP 9 20 2.32630161961136 NA 1.67008365295604 2.74055390352698 -1.07047025057094 0.960941351137883 0.974148667220236 1.10328852637303 1.11398083691929 1.0988777037755 0.0142767987805225 NA NA 0.529817698321236 0.0140297664531688 85.5679566387016 a32 loss_cnaDLBC2 184 BMS-754807 IGF1R 4 25 0.940007258491471 NA -0.527931706692583 1.38211770187064 -1.91004940856322 2.59101346536343 1.06645385198983 1.44103078644444 0.737182355127324 1.7910286553885 0.015351498420549 NA NA 0.664863334177593 0.237178405362229 87.8791365432281 a33 MLL2_mut 257 NPK76-II-72-1 PLK3 9 20 2.32630161961136 NA 0.239511841540353 1.44520157887601 -1.20568973733566 0.644390256241793 1.49807171394017 0.924097216912213 1.87105519622142 0.804827783687673 0.0156083754976594 NA NA 0.308077289962179 0.00533931697900932 87.8791365432281 a34 EP300_mut 94 TGX221 PI3Kbeta 5 22 2.30258509299405 NA 2.44781206791365 3.70971824696769 -1.26190617905404 1.74716654720692 0.841945130979102 1.21210189600998 0.722258665650026 1.49879859461454 0.0177287304396501 NA NA 0.829679934959071 0.183691196121122 90.6527999345367 a35 TP53_mut 136 Mitomycin C DNA crosslinker 16 13 2.77258872223978 NA -0.805515261697576 -1.93251926912857 1.12700400743099 1.20124268575092 0.962414244632653 1.02314618531486 0.938198434670578 1.17101758802537 0.0177450045947309 NA NA 0.336146495024578 0.00921528227635084 90.6527999345367 a36 loss_cnaDLBC2 304 SB52334 ALK5 4 25 2.99573227355399 NA 4.63825484165198 3.60537821836788 1.0328766232841 0.534201272246346 0.869399316466698 1.23137963580963 1.9334971235482 1.18803477725493 0.0182778943605561 NA NA 0.185256816250818 0.0178886884776139 90.6527999345367 a37 CREBBP_mut 1011 ABT-263 BCL2, BCL2L1, BCL2L2 7 25 0.693147180559945 NA -0.975152113147282 0.781231177161912 -1.75638329030919 0.910671194972648 1.66324971558928 1.1387372494147 1.92866898613384 1.05599494402253 0.018793797551249 NA NA 0.0945206737277076 0.00169956384711951 90.6527999345367 a38 loss_cnaDLBC2 302 PI-103 PI3Ka, PRKDC (DNAPK) 4 24 2.32630161961136 NA 0.739080142877895 -1.71594445066486 2.45502459354275 2.63615508342131 1.78491491034817 1.29030397480026 0.931289896024071 1.37542948367431 0.0190339517155879 NA NA 0.421189273246719 0.157824868118173 90.6527999345367 a39 loss_cnaDLBC2 1014 RDEA119 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 29 1.6094379124341 NA 1.24754198174107 2.93559626742896 -1.68805428568788 1.823044196977 1.02871040833034 1.53506336266755 0.925953571771351 1.640942166054 0.0191284482467948 NA NA 0.850943593427368 0.24761263227223 90.6527999345367 a40 TP53_mut 1242 (5Z)-7-Oxozeaenol MAP3K7 (TAK1) 18 11 2.30258509299405 NA 1.51916712555309 0.697326514309984 0.82184061124311 0.791922501641734 1.0021502954023 0.938507171756547 1.0377790876498 0.820077203003956 0.0203397210338256 NA NA 0.985894111860633 0.0329921706444145 90.6527999345367 a41 EP300_mut 238 CAL-101 PI3Kdelta 6 23 2.99573227355399 2.32630161961136 1.21282220690563 3.14201198681646 -1.92918977991083 2.57144593016402 1.628619758992 1.04845365623126 0.750235405411683 1.18455506219871 0.0227534285231699 NA NA 0.644404581202637 0.130264732935773 90.6527999345367 a42 PTEN_mut 11 Paclitaxel Microtubules 4 21 -2.27886856637673 NA -1.79561841534463 -4.02263281750165 2.22701440215702 2.18357664347286 1.25760725683107 1.57584147014979 1.01989293978483 1.77083456704017 0.0237290539728793 NA NA 0.0251740613560385 0.131701140770466 90.6527999345367 a43 loss_cnaDLBC2 261 TL-1-85 MAP3K7 (TAK1) 4 25 2.32630161961136 NA 2.74700300859987 1.34949789292065 1.39750511567922 1.53343149490662 1.06740379709956 1.23812514399523 0.911358036091673 1.30925627159716 0.0269315924889671 NA NA 0.637036105163416 0.164550146615173 90.6527999345367 a44 loss_cnaDLBC4_(CDKN2A) 341 EX-527 SIRT1 7 22 2.99573227355399 NA 5.12722915180709 4.57869966919722 0.548529482609874 0.493858408092461 0.575906711296002 0.981768001406839 1.11070192108014 0.952462389916382 0.0274894993244453 NA NA 0.684367146912746 0.0307860508459106 90.6527999345367 a45 loss_cnaDLBC4_(CDKN2A) 1003 Camptothecin TOP1 8 22 -2.30258509299405 NA -6.15159986350684 -4.66951514325006 -1.48208472025678 0.979671131331645 1.54180232171729 1.04206798849345 1.51283902613544 0.961267666665596 0.0285445760989375 NA NA 0.107947240415117 0.00561953543178506 90.6527999345367 a46 TP53_mut 326 GSK690693 AKT 16 12 2.32630161961136 NA 0.0392327503007849 2.07667811650759 -2.0374453662068 2.6324162718905 1.90475626265887 0.866189158137256 0.773982970688595 1.06966198570872 0.0310345054479739 NA NA 0.947356109618368 0.0251700432758727 90.6527999345367 a47 MLL2_mut 304 SB52334 ALK5 9 20 2.99573227355399 NA 3.18257564790211 4.0022146997343 -0.819639051832188 0.896354866703394 0.797295270905643 0.990042279769622 0.914413567972971 1.02802447442234 0.0329775194268405 NA NA 0.193831648004328 0.0336338017977505 90.6527999345367 a48 EP300_mut 1047 Nutlin-3a MDM2 6 26 2.07944154167984 1.38629436111989 3.54004167561755 2.28850361949806 1.2515380561195 0.856287622757005 1.12330264766969 1.15521618911397 1.46158606390911 1.11415926840004 0.0332861941592697 NA NA 0.0517074512062901 0.0134971493405255 90.6527999345367 a49 loss_cnaDLBC2 1060 PD-0325901 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 29 -1.38629436111989 0.693147180559945 -1.01216503820994 0.179144839401204 -1.19130987761115 1.4320152942856 0.796952635427466 1.39479815229272 0.831911420475062 1.49483146758422 0.0339941120708042 NA NA 0.549051314288273 0.284718063688992 90.6527999345367 a50 EP300_mut 326 GSK690693 AKT 6 22 2.32630161961136 NA -0.999415966718488 1.43383441832793 -2.43325038504642 1.89103533888234 2.45460278436873 1.03247581206205 1.28672919802998 0.991301077527379 0.0347148894553702 NA NA 0.947561399548926 0.0258139608137846 90.6527999345367 a51 ARID1A_mut 1033 Vismodegib SMO 3 27 2.30258509299405 NA 4.57896934047154 3.71027878714198 0.868690553329563 0.217202519345497 0.678000929847175 1.32440133174009 3.99944971148225 1.28125274625415 0.0349286154250369 NA NA 0.567434531609234 0.0013757321632164 90.6527999345367 a52 PTEN_mut 64 CMK RSK 4 21 1.38629436111989 NA 2.62080663657487 1.08665546606369 1.53415117051117 0.706393577752314 1.12692584809722 1.4186867285205 2.17180792525424 1.36135946575503 0.0352791136905045 NA NA 0.127657294162488 0.0106733584172778 90.6527999345367 a53 PTEN_mut 83 JW-7-52-1 MTOR 4 21 0.182321556793955 NA -0.259451127365493 -2.46450071521983 2.20504958785434 2.29770098371913 1.43365040290221 1.40137095149222 0.959676478131271 1.53806645147977 0.0359188156246835 NA NA 0.159556742162531 0.148794196046761 90.6527999345367 a54 EP300_mut 1239 YK 4-279 RNA helicase A 6 21 2.30258509299405 NA 2.74280158822935 1.41761288865191 1.32518869957744 0.859925116348141 1.56169311596367 0.914684333233876 1.54105127805214 0.848558968488319 0.0359252279740554 NA NA 0.361138261304024 0.015870745056855 90.6527999345367 a55 TP53_mut 190 Bleomycin DNA damage 16 13 4.15888308335967 NA 1.99182164412501 0.54916423332706 1.44265741079795 1.65488912913568 1.59027114935458 0.886977526714459 0.871754720844308 0.907177000213743 0.0372716133622894 NA NA 0.407998641160205 0.0245673988769686 90.6527999345367 a56 loss_cnaDLBC4_(CDKN2A) 293 MP470 PDGFR 7 21 2.99573227355399 NA 1.01027870663344 2.70366764513816 -1.69338893850472 1.96170083378031 1.56808173879096 1.01571693857022 0.863224865557842 1.07991114022562 0.0375863346152082 NA NA 0.454482726477106 0.0689843091299511 90.6527999345367 a57 PTEN_mut 326 GSK690693 AKT 6 22 2.32630161961136 NA -0.972363936490175 1.42645659190203 -2.39882052839221 1.68591443722422 2.49742163418159 1.01511363045735 1.42286018520712 0.960518838933782 0.0376387492463037 NA NA 0.947708393985763 0.0176564055122822 90.6527999345367 a58 ARID1A_mut 1502 Bicalutamide ANDR (androgen receptor) 3 25 2.30258509299405 NA 4.48855188118114 3.61043780573 0.878114075451141 0.28025849880236 0.650316170446833 1.39467298792336 3.13322906960403 1.35028792971238 0.0382642122508449 NA NA 0.44079720883356 0.0074475070973615 90.6527999345367 a59 TP53_mut 1036 PLX4720 BRAF 19 13 2.30258509299405 NA 3.10062177872229 3.71998177803673 -0.619359999314439 0.832725379023362 0.606905051081917 0.825159016640348 0.74377461635772 1.02052207047926 0.0399980285290818 NA NA 0.471745178645349 0.0212087877783852 90.6527999345367 a60 EP300_mut 1006 Cytarabine DNA synthesis 5 25 0.693147180559945 NA 1.28088881842184 -0.482661245289116 1.76355006371095 1.04129291914067 1.92837990505522 0.964637823963649 1.69361572646276 0.914524186384558 0.0409723533404865 NA NA 0.630621549337689 0.0146087876634203 90.6527999345367 a61 PTEN_mut 111 Salubrinal GADD34-PP1C 4 23 2.77258872223978 NA 3.90786343411702 2.761099653845 1.14676378027202 1.12925587725018 0.830636793786485 1.3152648721162 1.01550392906918 1.38058389521184 0.0416488038659639 NA NA 0.256292686420817 0.132276375742851 90.6527999345367 a62 CREBBP_mut 51 Dasatinib ABL, SRC, KIT, PDGFR 6 18 0.246860077931526 NA -2.27441344246711 0.386177252688606 -2.66059069515572 2.93782336817578 2.18945827215873 1.11775803026818 0.905633307971061 1.21518218866646 0.0431599120947531 NA NA 0.138738924331772 0.0812604738670436 90.6527999345367 a63 CREBBP_mut 1375 Temozolomide DNA akylating agent 6 24 3.40119738166216 NA 5.25179559821574 4.43883512474014 0.812960473475602 0.397691751048183 0.848614764251936 1.03263409228786 2.04419747538869 0.957985304665583 0.0434348836206252 NA NA 0.273107624384451 0.00305665593991542 90.6527999345367 a64 TP53_mut 1053 MK-2206 AKT1, AKT2 19 13 1.38629436111989 0.693147180559945 0.136429291784215 1.54552803883946 -1.40909874705524 1.7370224311445 1.5455691233704 0.847278520686455 0.811215055021948 0.911702185135814 0.0435804745648919 NA NA 0.199777656870028 0.0229371049680854 90.6527999345367 a65 loss_cnaDLBC2 179 5-Fluorouracil DNA antimetabolite 4 25 3.46573590279973 NA 0.235284898268197 1.89086217880682 -1.65557728053862 1.20316759569152 1.48760190957696 1.13493691298374 1.37601551643109 1.11291688312597 0.0437174536952919 NA NA 0.789749985894745 0.060893566050636 90.6527999345367 a66 loss_cnaDLBC4_(CDKN2A) 71 Pyrimethamine Dihydrofolate reductase (DHFR) 8 20 2.99573227355399 NA 3.55450009974114 2.71624688461652 0.838253215124619 0.95061686911866 1.21320148890154 0.729914157370806 0.881799221490551 0.690943114390336 0.0450169355505513 NA NA 0.154792453326853 0.0695568466396114 90.6527999345367 a67 loss_cnaDLBC4_(CDKN2A) 133 Doxorubicin DNA intercalating 8 21 0.0237165266173161 NA -3.20782073618809 -2.10193628822094 -1.10588444796715 1.06040035851818 1.22189044554268 0.935491365710812 1.04289331768289 0.905060230236924 0.0453403281051341 NA NA 0.385817506303499 0.0300352166288206 90.6527999345367 a68 loss_cnaDLBC4_(CDKN2A) 1005 Cisplatin DNA crosslinker 8 22 1.79175946922805 2.30258509299405 2.07922950817953 2.9754591229981 -0.896229614818566 0.801657220166668 0.979404086374455 0.955336296391785 1.11797111318006 0.91507645035076 0.0454599156922564 NA NA 0.0912909865918694 0.0222385927686966 90.6527999345367 a69 loss_cnaDLBC2 29 AZ628 BRAF 4 25 1.38629436111989 NA 0.490743371900666 1.76405321577963 -1.27330984387896 1.39623395088936 1.01516897741218 1.19641746893715 0.911960236368624 1.25428364362041 0.046045108265473 NA NA 0.106657475544154 0.164332753586483 90.6527999345367 a70 PTEN_mut 1026 17-AAG HSP90 5 27 0 NA -0.343332877127673 0.923732848447793 -1.26706572557547 1.42018736757343 1.00087801893263 1.18822102102942 0.892182084213584 1.26595419382545 0.0476275239307567 NA NA 0.0652001104787195 0.117385621468327 90.6527999345367 a71 PTEN_mut 258 STF-62247 stimulates autophagy 6 23 2.32630161961136 NA 2.39639698131221 3.41426809216094 -1.01787111084872 1.18839427098721 1.02542092417511 0.962527888704507 0.856509607710551 0.992637351990388 0.0487143114361228 NA NA 0.860362871232204 0.0959384459726935 90.6527999345367 a72 TP53_mut 1243 piperlongumine Increases ROS levels 19 11 2.30258509299405 NA 1.99008885293671 1.25165050502863 0.738438347908089 1.02501274703981 1.16007890367553 0.686791513445113 0.720418697270512 0.636541484866642 0.0490388283268875 NA NA 0.375910050013113 0.095949166525462 90.6527999345367 a73 ARID1A_mut 1013 Nilotinib ABL 3 27 0.693147180559945 NA 2.93588314480073 2.03149388168569 0.904389263115044 0.368549040997354 0.783411168267647 1.18793404546277 2.45391837316309 1.15442477685749 0.0499344271919684 NA NA 0.356140373923107 0.0217755789732328 90.6527999345367 a74 EP300_mut 1242 (5Z)-7-Oxozeaenol MAP3K7 (TAK1) 6 23 2.30258509299405 NA 1.87925121519617 1.03217794026907 0.8470732749271 0.428128704086768 0.976659806032096 0.940515719793393 1.9785481955338 0.867316612903862 0.049953265949326 NA NA 0.986313179170581 0.00505840258329355 90.6527999345367 a75 TP53_mut 228 KIN001-102 AKT1 17 12 2.32630161961136 NA 0.980298642400178 1.6076200724746 -0.627321430074424 0.972244473377818 0.733301126051776 0.710652927709729 0.645230132185739 0.855475885400632 0.0501735714941591 NA NA 0.61362931140951 0.0580840460209954 90.6527999345367 a76 ARID1A_mut 1060 PD-0325901 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 29 -1.38629436111989 0.693147180559945 -0.934373489254348 0.171097437785108 -1.10547092703946 1.28782158356363 0.826008371636509 1.27873234017066 0.858403789118382 1.33832896251314 0.0508867788105807 NA NA 0.553788072485994 0.273154069001952 90.6527999345367 a77 PTEN_mut 1009 ATRA Retinoic acid and retinoid X receptor agonist 4 26 2.30258509299405 NA 2.2299613327541 3.30372572186468 -1.07376438911058 0.911190752221848 0.86126314036392 1.23883964599462 1.1784188837434 1.24673208313184 0.0509086307254948 NA NA 0.28014607699046 0.0938673123070258 90.6527999345367 a78 TP53_mut 1066 AZD6482 PI3Kbeta 16 12 1.6094379124341 NA 1.05918489713551 2.14390645056879 -1.08472155343327 1.38996194106468 1.39161042168494 0.78000507297597 0.780396585968676 0.779472139997277 0.0529320988906244 NA NA 0.884230763900224 0.0523490063717245 90.6527999345367 a79 ARID1A_mut 253 XMD14-99 EPHB3, CAMK1 3 26 2.32630161961136 NA 2.21280553989276 3.29688180315232 -1.08407626325957 0.443488609868422 0.859573760730209 1.29691897944279 2.44442864853102 1.26117886886012 0.0530039204739136 NA NA 0.285995719106991 0.0236165437032477 90.6527999345367 a80 EP300_mut 1003 Camptothecin TOP1 5 25 -2.30258509299405 NA -3.685231744331 -5.34063893351605 1.65540718918505 0.996187745754271 1.50190607111408 1.14913236769358 1.66174217283876 1.10220420639029 0.0530379803417063 NA NA 0.114713219537163 0.0146929079406948 90.6527999345367 a81 MLL2_mut 333 T0901317 LXR 9 20 2.32630161961136 NA 2.18851317793057 3.23199393398649 -1.04348075605592 2.00395227224532 0.761299375990247 0.82553126504997 0.52071138145758 1.37065757435914 0.0534898514623014 NA NA 0.866359061987009 0.164175922418001 90.6527999345367 a82 loss_cnaDLBC4_(CDKN2A) 134 Etoposide TOP2 8 22 2.77258872223978 NA -0.620719063424743 0.970588571930354 -1.5913076353551 1.21618992189842 1.98350404104751 0.873278335132233 1.30843678828644 0.802270931857899 0.0538087276010769 NA NA 0.585721843868394 0.0154916728149192 90.6527999345367 a83 MLL2_mut 1091 BMS-536924 IGF1R 9 21 1.38629436111989 NA 2.76883746370504 2.02825989828596 0.740577565419078 0.595200652529153 1.03364248511213 0.796562642747603 1.2442485778068 0.716473612574794 0.0546354592573026 NA NA 0.960194603139268 0.0208428659380053 90.6527999345367 a84 MLL2_mut 330 XMD13-2 RIPK 9 20 2.32630161961136 NA 1.23247795406149 2.08722863463297 -0.854750680571477 1.19846218638979 0.929063117676154 0.840994559162079 0.713206215664009 0.920013575298788 0.0552002262627886 NA NA 0.654781213469745 0.080938377389274 90.6527999345367 a85 EP300_mut 1529 MLN4924 NEDD8-activating enzyme 5 22 0 NA 1.4731918388531 0.177702944318786 1.29548889453432 0.955551996147939 1.52429363290234 0.894439107636429 1.35574924206819 0.849894578426884 0.0554612431708235 NA NA 0.526149579154483 0.0380437486696963 90.6527999345367 a86 CREBBP_mut 17 Cyclopamine SMO 7 20 2.77258872223978 NA 3.35748119266377 4.28493721933544 -0.927456026671668 1.14237986254276 0.937019362690326 0.936637152957784 0.811863073817928 0.989793875773069 0.0556544004755418 NA NA 0.512657005607805 0.0853297533138146 90.6527999345367 a87 loss_cnaDLBC2 62 BMS-536924 IGF1R 4 21 1.63315443905142 NA 0.599573150545009 2.21838179758158 -1.61880864703657 2.10606152245563 1.23899240192692 1.17028330121449 0.768642620254073 1.30655252164497 0.0580877416341152 NA NA 0.0431222931348507 0.222640077661509 90.6527999345367 a88 loss_cnaDLBC2 55 A-770041 SRC family 4 21 1.63315443905142 NA 3.46683644143872 0.99990438826005 2.46693205317867 0.453653633042017 2.64880557776617 0.996558279775369 5.43791975529089 0.931337533371973 0.0584095769811026 NA NA 0.323316210707722 0.000601666610283327 90.6527999345367 a89 CREBBP_mut 238 CAL-101 PI3Kdelta 6 23 2.99573227355399 2.32630161961136 1.35247834949398 3.1055799496195 -1.75310160012552 2.5114372390566 1.69173746776743 0.937071976048428 0.698047147212034 1.03627284583292 0.0603858049861936 NA NA 0.654995418248313 0.155184231299289 90.6527999345367 a90 TP53_mut 1062 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 19 13 1.38629436111989 0.693147180559945 2.60398117501309 3.22063868138139 -0.616657506368302 0.942578709331091 0.718064066872276 0.717179780719012 0.654223886306447 0.858777837267811 0.0611424480876367 NA NA 0.792443083321433 0.0445930193827344 90.6527999345367 a91 ARID1A_mut 229 LY317615 PRKCB (PKCbeta) 3 26 2.99573227355399 2.32630161961136 3.11653838058803 2.11033389785602 1.00620448273202 0.567217252274919 0.970936799787568 1.06257093280668 1.77393137937266 1.03632335590964 0.0624238237236646 NA NA 0.145542474488024 0.06415633825295 90.6527999345367 a92 CREBBP_mut 1066 AZD6482 PI3Kbeta 6 22 1.6094379124341 NA 0.541565617972428 1.79202009332541 -1.25045447535299 1.21880218876578 1.44010123384845 0.89301428479962 1.02596999486788 0.868310120123529 0.0624789168925054 NA NA 0.884875121802152 0.0604527878360481 90.6527999345367 a93 EP300_mut 203 BMS-345541 IKBKB 6 23 2.77258872223978 NA 1.45122963261682 1.97803133118142 -0.5268016985646 0.765526784215197 0.63284920948226 0.798866810241706 0.688155802549308 0.832428469011728 0.0625018564767247 NA NA 0.438843510187243 0.165061557075124 90.6527999345367 a94 loss_cnaDLBC4_(CDKN2A) 1375 Temozolomide DNA akylating agent 7 23 3.40119738166216 NA 5.15353769592474 4.43339359615585 0.720144099768886 0.450200721244007 0.866739971509853 0.904650713965221 1.59960672159512 0.830865223066154 0.062785664849629 NA NA 0.278563687137832 0.00877954862228357 90.6527999345367 a95 ARID1A_mut 29 AZ628 BRAF 3 26 1.38629436111989 NA 0.3882879046271 1.72690154493123 -1.33861364030413 1.62669572270277 1.02099868560696 1.24221263840495 0.822903522534633 1.31108262838591 0.0638447257908837 NA NA 0.110247399577502 0.288130369297446 90.6527999345367 a96 loss_cnaDLBC4_(CDKN2A) 1042 BIRB 0796 p38, JNK2 8 21 2.30258509299405 NA 4.19788571456825 3.56061088114921 0.637274833419039 0.701980463259966 0.896329435578346 0.749541755380191 0.90782417285456 0.710982824086152 0.0638709007876144 NA NA 0.529633210958748 0.0606072147599512 90.6527999345367 a97 loss_cnaDLBC2 1133 JNJ-26854165 MDM2 3 27 2.30258509299405 NA 1.72962375929653 2.74987036106378 -1.02024660176725 0.704532922998919 0.848485785123153 1.21599372915038 1.44811770814693 1.20243216758095 0.064442926620913 NA NA 0.609055066960632 0.112382194632342 90.6527999345367 a98 CREBBP_mut 56 WH-4-023 SRC family, ABL 6 19 1.63315443905142 NA 0.346708843723566 2.25579783347089 -1.90908898974733 2.94323974134951 1.63624593868608 0.957124327932018 0.648635231077706 1.1667494137711 0.0665244706658575 NA NA 0.559395410247354 0.180107805516642 90.6527999345367 a99 TP53_mut 1039 SL 0101-1 RSK, AURKB, PIM3 19 13 2.30258509299405 NA 3.75525631050834 4.22645007651884 -0.471193766010507 0.733286990807145 0.68757307622318 0.658687920766794 0.642577560924481 0.685299908191231 0.0666098153906909 NA NA 0.81579875181219 0.0748392245750727 90.6527999345367 a100 EP300_mut 1038 NU-7441 PRKDC (DNAPK) 6 26 0.693147180559945 NA 1.1134188390617 1.90590694679479 -0.792488107733082 1.00729626938739 0.9815040410773 0.80386308619559 0.786747783961367 0.807422154740439 0.067949095619587 NA NA 0.666272059987634 0.122331298555607 90.6527999345367 a101 ARID1A_mut 306 TG101348 JAK2 3 26 2.32630161961136 NA -0.322361197772686 0.965128025525878 -1.28748922329856 0.828564402170656 1.09730517787103 1.19245661127846 1.5538794810948 1.17331919074375 0.0681013326584408 NA NA 0.797246108511503 0.0948052349697266 90.6527999345367 a102 TP53_mut 287 KIN001-244 PDPK1 (PDK1) 17 12 2.99573227355399 NA 1.78803851486285 2.45385864783891 -0.66582013297606 0.858882508107037 1.13321439248255 0.679434631574929 0.775216780748647 0.587550014712958 0.0683624583298975 NA NA 0.776510236247415 0.101838664894096 90.6527999345367 a103 TP53_mut 300 CX-5461 RNA Pol I 17 12 2.32630161961136 NA 2.08504982683369 1.00374082921461 1.08130899761908 0.977824496343738 1.82863435269159 0.778558486973012 1.10583136509904 0.591320509771396 0.0688924941124922 NA NA 0.429233276870224 0.0807680517803634 90.6527999345367 a104 loss_cnaDLBC2 177 GSK-650394 SGK3 4 25 2.77258872223978 NA 1.92271003376828 3.09316708399491 -1.17045705022664 0.730132040893527 1.19330833541312 1.01682934159498 1.60307586117471 0.980850477191574 0.0691185405849502 NA NA 0.819305579888986 0.0365063946217793 90.6527999345367 a105 loss_cnaDLBC4_(CDKN2A) 305 TPCA-1 IKK 7 22 2.99573227355399 NA 0.248961397865029 1.47745212547273 -1.2284907276077 1.53564123291557 1.41875692499575 0.849844179962464 0.799985505257169 0.86589232162612 0.0692059682645164 NA NA 0.752837727219033 0.0915225660803216 90.6527999345367 a106 TP53_mut 133 Doxorubicin DNA intercalating 16 13 0.0237165266173161 NA -1.99000858967226 -2.92023773133755 0.930229141665288 1.0709447161763 1.33560232833099 0.777898281575112 0.868606126548326 0.696486612768734 0.0693359767095498 NA NA 0.392295646502188 0.0535957879621735 90.6527999345367 a107 TP53_mut 1261 rTRAIL TR10A (DR4), TR10B (DR5) 18 12 -2.30258509299405 NA -1.79527292972887 -0.913358006832842 -0.881914922896032 1.53361638822774 0.663237068910429 0.697041003494889 0.575055750359566 1.32971295519542 0.07036110672895 NA NA 0.988069994619795 0.0409612522572861 90.6527999345367 a108 TP53_mut 1052 RO-3306 CDK1 19 13 1.6094379124341 NA 2.95279423712469 3.40401294884292 -0.451218711718224 0.936336610752036 0.616530267951981 0.547957365464932 0.481897969743829 0.731867898744215 0.0707678038645651 NA NA 0.218272277592465 0.110741720169189 90.6527999345367 a109 loss_cnaDLBC2 229 LY317615 PRKCB (PKCbeta) 4 25 2.99573227355399 2.32630161961136 2.944747083295 2.09757232611362 0.847174757181382 0.408411550911627 0.999152079089741 0.890080270629587 2.07431634901211 0.847893703982666 0.0709911196552376 NA NA 0.147150460262053 0.0137198790159865 90.6527999345367 a110 ARID1A_mut 1262 UNC1215 LMBL3 3 27 0 NA 2.20190963480943 1.68846640143467 0.513443233374761 0.162650940716859 0.476940351318913 1.11220973229537 3.15671849859485 1.07653552892915 0.0712634695234524 NA NA 0.540287779380985 0.00559232130520492 90.6527999345367 a111 loss_cnaDLBC4_(CDKN2A) 196 Phenformin AAPK1 (AMPK) agonist 7 22 8.29404964010203 NA 6.81281247321011 5.59494733018925 1.21786514302086 1.37924188841282 1.51162250944167 0.82109208734444 0.882996052579532 0.805667509853824 0.0738086299890873 NA NA 0.912458103020929 0.0723746094702845 90.6527999345367 a112 loss_cnaDLBC2 185 OSI-906 IGF1R 4 25 0.940007258491471 NA 0.9899422297949 2.44772761862071 -1.45778538882581 2.95763301311507 1.00944098297918 1.06384827932274 0.492889206457166 1.44415118209627 0.073880431973903 NA NA 0.311810375779329 0.398370561242565 90.6527999345367 a113 MLL2_mut 265 Tubastatin A HDAC6 8 20 2.99573227355399 NA 2.3291459142727 3.15744069894625 -0.828294784673553 0.574334679005017 1.21840336994181 0.764570254262937 1.44218138822559 0.67981984054518 0.074402931534512 NA NA 0.857608460122387 0.0222271843829515 90.6527999345367 a114 TP53_mut 1067 CCT007093 PPM1D 16 12 1.88706964903238 NA 3.43337533846005 3.84677230097644 -0.4133969625164 0.628095533704781 0.595250856121698 0.672831261789211 0.658175293936583 0.694492008310327 0.0751411037436109 NA NA 0.808531343333854 0.0881578350928964 90.6527999345367 a115 TP53_mut 303 PIK-93 PI4K, PI3K 17 12 2.99573227355399 NA 0.144749516472739 1.24607145613738 -1.10132193966464 1.50790295186735 1.43952334201273 0.743922366069525 0.730366591762945 0.765060147010039 0.0753624373302285 NA NA 0.563747031427868 0.0579092112247018 90.6527999345367 a116 MLL2_mut 165 DMOG Prolyl-4-Hydroxylase 9 21 8.29404964010203 NA 4.39758129950413 5.51455014272907 -1.11696884322495 0.617632171028264 1.77724814094949 0.726293992464151 1.80846933760812 0.628482212184624 0.0757858511683867 NA NA 0.903069683558303 0.0169005859762071 90.6527999345367 a117 TP53_mut 206 Ruxolitinib JAK1, JAK2, TYK2 17 12 1.65632149833295 0.0237165266173161 3.29159730239152 2.3740286039689 0.917568698422616 0.804803976030656 1.96385911175654 0.656228130586957 1.14011451949843 0.467227355022384 0.0757969143973479 NA NA 0.7469795649892 0.14880156416589 90.6527999345367 a118 PTEN_mut 9 MG-132 Proteasome 4 23 0 NA 0.505658479009532 -0.768791153654468 1.274449632664 1.52352075031461 0.94169013319547 1.23849738564577 0.836516097598815 1.35336411388252 0.0760862506547335 NA NA 0.0646194954344999 0.192673794213331 90.6527999345367 a119 EP300_mut 302 PI-103 PI3Ka, PRKDC (DNAPK) 6 22 2.32630161961136 NA -2.56123346996462 -1.03904297384806 -1.52219049611657 1.15152835305216 2.15180146062693 0.761588507849672 1.32188711817817 0.707402854756438 0.0766109034115251 NA NA 0.4430936857747 0.0343626273102158 90.6527999345367 a120 MLL2_mut 200 LAQ824 HDAC 9 20 0.0237165266173161 NA -4.03459562748635 -3.15972768626587 -0.874867941220478 0.406733258250822 1.40369141211861 0.730183397049958 2.15096238990363 0.623262302289098 0.077798777223686 NA NA 0.938158502443641 0.0170224823038692 90.6527999345367 a121 TP53_mut 1058 GDC0941 PI3K (class 1) 19 13 1.38629436111989 0.693147180559945 -0.361154987293672 1.02699754024082 -1.38815252753449 1.99095054611051 1.87222599538713 0.713948717087191 0.697231043858106 0.74144495961208 0.0782429536952537 NA NA 0.426808481200511 0.0548331338680367 90.6527999345367 a122 PTEN_mut 192 LFM-A13 BTK 5 24 2.77258872223978 NA 4.82389392886868 4.11777680561745 0.706117123251226 0.451388579747815 0.711230363759506 1.03987762297495 1.56432208286201 0.992810711172043 0.0789762224758595 NA NA 0.16854467466102 0.0198438272142202 90.6527999345367 a123 MLL2_mut 235 QL-XII-47 BTK, BMX 9 19 2.32630161961136 NA -0.339030539397427 0.603870356873475 -0.942900896270902 1.10532210272871 1.18545050233584 0.811876541827413 0.853055316584336 0.79539457312894 0.0802351332569181 NA NA 0.318747631944711 0.0552803847513433 90.6527999345367 a124 MLL2_mut 135 Gemcitabine DNA replication 9 19 0.0237165266173161 NA -4.7033301166744 -2.88338251945654 -1.81994759721785 1.22105552490731 2.54316691573216 0.819131735295663 1.49047079358328 0.715622551535869 0.082321229074666 NA NA 0.222326412410067 0.0167027396170848 90.6527999345367 a125 TP53_mut 266 Zibotentan, ZD4054 Endothelin A Receptor 17 12 2.99573227355399 NA 4.61202006884732 5.00968262612914 -0.397662557281822 0.602034420463824 0.626630973139485 0.649590152902172 0.660531264932414 0.634604056179176 0.0823590745843594 NA NA 0.812329119721023 0.100482899180014 90.6527999345367 a126 TP53_mut 1030 KU-55933 ATM 19 13 2.30258509299405 NA 2.88641904549955 3.47365176157336 -0.587232716073815 0.999227058085626 0.589172428929195 0.683604432722105 0.587686963960791 0.996707733152236 0.0829854769803731 NA NA 0.598396083837553 0.0457317660255864 90.6527999345367 a127 CREBBP_mut 1259 BMN-673 PARP1 6 24 2.30258509299405 NA 3.42893175769904 2.33069947498556 1.09823228271348 1.37505750480102 1.4279203833272 0.774152600895638 0.798680985252612 0.76911310710089 0.0830650092076538 NA NA 0.496538787773008 0.121040463397672 90.6527999345367 a128 CREBBP_mut 1192 GSK269962A ROCK1, ROCK2 6 24 1.6094379124341 NA 2.6392769607846 1.43467986322762 1.20459709755698 0.655150182153531 1.54666935344098 0.843044401260063 1.83865796022123 0.778832977376213 0.0834080882390832 NA NA 0.811977238703344 0.00859289211325449 90.6527999345367 a129 ARID1A_mut 119 Lapatinib ERBB2, EGFR 3 25 0.693147180559945 NA 3.13699458066634 2.4442306497313 0.692763930935034 0.177195786887338 0.7008244194659 1.02613229732973 3.90959595092122 0.988498562112021 0.0841026119070888 NA NA 0.317399755747367 0.00158048208228541 90.6527999345367 a130 EP300_mut 1053 MK-2206 AKT1, AKT2 6 26 1.38629436111989 0.693147180559945 -0.552890223684368 1.00005239965074 -1.55294262333511 1.00880474049594 1.80506789023597 0.91431233014517 1.53938870526288 0.860323665240148 0.0848498212055603 NA NA 0.208285893805023 0.0128906337226009 90.6527999345367 a131 EP300_mut 1066 AZD6482 PI3Kbeta 6 22 1.6094379124341 NA 0.595277564446127 1.77737138065077 -1.18209381620464 1.58658014710494 1.36585705382087 0.837777430235527 0.745057738407753 0.865459392619334 0.0854211138916112 NA NA 0.886061655173785 0.139018128504684 90.6527999345367 a132 TP53_mut 302 PI-103 PI3Ka, PRKDC (DNAPK) 16 12 2.32630161961136 NA -1.87015987790629 -0.691982349828701 -1.17817752807759 1.82178522747242 2.24593961194281 0.585523941119095 0.646715930237403 0.524581124894283 0.0866409496913546 NA NA 0.444927278394657 0.152010233155942 90.6527999345367 a133 TP53_mut 1072 BMS-708163 g-secretase 16 12 1.6094379124341 NA 3.21247940133812 3.56760259195969 -0.355123190621567 0.660678988468546 0.664130170625827 0.536325390065561 0.537512463420007 0.53471925584547 0.0866918209036641 NA NA 0.244440378371364 0.173437075628984 90.6527999345367 a134 MLL2_mut 274 PXD101, Belinostat HDAC 8 20 2.99573227355399 NA -2.16860030981264 -1.16121349248616 -1.00738681732648 0.742092518333399 1.50531304694035 0.749994607075519 1.35749491126643 0.669220810497897 0.0871873765755067 NA NA 0.964628155763788 0.0265260869014553 90.6527999345367 a135 CREBBP_mut 1230 IOX2 EGLN1 6 24 -2.30258509299405 NA -1.44378738472837 -0.460819047223438 -0.982968337504928 2.41698026024088 0.591011517802651 0.852310244645715 0.406692745354472 1.66319658398461 0.0873251993371799 NA NA 0.555694492826558 0.36689924276376 90.6527999345367 a136 TP53_mut 1029 AMG-706 VEGFR, RET, c-KIT, PDGFR 19 13 0.693147180559945 NA 2.52069766380118 2.82744466895089 -0.306747005149715 0.625546364624167 0.478964995719306 0.536793016876146 0.490366537952804 0.640437209172342 0.0885601473030724 NA NA 0.332178040483205 0.127395301236141 90.6527999345367 a137 PTEN_mut 1 Erlotinib EGFR 4 23 0.693147180559945 NA 2.98674211929966 2.09189776106973 0.894844358229931 0.180683401999643 0.831577567770282 1.14343098906002 4.95255429290454 1.0760804438596 0.0892794004853559 NA NA 0.165206103902305 0.000132545972730221 90.6527999345367 a138 CREBBP_mut 302 PI-103 PI3Ka, PRKDC (DNAPK) 5 23 2.32630161961136 NA -2.86623033476216 -1.03892150307105 -1.82730883169111 0.839636690069003 2.11332013170219 0.926781849963377 2.17630893611966 0.864662577278003 0.0894282300281423 NA NA 0.445395778984253 0.00582793421487664 90.6527999345367 a139 MLL2_mut 167 OSU-03012 PDPK1 (PDK1) 9 20 2.77258872223978 NA 1.05135048311393 1.47745210479127 -0.426101621677333 0.415792267635385 0.573372292529054 0.801584199068072 1.02479448235192 0.743150004332904 0.0900924990265175 NA NA 0.134181922874456 0.0347682210555295 90.6527999345367 a140 EP300_mut 283 GSK2126458 PI3K, MTOR 6 23 -2.05572501506252 0.0237165266173161 -5.61444703463314 -4.21762064080722 -1.39682639382592 1.17907596035015 1.76989936956277 0.83329289101274 1.18467888482019 0.789212323506837 0.0914814294619758 NA NA 0.741515004217499 0.040522425250306 90.6527999345367 a141 EP300_mut 1248 FK866 NAMPT 6 22 0 NA -2.77688183580904 -4.77671978568012 1.99983794987108 3.33162416326014 2.95444469075931 0.659875962948999 0.600259168463393 0.676891314339381 0.0922857680984369 NA NA 0.21757670130961 0.22228241058295 90.6527999345367 a142 TP53_mut 238 CAL-101 PI3Kdelta 17 12 2.99573227355399 2.32630161961136 2.26110311946898 3.4253713256033 -1.16426820613432 2.24122421594521 1.32185365082273 0.606216608995145 0.519478683949209 0.880784499410861 0.0924449119537892 NA NA 0.659352062949094 0.0912242502416774 90.6527999345367 a143 ARID1A_mut 1032 Afatinib ERBB2, EGFR 3 27 -0.693147180559945 NA 1.6916189176361 1.02135148617914 0.670267431456952 0.147461416880605 0.689851430214181 1.00652136084421 4.54537495729914 0.971611280488106 0.093021765882885 NA NA 0.386032552802613 0.000596776749989703 90.6527999345367 a144 TP53_mut 134 Etoposide TOP2 17 13 2.77258872223978 NA 1.09390118041738 -0.169932614771197 1.26383379518857 2.03372389544413 1.57814975213563 0.682323677482702 0.621438238504137 0.800832616472737 0.0931591210532537 NA NA 0.592009287152339 0.0655676869567557 90.6527999345367 a145 loss_cnaDLBC2 194 AUY922 HSP90 4 25 -1.36257783450257 NA -4.04008949120091 -2.93381935660768 -1.10627013459323 0.168202464821372 1.20459929347168 0.972895646154975 6.57701500253322 0.91837189394735 0.09348786562394 NA NA 0.692253627767175 0.000181384162404124 90.6527999345367 a146 ARID1A_mut 1014 RDEA119 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 29 1.6094379124341 NA 1.65748832198325 2.89318802533494 -1.23569970335168 1.38431350477526 1.13453801469055 1.07184232028881 0.89264440395118 1.08916553465044 0.094513857409466 NA NA 0.857741602089713 0.258334709045442 90.6527999345367 a147 EP300_mut 310 YM201636 FYV1 6 23 1.63315443905142 NA 0.323249344175526 1.03163582766952 -0.708386483493992 1.19618521583816 0.797022024612956 0.800766386854382 0.592204680441253 0.888791603767779 0.0947713402138037 NA NA 0.934308234036653 0.217220278861971 90.6527999345367 a148 TP53_mut 293 MP470 PDGFR 17 11 2.99573227355399 NA 2.7727968354041 1.51922048113324 1.25357635427086 1.47780965171752 2.04656156219429 0.729257418279407 0.848266454894208 0.612528045785635 0.0956930737687592 NA NA 0.468468829536629 0.0972920638335052 90.6527999345367 a149 MLL2_mut 331 QL-X-138 MNK2, PRKDC (DNAPK), MTOR, BTK, JAK3 9 20 2.32630161961136 NA -0.874485893505923 0.0453781331301663 -0.919864026636089 1.08146645596668 1.31529809422762 0.735549308313693 0.850571020082042 0.69935783429859 0.0961653151887189 NA NA 0.577507779859685 0.0629520804901798 90.6527999345367 a150 TP53_mut 1529 MLN4924 NEDD8-activating enzyme 17 10 0 NA 0.75391123762113 -0.154106707028041 0.908017944649171 1.32390841217492 1.70123106968031 0.617305638556607 0.68586160213113 0.533741689081545 0.097140173931941 NA NA 0.53409606726642 0.167241464606241 90.6527999345367 a151 ARID1A_mut 221 TAK-715 p38a 3 26 2.99573227355399 2.32630161961136 3.23097609129251 2.74048931594777 0.490486775344739 0.815816771818924 0.579538972974864 0.817152275123254 0.601221735428609 0.846339587529366 0.0974333937878998 NA NA 0.0192642896011322 0.408062749601452 90.6527999345367 a152 loss_cnaDLBC4_(CDKN2A) 1236 UNC0638 G9a(EHMT2), GLP(EHMT1) 7 23 2.99573227355399 NA 3.01915551261508 1.95136914343738 1.06778636917769 1.34016091496188 1.40338228863617 0.768149119549188 0.79675981985198 0.760866356818133 0.0976775388429382 NA NA 0.73330821230183 0.0968847190428301 90.6527999345367 a153 PTEN_mut 5 Sunitinib PDGFRA, PDGFRB, KDR, KIT, FLT3 4 21 2.07944154167984 NA 3.08361705079166 1.67003683242241 1.41358021836924 1.35873926137738 1.12698027441483 1.21877282759227 1.04036164888344 1.2543078618685 0.0980093867795088 NA NA 0.0137036849344142 0.125228573041776 90.6527999345367 a154 TP53_mut 249 XL-184 VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL 17 12 1.63315443905142 NA 1.84892846607044 2.50900247595983 -0.660074009889387 1.09021805453012 1.12837559261136 0.596853683559503 0.605451365574641 0.584977213448762 0.0984782093627411 NA NA 0.678381753174116 0.129122227518259 90.6527999345367 a155 TP53_mut 193 GW-2580 CSF1R (cFMS) 17 12 2.99573227355399 NA 4.77977177764153 4.37647564545304 0.403296132188493 0.540684028307036 0.641275857170821 0.690857060100211 0.745899843668908 0.62889648452969 0.0986100793500123 NA NA 0.570430242235639 0.08983381284628 90.6527999345367 a156 CREBBP_mut 1199 Tamoxifen ER 6 24 1.6094379124341 NA 2.30849743626176 3.01232568268856 -0.703828246426796 1.85975981515444 0.542806867940719 0.759111424885034 0.378451153042226 1.29664580165862 0.0987165493040925 NA NA 0.707840548863459 0.399424247740351 90.6527999345367 a157 loss_cnaDLBC4_(CDKN2A) 1067 CCT007093 PPM1D 7 21 1.88706964903238 NA 3.94948916005942 3.49756423365058 0.451924926408839 0.649597396193003 0.607572402015367 0.731833343059789 0.695700027520688 0.743820695129943 0.0989176465530519 NA NA 0.810222607890766 0.137136287305288 90.6527999345367 a158 MLL2_mut 276 CAY10603 HDAC6 9 20 2.99573227355399 NA -1.49072173979208 -0.517849867547589 -0.97287187224449 0.613942520960493 1.66190589062718 0.678612671837285 1.58463022030542 0.585395284854153 0.0990049488592803 NA NA 0.923161236007018 0.0300102593173409 90.6527999345367 a159 PTEN_mut 89 Parthenolide NFKB1 4 23 1.6094379124341 NA 3.44878032082565 2.0515725477263 1.39720777309935 0.488156424979861 1.2567289417517 1.1731556668915 2.86221322019267 1.1117813290365 0.0992551514040245 NA NA 0.0534750754468207 0.00217987809942647 90.6527999345367 a160 MLL2_mut 299 OSI-027 MTORC1/2 9 20 2.99573227355399 NA -2.18582394703137 -0.968146926616005 -1.21767702041537 1.19161856492717 1.78740481073725 0.745355436130163 1.0218681180834 0.681254192167646 0.0992759581264771 NA NA 0.418421917435354 0.0415302537210958 90.6527999345367 a161 loss_cnaDLBC4_(CDKN2A) 136 Mitomycin C DNA crosslinker 8 21 2.77258872223978 NA -1.96533814595259 -1.06134711991485 -0.90399102603774 0.830727428728849 1.27091955438528 0.77081727861377 1.0881921010132 0.711288942654581 0.100492455094854 NA NA 0.363275233588991 0.0370188011757325 90.6527999345367 a162 ARID1A_mut 150 Bicalutamide ANDR (androgen receptor) 3 26 0.0237165266173161 NA 2.44150561438915 1.95808004301902 0.483425571370133 0.211264393346875 0.502991107753862 0.991831726262568 2.28824916357958 0.961101625690561 0.10072428070205 NA NA 0.443903964405538 0.0254546694563836 90.6527999345367 a163 CREBBP_mut 1129 PF-4708671 RPS6KB1 (p70S6KA) 6 23 2.30258509299405 NA 4.00213814655402 3.45232804720841 0.549810099345612 0.676486114263073 0.759809617682414 0.737918231265912 0.812744101842423 0.723615609160954 0.102590067176448 NA NA 0.582762058341572 0.11975161571534 90.6527999345367 a164 TP53_mut 9 MG-132 Proteasome 16 11 0 NA -0.775807086107105 -0.295149930936452 -0.480657155170653 1.13923964935027 1.05037670902557 0.435159999804808 0.421910486915357 0.457604544198771 0.102859923479869 NA NA 0.0672232175132099 0.270857188089775 90.6527999345367 a165 TP53_mut 1032 Afatinib ERBB2, EGFR 17 13 -0.693147180559945 NA 0.93594791937526 1.28771017310506 -0.351762253729797 0.717644917718599 0.610873885170379 0.521933178446252 0.490161979893974 0.575834492632938 0.104020095674028 NA NA 0.387608509586505 0.15882364728832 90.6527999345367 a166 loss_cnaDLBC2 51 Dasatinib ABL, SRC, KIT, PDGFR 4 20 0.246860077931526 NA 1.37667348056952 -0.610099201434293 1.98677268200381 0.412934331000351 2.74180736466862 0.778340222314844 4.811352636122 0.724621542565567 0.10453008057961 NA NA 0.152291038935189 0.00563290958253802 90.6527999345367 a167 loss_cnaDLBC4_(CDKN2A) 1030 KU-55933 ATM 8 24 2.30258509299405 NA 3.58789746378662 2.97067729394384 0.61722016984278 0.440981668126405 0.958994210971828 0.712488192612351 1.3996504037575 0.643611987206159 0.108124358316852 NA NA 0.60109588598553 0.0204332836776498 90.6527999345367 a168 MLL2_mut 272 AR-42 HDAC 8 20 1.63315443905142 NA -2.44826473483123 -1.55007180461755 -0.89819293021367 0.580698167774974 1.46646812189721 0.696644669450492 1.54674662338823 0.612487183868447 0.108355364692513 NA NA 0.9852122439184 0.0283616632713907 90.6527999345367 a169 CREBBP_mut 1020 Lenalidomide TNFA 7 23 1.6094379124341 NA 3.49841372555749 2.97765354626442 0.520760179293071 0.424768906914013 0.895408380137856 0.636868627689177 1.22598469618797 0.581589575041609 0.10848357877078 NA NA 0.314321580499523 0.0459229671685412 90.6527999345367 a170 loss_cnaDLBC4_(CDKN2A) 230 GSK429286A ROCK2 7 22 2.99573227355399 2.32630161961136 4.04498615357184 3.59189150731209 0.453094646259744 1.0780272879873 0.634944089540457 0.599183644330133 0.420299793250764 0.713597706827498 0.109107891545193 NA NA 0.171620699423717 0.324644585009681 90.6527999345367 a171 EP300_mut 229 LY317615 PRKCB (PKCbeta) 6 23 2.99573227355399 2.32630161961136 1.76111388548568 2.33267883361332 -0.571564948127648 1.42937696249237 0.830235248918843 0.589524405179145 0.399869987502124 0.688437342153271 0.109182556143011 NA NA 0.152471137656319 0.384499665541394 90.6527999345367 a172 EP300_mut 135 Gemcitabine DNA replication 5 23 0.0237165266173161 NA -1.73483991307318 -3.84521910236426 2.11037918929108 3.03712975609757 2.06029454068007 0.942766368764046 0.694859738888047 1.0243094604301 0.110326761449267 NA NA 0.226628660009009 0.200566214191651 90.6527999345367 a173 loss_cnaDLBC2 283 GSK2126458 PI3K, MTOR 4 25 -2.05572501506252 0.0237165266173161 -3.16708608620654 -4.72094450406155 1.55385841785501 1.58062948627994 1.69964180870163 0.921169130930671 0.983063033647472 0.914226991769528 0.110345714259833 NA NA 0.742967867164158 0.14186241886386 90.6527999345367 a174 ARID1A_mut 1028 VX-702 p38 3 27 0.693147180559945 NA 2.7109124871937 1.96536041923509 0.745552067958611 0.169733801451499 0.801697018769713 0.963413232112895 4.39247846676933 0.929967369845952 0.11041599143862 NA NA 0.460550502080477 0.00083156026448967 90.6527999345367 a175 TP53_mut 55 A-770041 SRC family 15 10 1.63315443905142 NA 0.831580424579952 2.23916315505166 -1.40758273047171 2.86501442970392 1.96029801693304 0.552097112861419 0.491300398308003 0.718045275928979 0.110422892469181 NA NA 0.334681898436269 0.158271327095966 90.6527999345367 a176 PTEN_mut 1527 GDC0941 (rescreen) PI3K 5 22 1.38629436111989 NA -0.296086842853056 1.06185817155104 -1.3579450144041 1.68700347461055 1.34272795160713 0.967542832270016 0.804945001501898 1.01133294557453 0.110424808036478 NA NA 0.14289815357404 0.150819971113084 90.6527999345367 a177 loss_cnaDLBC2 1495 AZD-2281 PARP1, PARP2 3 27 2.30258509299405 NA 4.22623626497741 3.41633942421593 0.809896840761481 0.447699416354945 0.873076155884338 0.953062918096682 1.80901920166762 0.927635963143601 0.11163600417617 NA NA 0.415338719499615 0.0584775529837661 90.6527999345367 a178 CREBBP_mut 263 FR-180204 ERK 6 23 2.99573227355399 NA 4.12480826213032 4.71722011548507 -0.592411853354749 1.00542760976279 0.652969895129453 0.810221755150017 0.589213830615328 0.907257528675655 0.111792894976347 NA NA 0.410428797316816 0.218678435372514 90.6527999345367 a179 MLL2_mut 310 YM201636 FYV1 9 20 1.63315443905142 NA 0.484334401095657 1.06540552457956 -0.5810711234839 0.61002227140641 0.985282735202632 0.652352631060835 0.952540834524348 0.589750639814466 0.11262592674032 NA NA 0.934659732314534 0.0644957022338549 90.6527999345367 a180 TP53_mut 283 GSK2126458 PI3K, MTOR 17 12 -2.05572501506252 0.0237165266173161 -4.95546649614006 -3.87075220933198 -1.08471428680808 1.81385733668966 1.48427084810397 0.64284300063726 0.598015215897691 0.73080616532603 0.112852451172592 NA NA 0.743139705150959 0.0889398284680888 90.6527999345367 a181 PTEN_mut 1264 SGC0946 Q8TEK3 (DOT1L) 5 25 -0.693147180559945 NA 0.850810940671653 1.25479393107665 -0.403982990404994 0.574394212481209 0.532714453298121 0.749690837316678 0.703320092066927 0.758348094187927 0.113054041894322 NA NA 0.758231721730041 0.201181481348002 90.6527999345367 a182 TP53_mut 51 Dasatinib ABL, SRC, KIT, PDGFR 14 10 0.246860077931526 NA -0.796515728601526 0.445593009401358 -1.24210873800288 3.08519911696636 1.62487534869456 0.479702725253212 0.402602454788796 0.764433246526142 0.113218094301932 NA NA 0.153494345505348 0.215314164452199 90.6527999345367 a183 ARID1A_mut 300 CX-5461 RNA Pol I 3 26 2.32630161961136 NA 0.306784201041345 1.79116863090862 -1.48438442986727 2.46882065607643 1.29907019676418 1.04594711854885 0.601252434523262 1.14265143913291 0.115098233252745 NA NA 0.43659544343626 0.407432096159414 90.6527999345367 a184 loss_cnaDLBC2 326 GSK690693 AKT 4 24 2.32630161961136 NA 2.79362248535901 0.598890477561148 2.19473200779787 0.806924276243008 2.58633752596583 0.896560021026482 2.71987356486089 0.848586847526128 0.115295163959995 NA NA 0.949632741494422 0.00450146110053355 90.6527999345367 a185 loss_cnaDLBC4_(CDKN2A) 225 Genentech Cpd 10 AURKA, AURKB 7 22 2.32630161961136 NA 0.822231328883248 1.49070802796948 -0.668476699086234 1.0895092773537 1.04816198876208 0.632135246652716 0.613557601556078 0.637760867359567 0.115489712439587 NA NA 0.361386370691776 0.184684382999365 90.6527999345367 a186 EP300_mut 51 Dasatinib ABL, SRC, KIT, PDGFR 5 19 0.246860077931526 NA -1.53296487381744 0.0510281190883902 -1.58399299290583 3.67989798552285 2.26572961749176 0.613679804417047 0.430444811007653 0.699109452724268 0.115708141184363 NA NA 0.153821250011934 0.402248266504493 90.6527999345367 a187 EP300_mut 223 ZSTK474 PI3K 6 23 1.63315443905142 2.32630161961136 -1.73843211946055 -0.435494431762892 -1.30293768769766 2.29991870942956 1.64036349361493 0.731565294271348 0.566514669564485 0.794298149629217 0.116524598666085 NA NA 0.91812099485951 0.237287221205136 90.6527999345367 a188 TP53_mut 1025 SB 216763 GSK3A, GSK3B 17 13 2.30258509299405 NA 3.9682659796477 4.33462074235865 -0.366354762710944 0.801341172824836 0.568696602913554 0.515252977129553 0.45717701165846 0.644200722905729 0.116980162433424 NA NA 0.46981884886177 0.154472377800468 90.6527999345367 a189 EP300_mut 1017 Olaparib PARP1, PARP2 5 25 1.6094379124341 NA 3.63435336985683 2.88031108290062 0.754042286956205 0.493472199881886 0.881917636529039 0.900317518244529 1.52803397463259 0.85500307026843 0.118876049073065 NA NA 0.296104036118835 0.0234211203532124 90.6527999345367 a190 TP53_mut 179 5-Fluorouracil DNA antimetabolite 17 12 3.46573590279973 NA 2.02233600952002 1.15274849178358 0.869587517736447 1.38853537432055 1.6716221598988 0.57577675528902 0.626262415649268 0.520205784894054 0.119023044386916 NA NA 0.796231483702235 0.154374950480545 90.6527999345367 a191 MLL2_mut 152 CP466722 ATM 9 20 2.77258872223978 NA 1.04301218578334 1.75210540223738 -0.709093216454033 1.24675224692291 0.931272809612422 0.685230717451004 0.568752306806853 0.761423730119581 0.119545847865151 NA NA 0.610662584739225 0.152644968886811 90.6527999345367 a192 loss_cnaDLBC2 260 NG-25 MAP3K7 (TAK1) 4 25 2.32630161961136 NA 1.79664414798348 0.67532488723436 1.12131926074912 0.354448941521129 1.50059548384621 0.789828410172124 3.16355652223685 0.747249523819065 0.120156915124111 NA NA 0.295103756386352 0.00394768409922363 90.6527999345367 a193 MLL2_mut 1114 Cetuximab EGFR 9 19 4.18661983833127 NA 6.25161174332176 5.94722763697074 0.304384106351021 0.572704386513198 0.526860938703754 0.562237195670047 0.531485550868932 0.577731397396632 0.120573518708809 NA NA 0.365886730673772 0.198400912102472 90.6527999345367 a194 ARID1A_mut 292 Masitinib KIT 3 26 2.99573227355399 NA 2.15087028448981 2.78140771362191 -0.630537429132096 0.811103615574013 0.650565471205409 0.94990496263088 0.777382096473419 0.969214409679315 0.120770446159641 NA NA 0.569540710443993 0.308529842625313 90.6527999345367 a195 TP53_mut 1033 Vismodegib SMO 17 13 2.30258509299405 NA 3.64074498532182 4.00167465567517 -0.360929670353344 0.699992326402944 0.663586721900836 0.527191686623264 0.515619467156242 0.543907312249205 0.12094879855953 NA NA 0.582085385783823 0.161105562330988 90.6527999345367 a196 PTEN_mut 32 VX-680 AURKA, AURKB, AURKC, FLT3, ABL1, JAK2 4 20 0.693147180559945 NA 2.21454007481409 0.219170606340413 1.99536946847368 0.954618479794532 1.87965927570384 1.11972295319357 2.09022715431107 1.06155913162853 0.120957430643318 NA NA 0.0549543838998763 0.0125985335160624 90.6527999345367 a197 loss_cnaDLBC2 203 BMS-345541 IKBKB 4 25 2.77258872223978 NA 2.33741339876074 1.79409779271322 0.543315606047515 0.414431919439012 0.693077772009054 0.813489310989541 1.31098880313796 0.783917228325739 0.121535388338196 NA NA 0.448312654383793 0.0711566729541864 90.6527999345367 a198 CREBBP_mut 155 AP-24534 ABL 7 22 -0.669430653942629 NA -1.61281611404963 -0.316437561004218 -1.29637855304541 1.8469421828058 1.63389223297562 0.770018425905071 0.701905324982079 0.793429656425054 0.121987259277978 NA NA 0.213636094043931 0.130220429862264 90.6527999345367 a199 TP53_mut 186 Bexarotene Retinioic acid X family agonist 16 13 2.07944154167984 NA 2.9195501695752 3.49819814740026 -0.578647977825062 0.966063446815327 0.57995820289874 0.708000344643698 0.598975129151819 0.997740828447413 0.122155890945611 NA NA 0.171321528628558 0.0571153845501366 90.6527999345367 a200 loss_cnaDLBC2 63 BMS-509744 ITK 4 21 2.32630161961136 NA 2.11480539879977 2.89734018789801 -0.782534789098238 1.16523330715338 0.744407010170402 0.963991579775671 0.671569190731376 1.05121899499456 0.122868241966953 NA NA 0.0758972811347968 0.274889742937245 90.6527999345367 a201 TP53_mut 1028 VX-702 p38 17 13 0.693147180559945 NA 1.8691134066368 2.26327237446946 -0.394158967832657 0.823482312032964 0.723107560828285 0.504011455151904 0.478648978943556 0.545090369932194 0.123155151725856 NA NA 0.46198541204938 0.174943507538693 90.6527999345367 a202 loss_cnaDLBC4_(CDKN2A) 1192 GSK269962A ROCK1, ROCK2 7 23 1.6094379124341 NA 2.45595449175036 1.43809987130078 1.01785462044959 0.902924723185842 1.5620469297115 0.703755574388632 1.12728624470292 0.651615902883006 0.125006682721306 NA NA 0.814202091783072 0.0448280447018602 90.6527999345367 a203 loss_cnaDLBC2 91 KIN001-135 IKKE 3 24 1.6094379124341 NA 3.8763768250365 3.30912162229103 0.567255202745478 0.344057102396185 0.619720579744281 0.941770859415903 1.6487240019021 0.915340269931891 0.125018375182593 NA NA 0.567948897341018 0.0753770873592993 90.6527999345367 a204 MLL2_mut 290 KIN001-260 IKK 9 20 2.99573227355399 NA 2.66778752092066 3.29094819100757 -0.623160670086913 1.08974836308913 0.858441077772406 0.667929022649229 0.571839051283753 0.72592130808089 0.126658940055765 NA NA 0.656146413539588 0.153862829851976 90.6527999345367 a205 MLL2_mut 273 CUDC-101 HDAC, EGFR 8 20 1.63315443905142 NA -2.82204418078926 -1.84946132825129 -0.972582852537969 0.757205454712135 1.62431732800759 0.673970865923974 1.28443719796989 0.598764068921774 0.126821047898624 NA NA 0.885615641468156 0.0408950755420843 90.6527999345367 a206 TP53_mut 197 Bryostatin 1 PRKC 16 13 -4.8283137373023 NA -3.53511873492998 -3.04591398170862 -0.489204753221359 1.09724944089356 0.724942551771328 0.514969855052198 0.445846436543151 0.674818648768836 0.126898143186583 NA NA 0.5448285785676 0.162233549374041 90.6527999345367 a207 TP53_mut 1038 NU-7441 PRKDC (DNAPK) 19 13 0.693147180559945 NA 1.54452619647816 2.06831507061151 -0.523788874133345 1.13657235725762 0.755460607512989 0.522909471784899 0.4608495629765 0.693337109737173 0.127279787426892 NA NA 0.671749150004002 0.127867624582189 90.6527999345367 a208 ARID1A_mut 1149 TW 37 BCL2, BCL2L1 3 27 1.6094379124341 NA -0.432272423778886 -1.06312089717978 0.630848473400897 1.13034637639483 0.614251632579412 0.94929629302653 0.558101911568869 1.0270196120632 0.127489995619074 NA NA 0.751454837573886 0.436477893210181 90.6527999345367 a209 TP53_mut 156 AZD6482 PI3Kbeta 17 13 1.63315443905142 NA 1.23644219898099 2.19644826369316 -0.960006064712174 1.99573056577279 1.31297172217014 0.55289963845299 0.481029895105324 0.73117040413135 0.128705786129832 NA NA 0.857981746228875 0.124425730123578 90.6527999345367 a210 CREBBP_mut 294 MPS-1-IN-1 MPS1 6 23 2.99573227355399 NA 3.23811221290112 2.60433893536439 0.63377327753673 1.04299898347754 0.859374220444993 0.707161215866076 0.607645153616183 0.737482301026619 0.128811491689693 NA NA 0.81091079592805 0.213163749971537 90.6527999345367 a211 loss_cnaDLBC2 312 AV-951 VEGFR 4 25 -2.05572501506252 NA -0.0490199911714586 -0.429756212951088 0.38073622177963 0.348719135300796 0.517439277654527 0.759189486898786 1.09181339145962 0.735808505889713 0.129430248764571 NA NA 0.253944155851078 0.114882324507075 90.6527999345367 a212 loss_cnaDLBC2 197 Bryostatin 1 PRKC 4 25 -4.8283137373023 NA -2.65899906807069 -3.42091140995236 0.761912341881666 0.201202299887878 0.999148588486203 0.80677655329167 3.78679737908686 0.762561595604142 0.130081280904898 NA NA 0.545129916958925 0.00224341121947289 90.6527999345367 a213 loss_cnaDLBC4_(CDKN2A) 231 FMK RSK 6 22 2.99573227355399 2.32630161961136 4.88243172618646 4.48125714376692 0.401174582419548 0.94023446166854 0.606847507073814 0.586766085956845 0.426675046251362 0.661079723889763 0.130401127582625 NA NA 0.135267907025551 0.359152545467191 90.6527999345367 a214 MLL2_mut 224 AS605240 PI3Kgamma 9 20 2.99573227355399 2.32630161961136 1.6620508322556 2.5266184735695 -0.864567641313902 1.62703912592203 1.00899384214036 0.705730501088163 0.531374831458928 0.856861167239547 0.130680085421121 NA NA 0.246617935306722 0.16941001660086 90.6527999345367 a215 EP300_mut 1495 AZD-2281 PARP1, PARP2 6 24 2.30258509299405 NA 4.02386140503227 3.36569603410703 0.658165370925238 0.44352030154691 0.907166549892308 0.780481913158283 1.48395770978169 0.725517680301783 0.132004679966486 NA NA 0.417614305021432 0.0211445927217864 90.6527999345367 a216 TP53_mut 1498 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 18 12 1.38629436111989 NA 2.80486069115308 2.29425503210829 0.510605659044786 0.552052019757031 1.09684148916941 0.629626909363525 0.924923088352278 0.465523655046498 0.132799214336031 NA NA 0.498230730007129 0.156875097789647 90.6527999345367 a217 ARID1A_mut 32 VX-680 AURKA, AURKB, AURKC, FLT3, ABL1, JAK2 3 21 0.693147180559945 NA -1.11800295382917 0.79026577559772 -1.90826872942689 2.17521728558155 1.79042961384201 1.04347745209851 0.877277291825449 1.0658161117722 0.134052493956775 NA NA 0.0558254040521095 0.263695669763958 90.6527999345367 a218 loss_cnaDLBC4_(CDKN2A) 1019 Bosutinib SRC, ABL, TEC 8 22 0.693147180559945 NA 0.447503337214678 1.32202184490574 -0.87451850769106 0.746203015263538 1.34853962265851 0.713298959121592 1.17195788519054 0.64849300161239 0.135845741836541 NA NA 0.193898488508756 0.035060182399569 90.6527999345367 a219 MLL2_mut 279 BIX02189 MAP2K5 (MEK5) 9 20 2.99573227355399 NA 2.61144533827075 3.20682274907262 -0.595377410801868 1.01450780598619 0.816189364863737 0.676854296535787 0.586863311734809 0.729459897950602 0.137413699442135 NA NA 0.394318981799058 0.145512400346682 90.6527999345367 a220 loss_cnaDLBC4_(CDKN2A) 1062 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 8 24 1.38629436111989 0.693147180559945 3.27859317278074 2.71313332504004 0.565459847740703 0.706847803618151 0.925457616619363 0.643062451749544 0.799973975792634 0.611005666371077 0.137573409015518 NA NA 0.797016676417865 0.0902596758778257 90.6527999345367 a221 TP53_mut 260 NG-25 MAP3K7 (TAK1) 17 12 2.32630161961136 NA 0.555515132507296 1.21882846001407 -0.663313327506778 1.68159285580187 0.973109472533982 0.461984396249191 0.39445536725385 0.6816430691806 0.138134669331065 NA NA 0.297111439468283 0.191939297373295 90.6527999345367 a222 loss_cnaDLBC4_(CDKN2A) 1023 GW 441756 NTRK1 8 22 0.693147180559945 NA 0.827268442085268 2.12353493718094 -1.29626649509567 2.96497336358069 1.3162308557251 0.693169378818374 0.437193301976317 0.984832173974196 0.138251915281818 NA NA 0.340125561487283 0.26638499001591 90.6527999345367 a223 loss_cnaDLBC2 38 AZD-0530 SRC, ABL1 4 23 0.693147180559945 NA 2.76803147552264 2.01335560445551 0.754675871067137 0.282540718108 1.10248476272599 0.726457836448322 2.67103402341699 0.684522722292445 0.13877019234875 NA NA 0.214076586659468 0.0109933403839963 90.6527999345367 a224 loss_cnaDLBC2 56 WH-4-023 SRC family, ABL 4 21 1.63315443905142 NA 3.18567068431601 1.53322519814402 1.65244548617199 0.735043298587072 2.20599845746101 0.796680830065983 2.24809271691666 0.749069193853325 0.139210404334059 NA NA 0.569988511235909 0.0153036628971585 90.6527999345367 a225 MLL2_mut 204 Tipifarnib Farnesyl-transferase (FNTA) 9 20 2.77258872223978 NA 0.421458873695834 1.32300021853487 -0.901541344839035 1.40525362861885 1.65519754788175 0.56870472770453 0.641550625793519 0.544672958217457 0.139731287222162 NA NA 0.62007488264097 0.148238379149023 90.6527999345367 a226 MLL2_mut 1003 Camptothecin TOP1 8 22 -2.30258509299405 NA -5.85040710159622 -4.77903978394483 -1.07136731765139 1.15073046480609 1.59645316723194 0.715431541379828 0.931032375015743 0.671092230979134 0.140073540190145 NA NA 0.125160996855411 0.0590932163061567 90.6527999345367 a227 TP53_mut 1018 ABT-888 PARP1, PARP2 17 13 1.6094379124341 NA 3.41788563086111 3.68200429806729 -0.264118667206184 0.628873827183762 0.504045940773846 0.456413581074409 0.419986737862771 0.523997211049237 0.142116420162283 NA NA 0.3582718328935 0.212276442753243 90.6527999345367 a228 ARID1A_mut 268 YM155 BIRC5 (Survivin) 3 26 1.63315443905142 NA -5.70769345984951 -4.73561228098861 -0.972081178860908 0.0675608729806177 1.09952499691405 0.91863656304784 14.3882270310478 0.88409193205172 0.142651585991506 NA NA 0.808021585721046 0.000145547357843498 90.6527999345367 a229 loss_cnaDLBC2 1016 Temsirolimus MTOR 3 27 -1.6094379124341 NA -1.88680112811922 -3.52689283129406 1.64009170317484 0.86194783415443 1.87650495192702 0.899735274351642 1.90277373895112 0.874014055486826 0.142724215162465 NA NA 0.640024967318304 0.0488167562656748 90.6527999345367 a230 MLL2_mut 275 I-BET BRD2, BRD3, BRD4 9 20 2.99573227355399 NA 0.812182614832622 1.70665547752404 -0.894472862691417 0.988104758387661 1.50190072815382 0.652945524206454 0.905240922178103 0.59556057595826 0.143157451584675 NA NA 0.532151192842999 0.0699009860067827 90.6527999345367 a231 MLL2_mut 341 EX-527 SIRT1 9 20 2.99573227355399 NA 4.94334429073084 4.60659490842054 0.336749382310296 0.592112141230775 0.585688068992745 0.57309404132677 0.568725683635405 0.574963705320873 0.143286568481732 NA NA 0.699872004433523 0.175129785612074 90.6527999345367 a232 EP300_mut 303 PIK-93 PI4K, PI3K 6 23 2.99573227355399 NA -0.289520475364074 0.832640091559547 -1.12216056692362 1.08063817855254 1.59367894896608 0.742236527147997 1.03842395095341 0.704132138817319 0.143695695057756 NA NA 0.571472007468104 0.0660597208973546 90.6527999345367 a233 PTEN_mut 301 PHA-793887 CDK-pan 6 23 2.32630161961136 NA -1.05767595629822 0.0788405010498011 -1.13651645734802 0.868912677452341 1.90584471963875 0.645558071226168 1.30797545810966 0.596332138519368 0.143739617125939 NA NA 0.677724543694164 0.046337514636453 90.6527999345367 a234 loss_cnaDLBC2 252 WZ3105 CLK2, CNSK1E, FLT3, ULK1 4 25 0.246860077931526 2.32630161961136 -0.606111301647578 -1.58667280823559 0.980561506588012 1.90325885998122 1.01758988500689 0.852525826501067 0.515201335564879 0.963611687808172 0.143814879822111 NA NA 0.588909534149335 0.382086114419637 90.6527999345367 a235 MLL2_mut 305 TPCA-1 IKK 9 20 2.99573227355399 NA 0.539697753250574 1.46946983831001 -0.929772085059433 0.927939349758038 1.65719310110107 0.628611068950791 1.00197505936339 0.561052350774134 0.144282783698167 NA NA 0.758253873082719 0.0653335446546939 90.6527999345367 a236 MLL2_mut 175 PAC-1 CASP3 agonist 9 20 0.940007258491471 NA 0.737948660919845 1.32871048772787 -0.590761826808021 1.09275721194068 0.984151188991438 0.580578504211131 0.540615811410531 0.600275479434656 0.144521240999019 NA NA 0.78025464028023 0.18660662781285 90.6527999345367 a237 TP53_mut 3 Rapamycin MTOR 13 10 -2.30258509299405 NA -3.93182267905406 -2.92087673760481 -1.01094594144925 2.40901882430697 1.24319470189923 0.506831598147192 0.419650494736204 0.813183920350391 0.144895815568422 NA NA 0.388186102320128 0.207990241295239 90.6527999345367 a238 TP53_mut 223 ZSTK474 PI3K 17 12 1.63315443905142 2.32630161961136 -1.11308901964228 -0.127037609449256 -0.986051410193024 1.86661259617196 1.6824367811555 0.549680729890733 0.528257128562839 0.586085267058772 0.145831588698137 NA NA 0.918675640529697 0.149871695974232 90.6527999345367 a239 MLL2_mut 89 Parthenolide NFKB1 9 18 1.6094379124341 NA 1.65765627969355 2.55902129798698 -0.901365018293429 1.19616077428093 1.23173060995327 0.738544677796816 0.75354838385775 0.731787463110644 0.14631334658603 NA NA 0.0563759517387823 0.085716540243855 90.6527999345367 a240 EP300_mut 184 BMS-754807 IGF1R 5 24 0.940007258491471 NA 2.03544302185621 0.927666692113109 1.1077763297431 0.818959385382588 1.50730704141239 0.776598920766055 1.35266333046002 0.734937407779292 0.146567958130602 NA NA 0.687332843147663 0.0414647694780805 90.6527999345367 a241 PTEN_mut 1053 MK-2206 AKT1, AKT2 5 27 1.38629436111989 0.693147180559945 -0.538153850374036 0.939807048173452 -1.47796089854749 0.950542674808406 1.81311947048731 0.857664473211502 1.55486012118855 0.815148103919624 0.147139621363871 NA NA 0.215051627830095 0.0219628064068214 90.6527999345367 a242 PTEN_mut 1047 Nutlin-3a MDM2 5 27 2.07944154167984 1.38629436111989 3.39554995283292 2.36161460727742 1.03393534555551 1.42570659927574 1.07786848884599 0.914624547321779 0.725209062005288 0.959240720231539 0.147235177196218 NA NA 0.061589022690427 0.18507762002024 90.6527999345367 a243 ARID1A_mut 255 CP724714 ERBB2 3 26 2.32630161961136 NA 4.42729485531075 3.66760751692408 0.759687338386669 0.512204608969812 0.855280628870305 0.910113307845865 1.48317161751944 0.888231666593572 0.147821735176593 NA NA 0.850777127213854 0.0995404522317843 90.6527999345367 a244 loss_cnaDLBC4_(CDKN2A) 207 AS601245 JNK 8 21 2.07944154167984 NA 2.32163463803507 1.86014037403418 0.461494264000891 1.0187094458368 0.589986498818864 0.635778462372583 0.453018538197418 0.782211567425338 0.148027380116494 NA NA 0.850113675845553 0.258853890972532 90.6527999345367 a245 loss_cnaDLBC2 1066 AZD6482 PI3Kbeta 3 25 1.6094379124341 NA 2.71999782980123 1.3805536908636 1.33944413893763 1.33420700353536 1.44315446420087 0.933366601595095 1.0039252795019 0.928136365277665 0.148433248276466 NA NA 0.888052312497066 0.215782315957207 90.6527999345367 a246 MLL2_mut 201 Epothilone B Microtubules 9 20 -3.44201937618241 NA -5.43454748957413 -4.66615241605741 -0.768395073516723 0.7819660970111 1.52902999832567 0.568575299118637 0.982644997594846 0.502537605120983 0.14845009040722 NA NA 0.72856593580081 0.0854006600569104 90.6527999345367 a247 PTEN_mut 88 MS-275 HDAC 4 25 1.6094379124341 NA 1.24868252547158 -0.19406816395963 1.44275068943121 1.42706715187411 1.39641938203149 1.03064087176014 1.01099004874193 1.03317864818828 0.149355227357965 NA NA 0.0835226544350169 0.133232986466563 90.6527999345367 a248 ARID1A_mut 1498 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 27 1.38629436111989 NA 1.90468837372723 2.67794398906938 -0.773255615342148 0.681495802370517 0.826217521337105 0.946768863009641 1.1346447221721 0.935898350461938 0.150149084478756 NA NA 0.49974551473683 0.176058675744478 90.6527999345367 a249 CREBBP_mut 1010 Gefitinib EGFR 7 23 -0.693147180559945 NA 0.690731447498813 1.10601383301783 -0.415282385519019 0.808041409339454 0.59248144819916 0.644079838951995 0.513937009563034 0.700920487521194 0.150732677298133 NA NA 0.981458588475233 0.242723146730203 90.6527999345367 a250 PTEN_mut 1502 Bicalutamide ANDR (androgen receptor) 5 23 2.30258509299405 NA 3.2673204746878 3.79956514840671 -0.532244673718914 1.0631272173848 0.551358389962354 0.810619509406556 0.500640624203176 0.965333408194359 0.150808224312286 NA NA 0.461140175498308 0.331604316557117 90.6527999345367 a251 PTEN_mut 1057 NVP-BEZ235 PI3K (Class 1) and MTORC1/2 5 27 -1.38629436111989 0.693147180559945 -3.79557025445906 -3.04163721268821 -0.753933041770855 0.844152526088132 0.993089416222727 0.773623965595665 0.893124190795992 0.759179414718246 0.151816957453 NA NA 0.582507799204926 0.123093511813241 90.6527999345367 a252 MLL2_mut 225 Genentech Cpd 10 AURKA, AURKB 9 20 2.32630161961136 NA 0.953426599872472 1.49851782593295 -0.545091226060482 0.852267919859768 1.14504834207588 0.511002537617018 0.639577312906687 0.476042107595455 0.152206593765209 NA NA 0.365341748338042 0.16907894273998 90.6527999345367 a253 CREBBP_mut 1053 MK-2206 AKT1, AKT2 7 25 1.38629436111989 0.693147180559945 -0.0313270637495965 0.916132419802408 -0.947459483552004 1.45135607462199 1.83432657930778 0.536988274470578 0.652809810162385 0.516516248654886 0.153510383158397 NA NA 0.215558032778579 0.176705283568932 90.6527999345367 a254 MLL2_mut 199 Pazopanib VEGFR, PDGFRA, PDGFRB, KIT 9 20 2.07944154167984 NA 2.47742874940742 3.09558326691142 -0.618154517504003 1.24822104401708 0.783773415806158 0.653799876874718 0.495228405631288 0.788690334525054 0.153934860023063 NA NA 0.369893167972963 0.198381725147197 90.6527999345367 a255 CREBBP_mut 283 GSK2126458 PI3K, MTOR 6 23 -2.05572501506252 0.0237165266173161 -5.39476917902641 -4.27492790748724 -1.11984127153918 1.64331146003009 1.72787096909346 0.653911662199698 0.681454063199114 0.648104685806899 0.154327154427389 NA NA 0.745479596847828 0.178947368604745 90.6527999345367 a256 loss_cnaDLBC4_(CDKN2A) 277 ABT-869 VEGFR and PDGFR family 7 22 0.0237165266173161 NA 2.20818131218068 1.70042261338433 0.507758698796351 0.566133645745703 0.851218637723038 0.637302315842182 0.89688839837021 0.596507966689471 0.154364447810209 NA NA 0.966592252986639 0.0898322842211072 90.6527999345367 a257 PTEN_mut 1377 Afatinib (rescreen) ERBB2, EGFR 5 25 2.30258509299405 NA 2.70637734140947 3.51375081190468 -0.807373470495204 1.71137227628103 0.716298093608883 0.871533517495737 0.471769632875964 1.12714731157172 0.155727578384196 NA NA 0.131212585912392 0.354720948475084 90.6527999345367 a258 loss_cnaDLBC2 1029 AMG-706 VEGFR, RET, c-KIT, PDGFR 3 29 0.693147180559945 NA 3.07660558174439 2.60069722632244 0.475908355421948 0.316004919743395 0.588801433348712 0.828159142254116 1.50601565256769 0.808266299073522 0.156305068398471 NA NA 0.339605577699834 0.0950981793415672 90.6527999345367 a259 MLL2_mut 300 CX-5461 RNA Pol I 9 20 2.32630161961136 NA 1.00526278534498 1.92216859693216 -0.916905811587178 1.56520257762858 1.36669023935768 0.641916587206734 0.585806479424773 0.67089511959792 0.156656806561038 NA NA 0.44082169512877 0.152060548623258 90.6527999345367 a260 PTEN_mut 3 Rapamycin MTOR 4 19 -2.30258509299405 NA -2.01303751293942 -3.80370063957859 1.79066312663917 1.73022275183 1.96850940034641 0.924802867533058 1.03493213503594 0.909654343699888 0.157544532280899 NA NA 0.389706942118858 0.128418825458143 90.6527999345367 a261 loss_cnaDLBC2 1038 NU-7441 PRKDC (DNAPK) 3 29 0.693147180559945 NA 2.54282060421894 1.67605627028889 0.866764333930055 0.61666704018408 1.02496630038888 0.864231208660887 1.40556293339647 0.845651543471427 0.158194253901837 NA NA 0.673549385333795 0.113145697996271 90.6527999345367 a262 TP53_mut 310 YM201636 FYV1 17 12 1.63315443905142 NA 0.68135319870455 1.17367631028956 -0.492323111585007 0.993817172784512 0.739151995005327 0.547745415070571 0.495385997613222 0.666064780872924 0.159863294884208 NA NA 0.935347838514633 0.137853465028278 90.6527999345367 a263 EP300_mut 1264 SGC0946 Q8TEK3 (DOT1L) 6 24 -0.693147180559945 NA 0.915849766934337 1.25536684911118 -0.339517082176848 0.618835799176353 0.525127858976554 0.625205627846592 0.548638399117718 0.646541744782971 0.160028063937307 NA NA 0.760589084714408 0.256404056309475 90.6527999345367 a264 loss_cnaDLBC2 201 Epothilone B Microtubules 4 25 -3.44201937618241 NA -5.79443864320536 -4.76224884617975 -1.0321897970256 0.850113762319273 1.40141752835388 0.763841181730527 1.21417843443634 0.736532672199428 0.160288130466397 NA NA 0.729159729845117 0.0887352818623382 90.6527999345367 a265 MLL2_mut 268 YM155 BIRC5 (Survivin) 9 20 1.63315443905142 NA -5.24640899253598 -4.65156593762143 -0.594843054914549 1.16617756610011 1.01821770658746 0.558955620794485 0.51007931571159 0.584200265882389 0.161219905786976 NA NA 0.808707172176058 0.208254383762132 90.6527999345367 a266 ARID1A_mut 34 Imatinib ABL, KIT, PDGFR 3 24 0.693147180559945 NA 3.06410408733832 2.64536193651244 0.418742150825886 0.271685465608513 0.527775270435966 0.817818270389929 1.54127549623606 0.793409949806829 0.161571924413884 NA NA 0.346514947160233 0.0886118613124995 90.6527999345367 a267 loss_cnaDLBC2 274 PXD101, Belinostat HDAC 4 24 2.99573227355399 NA -0.527674925274744 -1.60259885946355 1.07492393418881 1.70470098640398 1.31921763571145 0.785047868324751 0.630564505307371 0.814819257331343 0.162034127515343 NA NA 0.965320938217618 0.301788836646571 90.6527999345367 a268 ARID1A_mut 1129 PF-4708671 RPS6KB1 (p70S6KA) 3 26 2.30258509299405 NA 4.13782232376195 3.50011180745506 0.63771051630689 0.663908051759481 0.760319093682027 0.846218120892296 0.960540416126658 0.838740630882522 0.164428550260594 NA NA 0.588109852205436 0.230558354574019 90.6527999345367 a269 EP300_mut 1129 PF-4708671 RPS6KB1 (p70S6KA) 6 23 2.30258509299405 NA 3.98338117623684 3.45722116989984 0.526160006336999 0.724471939008836 0.753349955218317 0.703341336377835 0.726266923542751 0.69842707587939 0.165340404329252 NA NA 0.588170406887262 0.154454186465935 90.6527999345367 a270 EP300_mut 1059 AZD8055 MTORC1/2 6 26 0.693147180559945 NA -1.79446148199482 -1.12973462104078 -0.664726860954042 0.728675094899891 1.01672370904015 0.682019127008197 0.91224040125231 0.653793016769114 0.16591093925598 NA NA 0.664912339211045 0.092825647743158 90.6527999345367 a271 MLL2_mut 1067 CCT007093 PPM1D 6 22 1.88706964903238 NA 3.92757767423262 3.52408213553102 0.4034955387016 0.734912851426602 0.598369764615894 0.643593236846914 0.549038621270998 0.674324744601045 0.166458509434755 NA NA 0.813264812451009 0.256209113956583 90.6527999345367 a272 PTEN_mut 329 QL-XI-92 DDR1 6 23 2.32630161961136 NA 3.21850296578621 2.29493207914194 0.923570886644272 0.903525713584647 1.3088714104109 0.7425314240439 1.02218550369762 0.705623852196704 0.167914986913097 NA NA 0.277045689216849 0.0687886319618283 90.6527999345367 a273 PTEN_mut 228 KIN001-102 AKT1 6 23 2.32630161961136 NA 0.810525769824558 1.35188535528482 -0.541359585460263 0.906291224423861 0.912191454326143 0.594181290986967 0.59733512900824 0.593471450420655 0.170256130341048 NA NA 0.626959231495911 0.229974412647097 90.6527999345367 a274 TP53_mut 1377 Afatinib (rescreen) ERBB2, EGFR 18 12 2.30258509299405 NA 3.52160379472063 3.16556572497441 0.356038069746223 0.679652286029529 1.2784850294767 0.370673903059647 0.523853265948927 0.27848434790977 0.170616196161013 NA NA 0.132173802806087 0.389990340262208 90.6527999345367 a275 loss_cnaDLBC2 199 Pazopanib VEGFR, PDGFRA, PDGFRB, KIT 4 25 2.07944154167984 NA 3.48329936134541 2.81101306550054 0.672286295844867 1.05369786085348 0.949090754153393 0.699368591617811 0.638025681574719 0.708347745358197 0.170695914492657 NA NA 0.371333379942737 0.299031657325854 90.6527999345367 a276 MLL2_mut 1261 rTRAIL TR10A (DR4), TR10B (DR5) 9 21 -2.30258509299405 NA -1.95069728135045 -1.22471110880761 -0.725986172542836 1.41269493684624 1.2477224945152 0.559742423507276 0.513901588805548 0.581849069592126 0.171243207136731 NA NA 0.988381388175448 0.203848988982782 90.6527999345367 a277 loss_cnaDLBC4_(CDKN2A) 202 GSK-1904529A IGF1R 8 21 0.0237165266173161 NA 2.21264730529704 1.79205656860636 0.420590736690682 0.518304863412247 0.818627011910805 0.55902394834467 0.811473644915723 0.513775786250879 0.172035202088911 NA NA 0.741474863305678 0.115733969653285 90.6527999345367 a278 EP300_mut 256 JW-7-24-1 LCK 6 23 2.32630161961136 NA -0.367876075886145 0.169086624375274 -0.53696270026142 1.01815230925455 1.00047095455196 0.534946605338236 0.527389365403065 0.53670993427479 0.173098231510858 NA NA 0.332163255046541 0.28272718320691 90.6527999345367 a279 EP300_mut 30 Sorafenib PDGFRA, PDGFRB, KDR, KIT, FLT3 5 23 1.38629436111989 NA 2.28801970199485 1.50050142524101 0.787518276753838 1.21040165550111 0.807229624332886 0.893543048573579 0.650625578025835 0.975581486376522 0.173615402371798 NA NA 0.0280818523607515 0.225725252709544 90.6527999345367 a280 EP300_mut 1030 KU-55933 ATM 6 26 2.30258509299405 NA 2.64288599460001 3.23623533835943 -0.593349343759412 0.645002182916824 0.916580111179439 0.676431574179277 0.919918349851426 0.647351318801693 0.174546657913214 NA NA 0.605760903315209 0.091495717833661 90.6527999345367 a281 loss_cnaDLBC2 256 JW-7-24-1 LCK 4 25 2.32630161961136 NA 0.647779260810783 -0.0363752455171478 0.684154506327931 1.62608454161653 0.890446219675497 0.68463747170487 0.420737353328381 0.768327711669386 0.175157282672157 NA NA 0.332327601261455 0.466382891584209 90.6527999345367 a282 MLL2_mut 226 GSK1070916 AURKB 8 17 0.940007258491471 2.32630161961136 -0.701577593403179 0.986231024229205 -1.68780861763238 2.94478380139229 2.2374042194364 0.682164356600898 0.573151963425767 0.754360165664452 0.175705809375998 NA NA 0.32628186210631 0.17847310188875 90.6527999345367 a283 loss_cnaDLBC2 1062 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 29 1.38629436111989 0.693147180559945 2.18267056781893 2.92399770619827 -0.741327138379345 1.94354639182464 0.757483607708661 0.835458411225875 0.38143012253151 0.97867086605585 0.176972210721788 NA NA 0.798341221115539 0.577643717399628 90.6527999345367 a284 MLL2_mut 1005 Cisplatin DNA crosslinker 8 22 1.79175946922805 2.30258509299405 2.25957103323808 2.90988038661317 -0.650309353375087 0.905912484176109 1.00306576029152 0.663796981538643 0.717850084565858 0.648321754284672 0.177323865164575 NA NA 0.10439889534971 0.113881074784193 90.6527999345367 a285 PTEN_mut 225 Genentech Cpd 10 AURKA, AURKB 6 23 2.32630161961136 NA 0.733659275155762 1.48474957680769 -0.751090301651923 0.865333450905837 1.08999920263226 0.713950263420262 0.86797788859968 0.689074175318755 0.177422105522686 NA NA 0.36747656308455 0.10524761668988 90.6527999345367 a286 loss_cnaDLBC2 1529 MLN4924 NEDD8-activating enzyme 3 24 0 NA -0.660498137067852 0.552371599186764 -1.21286973625462 1.04301400453777 1.52064246298993 0.815054344530023 1.16285086391732 0.797603490481149 0.177813665684297 NA NA 0.542121186883321 0.165994825074669 90.6527999345367 a287 loss_cnaDLBC2 272 AR-42 HDAC 4 24 1.63315443905142 NA -0.956467697530198 -1.94840346587 0.991935768339806 2.13272345884052 1.15742399611009 0.758577620056371 0.465102854394016 0.857020220484054 0.178384408326358 NA NA 0.985441775330089 0.425145363081401 90.6527999345367 a288 PTEN_mut 235 QL-XII-47 BTK, BMX 6 22 2.32630161961136 NA 0.975900494192041 0.116675407312134 0.859225086879907 1.37954232047872 1.14440058685372 0.720086797899075 0.622833438398428 0.750807974716403 0.178938786720674 NA NA 0.33087873802622 0.204302530297119 90.6527999345367 a289 ARID1A_mut 266 Zibotentan, ZD4054 Endothelin A Receptor 3 26 2.99573227355399 NA 5.24506220724723 4.72251331008509 0.522548897162132 0.0269933549478838 0.647918863904459 0.838084944230866 19.3584272192552 0.806503601412639 0.179426403642125 NA NA 0.816662218505153 0.00038480937326202 90.6527999345367 a290 EP300_mut 1378 Bleomycin (50 uM) DNA damage 6 25 3.91202300542815 NA 4.06182235454999 3.2226726183154 0.839149736234583 1.22197600844927 1.62067701523984 0.538183532086936 0.686715394109493 0.517777279707023 0.17979954339037 NA NA 0.4363905281804 0.189483259360719 90.6527999345367 a291 TP53_mut 1043 JNK Inhibitor VIII JNK 19 13 2.30258509299405 NA 4.05695622948871 4.34509768717689 -0.288141457688179 0.699363712505057 0.548657530679219 0.447889348621455 0.41200515916973 0.525175435633719 0.180291109700179 NA NA 0.625887831629398 0.202694920109889 90.6527999345367 a292 CREBBP_mut 94 TGX221 PI3Kbeta 7 20 2.30258509299405 NA 2.96068328200696 3.65640393994044 -0.695720657933477 1.59539985653422 0.911986764168988 0.624026392094258 0.436079177946545 0.762862670016297 0.180861269142803 NA NA 0.84281360376688 0.308624430787345 90.6527999345367 a293 EP300_mut 1375 Temozolomide DNA akylating agent 6 24 3.40119738166216 NA 4.9425874519088 4.51613716131687 0.426450290591934 0.453634271334638 0.899871252367946 0.509010192747755 0.940075116761512 0.473901449201495 0.181124315412994 NA NA 0.29345091572945 0.12128110839207 90.6527999345367 a294 TP53_mut 176 IPA-3 PAK1, PAK2, PAK3 16 13 3.46573590279973 NA 2.68313827030917 3.05568120354786 -0.372542933238688 1.21253227679809 1.41253915260149 0.285426820294624 0.30724372486187 0.263739898857013 0.1815782802172 NA NA 0.0494059098281072 0.459365949496586 90.6527999345367 a295 loss_cnaDLBC4_(CDKN2A) 1020 Lenalidomide TNFA 8 22 1.6094379124341 NA 3.39498685461246 2.99159240027657 0.403394454335892 0.449606424705841 0.920841046119157 0.486867060988603 0.897216837147772 0.438071756288428 0.18195246168709 NA NA 0.321439110749799 0.122779211462715 90.6527999345367 a296 loss_cnaDLBC4_(CDKN2A) 282 EKB-569 EGFR 7 22 0.916290731874155 2.99573227355399 -0.292295502454248 0.507116365554449 -0.799411868008697 1.44193157962673 1.26537435023133 0.611792028228608 0.554403467753745 0.631759184831391 0.1830474193842 NA NA 0.837635456576517 0.22066922624333 90.6527999345367 a297 ARID1A_mut 6 PHA-665752 MET 3 24 0.693147180559945 NA 3.06022687674452 2.53018571025865 0.530041166485863 0.175811976636036 0.712668756607456 0.773360247210686 3.01481831117313 0.743741270501373 0.183532539603082 NA NA 0.350307312729567 0.0100119216896583 90.6527999345367 a298 loss_cnaDLBC4_(CDKN2A) 249 XL-184 VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL 7 22 1.63315443905142 NA 2.60226785802637 1.96926993766049 0.632997920365876 1.43467611899372 1.01442229708137 0.564418324288431 0.441213115619336 0.623998429635368 0.183952857393684 NA NA 0.684057992234609 0.3098218642348 90.6527999345367 a299 TP53_mut 329 QL-XI-92 DDR1 17 12 2.32630161961136 NA 2.79577606188776 2.04718854690749 0.748587514980268 1.17389225074719 1.34298238052458 0.601007260185351 0.637696956005789 0.557406802826306 0.18403174587616 NA NA 0.27830388086676 0.134083932853605 90.6527999345367 a300 loss_cnaDLBC2 1 Erlotinib EGFR 4 23 0.693147180559945 NA 2.66736366104898 2.1474418407655 0.519921820283478 0.16505124674668 0.880006834256626 0.628306441168395 3.15006296851215 0.59081566192912 0.184543503356596 NA NA 0.175041286381093 0.0161431871460438 90.6527999345367 a301 PTEN_mut 253 XMD14-99 EPHB3, CAMK1 6 23 2.32630161961136 NA 2.82673177078254 3.27812838595406 -0.451396615171525 0.737830663433719 0.912897458620086 0.511150082198564 0.611788907051943 0.494465847077552 0.184894952003199 NA NA 0.304390515065723 0.235556130121725 90.6527999345367 a302 loss_cnaDLBC2 1072 BMS-708163 g-secretase 3 25 1.6094379124341 NA 3.81190049469282 3.31100800163391 0.500892493058906 0.189408150171525 0.692826138877028 0.750158533511929 2.64451393778624 0.722969970317202 0.185546249094267 NA NA 0.255557450145317 0.0159221280865476 90.6527999345367 a303 CREBBP_mut 5 Sunitinib PDGFRA, PDGFRB, KDR, KIT, FLT3 6 19 2.07944154167984 NA 1.19615475965442 2.11727963821636 -0.921124878561941 0.847031552802572 1.29524450855109 0.760010207749732 1.08747410354929 0.711159068794159 0.187205844134033 NA NA 0.0157151801077838 0.064248149883023 90.6527999345367 a304 loss_cnaDLBC4_(CDKN2A) 1129 PF-4708671 RPS6KB1 (p70S6KA) 7 22 2.30258509299405 NA 3.88116895647634 3.46582687589923 0.415342080577112 0.533545017706548 0.810742939727742 0.547976840332792 0.778457424946946 0.512298115992955 0.187927179790975 NA NA 0.589556710506249 0.137873400281419 90.6527999345367 a305 TP53_mut 1007 Docetaxel Microtubules 17 12 -4.38202663467388 NA -4.62210103137491 -4.0685511991212 -0.55354983225371 0.891039617248875 1.23669387055332 0.529335167421463 0.621240426955223 0.447604573317763 0.18934586919704 NA NA 0.776445241623705 0.200578180830003 90.6527999345367 a306 loss_cnaDLBC4_(CDKN2A) 344 THZ-2-49 CDK9 7 22 2.99573227355399 NA -0.205368950504822 0.693938150471036 -0.899307100975858 0.910895676577618 1.75278786269721 0.560544551632949 0.98727782346569 0.513072414588719 0.189384499607657 NA NA 0.716969183148294 0.0917049871809857 90.6527999345367 a307 EP300_mut 266 Zibotentan, ZD4054 Endothelin A Receptor 6 23 2.99573227355399 NA 4.48229198199909 4.85333829530259 -0.371046313303498 0.853042945448459 0.561544241322085 0.592864104073944 0.434967917246456 0.660760606198929 0.189443132360975 NA NA 0.816945567137086 0.350459244957026 90.6527999345367 a308 loss_cnaDLBC2 52 GNF-2 ABL [T315I] 4 21 0.246860077931526 NA 2.57102104552216 2.18092038846892 0.390100657053241 0.26830454257861 0.607645065594173 0.678603826319593 1.45394726941288 0.641987698314951 0.189618665378276 NA NA 0.441196894207241 0.064795782809747 90.6527999345367 a309 CREBBP_mut 1219 PFI-1 BRD2, BRD3, BRD4 6 24 2.30258509299405 NA 2.61453864388104 1.96259527995053 0.65194336393051 0.829980070213831 1.07035099316495 0.632007445449405 0.785492793534846 0.609093062083081 0.190307768637058 NA NA 0.833725326324607 0.138017448925951 90.6527999345367 a310 loss_cnaDLBC4_(CDKN2A) 52 GNF-2 ABL [T315I] 8 17 0.246860077931526 NA 2.43664948692042 2.15236567321015 0.28428381371027 0.55301752641558 0.587977869590957 0.492213647130656 0.514059320240489 0.483494070802426 0.195181938462491 NA NA 0.441642045516777 0.25888867745838 90.6527999345367 a311 PTEN_mut 1019 Bosutinib SRC, ABL, TEC 4 26 0.693147180559945 NA 2.03903403458716 0.942629659511347 1.09640437507582 1.51952799385749 1.1913020414991 0.890905135095633 0.721542728734119 0.920341220683319 0.195191234731222 NA NA 0.19836591897108 0.247458057161337 90.6527999345367 a312 loss_cnaDLBC4_(CDKN2A) 1033 Vismodegib SMO 8 22 2.30258509299405 NA 4.05452925835025 3.70355460033846 0.350974658011793 0.427191711915846 0.758555310919344 0.508084141705747 0.821585831892106 0.46268828780122 0.195592955971671 NA NA 0.587227702936558 0.126720519501654 90.6527999345367 a313 TP53_mut 38 AZD-0530 SRC, ABL1 15 12 0.693147180559945 NA 1.95389786782608 2.33923639893134 -0.385338531105262 1.26424005821513 0.710593862284506 0.36456262806559 0.304798545656976 0.542276751260456 0.195895143984015 NA NA 0.218985343183351 0.328071604447923 90.6527999345367 a314 EP300_mut 9 MG-132 Proteasome 5 22 0 NA -0.943811132057375 -0.497295770805808 -0.446515361251567 1.38521119238278 1.05828671399954 0.399729789352994 0.322344609765599 0.421922863950613 0.19677798779914 NA NA 0.0727491383042561 0.527659848928709 90.6527999345367 a315 EP300_mut 333 T0901317 LXR 6 23 2.32630161961136 NA 3.556075388832 2.73913238904838 0.816942999783613 0.825311643005075 1.40316796917724 0.621036712843714 0.989860020402729 0.582213261511832 0.197204659761521 NA NA 0.871611140559391 0.0890961902925192 90.6527999345367 a316 TP53_mut 1372 Trametinib MAP2K1 (MEK1), MAP2K2 (MEK2) 18 12 0 NA 0.946228297866898 0.164994853215708 0.78123344465119 0.876734891662962 2.375463033148 0.476901827741921 0.891071465365514 0.328876279592483 0.197311883703421 NA NA 0.894207194344916 0.295134777558431 90.6527999345367 a317 ARID1A_mut 333 T0901317 LXR 3 26 2.32630161961136 NA 3.86088153926537 2.79822510243495 1.06265643683041 0.990484353704661 1.3401129322211 0.806631310130895 1.07286544492683 0.792960362727917 0.198035028626962 NA NA 0.871626472168651 0.192277904908882 90.6527999345367 a318 CREBBP_mut 1058 GDC0941 PI3K (class 1) 7 25 1.38629436111989 0.693147180559945 -0.606369611201506 0.429344421718458 -1.03571403291996 1.73574139090489 2.08509910642277 0.5127127399847 0.596698355150716 0.496721728827967 0.198123739112166 NA NA 0.43834432109876 0.208851882501133 90.6527999345367 a319 PTEN_mut 55 A-770041 SRC family 4 21 1.63315443905142 NA 3.19773165119276 1.05116244354499 2.14656920764777 0.629937250113295 2.68994816838128 0.852257671429413 3.40759211693182 0.797996494088399 0.198664504792777 NA NA 0.344528793198056 0.00402324754896302 90.6527999345367 a320 loss_cnaDLBC2 1061 SB590885 BRAF 3 29 1.6094379124341 NA 3.81168002629611 3.1789738740012 0.632706152294914 0.613941801349682 0.799863608488447 0.802078401553638 1.0305637291743 0.791017550467859 0.199166072340019 NA NA 0.922476106814982 0.206149639855771 90.6527999345367 a321 MLL2_mut 266 Zibotentan, ZD4054 Endothelin A Receptor 9 20 2.99573227355399 NA 4.99697176840519 4.67738933841537 0.319582429989826 0.584974020428534 0.643157236492195 0.510122805385777 0.546319013886651 0.496896267128768 0.199262160800841 NA NA 0.817206501957234 0.204700393534029 90.6527999345367 a322 loss_cnaDLBC4_(CDKN2A) 206 Ruxolitinib JAK1, JAK2, TYK2 7 22 1.65632149833295 0.0237165266173161 2.31334670696886 3.10236683815912 -0.789020131190264 2.48860604635438 0.93210330327487 0.550806404686341 0.317053047566978 0.846494297808092 0.199626796305318 NA NA 0.754091164206202 0.44066986976861 90.6527999345367 a323 ARID1A_mut 1019 Bosutinib SRC, ABL, TEC 3 27 0.693147180559945 NA 1.89619216387407 0.999108547926721 0.897083615947346 1.9054263030421 1.19518345142672 0.712383507395863 0.470804677417914 0.750582360286593 0.199629651303845 NA NA 0.1986360569838 0.502471918395464 90.6527999345367 a324 MLL2_mut 208 SB-715992 KIF11 9 20 -2.05572501506252 NA -3.87343703478245 -3.32540427517597 -0.548032759606484 0.752311715088708 1.21441763260015 0.499135428295727 0.728465008074298 0.451272070575184 0.20008404093229 NA NA 0.727545967667298 0.151225521105201 90.6527999345367 a325 CREBBP_mut 223 ZSTK474 PI3K 6 23 1.63315443905142 2.32630161961136 -1.58351992823919 -0.475906307733682 -1.10761362050551 2.36845394582717 1.64921793035492 0.613917565091174 0.467652589342911 0.671599307841107 0.200688147063581 NA NA 0.919431160961617 0.31990805057485 90.6527999345367 a326 loss_cnaDLBC4_(CDKN2A) 1378 Bleomycin (50 uM) DNA damage 7 24 3.91202300542815 NA 2.77026593372303 3.56441200204682 -0.794146068323789 1.89740929652651 1.45800462168933 0.509358738309612 0.418542309125181 0.54468007611913 0.201095133720443 NA NA 0.43774945232873 0.335698558260045 90.6527999345367 a327 loss_cnaDLBC2 196 Phenformin AAPK1 (AMPK) agonist 4 25 8.29404964010203 NA 6.83983354832602 5.73676777533321 1.10306577299281 0.787678566893896 1.59710893979163 0.72167097678212 1.40040089873539 0.690664077765869 0.201265198373462 NA NA 0.915088350789476 0.0620721093153253 90.6527999345367 a328 loss_cnaDLBC2 1007 Docetaxel Microtubules 3 26 -4.38202663467388 NA -3.61613235309865 -4.48268980244353 0.86655744934488 0.830639143327421 1.06362773826645 0.826751908388617 1.04324176907144 0.814718738679414 0.201531646068998 NA NA 0.776834398879138 0.201853019332196 90.6527999345367 a329 loss_cnaDLBC2 110 Roscovitine CDKs 4 24 2.77258872223978 NA 2.73747602549577 3.44675245027001 -0.709276424774244 0.300947221520164 0.991655021053485 0.755935274918554 2.35681333488145 0.715245130328432 0.202529006526319 NA NA 0.481855801900369 0.0122017735191711 90.6527999345367 a330 CREBBP_mut 291 KIN001-266 MAP3K8 (COT) 6 23 2.99573227355399 NA 2.43678781861662 2.77912210508582 -0.342334286469193 0.553330089159192 0.545599276034856 0.625794855745289 0.618680048629533 0.627446372284633 0.202742231232897 NA NA 0.742770761101659 0.214071682799746 90.6527999345367 a331 CREBBP_mut 207 AS601245 JNK 7 22 2.07944154167984 NA 1.67736488370374 2.08611230786692 -0.408747424163187 0.406626668235661 0.804172659627295 0.556375266640561 1.00521548657084 0.508283164404802 0.202889430069851 NA NA 0.851473955538717 0.0903903788099901 90.6527999345367 a332 ARID1A_mut 1039 SL 0101-1 RSK, AURKB, PIM3 3 29 2.30258509299405 NA 4.47022418666588 3.89251890808296 0.577705278582929 0.368113073360884 0.753260116875735 0.787172614280925 1.56936908898253 0.766939952932929 0.20315430307309 NA NA 0.821250283647432 0.0847913775207055 90.6527999345367 a333 loss_cnaDLBC4_(CDKN2A) 1261 rTRAIL TR10A (DR4), TR10B (DR5) 7 23 -2.30258509299405 NA -0.876117659792266 -1.61488631298122 0.73876865318895 0.780092016278497 1.41167309998207 0.567245685136711 0.947027578507105 0.523328420155015 0.20349509275271 NA NA 0.988437110752687 0.0923778236647871 90.6527999345367 a334 ARID1A_mut 133 Doxorubicin DNA intercalating 3 26 0.0237165266173161 NA -3.35214287300395 -2.29795382012048 -1.05418905288347 1.71193403349707 1.19943037282746 0.846975096601237 0.61578836114965 0.878908085676029 0.203564917323056 NA NA 0.407616388664975 0.398605101023291 90.6527999345367 a335 loss_cnaDLBC4_(CDKN2A) 224 AS605240 PI3Kgamma 7 22 2.99573227355399 2.32630161961136 1.65589989875873 2.44997853047178 -0.79407863171305 1.68498636898253 1.08621880359778 0.638106240042154 0.47126709528965 0.731048504300326 0.203672462861149 NA NA 0.252664194176095 0.276465149690235 90.6527999345367 a336 PTEN_mut 156 AZD6482 PI3Kbeta 6 24 1.63315443905142 NA 0.845539253915344 1.85417122029983 -1.00863196638449 2.6116007513069 1.50675974840143 0.574455797112198 0.386212159680129 0.669404639627902 0.20377878314291 NA NA 0.859805466098329 0.399223397094573 90.6527999345367 a337 PTEN_mut 1373 Dabrafenib BRAF 5 25 2.30258509299405 NA 2.19522177748744 3.04452647082798 -0.849304693340532 1.3416165691406 1.48268568701747 0.580377577311566 0.633045769466439 0.572815061733664 0.204077205026317 NA NA 0.707789066013164 0.250480505613107 90.6527999345367 a338 MLL2_mut 136 Mitomycin C DNA crosslinker 9 20 2.77258872223978 NA -1.79555514779425 -1.09254991778422 -0.703005230010029 1.06841422736995 1.24963127331807 0.586425771624676 0.657989394001775 0.562570131702436 0.204371451497509 NA NA 0.373316696703942 0.137819254032297 90.6527999345367 a339 loss_cnaDLBC4_(CDKN2A) 1028 VX-702 p38 8 22 0.693147180559945 NA 2.31825619602998 1.93870087330403 0.379555322725953 0.795761126057631 0.786531376461304 0.481150831826695 0.476971430618068 0.482568571432733 0.205170142654519 NA NA 0.468415003248166 0.268455102192142 90.6527999345367 a340 loss_cnaDLBC2 154 CHIR-99021 GSK3B 4 26 0.940007258491471 NA 3.23895007027754 2.68350647234673 0.555443597930808 0.345798232896469 0.906284702222758 0.64301852020775 1.6062649981705 0.612879812015501 0.205419054252612 NA NA 0.385056023725022 0.0463064671812544 90.6527999345367 a341 EP300_mut 1058 GDC0941 PI3K (class 1) 6 26 1.38629436111989 0.693147180559945 -0.86041260600496 0.448134573099257 -1.30854717910422 2.01457220891512 1.99646194941436 0.65443990983626 0.649540966222744 0.65543306722578 0.206405897123516 NA NA 0.43881866192644 0.191493587053796 90.6527999345367 a342 ARID1A_mut 203 BMS-345541 IKBKB 3 26 2.77258872223978 NA 2.32242744431534 1.81672369538183 0.505703748933512 0.232368249407364 0.700453998624021 0.747007591866458 2.17630313187481 0.721965682153177 0.206578686090263 NA NA 0.455345942487273 0.0309608772762723 90.6527999345367 a343 ARID1A_mut 1043 JNK Inhibitor VIII JNK 3 29 2.30258509299405 NA 4.61928373235888 4.12795127918995 0.491332453168934 0.141909939424909 0.66441497443095 0.764207375672813 3.46228358041772 0.739496357061707 0.206656399731897 NA NA 0.627095923657929 0.00447629597574715 90.6527999345367 a344 TP53_mut 1049 PD-173074 FGFR1, FGFR3 19 13 0.693147180559945 NA 1.87475234276786 2.17639674340772 -0.301644400639867 0.897897300487299 0.672031790021194 0.370071976200762 0.335945325235036 0.448854362425851 0.206697160867127 NA NA 0.306719645509149 0.286292038141353 90.6527999345367 a345 CREBBP_mut 200 LAQ824 HDAC 7 22 0.0237165266173161 NA -2.89852363981774 -3.60073858608956 0.702214946271812 2.17848743721326 0.768963784590207 0.570599534846515 0.322340599388579 0.913196382383642 0.206916634155542 NA NA 0.939966839917486 0.432668357785706 90.6527999345367 a346 ARID1A_mut 269 NSC-207895 MDM4 3 25 2.99573227355399 NA 2.06849750452544 3.15131789507904 -1.08282039055361 0.482902311563045 1.32277678876982 0.847329903010931 2.24231767921914 0.818596455385818 0.208504270812611 NA NA 0.334559098166378 0.0268066916021648 90.6527999345367 a347 MLL2_mut 1526 RDEA119 (rescreen) MAP2K1 (MEK1), MAP2K2 (MEK2) 9 18 1.6094379124341 NA 3.21261630929465 2.72050438245097 0.492111926843685 0.806810504127312 0.954081984920707 0.541047968763533 0.609947347396003 0.515796267638975 0.209039182280388 NA NA 0.866683337284603 0.176713231726289 90.6527999345367 a348 loss_cnaDLBC4_(CDKN2A) 1259 BMN-673 PARP1 7 23 2.30258509299405 NA 1.8870072714381 2.75223161068613 -0.86522433924803 1.55609682686727 1.40765899494857 0.60053532268448 0.556022173112386 0.614654786672706 0.209039487070432 NA NA 0.507935713189553 0.21990954378983 90.6527999345367 a349 ARID1A_mut 287 KIN001-244 PDPK1 (PDK1) 3 26 2.99573227355399 NA 1.33231967385327 2.14792305789137 -0.815603384038096 0.930892054544062 1.01044523725721 0.811732688628699 0.876152481973399 0.807172278086042 0.20947785747171 NA NA 0.78383093752031 0.263568093568112 90.6527999345367 a350 EP300_mut 133 Doxorubicin DNA intercalating 5 24 0.0237165266173161 NA -1.66707016644134 -2.5611615462474 0.894091379806063 1.52160776984159 1.18408466419678 0.721099971870063 0.587596486773426 0.755090752241575 0.210282811254735 NA NA 0.40804379031628 0.270027615922714 90.6527999345367 a351 ARID1A_mut 277 ABT-869 VEGFR and PDGFR family 3 26 0.0237165266173161 NA 2.39304366498042 1.75720906479919 0.63583460018123 0.19309987903276 0.832975954953445 0.7915748886356 3.29277575608091 0.763328876902295 0.210490086041831 NA NA 0.966892258110438 0.00601185828679528 90.6527999345367 a352 CREBBP_mut 326 GSK690693 AKT 5 23 2.32630161961136 NA -0.391546023124098 1.19589528341409 -1.58744130653819 2.16112609175404 2.55206521397035 0.63601716460725 0.734543584752044 0.622022234325488 0.210872416394926 NA NA 0.950562485486613 0.195354138265934 90.6527999345367 a353 MLL2_mut 1001 AICAR AAPK1 (AMPK) agonist 8 22 7.60090245954208 NA 6.28051781840795 6.72691858137667 -0.446400762968718 0.704882810559582 0.834248690628192 0.555320580776027 0.633297842253148 0.535093153856288 0.21110176809199 NA NA 0.725852459532522 0.165905375856427 90.6527999345367 a354 CREBBP_mut 133 Doxorubicin DNA intercalating 7 22 0.0237165266173161 NA -2.98442125185841 -2.22328541723343 -0.761135834624973 1.26316393113232 1.23763197151737 0.612164870363013 0.602562989542205 0.614993675132519 0.211473874715954 NA NA 0.408117869996166 0.193251586898155 90.6527999345367 a355 TP53_mut 177 GSK-650394 SGK3 16 13 2.77258872223978 NA 3.17136333297626 2.63678491594813 0.53457841702813 1.15459115362279 1.24006201796633 0.447970410331096 0.463002349663575 0.43109006588624 0.212761375498736 NA NA 0.825296220169226 0.245020711649801 90.6527999345367 a356 EP300_mut 1091 BMS-536924 IGF1R 6 24 1.38629436111989 NA 2.70246527923158 2.13742514008172 0.565040139149867 0.444825434332811 1.04540126555701 0.584962966308511 1.27025141895801 0.540500722321972 0.212928154784719 NA NA 0.961769047255226 0.057347471701286 90.6527999345367 a357 CREBBP_mut 55 A-770041 SRC family 6 19 1.63315443905142 NA 0.0956989027675595 1.80479707908477 -1.70909817631721 3.25590669317699 2.2981209678049 0.673594726846506 0.524922344948876 0.743693739476948 0.213148189048958 NA NA 0.345651939515068 0.272875848635405 90.6527999345367 a358 PTEN_mut 226 GSK1070916 AURKB 6 19 0.940007258491471 2.32630161961136 -0.523904164334327 0.752459560561948 -1.27636372489627 3.19726739409679 2.33039708865466 0.501695792327608 0.399204560510911 0.54770224830358 0.213172819734296 NA NA 0.329403150830679 0.396604677433569 90.6527999345367 a359 ARID1A_mut 1062 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 29 1.38629436111989 0.693147180559945 3.49427286362313 2.7883147100806 0.705958153542531 0.173311533826907 0.920010115443151 0.793264906737911 4.07334779142627 0.767337382157461 0.214328727337254 NA NA 0.799310008186406 0.0020530791862342 90.6527999345367 a360 EP300_mut 38 AZD-0530 SRC, ABL1 5 22 0.693147180559945 NA 1.72858820424175 2.21528926287993 -0.486701058638186 1.63145570417316 0.907872372136256 0.460255420305973 0.298323183028038 0.53608973416931 0.214376428305957 NA NA 0.220230555519475 0.549978245331894 90.6527999345367 a361 loss_cnaDLBC2 276 CAY10603 HDAC6 4 25 2.99573227355399 NA 0.0619833004043364 -0.960857048427914 1.02284034883225 1.81602374730971 1.41222897468441 0.69932513491651 0.563230712344761 0.724273731220407 0.214778573835496 NA NA 0.924916078417686 0.348762055570236 90.6527999345367 a362 TP53_mut 277 ABT-869 VEGFR and PDGFR family 17 12 0.0237165266173161 NA 1.66610896348013 2.04522619171316 -0.379117228233026 0.902123069844709 0.637887549386188 0.470947058571828 0.420250009012947 0.594332384442736 0.214779690509177 NA NA 0.96691115033561 0.196045917673018 90.6527999345367 a363 loss_cnaDLBC2 1039 SL 0101-1 RSK, AURKB, PIM3 3 29 2.30258509299405 NA 4.45666613167397 3.89392146549591 0.562744666178057 0.528235160028944 0.747533063126753 0.765689228984579 1.06532981664307 0.752802376157424 0.215258564436729 NA NA 0.821508294852741 0.19461124890563 90.6527999345367 a364 CREBBP_mut 1268 XAV 939 TNKS1 (tankyrase-1) 6 23 1.6094379124341 NA 2.54764057502426 2.98754046108206 -0.439899886057802 1.17430972798746 0.780347062738171 0.507430056825427 0.374602948075467 0.563723382919173 0.215363661568668 NA NA 0.315785219935381 0.417264891286239 90.6527999345367 a365 TP53_mut 330 XMD13-2 RIPK 17 12 2.32630161961136 NA 2.04692017655963 1.50326927314159 0.543650903418042 0.898574327552421 1.25868589416441 0.512802445637082 0.605014951739011 0.431919437516976 0.215486425349909 NA NA 0.668056091131936 0.215148726778343 90.6527999345367 a366 loss_cnaDLBC2 171 AKT inhibitor VIII AKT1, AKT2, AKT3 4 26 0.940007258491471 NA 1.52605148950753 2.10880682221725 -0.582755332709722 0.694208903406996 0.825110259269618 0.717595037534636 0.839452403807716 0.706275708201195 0.217312297881421 NA NA 0.568724041969168 0.196054092100995 90.6527999345367 a367 TP53_mut 1008 Methotrexate Dihydrofolate reductase (DHFR) 17 13 -1.6094379124341 NA -2.38900265957453 -2.80556012028759 0.41655746071306 1.46906542981844 1.12297838110862 0.312777593476199 0.283552694289826 0.370939875353459 0.217790375301854 NA NA 0.148397472633549 0.386231416178926 90.6527999345367 a368 ARID1A_mut 38 AZD-0530 SRC, ABL1 3 24 0.693147180559945 NA 2.76102720328575 2.04567596644625 0.715351236839501 0.156242633870946 1.0935998846857 0.681368231124119 4.5784637593243 0.654125194101581 0.218137763868252 NA NA 0.220468647656825 0.00667881547229971 90.6527999345367 a369 ARID1A_mut 263 FR-180204 ERK 3 26 2.99573227355399 NA 4.04601461166827 4.65795647668976 -0.611941865021485 1.20321813859493 0.698625288664005 0.818353539587112 0.508587632942505 0.875922865878092 0.219231564965045 NA NA 0.419628534363168 0.472723532024502 90.6527999345367 a370 MLL2_mut 329 QL-XI-92 DDR1 9 20 2.32630161961136 NA 1.98357662957077 2.71211329744224 -0.728536667871472 1.42907529858672 1.17423067300728 0.580439674246978 0.509795857917322 0.620437435862276 0.219289182268945 NA NA 0.280659782047236 0.203232654878994 90.6527999345367 a371 EP300_mut 260 NG-25 MAP3K7 (TAK1) 6 23 2.32630161961136 NA 0.296735733319663 0.96909932055978 -0.672363587240117 1.99019325592833 1.2933379993235 0.464367187536864 0.337838340692442 0.519866877484314 0.220283086170283 NA NA 0.303569129968102 0.461418050559043 90.6527999345367 a372 ARID1A_mut 1072 BMS-708163 g-secretase 3 25 1.6094379124341 NA 3.77661761696839 3.31524194696084 0.461375670007543 0.211631570483766 0.695348330884382 0.68796057241788 2.18008905265358 0.663517332990129 0.220608315185843 NA NA 0.257941902523617 0.0336439129229006 90.6527999345367 a373 MLL2_mut 1054 PD-0332991 CDK4, CDK6 9 23 1.38629436111989 0.693147180559945 0.952963486348757 1.64349212620171 -0.69052863985295 1.81482447572017 1.35474240539111 0.463015056454384 0.380493347478647 0.509712132066609 0.220807951467983 NA NA 0.671021762614841 0.321970464350104 90.6527999345367 a374 PTEN_mut 38 AZD-0530 SRC, ABL1 4 23 0.693147180559945 NA 2.8672178079306 1.996105807515 0.871112000415601 0.0983381296572968 1.0934900591662 0.848747434245649 8.85833403026252 0.796634585850591 0.221101614343006 NA NA 0.220652884986276 0.00104275152579575 90.6527999345367 a375 CREBBP_mut 256 JW-7-24-1 LCK 6 23 2.32630161961136 NA -0.442323642376617 0.188507728677136 -0.630831371053753 0.74114629031569 1.04306741316997 0.634576304253102 0.851156349693192 0.604784851955638 0.222188269001181 NA NA 0.335565763960299 0.118966756904201 90.6527999345367 a376 EP300_mut 17 Cyclopamine SMO 5 22 2.77258872223978 NA 3.58696331865215 4.14846800645884 -0.561504687806683 0.975666411964422 1.06637462089113 0.533553508194966 0.575508883898278 0.526554811795364 0.222703915506632 NA NA 0.531735142667606 0.294803208074409 90.6527999345367 a377 PTEN_mut 37 Crizotinib MET, ALK 4 22 0.693147180559945 NA 2.6172171387206 1.89395475404802 0.723262384672581 0.352886720292124 0.952120707620145 0.80422914380965 2.04955965493361 0.759633078961592 0.224050153688716 NA NA 0.362785102392237 0.0186215454832822 90.6527999345367 a378 EP300_mut 179 5-Fluorouracil DNA antimetabolite 6 23 3.46573590279973 NA 2.3244087146037 1.48983659894005 0.834572115663656 0.825191937859694 1.65400655139591 0.543811188416734 1.0113672678726 0.504576064078653 0.224454159321502 NA NA 0.799922290247972 0.101781224273713 90.6527999345367 a379 loss_cnaDLBC2 1015 CI-1040 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 27 2.30258509299405 NA 1.9292962867495 2.74314685239631 -0.813850565646808 0.669150815756901 1.00995224590014 0.822478715891612 1.21624385188298 0.805830739968744 0.224533575450885 NA NA 0.127530100100679 0.152711939664876 90.6527999345367 a380 EP300_mut 1372 Trametinib MAP2K1 (MEK1), MAP2K2 (MEK2) 6 24 0 NA 1.35925102148743 0.452355894636171 0.906895126851258 0.415476708459204 1.80243553175931 0.551973914481591 2.18278211121504 0.50314982748152 0.224651619262859 NA NA 0.894578857232547 0.0333209121285764 90.6527999345367 a381 EP300_mut 37 Crizotinib MET, ALK 5 21 0.693147180559945 NA 2.52769847842904 1.88082765484731 0.646870823581732 0.609558621152411 0.94882059877031 0.717795989106661 1.06121183612952 0.681763048167471 0.225007115489939 NA NA 0.362848861890843 0.0902406099152737 90.6527999345367 a382 CREBBP_mut 211 TL-2-105 CRAF 6 23 2.32630161961136 1.63315443905142 2.51918831711202 2.98633656268603 -0.467148245574006 0.745910085312475 0.710475247779313 0.651377865231516 0.626279567433801 0.657515159091244 0.22620199616524 NA NA 0.132230890004577 0.207217413757936 90.6527999345367 a383 TP53_mut 52 GNF-2 ABL [T315I] 15 10 0.246860077931526 NA 2.14690714807159 2.38798051188622 -0.241073363814631 0.581499780173381 0.580157661745968 0.414946211400554 0.414571719601944 0.415530776735978 0.226868285453398 NA NA 0.443918697358196 0.321669275648652 90.6527999345367 a384 ARID1A_mut 1025 SB 216763 GSK3A, GSK3B 3 27 2.30258509299405 NA 4.58846953181925 4.07574750774873 0.512722024070527 0.172158006039038 0.743562439828124 0.714106990349226 2.97820610186589 0.689548041438246 0.227196670112339 NA NA 0.478068987909011 0.0105710334492288 90.6527999345367 a385 PTEN_mut 1261 rTRAIL TR10A (DR4), TR10B (DR5) 5 25 -2.30258509299405 NA -0.794704795800535 -1.57206739352445 0.777362597723911 0.56228442935936 1.39403185745201 0.594312307337158 1.38250777922056 0.55763617851945 0.22835146464885 NA NA 0.988473256591771 0.0550762761133636 90.6527999345367 a386 CREBBP_mut 38 AZD-0530 SRC, ABL1 7 20 0.693147180559945 NA 1.64547392553087 2.29304936629256 -0.64757544076169 1.44747946888127 0.863740866524018 0.626080469268243 0.447381434198987 0.749733474308967 0.228895900161443 NA NA 0.221123797847125 0.298610090941555 90.6527999345367 a387 loss_cnaDLBC2 1017 Olaparib PARP1, PARP2 3 27 1.6094379124341 NA 3.54100637861961 2.94653795503485 0.59446842358476 0.613076284585705 0.8836973350409 0.685524954347816 0.969648375791408 0.672705914132067 0.228927449501207 NA NA 0.304900432096855 0.226778095291042 90.6527999345367 a388 loss_cnaDLBC2 1371 PLX4720 (rescreen) BRAF 3 27 2.30258509299405 NA 2.92615130156177 3.43340127749528 -0.507249975933514 1.32456883687539 0.704496673687163 0.662528887183771 0.382954786351534 0.720017559882422 0.229302535705809 NA NA 0.200083200527387 0.577191552527169 90.6527999345367 a389 loss_cnaDLBC4_(CDKN2A) 170 Shikonin unknown 8 22 2.77258872223978 NA -0.78652753211267 -0.228662247268267 -0.557865284844403 0.907364950681261 1.12160268432616 0.520365426943706 0.614819080707879 0.497382266144948 0.229553197517661 NA NA 0.880460131868983 0.183085395356772 90.6527999345367 a390 MLL2_mut 1259 BMN-673 PARP1 9 21 2.30258509299405 NA 2.00814765926571 2.78271661964077 -0.774568960375063 1.24356640887961 1.5163752342845 0.536516630778937 0.622860954464757 0.510802961471831 0.229654588428785 NA NA 0.509006980728965 0.161015684506493 90.6527999345367 a391 ARID1A_mut 52 GNF-2 ABL [T315I] 3 22 0.246860077931526 NA 2.60231388646162 2.19438503093414 0.407928855527481 0.128595128790478 0.603148375024191 0.706279307581546 3.17219524070874 0.676332511898287 0.229696710751354 NA NA 0.444103112440907 0.0136265751802661 90.6527999345367 a392 EP300_mut 261 TL-1-85 MAP3K7 (TAK1) 6 23 2.32630161961136 NA 1.04739148060567 1.67135262929486 -0.623961148689183 0.997951249406029 1.24865410087637 0.517309742009389 0.625242113841291 0.499706963082294 0.230040582443257 NA NA 0.659152998362638 0.227224574899744 90.6527999345367 a393 EP300_mut 219 AT-7519 CDK9 6 23 2.32630161961136 NA -1.66942406511382 -0.983704591884351 -0.685719473229466 0.693198254554768 1.25485048511917 0.585415305986159 0.989211194234606 0.546455120638812 0.230120467487796 NA NA 0.808004214587261 0.0958231806443949 90.6527999345367 a394 PTEN_mut 1007 Docetaxel Microtubules 4 25 -4.38202663467388 NA -5.01916914545164 -4.29286621364085 -0.726302931810785 1.32052990031691 1.01307749962073 0.690607589769279 0.550008698505412 0.716927315119221 0.230344278135182 NA NA 0.777651430112297 0.358584640262421 90.6527999345367 a395 TP53_mut 1011 ABT-263 BCL2, BCL2L1, BCL2L2 19 13 0.693147180559945 NA 0.193412416190501 0.694606056107486 -0.501193639916985 1.32866697952827 2.13160061042615 0.295500425978438 0.37721539530916 0.235125490894275 0.230577609894885 NA NA 0.118421181682871 0.46070257554424 90.6527999345367 a396 loss_cnaDLBC2 206 Ruxolitinib JAK1, JAK2, TYK2 4 25 1.65632149833295 0.0237165266173161 2.10905245126902 3.04037150332826 -0.931319052059239 1.50591605196887 1.42764153900038 0.648302864279229 0.61844021839173 0.652347964539713 0.230627051615255 NA NA 0.755058229416787 0.31313342564962 90.6527999345367 a397 CREBBP_mut 1494 SN-38 TOP1 6 25 -2.99573227355399 NA -3.98310330574455 -4.80915594984057 0.826052644096018 1.59841388761025 1.55349228364545 0.529069995599207 0.516795212115575 0.531739135618742 0.230785212867018 NA NA 0.628922884744207 0.288484231447624 90.6527999345367 a398 CREBBP_mut 1015 CI-1040 MAP2K1 (MEK1), MAP2K2 (MEK2) 7 23 2.30258509299405 NA 2.19832927223703 2.80280647692564 -0.604477204688611 1.10967116823152 0.949995422584135 0.612817621730695 0.544735433337396 0.636294860289263 0.231639491244242 NA NA 0.127835534855767 0.225371207930631 90.6527999345367 a399 EP300_mut 300 CX-5461 RNA Pol I 6 23 2.32630161961136 NA 2.35824856368083 1.44961937498535 0.908629188695481 0.236532831767998 1.59683813011158 0.628805289136698 3.84145060076356 0.569017717927359 0.231733654548736 NA NA 0.445910129617041 0.0146857161409188 90.6527999345367 a400 ARID1A_mut 55 A-770041 SRC family 3 22 1.63315443905142 NA 2.94948485323243 1.18258560725085 1.76689924598158 0.606677910143194 2.69400514458378 0.684733190470299 2.91241730816364 0.655863352575211 0.232051915420087 NA NA 0.346988212621559 0.0182488051543911 90.6527999345367 a401 CREBBP_mut 292 Masitinib KIT 6 23 2.99573227355399 NA 2.43508326901628 2.78950920841484 -0.354425939398557 0.41039067305752 0.723820057744744 0.523664793282748 0.863630590719788 0.489660290021344 0.2323661220727 NA NA 0.576868917535503 0.137909392132914 90.6527999345367 a402 loss_cnaDLBC2 308 XL-880 MET 4 25 1.63315443905142 NA 0.0713811046481914 -0.48069404400834 0.552075148656531 0.733946749263569 0.851895884515199 0.657538328220998 0.752200550258551 0.64805471970405 0.233431192888039 NA NA 0.905489228432744 0.237937085530159 90.6527999345367 a403 PTEN_mut 62 BMS-536924 IGF1R 4 21 1.63315443905142 NA 3.05836272572662 1.75004092611842 1.3083217996082 1.29738383271822 1.44935505857455 0.914623400909337 1.00843078710721 0.902692402298538 0.233815933444602 NA NA 0.0534592603796088 0.135251868406913 90.6527999345367 a404 ARID1A_mut 288 KIN001-055 JAK3, MNK1 3 26 2.32630161961136 NA 3.22348502903559 3.83571074047351 -0.612225711437918 1.52818985090483 0.739463907690501 0.742819203489499 0.400621500709106 0.827931836930387 0.233883468691531 NA NA 0.862481537635928 0.561007127106365 90.6527999345367 a405 ARID1A_mut 1373 Dabrafenib BRAF 3 27 2.30258509299405 NA 1.89263424201454 3.01523584933678 -1.12260160732224 1.78132963385843 1.43066545379403 0.769689906394241 0.630204306931467 0.784670940606813 0.234960680664683 NA NA 0.708848657055978 0.389858364120791 90.6527999345367 a406 ARID1A_mut 1052 RO-3306 CDK1 3 29 1.6094379124341 NA 3.63972506970926 3.08400288383446 0.555722185874799 0.367546840574971 0.8619766888633 0.663043323392226 1.51197650075146 0.644706745617028 0.235371228420066 NA NA 0.232999539996435 0.0929949236738698 90.6527999345367 a407 PTEN_mut 1005 Cisplatin DNA crosslinker 4 26 1.79175946922805 2.30258509299405 3.47727678746865 2.62249344698153 0.854783340487118 1.35582165500925 0.92319087927081 0.873355720533354 0.630454114174246 0.925900980696728 0.235656411588697 NA NA 0.106989248954703 0.300023697088057 90.6527999345367 a408 TP53_mut 1061 SB590885 BRAF 19 13 1.6094379124341 NA 3.10179083100634 3.43778897198482 -0.335998140978474 0.793432293989265 0.793361437714094 0.423489371373148 0.423474244146433 0.423512065253112 0.236796510473817 NA NA 0.922812691916113 0.250043953949022 90.6527999345367 a409 loss_cnaDLBC2 1372 Trametinib MAP2K1 (MEK1), MAP2K2 (MEK2) 3 27 0 NA -0.456534719876723 0.754875991104549 -1.21141071098127 0.786934093930852 1.69083367630232 0.737385391975241 1.53940554911034 0.716457643326871 0.237601151085668 NA NA 0.894736113505915 0.0886308923182614 90.6527999345367 a410 TP53_mut 94 TGX221 PI3Kbeta 16 11 2.30258509299405 NA 3.26910456219383 3.7770171616142 -0.507912599420373 1.38875683055799 0.545247940558847 0.449620086586103 0.365731846097417 0.931525938272764 0.237895249883282 NA NA 0.844118700194057 0.20039041986944 90.6527999345367 a411 PTEN_mut 219 AT-7519 CDK9 6 23 2.32630161961136 NA -1.66099123870439 -0.985904459643332 -0.675086779061055 0.408609328602697 1.2841509066125 0.575803064698002 1.65215704049053 0.525706733986496 0.237940771265994 NA NA 0.808178696872651 0.0421107294564638 90.6527999345367 a412 loss_cnaDLBC4_(CDKN2A) 1018 ABT-888 PARP1, PARP2 8 22 1.6094379124341 NA 3.71571948426136 3.46565253297376 0.250066951287606 0.53451197499529 0.598552571649624 0.428782691786255 0.46784162560588 0.417786111249035 0.237955332445825 NA NA 0.365066910541674 0.291464091028211 90.6527999345367 a413 ARID1A_mut 1018 ABT-888 PARP1, PARP2 3 27 1.6094379124341 NA 3.88851882103247 3.49276130134875 0.39575751968372 0.263136394586157 0.599005165052299 0.680598925231809 1.50400145257801 0.660691330848819 0.238197065132038 NA NA 0.365079680562275 0.0944445724618573 90.6527999345367 a414 TP53_mut 1239 YK 4-279 RNA helicase A 18 9 2.30258509299405 NA 1.92121898888848 1.29385982123042 0.627359167658058 1.5951750930941 1.37162842290046 0.410789243622906 0.393285458363816 0.457382740969625 0.238281528270621 NA NA 0.391175897040776 0.302871696249698 90.6527999345367 a415 loss_cnaDLBC4_(CDKN2A) 1091 BMS-536924 IGF1R 7 23 1.38629436111989 NA 2.63721622010585 2.13271658680912 0.504499633296733 0.855205636948774 0.99780509463801 0.520630721153973 0.589916169281462 0.505609398075642 0.238367739088615 NA NA 0.961885004420023 0.215050470423648 90.6527999345367 a416 loss_cnaDLBC4_(CDKN2A) 1025 SB 216763 GSK3A, GSK3B 8 22 2.30258509299405 NA 4.36179520598759 4.04164680258058 0.320148403407011 0.592830334044791 0.758527308478386 0.444228850366311 0.540033775300747 0.42206575798732 0.239058027458516 NA NA 0.478662374716295 0.244178142019939 90.6527999345367 a417 CREBBP_mut 1001 AICAR AAPK1 (AMPK) agonist 7 23 7.60090245954208 NA 6.91728760948576 6.51371035091956 0.403577258566198 0.608955388525691 0.857147096776562 0.498005231819384 0.662736985616101 0.470837806117427 0.23906757707658 NA NA 0.726731290862482 0.187710138538807 90.6527999345367 a418 EP300_mut 1057 NVP-BEZ235 PI3K (Class 1) and MTORC1/2 6 26 -1.38629436111989 0.693147180559945 -3.63362094466887 -3.0500127056486 -0.583608239020269 0.675761210840089 1.03820194635971 0.591246744500832 0.863630864954119 0.562133639863226 0.240749507009042 NA NA 0.586948182117485 0.116148741330558 90.6527999345367 a419 PTEN_mut 1030 KU-55933 ATM 5 27 2.30258509299405 NA 2.64966334864929 3.21300437117403 -0.563341022524737 0.569322272498001 0.923290125469464 0.63703386101343 0.989494087510365 0.610145182954595 0.240912918059707 NA NA 0.608698374262411 0.104828088491054 90.6527999345367 a420 loss_cnaDLBC4_(CDKN2A) 333 T0901317 LXR 7 22 2.32630161961136 NA 2.37117979334261 3.07901085125939 -0.707831057916785 1.79260477301955 1.15378759871154 0.535147383585673 0.394861750102607 0.61348471651735 0.24116302704226 NA NA 0.872330168140592 0.356143881147791 90.6527999345367 a421 loss_cnaDLBC4_(CDKN2A) 1052 RO-3306 CDK1 8 24 1.6094379124341 NA 3.39009810889665 3.05143641538141 0.338661693515238 0.392246934031483 0.935966318875882 0.402619739590812 0.863389013738107 0.361831068795273 0.241425840856724 NA NA 0.233286247292323 0.162481787797044 90.6527999345367 a422 MLL2_mut 328 SNX-2112 HSP90 8 20 0.940007258491471 NA -3.16996029944061 -2.50947814957361 -0.660482149866998 0.591636267522666 1.46613532137319 0.511852999307218 1.11636521647432 0.450491943164147 0.241922841250686 NA NA 0.910058725400049 0.101395156618242 90.6527999345367 a423 EP300_mut 1021 Axitinib PDGFR, KIT, VEGFR 5 25 0.693147180559945 NA 2.10881131563104 1.61451394627696 0.494297369354084 0.793593395062113 0.909197890415141 0.553153395570709 0.622859731985794 0.54366312830795 0.2421883406834 NA NA 0.843625450409314 0.259304705432579 90.6527999345367 a424 EP300_mut 175 PAC-1 CASP3 agonist 5 24 0.940007258491471 NA 1.61200547717019 1.04815501320771 0.563850463962484 1.13434612928431 1.01422796316424 0.545887991044116 0.49707091107917 0.555940562123091 0.242732243714759 NA NA 0.78343589780689 0.34717657411316 90.6527999345367 a425 PTEN_mut 1372 Trametinib MAP2K1 (MEK1), MAP2K2 (MEK2) 5 25 0 NA -0.178908049556938 0.796263513919094 -0.975171563476032 2.73702537815537 1.37848258634473 0.593586834576874 0.356288827739424 0.70742392623316 0.2432350650452 NA NA 0.894801257492526 0.476590330758438 90.6527999345367 a426 PTEN_mut 172 Embelin XIAP 5 24 3.46573590279973 NA 3.20067625807864 2.56761495426091 0.63306130381773 1.52837549879067 1.06858074957171 0.551267374403327 0.414205346996624 0.592431881326202 0.243879155359142 NA NA 0.824069214648052 0.419184304455225 90.6527999345367 a427 loss_cnaDLBC2 1058 GDC0941 PI3K (class 1) 3 29 1.38629436111989 0.693147180559945 1.59639732896375 0.0586148716434371 1.53778245732031 2.5428427422967 1.97235469590047 0.763009402814113 0.604749334963351 0.779668312457485 0.245259067329009 NA NA 0.440774265319805 0.405868286952829 90.6527999345367 a428 CREBBP_mut 190 Bleomycin DNA damage 7 22 4.15888308335967 NA 0.597311824190933 1.58304993499616 -0.985738110805224 2.00382420487989 1.64900051543533 0.568431911984628 0.491928437836348 0.597779140502569 0.246100600520134 NA NA 0.434882483635001 0.268889962034802 90.6527999345367 a429 ARID1A_mut 346 THZ-2-102-1 CDK7 3 26 0.916290731874155 2.99573227355399 -4.60446062528374 -3.66467883199739 -0.939781793286346 1.28340863422369 1.41689313224059 0.667724415650792 0.732254535481448 0.663269354549153 0.246457903287371 NA NA 0.368139163231477 0.332180698762778 90.6527999345367 a430 MLL2_mut 1028 VX-702 p38 8 22 0.693147180559945 NA 2.29276314940338 1.94797107207734 0.344792077326045 0.737822703297989 0.809496148505951 0.435241337847494 0.467310203094675 0.425934178886968 0.246537934202558 NA NA 0.470592044067594 0.28944086956843 90.6527999345367 a431 PTEN_mut 308 XL-880 MET 6 23 1.63315443905142 NA -0.758448458216633 -0.31222330140504 -0.446225156811593 0.713883609508851 0.868352426403758 0.530029069730003 0.625067098989139 0.513875637636684 0.247107871842249 NA NA 0.90563703688145 0.224749755536128 90.6527999345367 a432 PTEN_mut 256 JW-7-24-1 LCK 6 23 2.32630161961136 NA -0.295302522555599 0.150154393071653 -0.445456915627252 0.547383219210312 1.0899028658764 0.440335717232347 0.813793517948715 0.408712491336607 0.247181463101391 NA NA 0.336970569572055 0.180578024690989 90.6527999345367 a433 MLL2_mut 1194 SB-505124 TGFR1 (ALK5) 9 21 2.30258509299405 NA 3.65010030507336 3.44858400699263 0.201516298080727 0.374017774191233 0.596444068944472 0.371606330514171 0.538788025559699 0.337862858519746 0.248240591802367 NA NA 0.233790197036576 0.274738663229931 90.6527999345367 a434 CREBBP_mut 1261 rTRAIL TR10A (DR4), TR10B (DR5) 6 24 -2.30258509299405 NA -0.874287372453625 -1.58456185759967 0.710274485146045 0.376309433937209 1.43394775014752 0.542476660588681 1.88747456505319 0.495328009736042 0.249807032463585 NA NA 0.988500771573634 0.0405421959141447 90.6527999345367 a435 EP300_mut 1016 Temsirolimus MTOR 5 25 -1.6094379124341 NA -4.15072942273763 -3.20531450862437 -0.945414914113264 1.28473346529593 1.93622609744281 0.509053629750286 0.735884087751613 0.488277125983314 0.249899772004474 NA NA 0.645174014518808 0.20877213293895 90.6527999345367 a436 MLL2_mut 1031 Elesclomol HSP70 8 22 -1.6094379124341 NA -3.36512486719798 -2.69476659679071 -0.670358270407271 1.14614196949226 1.34696850621551 0.51578940484687 0.584882403969764 0.497679245887294 0.250547652797139 NA NA 0.671346584448505 0.197700773507575 90.6527999345367 a437 MLL2_mut 207 AS601245 JNK 9 20 2.07944154167984 NA 2.23455073554372 1.87625341695525 0.358297318588475 0.830305638704985 0.693874676423682 0.486198312123588 0.431524612005894 0.516371804250279 0.251003120564956 NA NA 0.852344812385633 0.2788033931999 90.6527999345367 a438 loss_cnaDLBC4_(CDKN2A) 9 MG-132 Proteasome 8 19 0 NA -0.32600500367921 -0.686922241504261 0.360917237825051 1.25784432010396 1.05930715980925 0.322692488389231 0.286933153854224 0.3407106564729 0.251569260876395 NA NA 0.0747658206921114 0.490666585627073 90.6527999345367 a439 loss_cnaDLBC4_(CDKN2A) 177 GSK-650394 SGK3 8 21 2.77258872223978 NA 2.52338996340357 3.08728083465321 -0.563890871249637 1.15101845478696 1.21208482152322 0.471263118452956 0.48990602097167 0.465223935847161 0.252347303013055 NA NA 0.826109839455702 0.265687441510279 90.6527999345367 a440 MLL2_mut 104 Bortezomib Proteasome 9 19 -3.91202300542815 NA -6.53848811390913 -5.89335506690246 -0.645133047006669 0.748880162497949 1.21817454672674 0.588945308278815 0.861463661762353 0.529589990810558 0.253370240418191 NA NA 0.0803917617014203 0.0980453038000065 90.6527999345367 a441 MLL2_mut 269 NSC-207895 MDM4 8 20 2.99573227355399 NA 2.5249178981995 3.23945483524782 -0.714536937048314 1.2801765227601 1.28167797314925 0.557676958611749 0.558155007801384 0.55750114460702 0.253565102313532 NA NA 0.337250892478823 0.205219210075518 90.6527999345367 a442 loss_cnaDLBC4_(CDKN2A) 88 MS-275 HDAC 8 21 1.6094379124341 NA 0.364945805641936 -0.132216211535233 0.497162017177169 1.3332211496128 1.52007743258549 0.337308346392307 0.372902888107915 0.32706361302368 0.253832524445631 NA NA 0.0880272796939976 0.402505435969158 90.6527999345367 a443 MLL2_mut 1011 ABT-263 BCL2, BCL2L1, BCL2L2 9 23 0.693147180559945 NA -0.254154585152334 0.651830691451645 -0.905985276603979 1.95185178365462 1.54408783661521 0.544910260145738 0.464167045977039 0.58674464957252 0.254041446111327 NA NA 0.119266613438455 0.235562138595334 90.6527999345367 a444 EP300_mut 1020 Lenalidomide TNFA 5 25 1.6094379124341 NA 3.56282359859475 3.00643238600042 0.556391212594333 0.458665349560364 0.867112653009658 0.677455863613626 1.21306572019805 0.641659662862901 0.254417953249525 NA NA 0.325764762556406 0.0629942604472203 90.6527999345367 a445 PTEN_mut 1016 Temsirolimus MTOR 4 26 -1.6094379124341 NA -4.21750598581476 -3.23140330330917 -0.986102682505591 1.57239077700219 1.89223108787894 0.529993422976175 0.627135885638826 0.521132270166296 0.254817576021134 NA NA 0.645342638475583 0.313953233673436 90.6527999345367 a446 ARID1A_mut 177 GSK-650394 SGK3 3 26 2.77258872223978 NA 2.17523855260621 3.01901159912028 -0.84377304651407 1.29910302780297 1.18673841032715 0.705835809566055 0.649504333725593 0.711001716276686 0.25507692312729 NA NA 0.826160026983584 0.378583396956221 90.6527999345367 a447 PTEN_mut 1170 CCT018159 HSP90 5 25 2.30258509299405 NA 2.47121233905906 2.91497650502726 -0.443764165968195 1.26665778246842 0.800666415782776 0.502886806914488 0.350342588274635 0.554243511680638 0.25607817900578 NA NA 0.651985701265687 0.487257575522664 90.6527999345367 a448 ARID1A_mut 176 IPA-3 PAK1, PAK2, PAK3 3 26 3.46573590279973 NA 1.95256149615456 2.95370705702328 -1.00114556086871 0.403519413878514 1.32620797656511 0.781619089924342 2.48103443461614 0.754893333896006 0.256256323317482 NA NA 0.0514850089173663 0.0186099784400871 90.6527999345367 a449 MLL2_mut 1072 BMS-708163 g-secretase 6 22 1.6094379124341 NA 3.60120424695171 3.30016709287346 0.301037154078248 0.815365032859556 0.636682426896343 0.44615979923121 0.369205376667288 0.472821521941047 0.256568442601685 NA NA 0.25996090482691 0.430979946935056 90.6527999345367 a450 EP300_mut 177 GSK-650394 SGK3 5 24 2.77258872223978 NA 3.46329817840277 2.82098026428884 0.642317914113933 1.13645330702604 1.20912556349355 0.535873431498863 0.565195164766428 0.531225154365335 0.256699467101142 NA NA 0.826189540602743 0.29861071807084 90.6527999345367 a451 PTEN_mut 110 Roscovitine CDKs 4 24 2.77258872223978 NA 3.92769997981075 3.24838179121751 0.679318188593237 1.23172373114557 0.896384970192489 0.721761057641843 0.551518308380266 0.757842011170001 0.256818233002097 NA NA 0.484844031895818 0.356935774570264 90.6527999345367 a452 EP300_mut 204 Tipifarnib Farnesyl-transferase (FNTA) 5 24 2.77258872223978 NA 1.71122211974796 0.904042651467504 0.80717946828046 2.06522031031365 1.52001231697402 0.500589312999537 0.390844242742253 0.531034820748926 0.256909168577102 NA NA 0.626145998295223 0.44555815242591 90.6527999345367 a453 MLL2_mut 30 Sorafenib PDGFRA, PDGFRB, KDR, KIT, FLT3 9 19 1.38629436111989 NA 1.27371503954378 1.81516820708544 -0.541453167541664 0.682843039845514 0.978163599841473 0.603153555108765 0.792939425236234 0.553540499390302 0.256980093149101 NA NA 0.0297657930691406 0.104440142722791 90.6527999345367 a454 CREBBP_mut 1502 Bicalutamide ANDR (androgen receptor) 5 23 2.30258509299405 NA 4.04655052608604 3.63016731114623 0.416383214939815 0.378539876444029 0.709901256051063 0.621763611442689 1.09997186782878 0.586536805493219 0.2576583532723 NA NA 0.468193536501397 0.0904710989440676 90.6527999345367 a455 ARID1A_mut 140 Vinorelbine Microtubules 3 27 -2.74887219562247 NA -5.35544220797288 -4.39150236348882 -0.96393984448406 0.843854302703047 1.39442398485173 0.707480965014059 1.1423060134864 0.691281744258403 0.25778637934378 NA NA 0.92012053151699 0.171267851912613 90.6527999345367 a456 TP53_mut 231 FMK RSK 17 11 2.99573227355399 2.32630161961136 4.4864888133919 4.69199433566624 -0.205505522274347 0.620112425184435 0.804846848973306 0.29485015235705 0.33140042664558 0.255334940475319 0.258102331415774 NA NA 0.143050626539997 0.481121171732864 90.6527999345367 a457 loss_cnaDLBC2 262 VX-11e ERK 4 25 1.63315443905142 NA 1.31005618210659 2.14300326023295 -0.83294707812636 1.18618179290103 1.26303222107853 0.663847918864964 0.702208618536651 0.659482049804785 0.258973263304587 NA NA 0.536299343370786 0.263279587842922 90.6527999345367 a458 loss_cnaDLBC2 150 Bicalutamide ANDR (androgen receptor) 4 25 0.0237165266173161 NA 2.25615994710162 1.96839832693022 0.287761620171402 0.218460716631269 0.524965239062152 0.575212313151619 1.31722363914563 0.548153665727443 0.25950883624838 NA NA 0.456396062020348 0.086622045995043 90.6527999345367 a459 ARID1A_mut 279 BIX02189 MAP2K5 (MEK5) 3 26 2.99573227355399 NA 2.41442564006538 3.09216100406512 -0.677735363999739 1.3531315823219 0.853083200225977 0.753285540830314 0.500864345237424 0.794454003806675 0.260074516876113 NA NA 0.402873211047411 0.478928754140638 90.6527999345367 a460 loss_cnaDLBC4_(CDKN2A) 330 XMD13-2 RIPK 7 22 2.32630161961136 NA 1.39174284510678 1.95884883470297 -0.56710598959619 0.863850059135735 1.11782044618893 0.531684407825319 0.656486601579409 0.507331916793674 0.26014124827012 NA NA 0.669675074394077 0.183999140908931 90.6527999345367 a461 loss_cnaDLBC2 1149 TW 37 BCL2, BCL2L1 3 27 1.6094379124341 NA -0.57955650585849 -1.04675599917094 0.467199493312448 0.533662784329502 0.687271099190899 0.689639024576706 0.875458261342772 0.67978923289873 0.260705403784467 NA NA 0.756198337621516 0.263903085342378 90.6527999345367 a462 ARID1A_mut 1170 CCT018159 HSP90 3 27 2.30258509299405 NA 3.37929279721384 2.78120725664205 0.598085540571791 1.14022351666109 0.856149475599632 0.680037794120002 0.524533595240309 0.698576075343506 0.260742021820498 NA NA 0.652138504540536 0.461808187286604 90.6527999345367 a463 PTEN_mut 283 GSK2126458 PI3K, MTOR 6 23 -2.05572501506252 0.0237165266173161 -5.26786731971841 -4.30803274035019 -0.959834579368222 0.597812708674206 1.89473899476093 0.554957142835561 1.60557740817669 0.506578785796999 0.261836974725216 NA NA 0.749155098348428 0.0489980565165659 90.6527999345367 a464 loss_cnaDLBC4_(CDKN2A) 1527 GDC0941 (rescreen) PI3K 6 21 1.38629436111989 NA 1.51316210276079 0.609593949680618 0.903568153080171 1.07347918027957 1.53600196875199 0.620878815954722 0.841719308282117 0.588259762332417 0.261929260776027 NA NA 0.15354130828725 0.128370819871195 90.6527999345367 a465 EP300_mut 268 YM155 BIRC5 (Survivin) 6 23 1.63315443905142 NA -5.30192144957904 -4.71467265164253 -0.58724879793651 0.369095136767632 1.17651947317451 0.546877367006675 1.59104994739126 0.499140737851096 0.262393191450446 NA NA 0.811285557855816 0.0517951157812285 90.6527999345367 a466 loss_cnaDLBC2 1261 rTRAIL TR10A (DR4), TR10B (DR5) 3 27 -2.30258509299405 NA -0.608341655969199 -1.53519199441505 0.926850338445847 0.534978734352815 1.35207096108699 0.707136101850832 1.73249940405032 0.68550421177651 0.262492498769699 NA NA 0.988515687257812 0.0643827783664828 90.6527999345367 a467 TP53_mut 229 LY317615 PRKCB (PKCbeta) 17 12 2.99573227355399 2.32630161961136 2.09716279659963 2.38054407865223 -0.283381282052598 1.09989434364207 0.798485910070049 0.286748260265282 0.257644094353863 0.354898287469765 0.263183410478049 NA NA 0.162761954856983 0.428547371852489 90.6527999345367 a468 TP53_mut 1373 Dabrafenib BRAF 18 12 2.30258509299405 NA 3.16769852410568 2.50589143535287 0.661807088752814 1.14539684905096 1.84660383327625 0.452809210170265 0.577797196928877 0.358391484316716 0.264795840001607 NA NA 0.709720804203242 0.283788066627815 90.6527999345367 a469 EP300_mut 56 WH-4-023 SRC family, ABL 5 20 1.63315443905142 NA 0.949713621497129 2.00959218954014 -1.05987856804301 2.02070960818792 2.14350605422086 0.499316101636779 0.524508105344964 0.494460263340968 0.264915321553023 NA NA 0.578325793162024 0.337368580664838 90.6527999345367 a470 PTEN_mut 331 QL-X-138 MNK2, PRKDC (DNAPK), MTOR, BTK, JAK3 6 23 2.32630161961136 NA -0.720413144846172 -0.114797022168389 -0.605616122677783 0.514673040978353 1.42077010543128 0.465331769076783 1.17670069045496 0.42625905511571 0.265820670996571 NA NA 0.588734928248332 0.108687642001013 90.6527999345367 a471 ARID1A_mut 204 Tipifarnib Farnesyl-transferase (FNTA) 3 26 2.77258872223978 NA 0.0769559932527459 1.15470254823853 -1.07774655498578 1.74200533523598 1.59628722002347 0.670434604678601 0.618681546598008 0.675158293236187 0.266029031886082 NA NA 0.626470699783635 0.397958791414201 90.6527999345367 a472 CREBBP_mut 156 AZD6482 PI3Kbeta 7 23 1.63315443905142 NA 0.969891023634034 1.86017859327173 -0.890287569637695 1.92614199078134 1.71476434343652 0.505215032589332 0.462212845106269 0.519189457749914 0.266103043094241 NA NA 0.860791593930781 0.300549157627668 90.6527999345367 a473 PTEN_mut 222 BX-912 PDPK1 (PDK1) 6 23 2.32630161961136 NA 0.538533836245531 1.14674505834859 -0.608211222103055 1.5502037214159 1.4910737739697 0.404880492392977 0.392342769986087 0.407901495365858 0.267589213682672 NA NA 0.282113635336501 0.414747742111327 90.6527999345367 a474 loss_cnaDLBC4_(CDKN2A) 1015 CI-1040 MAP2K1 (MEK1), MAP2K2 (MEK2) 8 22 2.30258509299405 NA 2.25935112048146 2.80809295050442 -0.548741830022956 0.885779830989027 1.02225642395972 0.554339082716853 0.619501382651999 0.536794699609123 0.270230518211846 NA NA 0.129320996846008 0.171892337699116 90.6527999345367 a475 loss_cnaDLBC4_(CDKN2A) 119 Lapatinib ERBB2, EGFR 8 20 0.693147180559945 NA 2.71286079295141 2.44069318208351 0.272167610867895 0.656109691501177 0.714488116234895 0.389227642891285 0.414820287511949 0.380926714781659 0.27046499883254 NA NA 0.334520767715526 0.350239871268604 90.6527999345367 a476 TP53_mut 1009 ATRA Retinoic acid and retinoid X receptor agonist 17 13 2.30258509299405 NA 2.96326348848357 3.41855652271364 -0.45529303423007 0.905772794806494 0.929976896130462 0.496923127551221 0.502656998356124 0.489574564835425 0.270779259532653 NA NA 0.303300040543728 0.19078767500111 90.6527999345367 a477 TP53_mut 1264 SGC0946 Q8TEK3 (DOT1L) 18 12 -0.693147180559945 NA 1.10186545514928 1.31586039896561 -0.213994943816327 0.585346386150308 0.491391761718526 0.388832952647728 0.365586854005752 0.435487447058393 0.271168523199484 NA NA 0.763902304282775 0.289293780261156 90.6527999345367 a478 CREBBP_mut 277 ABT-869 VEGFR and PDGFR family 6 23 0.0237165266173161 NA 2.1545287224969 1.73649540629299 0.41803331620391 0.441548004379318 0.871304837534895 0.516646259318927 0.946744888568882 0.479778486467049 0.27150106999432 NA NA 0.967124206024068 0.121373374914915 90.6527999345367 a479 EP300_mut 1019 Bosutinib SRC, ABL, TEC 5 25 0.693147180559945 NA 1.80241388036688 0.946097515352371 0.85631636501451 1.69244159572298 1.15580853079479 0.686869813237433 0.505965090422342 0.7408808139058 0.271654329501928 NA NA 0.202231475399833 0.330837077175305 90.6527999345367 a480 ARID1A_mut 1057 NVP-BEZ235 PI3K (Class 1) and MTORC1/2 3 29 -1.38629436111989 0.693147180559945 -2.51721825402669 -3.22587590526886 0.708657651242171 0.125116120817032 1.02632516448367 0.714336317458731 5.66399954389973 0.690480634954211 0.271688955949878 NA NA 0.588043376703329 0.00165064877164175 90.6527999345367 a481 loss_cnaDLBC4_(CDKN2A) 1006 Cytarabine DNA synthesis 8 22 0.693147180559945 NA -0.793418449155215 0.0311482069601364 -0.824566656115351 1.76386691387424 1.96124518499842 0.430850850342696 0.467476684113449 0.420430174881993 0.272095527882161 NA NA 0.649284810273869 0.290931476712183 90.6527999345367 a482 MLL2_mut 6 PHA-665752 MET 8 19 0.693147180559945 NA 2.78017529753035 2.50861764716834 0.271557650362015 0.58814242319946 0.73242741977548 0.390700437109181 0.461720902370479 0.370763905105108 0.272116802606589 NA NA 0.355964703267065 0.324490974392549 90.6527999345367 a483 TP53_mut 1006 Cytarabine DNA synthesis 17 13 0.693147180559945 NA 0.114624708157457 -0.585439006061191 0.700063714218648 1.96027594684449 1.85854547841834 0.36512270277542 0.357125085039972 0.376672899505487 0.272294828208736 NA NA 0.649290972222147 0.327109404127088 90.6527999345367 a484 MLL2_mut 277 ABT-869 VEGFR and PDGFR family 9 20 0.0237165266173161 NA 2.07261209565287 1.71065289094221 0.361959204710661 0.573562769462362 0.890393182924115 0.447111965785251 0.631071652453923 0.406516145509965 0.272619963753399 NA NA 0.967127832080162 0.20255995403488 90.6527999345367 a485 TP53_mut 235 QL-XII-47 BTK, BMX 16 12 2.32630161961136 NA 0.565070604197844 -0.0515723117621931 0.616642915960037 1.18530436596449 1.23646057010879 0.51079920953027 0.520240145625611 0.498716199179551 0.27281660961283 NA NA 0.336721925463425 0.19665286025965 90.6527999345367 a486 CREBBP_mut 1062 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 7 25 1.38629436111989 0.693147180559945 3.20105625512269 2.75746205589392 0.443594199228778 0.398228645981067 0.980797360675781 0.495554636764772 1.11391835747011 0.45227915267139 0.273919459980528 NA NA 0.800493491571285 0.0847191477011869 90.6527999345367 a487 loss_cnaDLBC4_(CDKN2A) 300 CX-5461 RNA Pol I 7 22 2.32630161961136 NA 1.04528254880852 1.82607996204947 -0.780797413240951 2.00768360769272 1.25135982999928 0.537058127662288 0.388904611388576 0.623959147898649 0.273987153696421 NA NA 0.447966693453534 0.361793496436559 90.6527999345367 a488 CREBBP_mut 1529 MLN4924 NEDD8-activating enzyme 4 23 0 NA 1.24805857737103 0.273182159121508 0.974876418249518 0.989971061547167 1.55364997272731 0.65110893299086 0.984752439860152 0.627474936673283 0.274243414602508 NA NA 0.547387523745824 0.150702055234718 90.6527999345367 a489 loss_cnaDLBC4_(CDKN2A) 1029 AMG-706 VEGFR, RET, c-KIT, PDGFR 8 24 0.693147180559945 NA 2.81592795353344 2.58844219501319 0.227485758520251 0.521083562139417 0.60114126788086 0.389901263577174 0.436562914374541 0.378423127266213 0.274440938005569 NA NA 0.346398265964283 0.321815715648412 90.6527999345367 a490 ARID1A_mut 194 AUY922 HSP90 3 26 -1.36257783450257 NA -3.83423588198442 -3.00012054746317 -0.834115334521258 0.776667257911488 1.20087754206828 0.710054741194387 1.07396742430504 0.694588170151518 0.275716192465724 NA NA 0.701403630178682 0.191488083897661 90.6527999345367 a491 loss_cnaDLBC4_(CDKN2A) 1039 SL 0101-1 RSK, AURKB, PIM3 8 24 2.30258509299405 NA 4.19128046425162 3.86514488251627 0.326135581735352 0.791252678473883 0.723663676887555 0.440731602291861 0.412176275174677 0.450672863861354 0.275979523388852 NA NA 0.822578131375787 0.324360994225044 90.6527999345367 a492 loss_cnaDLBC2 295 NVP-BHG712 EPHB4 4 25 2.32630161961136 NA 1.98446523477544 1.18808338312416 0.79638185165128 1.17106700521342 1.55719147145908 0.524230984917163 0.68004806565799 0.511421919685364 0.276052570345811 NA NA 0.26966401137101 0.284757466839638 90.6527999345367 a493 PTEN_mut 1054 PD-0332991 CDK4, CDK6 5 27 1.38629436111989 0.693147180559945 0.714467924888444 1.58535743167911 -0.870889506790662 1.20794628077153 1.52887776662873 0.584455885267946 0.720967083266659 0.569626641056484 0.276100512181438 NA NA 0.672712206713266 0.202029761599371 90.6527999345367 a494 loss_cnaDLBC4_(CDKN2A) 290 KIN001-260 IKK 7 22 2.99573227355399 NA 3.42694659734271 2.99274660577448 0.434199991568231 1.16385349332599 0.893994374458751 0.452038538915089 0.373071004261368 0.485685373390753 0.277091127314638 NA NA 0.663316111697197 0.390396021210709 90.6527999345367 a495 loss_cnaDLBC2 1018 ABT-888 PARP1, PARP2 3 27 1.6094379124341 NA 3.85906378523965 3.49603408310351 0.36302970213614 0.385932224054898 0.596032761014276 0.62211659609933 0.940656621833424 0.609076758664017 0.277268505153654 NA NA 0.366956613746268 0.238267660555681 90.6527999345367 a496 CREBBP_mut 1242 (5Z)-7-Oxozeaenol MAP3K7 (TAK1) 6 23 2.30258509299405 NA 1.59075874159169 1.10743684642676 0.483321895164934 1.08253158994852 0.913160544704014 0.510471756982942 0.446473710007779 0.529284689278373 0.278696355603238 NA NA 0.98701077113463 0.348764542291033 90.6527999345367 a497 MLL2_mut 1010 Gefitinib EGFR 8 22 -0.693147180559945 NA 1.22835462175312 0.929390968994401 0.298963652758721 0.462008767458597 0.708699303020898 0.455886644230073 0.647095193459748 0.421848379819706 0.279650045259828 NA NA 0.981769247673127 0.194606577494663 90.6527999345367 a498 MLL2_mut 245 UNC0638 G9a(EHMT2), GLP(EHMT1) 9 20 3.68887945411394 NA 1.65544016464084 1.97463742597132 -0.319197261330476 0.588330350897097 0.735225774815283 0.459312424476233 0.542547670443584 0.434148627896881 0.280132634518303 NA NA 0.834780445080922 0.227275366612901 90.6527999345367 a499 MLL2_mut 1057 NVP-BEZ235 PI3K (Class 1) and MTORC1/2 9 23 -1.38629436111989 0.693147180559945 -2.82567397960924 -3.29004305210408 0.464369072494838 0.87639108388935 1.03024408159377 0.46832475039613 0.529865126461588 0.450736947477989 0.280469768961947 NA NA 0.588325860745799 0.217360747043273 90.6527999345367 a500 CREBBP_mut 288 KIN001-055 JAK3, MNK1 6 23 2.32630161961136 NA 3.44554237077283 3.85763826586005 -0.412095895087219 1.18913119469507 0.722078731155044 0.497295578410839 0.346552085190982 0.570707704446614 0.280731451436875 NA NA 0.863156124300956 0.448473170703162 90.6527999345367 a501 MLL2_mut 159 HG-6-64-1 BRAFV600E, TAK, MAP4K5 9 21 1.63315443905142 NA 0.00648453693675298 0.806437910392836 -0.799953373456083 1.16208377952212 1.77123719234924 0.493576994944326 0.688378400553054 0.451635374929703 0.281135984980602 NA NA 0.424163775744794 0.157416774741555 90.6527999345367 a502 MLL2_mut 140 Vinorelbine Microtubules 9 21 -2.74887219562247 NA -4.89855768815471 -4.31189863070115 -0.58665905745356 0.76862965935658 1.54261538533378 0.429173288516358 0.763253213445669 0.380301572920345 0.283618039281984 NA NA 0.920316870557586 0.176801327895734 90.6527999345367 a503 loss_cnaDLBC4_(CDKN2A) 346 THZ-2-102-1 CDK7 7 22 0.916290731874155 2.99573227355399 -4.1991170782386 -3.62278236182333 -0.576334716415262 1.22007351076378 1.46651572476319 0.407170255908578 0.472377042309912 0.392995933615595 0.284062428394928 NA NA 0.36994724002732 0.321234230429107 90.6527999345367 a504 loss_cnaDLBC4_(CDKN2A) 299 OSI-027 MTORC1/2 7 22 2.99573227355399 NA -2.02023781373439 -1.13153133452099 -0.888706479213402 0.962340706157747 1.84537562164318 0.526013503717184 0.92348424370581 0.481585683039462 0.286232568121324 NA NA 0.432576818868638 0.112556251931027 90.6527999345367 a505 ARID1A_mut 222 BX-912 PDPK1 (PDK1) 3 26 2.32630161961136 NA 0.0580160179501523 1.13201120406308 -1.07399518611293 1.5272539141128 1.48217622658408 0.722955369646348 0.703219796124621 0.724606944066383 0.286331719183016 NA NA 0.282964829182042 0.347426633102701 90.6527999345367 a506 loss_cnaDLBC4_(CDKN2A) 1043 JNK Inhibitor VIII JNK 8 24 2.30258509299405 NA 4.37488319913462 4.1070571958545 0.267826003280121 0.577399649515582 0.668970976643608 0.412826634051957 0.463848572656421 0.40035519122798 0.286406270986581 NA NA 0.629844860031757 0.294143299967639 90.6527999345367 a507 loss_cnaDLBC2 1259 BMN-673 PARP1 3 27 2.30258509299405 NA 1.6303427627831 2.65256850583327 -1.02222574305017 1.37751882680261 1.46133233324963 0.702316541831607 0.74207751150878 0.699516270044476 0.287526437040982 NA NA 0.51147464562352 0.326606753107401 90.6527999345367 a508 PTEN_mut 1268 XAV 939 TNKS1 (tankyrase-1) 4 25 1.6094379124341 NA 3.19810041612656 2.84827489562107 0.349825520505488 0.384793056734625 0.920742238554395 0.398657546389154 0.909126384644585 0.379938603723371 0.288193878420344 NA NA 0.319571120971597 0.218426406902679 90.6527999345367 a509 EP300_mut 1072 BMS-708163 g-secretase 6 22 1.6094379124341 NA 3.16116015250674 3.42017911863117 -0.259018966124432 0.736417818475946 0.663186340513127 0.382099248370188 0.351728271133478 0.390567402103036 0.288547554496934 NA NA 0.261485255401022 0.459902607967168 90.6527999345367 a510 CREBBP_mut 11 Paclitaxel Microtubules 6 19 -2.27886856637673 NA -4.42981433519144 -3.42520404304023 -1.00461029215121 1.3925137131963 1.63812492917089 0.632639657831865 0.721436552208367 0.613268423098644 0.289121718796679 NA NA 0.0394558734519976 0.171807349374469 90.6527999345367 a511 CREBBP_mut 333 T0901317 LXR 6 23 2.32630161961136 NA 3.42434193120054 2.77349763886529 0.650844292335254 0.879824311838675 1.41438631578547 0.488738385243284 0.739743473302193 0.460160201687057 0.289580226776409 NA NA 0.87295408157169 0.185339942309351 90.6527999345367 a512 PTEN_mut 199 Pazopanib VEGFR, PDGFRA, PDGFRB, KIT 5 24 2.07944154167984 NA 3.40356907355802 2.79961161312938 0.603957460428639 0.646561051005196 1.00707008331252 0.627669354012655 0.934107397112272 0.599717408387373 0.289614347305355 NA NA 0.378297102665244 0.124136606489227 90.6527999345367 a513 MLL2_mut 134 Etoposide TOP2 9 21 2.77258872223978 NA -0.0810686532734812 0.815086378787199 -0.89615503206068 1.43939302453179 2.0759997016317 0.467765646004001 0.622592312723054 0.431673969585022 0.289705317812007 NA NA 0.603674932370539 0.188383820738295 90.6527999345367 a514 loss_cnaDLBC4_(CDKN2A) 287 KIN001-244 PDPK1 (PDK1) 7 22 2.99573227355399 NA 2.41182034887777 1.95273709475414 0.459083254123636 1.37567631828906 0.888368899401988 0.451390753806302 0.333714586796551 0.516770965792106 0.290293074869566 NA NA 0.785707715240257 0.43185786554427 90.6527999345367 a515 EP300_mut 55 A-770041 SRC family 5 20 1.63315443905142 NA 0.519864390165703 1.61330079841937 -1.09343640825367 2.96998223458691 2.52694288605812 0.419037118804138 0.368162609028451 0.432711168220887 0.290719783023469 NA NA 0.350413052757871 0.479691898115998 90.6527999345367 a516 loss_cnaDLBC2 1008 Methotrexate Dihydrofolate reductase (DHFR) 3 27 -1.6094379124341 NA -3.23574842909746 -2.49548449960049 -0.740263929496971 0.946637940986041 1.35405175965575 0.556966785488327 0.781992668417552 0.546702830388976 0.292138928613764 NA NA 0.15142224762121 0.308751662355656 90.6527999345367 a517 MLL2_mut 1014 RDEA119 MAP2K1 (MEK1), MAP2K2 (MEK2) 9 23 1.6094379124341 NA 3.12897203595061 2.63974649465685 0.489225541293759 1.30845466765134 1.1437642272571 0.411144123811202 0.373895675095808 0.427732857554906 0.292257360996592 NA NA 0.861843243646348 0.342898311963937 90.6527999345367 a518 ARID1A_mut 1026 17-AAG HSP90 3 29 0 NA 0.168692722059985 0.783380839871452 -0.614688117811466 0.951738081098406 1.16569344779685 0.533275152489058 0.645858487770134 0.527315409530028 0.292418744567663 NA NA 0.0784377477778237 0.383061234827521 90.6527999345367 a519 CREBBP_mut 298 OSI-930 KIT, VEGFR, PDGFR 6 23 2.32630161961136 NA 2.56198374007699 3.0910897950059 -0.529106054928911 0.790267423908115 1.13958586451821 0.488362871369973 0.669527857180699 0.464296786580979 0.292710709801419 NA NA 0.905477503317231 0.213132236790579 90.6527999345367 a520 CREBBP_mut 1042 BIRB 0796 p38, JNK2 7 22 2.30258509299405 NA 4.02037104680583 3.64605985877448 0.374311188031347 0.523786173688265 0.963132726567595 0.423159109995963 0.714625942482629 0.388639257815809 0.292763635975376 NA NA 0.548010115296833 0.204711820014422 90.6527999345367 a521 CREBBP_mut 1239 YK 4-279 RNA helicase A 5 22 2.30258509299405 NA 2.44258629814794 1.54607948637848 0.896506811769461 1.06661571520454 1.58632856861787 0.591675019833015 0.84051528492391 0.565145726745981 0.29292882897317 NA NA 0.393997100671821 0.161082621329858 90.6527999345367 a522 MLL2_mut 60 BI-2536 PLK1, PLK2, PLK3 8 17 -1.36257783450257 NA -2.81972476812649 -2.05231574991825 -0.767409018208244 1.18472241672 1.28712802810087 0.61058380750395 0.647754281828209 0.596218092881204 0.292971863633149 NA NA 0.0330227805347333 0.162594379227308 90.6527999345367 a523 EP300_mut 1046 681640 WEE1, CHEK1 6 26 0.693147180559945 NA 2.01835008368056 1.6905111501519 0.327838933528657 0.690806330935277 0.783122980755824 0.426591792502864 0.474574303748489 0.418630204431297 0.293443543436508 NA NA 0.592510998519912 0.336269756827813 90.6527999345367 a524 TP53_mut 333 T0901317 LXR 17 12 2.32630161961136 NA 3.13641714602661 2.58478381655437 0.551633329472249 1.26737915200335 1.41602391398214 0.414779012548024 0.435255170956757 0.389564981230399 0.293938526220946 NA NA 0.873003622631924 0.292410892039235 90.6527999345367 a525 MLL2_mut 282 EKB-569 EGFR 9 20 0.916290731874155 2.99573227355399 -0.0930858993200978 0.497413230944951 -0.590499130265048 1.11151633198964 1.40385214958744 0.446002858158198 0.531255469011456 0.420627720973737 0.293970415361211 NA NA 0.83972735190489 0.238574938195835 90.6527999345367 a526 loss_cnaDLBC4_(CDKN2A) 1038 NU-7441 PRKDC (DNAPK) 8 24 0.693147180559945 NA 2.0711802184867 1.65269382929754 0.418486389189163 0.83351010770628 1.0694311149657 0.410571055438992 0.502077161776463 0.391316825677535 0.293983778716292 NA NA 0.67830602445389 0.271281293637874 90.6527999345367 a527 ARID1A_mut 151 QS11 ARFGAP 3 26 2.32630161961136 NA 1.74358712902104 2.48504113692619 -0.741454007905145 0.567013671073095 1.10287766817273 0.691392863397716 1.30764749728506 0.672290344888026 0.295043896095315 NA NA 0.567953381474575 0.130649039218307 90.6527999345367 a528 MLL2_mut 1053 MK-2206 AKT1, AKT2 9 23 1.38629436111989 0.693147180559945 1.3322959705087 0.464928578879772 0.867367391628926 1.73550518617167 1.77532905111938 0.491482749234884 0.499778046496214 0.488567114407344 0.295525501475864 NA NA 0.222980538155068 0.225928626310449 90.6527999345367 a529 loss_cnaDLBC2 1046 681640 WEE1, CHEK1 3 29 0.693147180559945 NA 2.22274760060682 1.70328095186939 0.519466648737426 0.701282910374413 0.768226758781814 0.679977907546553 0.740737641047154 0.676189214706801 0.295687957485274 NA NA 0.592576954413183 0.327290760847153 90.6527999345367 a530 MLL2_mut 147 NSC-87877 PTPN6 (SHP-1), PTPN11 (SHP-2) 9 21 2.77258872223978 NA 4.66181326317215 4.43857713428344 0.223236128888705 0.509048212371272 0.661007402280188 0.359250500131674 0.438536318296486 0.337721072591074 0.295717466806049 NA NA 0.406269954619662 0.328354473154331 90.6527999345367 a531 PTEN_mut 306 TG101348 JAK2 6 23 2.32630161961136 NA 0.415368664821402 0.940610133975059 -0.525241469153657 0.748069738794242 1.20269791514841 0.463845417043412 0.702129015404706 0.43671936447054 0.295928794529862 NA NA 0.80575044515817 0.207174457125405 90.6527999345367 a532 EP300_mut 1008 Methotrexate Dihydrofolate reductase (DHFR) 5 25 -1.6094379124341 NA -2.20852676933978 -2.64170771719227 0.433180947852493 0.962853925816933 1.39121460786625 0.323646084748203 0.449892695286007 0.311368889747986 0.295953641829987 NA NA 0.151551457118138 0.42326825335549 90.6527999345367 a533 PTEN_mut 56 WH-4-023 SRC family, ABL 4 21 1.63315443905142 NA 2.96030636000634 1.57615173610776 1.38415462389858 0.932190861922796 2.22575690224316 0.65828840135758 1.48484036953927 0.621880414030659 0.296750678117728 NA NA 0.579676091954751 0.064078841810506 90.6527999345367 a534 MLL2_mut 1037 BX-795 TBK1, PDPK1, IKK, AURKB, AURKC 9 23 1.6094379124341 NA 1.6248782136993 1.11083761448904 0.514040599210261 1.22664731268951 1.17994319977746 0.431033654021352 0.419061448138009 0.435648596735172 0.29747191430833 NA NA 0.849875297713565 0.299390546555099 90.6527999345367 a535 PTEN_mut 1031 Elesclomol HSP70 4 26 -1.6094379124341 NA -3.42592955803241 -2.78854407057114 -0.637385487461267 1.18714792778137 1.33110978640435 0.484174131195542 0.53690485620647 0.478837654092381 0.297745113014781 NA NA 0.672716613103544 0.378183032280116 90.6527999345367 a536 CREBBP_mut 1248 FK866 NAMPT 6 22 0 NA -2.99221070121158 -4.71799373147943 1.72578303026785 3.98051622074678 2.79789942793199 0.563793818272557 0.433557592674268 0.616813818623718 0.298763586336006 NA NA 0.233692454835537 0.35492064423101 90.6527999345367 a537 TP53_mut 1017 Olaparib PARP1, PARP2 17 13 1.6094379124341 NA 3.1820372731219 2.77576232913287 0.406274943989032 0.713333256809701 1.02682294882433 0.471445119470711 0.569544375101826 0.395662119213638 0.300086161089576 NA NA 0.308243704931104 0.236662181214957 90.6527999345367 a538 loss_cnaDLBC4_(CDKN2A) 286 KIN001-236 TIE2 7 22 2.32630161961136 NA 3.32084657599517 2.88509676323353 0.435749812761645 1.16568597854841 0.899211799634087 0.451643253259892 0.373814063804963 0.484590852721197 0.30016528343874 NA NA 0.889571915044029 0.389738208687964 90.6527999345367 a539 loss_cnaDLBC4_(CDKN2A) 257 NPK76-II-72-1 PLK3 7 22 2.32630161961136 NA 0.656393236546103 1.2029493407073 -0.546556104161201 1.17058237802335 1.46672707209787 0.388643636793141 0.466909560935059 0.372636541970592 0.300288029338936 NA NA 0.352454909697767 0.332063081361006 90.6527999345367 a540 loss_cnaDLBC4_(CDKN2A) 1024 CEP-701 FLT3, JAK2, NTRK1, RET 8 22 0.693147180559945 NA -2.17594885457066 -1.61239777577789 -0.56355107879277 0.738007337143543 1.38165389369319 0.450065356538346 0.76361175618388 0.40788151169059 0.301283530274062 NA NA 0.85187685211251 0.165286813595162 90.6527999345367 a541 MLL2_mut 306 TG101348 JAK2 9 20 2.32630161961136 NA 0.487450269107344 0.986959632419433 -0.499509363312089 0.70618494274116 1.26481110828463 0.442631619397421 0.707335052165188 0.394928033158671 0.301316067382724 NA NA 0.805840210904905 0.186544558336236 90.6527999345367 a542 loss_cnaDLBC2 341 EX-527 SIRT1 4 25 2.99573227355399 NA 4.99422506954435 4.66580386027244 0.328421209271906 0.487996032411134 0.610323136409637 0.54922846258444 0.672999752988182 0.538110370850297 0.301884370425247 NA NA 0.705826051365029 0.28632000632011 90.6527999345367 a543 MLL2_mut 133 Doxorubicin DNA intercalating 9 20 0.0237165266173161 NA -2.82393189161601 -2.21939204588001 -0.604539845736 1.12729705676614 1.30548449895134 0.481579258336093 0.536273772833432 0.463077000317974 0.302533732612388 NA NA 0.412629535248695 0.220232601866917 90.6527999345367 a544 PTEN_mut 245 UNC0638 G9a(EHMT2), GLP(EHMT1) 6 23 3.68887945411394 NA 1.62022720418953 1.94218899026334 -0.321961786073808 0.660481647145277 0.707029262372648 0.46083854634202 0.487465151326136 0.45537264609582 0.302601611571913 NA NA 0.835111003003234 0.324447132446328 90.6527999345367 a545 ARID1A_mut 1261 rTRAIL TR10A (DR4), TR10B (DR5) 3 27 -2.30258509299405 NA -0.674728863894598 -1.52781563797889 0.853086774084292 0.412762566582391 1.36038239483227 0.648473455501024 2.06677359613232 0.627093365310326 0.303317746606526 NA NA 0.988558065572892 0.0399806108450415 90.6527999345367 a546 TP53_mut 150 Bicalutamide ANDR (androgen receptor) 16 13 0.0237165266173161 NA 1.93788378203624 2.09449672685247 -0.156612944816234 0.565944189106138 0.414580636176384 0.310547915888538 0.27672860298043 0.377762324503749 0.304273662319147 NA NA 0.458280502300285 0.397962169791157 90.6527999345367 a547 loss_cnaDLBC4_(CDKN2A) 150 Bicalutamide ANDR (androgen receptor) 8 21 0.0237165266173161 NA 2.14565681102656 1.95568302254522 0.18997378848134 0.272585230348803 0.56185618859691 0.377611748844772 0.69693353612097 0.3381181738974 0.30447344412066 NA NA 0.458288099746141 0.23451282175413 90.6527999345367 a548 EP300_mut 1261 rTRAIL TR10A (DR4), TR10B (DR5) 6 24 -2.30258509299405 NA -0.942306571781233 -1.56755705776777 0.625250485986536 0.715438108045346 1.41400717984411 0.474850689432572 0.87394070703724 0.442183388386661 0.304522017144971 NA NA 0.988559201576795 0.147148551286558 90.6527999345367 a549 ARID1A_mut 260 NG-25 MAP3K7 (TAK1) 3 26 2.32630161961136 NA 1.57639377767561 0.743866055375619 0.83252772229999 0.858425401435387 1.4888586780657 0.573532042107278 0.969831182660609 0.55917175657101 0.305108802223123 NA NA 0.307756249833285 0.229025034400551 90.6527999345367 a550 TP53_mut 226 GSK1070916 AURKB 15 10 0.940007258491471 2.32630161961136 0.968907818973088 -0.338031061992526 1.30693888096561 1.75472864517113 3.38196636373366 0.518649470815211 0.744809680153229 0.386443488906485 0.305149860334669 NA NA 0.334881824416502 0.282025888399919 90.6527999345367 a551 MLL2_mut 223 ZSTK474 PI3K 9 20 1.63315443905142 2.32630161961136 -1.24304699112926 -0.462977086357323 -0.780069904771941 2.38384214660704 1.53014343106979 0.427387585734082 0.327232197770404 0.509801819184073 0.306023592794943 NA NA 0.920353620915717 0.386414936700639 90.6527999345367 a552 TP53_mut 1023 GW 441756 NTRK1 17 13 0.693147180559945 NA 2.15840505386506 1.28023309530437 0.878171958560688 1.32247293818634 2.48517238634832 0.459890409481426 0.664037753214842 0.353364604960489 0.306206202155036 NA NA 0.350417911195593 0.263873415332224 90.6527999345367 a553 ARID1A_mut 299 OSI-027 MTORC1/2 3 26 2.99573227355399 NA -2.38726277417825 -1.22590637434876 -1.16135639982949 0.854262798675463 1.74559033086296 0.684879158004041 1.35948375796087 0.665308680562725 0.306397138624894 NA NA 0.433388666278 0.120036930912404 90.6527999345367 a554 ARID1A_mut 1377 Afatinib (rescreen) ERBB2, EGFR 3 27 2.30258509299405 NA 3.98239092705816 3.31216608235147 0.67022484470669 0.755330273106488 0.968570113592046 0.701865525994561 0.887326866895218 0.691973492988638 0.306398935898525 NA NA 0.138045407329356 0.258871276590387 90.6527999345367 a555 CREBBP_mut 1371 PLX4720 (rescreen) BRAF 6 24 2.30258509299405 NA 3.71673548760843 3.29916147797531 0.417574009633123 0.830147936805406 0.746737601966969 0.547780313110175 0.503011561096014 0.559197780496386 0.306518238309056 NA NA 0.203379484286547 0.297381672172618 90.6527999345367 a556 loss_cnaDLBC4_(CDKN2A) 91 KIN001-135 IKKE 8 19 1.6094379124341 NA 3.5433607064402 3.30006125045119 0.243299455989007 0.486713481457664 0.664019130773564 0.392728872221768 0.499882302952338 0.366404286734285 0.306613974935958 NA NA 0.578545257494453 0.303778133130552 90.6527999345367 a557 loss_cnaDLBC2 303 PIK-93 PI4K, PI3K 4 25 2.99573227355399 NA 1.40109608569384 0.472368596436391 0.928727489257446 1.35211929315886 1.57120044408675 0.599802199263996 0.686868010800828 0.591094212551131 0.306892630409029 NA NA 0.579610775413518 0.274938471310099 90.6527999345367 a558 PTEN_mut 1091 BMS-536924 IGF1R 5 25 1.38629436111989 NA 1.84543638844342 2.33143252380534 -0.485996135361922 0.949048124768071 0.98045078653258 0.497933313746938 0.512087978131446 0.495686414899696 0.306950982847939 NA NA 0.962133079698555 0.339651700771926 90.6527999345367 a559 ARID1A_mut 245 UNC0638 G9a(EHMT2), GLP(EHMT1) 3 26 3.68887945411394 NA 1.46585174837001 1.92285210600322 -0.457000357633213 0.481906504027817 0.711219899616118 0.655830965620755 0.948317471985882 0.642558451865422 0.307571075618785 NA NA 0.835179793561701 0.235061195394532 90.6527999345367 a560 ARID1A_mut 135 Gemcitabine DNA replication 3 25 0.0237165266173161 NA -4.92682340075523 -3.29335074869913 -1.63347265205611 2.052438398427 2.35409618167901 0.700376673070659 0.79586927106217 0.693885264658585 0.308275793305601 NA NA 0.24063461554651 0.299919536784334 90.6527999345367 a561 loss_cnaDLBC2 1032 Afatinib ERBB2, EGFR 3 27 -0.693147180559945 NA 1.44919600058516 1.04828736585147 0.400908634733691 0.308229203135091 0.707264014068728 0.583991716207591 1.30068348701528 0.566844384499863 0.308634626214182 NA NA 0.401736566506085 0.134808867854949 90.6527999345367 a562 loss_cnaDLBC2 153 Midostaurin KIT 4 26 -0.669430653942629 NA -0.70312660496551 -0.19413513107581 -0.5089914738897 0.394968376335674 0.92417835614051 0.57657495271838 1.28868918218688 0.550750264283742 0.310565665350101 NA NA 0.799786903403863 0.0887150786066834 90.6527999345367 a563 EP300_mut 1236 UNC0638 G9a(EHMT2), GLP(EHMT1) 6 24 2.99573227355399 NA 2.70505736466967 2.07438477913947 0.630672585530196 1.06032207071771 1.51360617530763 0.437013342153509 0.594793415083123 0.416668877161536 0.310808203961697 NA NA 0.741474825934123 0.261148827046532 90.6527999345367 a564 loss_cnaDLBC2 54 CGP-082996 CDK4 4 21 1.63315443905142 NA 2.57050643712604 2.07075135843618 0.49975507868986 0.392024591893039 1.09663889903718 0.4840825977111 1.27480543064047 0.455715257892668 0.310834981019071 NA NA 0.307816679776719 0.128557495786601 90.6527999345367 a565 MLL2_mut 1038 NU-7441 PRKDC (DNAPK) 9 23 0.693147180559945 NA 2.03447446371225 1.64886189033149 0.385612573380758 1.01925900812751 1.02126637688494 0.377780627691658 0.378326382505237 0.377582756182527 0.310939757376626 NA NA 0.678701983052291 0.351762230776816 90.6527999345367 a566 ARID1A_mut 331 QL-X-138 MNK2, PRKDC (DNAPK), MTOR, BTK, JAK3 3 26 2.32630161961136 NA -1.01731271665413 -0.150418162653369 -0.866894554000765 0.518098006528944 1.34045590642211 0.668106737006665 1.67322503286323 0.646716202933257 0.310944748600264 NA NA 0.590269353610468 0.0723974442976109 90.6527999345367 a567 CREBBP_mut 1262 UNC1215 LMBL3 6 24 0 NA 1.9067944027278 1.69806480528323 0.208729597444577 0.375702222967192 0.50061190740366 0.434226346612434 0.555571898925932 0.416948926618861 0.311211020046659 NA NA 0.5569728914676 0.283844877948179 90.6527999345367 a568 EP300_mut 201 Epothilone B Microtubules 5 24 -3.44201937618241 NA -4.38124322415851 -5.01365665027178 0.632413426113267 1.77097481483945 1.29844178606524 0.458701314702881 0.357099051219766 0.487055663873631 0.31169900849316 NA NA 0.733944242460574 0.48347932319624 90.6527999345367 a569 loss_cnaDLBC4_(CDKN2A) 1017 Olaparib PARP1, PARP2 8 22 1.6094379124341 NA 2.6943299455847 3.11931383441464 -0.424983888829938 1.00810655226332 0.81170874368648 0.491311504664519 0.421566438464068 0.523566971694574 0.311848223719734 NA NA 0.308699942315769 0.307486334865646 90.6527999345367 a570 TP53_mut 281 CH5424802 ALK 17 12 1.63315443905142 NA 3.24705896045525 2.70369824289172 0.543360717563533 0.559377862810174 1.82860132448148 0.436761120722927 0.971366143868877 0.297145534288404 0.312579012910082 NA NA 0.554720952896929 0.337754429751855 90.6527999345367 a571 TP53_mut 1495 AZD-2281 PARP1, PARP2 18 12 2.30258509299405 NA 3.65103974339988 3.26676315563038 0.384276587769492 0.685983052191715 1.08408947062888 0.444492467972137 0.560183792502933 0.354469440189815 0.313387432782641 NA NA 0.428437436519964 0.29063822463825 90.6527999345367 a572 PTEN_mut 292 Masitinib KIT 6 23 2.99573227355399 NA 2.43668365920054 2.78909171532329 -0.352408056122751 0.190865750322207 0.744460804952209 0.520540560400603 1.84636612659861 0.473373552749193 0.314066781410441 NA NA 0.579924981996325 0.0524470300496587 90.6527999345367 a573 ARID1A_mut 1061 SB590885 BRAF 3 29 1.6094379124341 NA 3.6889775263912 3.19166723606033 0.497310290330876 0.323111191348767 0.821038216776856 0.623529069630832 1.53913050258318 0.605709064656166 0.314764352754376 NA NA 0.92333579584451 0.0898461304166471 90.6527999345367 a574 TP53_mut 166 FTI-277 Farnesyl transferase (FNTA) 17 13 0.0237165266173161 NA 1.76639210534204 1.93663656014999 -0.170244454807943 0.570370894051609 0.638910245521876 0.283408581184404 0.298480263602895 0.266460674251489 0.315108042510007 NA NA 0.35208084395526 0.456148171616448 90.6527999345367 a575 MLL2_mut 1230 IOX2 EGLN1 9 21 -2.30258509299405 NA -0.35019802231492 -0.789076154328497 0.438878132013577 0.593418242417045 1.37568169381092 0.364167356133981 0.739576407738979 0.31902593019014 0.315268431616949 NA NA 0.569708961693161 0.232367289532475 90.6527999345367 a576 ARID1A_mut 1016 Temsirolimus MTOR 3 27 -1.6094379124341 NA -2.35398129369344 -3.47498392400804 1.1210026303146 1.53853340226024 1.88286366700071 0.602565391471441 0.728617674902443 0.595371109423069 0.315359877158099 NA NA 0.647129819973355 0.334892455877453 90.6527999345367 a577 EP300_mut 1498 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 6 24 1.38629436111989 NA 2.95071051916797 2.51309540462696 0.437615114541015 0.47886657675502 0.890187796347181 0.526111597920224 0.913856042128601 0.491598645068755 0.3156154982853 NA NA 0.508230268528501 0.121959765284846 90.6527999345367 a578 loss_cnaDLBC2 140 Vinorelbine Microtubules 4 26 -2.74887219562247 NA -5.14061450180192 -4.38747817041958 -0.753136331382344 0.560152135588305 1.43638694580599 0.549900435023194 1.34452103907692 0.524326911756875 0.315665856446581 NA NA 0.920530534408885 0.0849940750388099 90.6527999345367 a579 CREBBP_mut 199 Pazopanib VEGFR, PDGFRA, PDGFRB, KIT 7 22 2.07944154167984 NA 2.5349160091229 3.02109600086522 -0.486179991742317 0.863373122307042 0.994753350029283 0.502718739446397 0.563116894863697 0.488744261809226 0.315670122506388 NA NA 0.379352044618821 0.236308062127982 90.6527999345367 a580 PTEN_mut 1194 SB-505124 TGFR1 (ALK5) 5 25 2.30258509299405 NA 3.35525676696662 3.5397953223069 -0.184538555340274 0.840411266781869 0.479704875304163 0.337968150673107 0.219581248650931 0.384691848760688 0.316218094039409 NA NA 0.23661699240173 0.65628115506445 90.6527999345367 a581 CREBBP_mut 222 BX-912 PDPK1 (PDK1) 6 23 2.32630161961136 NA 0.391878105958821 1.18500307494512 -0.793124968986298 1.27924283192365 1.53019435584734 0.533400985029372 0.619995632724122 0.518316490944777 0.317587756125312 NA NA 0.284237797856382 0.226761211210852 90.6527999345367 a582 loss_cnaDLBC4_(CDKN2A) 205 BMS-708163 g-secretase 7 22 2.32630161961136 0.940007258491471 4.28911647565408 4.06108598827573 0.228030487378347 0.431543537309714 0.699925351651228 0.350851745755756 0.528406678964333 0.325792581795172 0.317781876401728 NA NA 0.2372779388816 0.316876169299614 90.6527999345367 a583 loss_cnaDLBC2 30 Sorafenib PDGFRA, PDGFRB, KDR, KIT, FLT3 3 25 1.38629436111989 NA 1.06731856914136 1.70998702332373 -0.642668454182372 0.484777984646717 0.939121477058154 0.704493761898804 1.32569645185253 0.684329418378934 0.318323211840245 NA NA 0.0306524610468391 0.126880667544291 90.6527999345367 a584 MLL2_mut 1264 SGC0946 Q8TEK3 (DOT1L) 9 21 -0.693147180559945 NA 1.33523295162483 1.12413363884052 0.21109931278431 0.556075289501109 0.550275047670395 0.382468917545404 0.379623617107138 0.38362508654173 0.31904526605046 NA NA 0.764840805941379 0.354249293046645 90.6527999345367 a585 MLL2_mut 17 Cyclopamine SMO 9 18 2.77258872223978 NA 4.29745573157771 3.91800061950866 0.379455112069048 1.06932825197175 1.05609813424587 0.357858450452587 0.354853723699308 0.359299102767574 0.319348204688184 NA NA 0.536008316131172 0.395745616438101 90.6527999345367 a586 PTEN_mut 1059 AZD8055 MTORC1/2 5 27 0.693147180559945 NA -1.70400269690383 -1.17110576127815 -0.532896935625681 0.483888287284048 1.0472943573456 0.537813021073538 1.1012809146853 0.508832050786874 0.319868170712649 NA NA 0.669994444271484 0.0956919936033294 90.6527999345367 a587 ARID1A_mut 1015 CI-1040 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 27 2.30258509299405 NA 2.04607170448337 2.73017180598144 -0.684100101498064 1.42495142470375 0.95835227106005 0.684829477592584 0.480086611822779 0.71382947811181 0.319993825274122 NA NA 0.130893976123404 0.495384474052766 90.6527999345367 a588 MLL2_mut 1046 681640 WEE1, CHEK1 9 23 0.693147180559945 NA 1.55221550982261 1.8301500355491 -0.277934525726488 0.922486413220779 0.704999006058456 0.3614076386775 0.301288476169643 0.394233925633992 0.320006627950585 NA NA 0.593252078103818 0.430889680336795 90.6527999345367 a589 CREBBP_mut 1527 GDC0941 (rescreen) PI3K 5 22 1.38629436111989 NA 1.5122677391756 0.650868493817258 0.861399245358347 1.85339867697281 1.38003650307048 0.587552151441026 0.464767379010589 0.624185841056955 0.320323610957492 NA NA 0.155818579009792 0.371898150888592 90.6527999345367 a590 TP53_mut 203 BMS-345541 IKBKB 17 12 2.77258872223978 NA 1.78166207137001 1.99282026663196 -0.211158195261952 0.725318383643817 0.627454265482907 0.307303502101015 0.291124835690977 0.336531611749325 0.320899046501864 NA NA 0.460663793188302 0.410683406011784 90.6527999345367 a591 loss_cnaDLBC4_(CDKN2A) 1032 Afatinib ERBB2, EGFR 8 22 -0.693147180559945 NA 1.26760793536023 1.02320379076652 0.244404144593713 0.687282735477742 0.689127074317939 0.354894802330468 0.355609317646868 0.354657585954827 0.321437088224383 NA NA 0.402204604642872 0.405607474781934 90.6527999345367 a592 MLL2_mut 190 Bleomycin DNA damage 9 20 4.15888308335967 NA 0.789328110280091 1.59521641733656 -0.805888307056467 1.97355051366425 1.64100034002139 0.461523240347976 0.408344403387066 0.491095758728462 0.322251475084554 NA NA 0.438130133684094 0.303837478162698 90.6527999345367 a593 TP53_mut 1219 PFI-1 BRD2, BRD3, BRD4 19 11 2.30258509299405 NA 2.23249291452675 1.85201392782643 0.380478986700314 0.83772270009471 1.34884787430825 0.362619848503009 0.454182495779687 0.282077018429852 0.323198463818944 NA NA 0.835992972748118 0.411318950984064 90.6527999345367 a594 ARID1A_mut 312 AV-951 VEGFR 3 26 -2.05572501506252 NA -0.128232923537108 -0.405972558378912 0.277739634841804 0.0785938113663069 0.531815270909513 0.542262863845343 3.53386138187556 0.522248325751933 0.323246649107908 NA NA 0.266004505498715 0.0222131511694144 90.6527999345367 a595 ARID1A_mut 5 Sunitinib PDGFRA, PDGFRB, KDR, KIT, FLT3 3 22 2.07944154167984 NA 1.11208311670175 2.00313601517873 -0.891052898476975 0.737013983731448 1.2812143856408 0.716635237333517 1.20900405982209 0.695475252591167 0.32330733451488 NA NA 0.0174024329854479 0.154199383893055 90.6527999345367 a596 PTEN_mut 1192 GSK269962A ROCK1, ROCK2 5 25 1.6094379124341 NA 1.03920749999496 1.80287763928782 -0.763670139292863 1.66905283277085 1.45141500515458 0.514442722411493 0.457547013670662 0.526155604414144 0.323795612525844 NA NA 0.818886650341817 0.381894849636794 90.6527999345367 a597 EP300_mut 32 VX-680 AURKA, AURKB, AURKC, FLT3, ABL1, JAK2 5 19 0.693147180559945 NA 1.55758464966456 0.28703416724957 1.27055048241499 1.40153131338737 1.95629642734073 0.680265665873647 0.90654448479227 0.649467261023472 0.324423306801463 NA NA 0.0630803245540421 0.135099069572379 90.6527999345367 a598 MLL2_mut 291 KIN001-266 MAP3K8 (COT) 9 20 2.99573227355399 NA 2.54491251380534 2.78181613522128 -0.236903621415941 0.700328337112258 0.479333170161084 0.427562168485874 0.338275075934799 0.494235817930829 0.325221205932378 NA NA 0.745930055919762 0.375315337920911 90.6527999345367 a599 loss_cnaDLBC4_(CDKN2A) 1264 SGC0946 Q8TEK3 (DOT1L) 7 23 -0.693147180559945 NA 1.36288353949377 1.13407470451383 0.228808834979938 0.564242685823957 0.548525885470321 0.414560241781749 0.405514933074961 0.417134069769107 0.325227916499392 NA NA 0.764948440762149 0.367295558839495 90.6527999345367 a600 loss_cnaDLBC2 273 CUDC-101 HDAC, EGFR 4 24 1.63315443905142 NA -1.44044546856182 -2.24182492237886 0.801379453817044 1.96663219817922 1.41026833311037 0.539598728846962 0.407488219993038 0.56824608126142 0.325252685842124 NA NA 0.888730882095566 0.483205330345135 90.6527999345367 a601 loss_cnaDLBC4_(CDKN2A) 1262 UNC1215 LMBL3 7 23 0 NA 1.88469271229854 1.69571620682933 0.188976505469212 0.412067833533541 0.498566830599273 0.392603657494975 0.458605331672484 0.379039466468444 0.325934358287061 NA NA 0.557420219891714 0.332973320856728 90.6527999345367 a602 ARID1A_mut 302 PI-103 PI3Ka, PRKDC (DNAPK) 3 25 2.32630161961136 NA -2.57750342148209 -1.21975343919995 -1.35774998228214 0.849691871028919 2.12531144990093 0.660548971092648 1.59793217821184 0.638847535661384 0.325995058620989 NA NA 0.46286931102623 0.082551295778018 90.6527999345367 a603 MLL2_mut 185 OSI-906 IGF1R 9 20 0.940007258491471 NA 1.78249998536134 2.45552297582226 -0.673022990460921 1.30694218079943 1.47879556138674 0.470635334788158 0.514960034459403 0.455115641427674 0.326138215114009 NA NA 0.332560322856859 0.234833881382471 90.6527999345367 a604 PTEN_mut 1498 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 5 25 1.38629436111989 NA 2.32141104111197 2.6564599048198 -0.335048863707826 0.663807875213047 0.867503231535058 0.398190590557255 0.504737705319169 0.38622203529427 0.32672829567027 NA NA 0.508588880819247 0.362039192898912 90.6527999345367 a605 MLL2_mut 271 VNLG/124 HDAC, RAR 9 20 1.63315443905142 NA 2.62115743145872 2.89601944133397 -0.274862009875249 1.21839344596651 0.764301476279928 0.297968505401025 0.225593802055632 0.359625119675393 0.326795734016054 NA NA 0.224808497257169 0.545546005615472 90.6527999345367 a606 ARID1A_mut 166 FTI-277 Farnesyl transferase (FNTA) 3 27 0.0237165266173161 NA 2.13760102463356 1.80711622218014 0.330484802453414 0.713772702503051 0.588456743752033 0.552392437886015 0.46301126576356 0.561612736980844 0.327646907972947 NA NA 0.352536322470015 0.510576053117702 90.6527999345367 a607 TP53_mut 1013 Nilotinib ABL 17 13 0.693147180559945 NA 2.02465133800684 2.24914703798457 -0.224495699977731 0.816860217295914 0.784732581700769 0.279484709335718 0.274827559506923 0.286079239237367 0.327746112555076 NA NA 0.38180186569653 0.452336030207499 90.6527999345367 a608 MLL2_mut 302 PI-103 PI3Ka, PRKDC (DNAPK) 9 19 2.32630161961136 NA -2.00475226439856 -1.06229346657147 -0.942458797827086 1.73615682385268 2.17626292911717 0.459527678029233 0.54284197422655 0.433062928756227 0.32874578042961 NA NA 0.462967798382049 0.232185749037369 90.6527999345367 a609 loss_cnaDLBC4_(CDKN2A) 1114 Cetuximab EGFR 6 22 4.18661983833127 NA 6.21630776833318 5.99836291737913 0.217944850954049 0.622518409774961 0.535619677732269 0.393834660565811 0.350101856478165 0.406902248021943 0.328764774568681 NA NA 0.379857571675951 0.45918374022311 90.6527999345367 a610 CREBBP_mut 1046 681640 WEE1, CHEK1 7 25 0.693147180559945 NA 1.51607884317122 1.81803354015337 -0.30195469698215 0.662525565011918 0.793457651002695 0.392630003370051 0.455763087386248 0.380555530091076 0.329034829167613 NA NA 0.593485648086945 0.329681157210153 90.6527999345367 a611 loss_cnaDLBC2 1010 Gefitinib EGFR 3 27 -0.693147180559945 NA 1.37162621522148 0.968835542453236 0.402790672768242 0.692731331216958 0.655393878528405 0.612021948416676 0.581452945199747 0.61457802088822 0.329163895601013 NA NA 0.981843566676564 0.422816208720885 90.6527999345367 a612 loss_cnaDLBC2 1020 Lenalidomide TNFA 3 27 1.6094379124341 NA 2.60655258829066 3.15389888437453 -0.547346296083872 0.634687029620397 0.844940991162141 0.658115371158793 0.862387713218651 0.64779233320311 0.329454136417259 NA NA 0.328881939550805 0.269723316019973 90.6527999345367 a613 ARID1A_mut 11 Paclitaxel Microtubules 3 22 -2.27886856637673 NA -4.66365972907372 -3.53030834734963 -1.13335138172409 1.46538314097529 1.61708198782464 0.706375476756177 0.773416419251134 0.700862040550407 0.330847042115536 NA NA 0.0402017228251993 0.311273880948192 90.6527999345367 a614 PTEN_mut 1175 AG-014699 PARP1, PARP2 5 25 1.6094379124341 NA 3.10494444229322 3.34167857136939 -0.236734129076171 0.705461663623151 0.62497427830887 0.371583523736528 0.335573343362612 0.378790195520933 0.33113692591868 NA NA 0.407855992475971 0.51466630133774 90.6527999345367 a615 loss_cnaDLBC4_(CDKN2A) 194 AUY922 HSP90 8 21 -1.36257783450257 NA -3.46251093640189 -2.9431311613705 -0.519379775031396 0.744791302332865 1.29778079531605 0.440311087342326 0.697349409699837 0.400206087889373 0.331231659736488 NA NA 0.702756528851453 0.192829026026348 90.6527999345367 a616 EP300_mut 1192 GSK269962A ROCK1, ROCK2 6 24 1.6094379124341 NA 2.18480209160989 1.54829858052129 0.636503511088597 0.604821139012382 1.61995369698319 0.427101149618344 1.0523830435688 0.392914632235442 0.331775934983729 NA NA 0.818992594333185 0.136662978292199 90.6527999345367 a617 ARID1A_mut 1010 Gefitinib EGFR 3 27 -0.693147180559945 NA 1.36859812380082 0.969171997055532 0.399426126745284 0.341327875362907 0.676589326959671 0.606727412500384 1.17021244256891 0.590352390777652 0.333284722725699 NA NA 0.981849075837345 0.164891189138185 90.6527999345367 a618 ARID1A_mut 201 Epothilone B Microtubules 3 26 -3.44201937618241 NA -5.63073543951818 -4.82083728495234 -0.809898154565843 1.1648980583628 1.39282475380595 0.588060765339594 0.695252386036348 0.581478863261701 0.333350421563244 NA NA 0.734382566782058 0.35367326257283 90.6527999345367 a619 MLL2_mut 1494 SN-38 TOP1 9 22 -2.99573227355399 NA -5.11938545336345 -4.45695679546412 -0.662428657899334 1.15500189263246 1.69763900137248 0.422782590417447 0.573530365729133 0.390205843152628 0.333357468310605 NA NA 0.632018338377833 0.223214632642691 90.6527999345367 a620 loss_cnaDLBC4_(CDKN2A) 154 CHIR-99021 GSK3B 8 22 0.940007258491471 NA 2.97769821381961 2.67751740234401 0.300180811475597 0.735817910849089 0.916604066365343 0.343096440960545 0.407955293082234 0.327492341012537 0.333372151089454 NA NA 0.39094884431063 0.370381347373758 90.6527999345367 a621 loss_cnaDLBC4_(CDKN2A) 127 GSK269962A ROCK1, ROCK2 8 20 0.916290731874155 NA 1.77569810418845 1.37920989022746 0.396488213960983 1.00587900632725 1.22457743901845 0.338958078993246 0.3941708808584 0.323775533770069 0.333461263756663 NA NA 0.374382066336986 0.390342691058184 90.6527999345367 a622 TP53_mut 1230 IOX2 EGLN1 19 11 -2.30258509299405 NA -0.800502402615551 -0.410257799276114 -0.390244603339437 1.44787346136672 0.555481480922143 0.323207300428068 0.269529495326938 0.702533957912693 0.333789807618747 NA NA 0.57024653912869 0.304051560822543 90.6527999345367 a623 PTEN_mut 153 Midostaurin KIT 6 24 -0.669430653942629 NA -0.561717821461688 -0.18707137079429 -0.374646450667398 1.17846020171152 0.810292170175793 0.422226304919657 0.317911839638951 0.462359707346201 0.334362345426225 NA NA 0.800142266162342 0.488257631618949 90.6527999345367 a624 CREBBP_mut 83 JW-7-52-1 MTOR 6 19 0.182321556793955 NA -2.84304309335974 -1.88074005099579 -0.96230304236395 1.72392749438236 1.73525828938193 0.555345266798445 0.558203895175254 0.554558965804859 0.334896675972612 NA NA 0.192954418939399 0.266285950085599 90.6527999345367 a625 CREBBP_mut 228 KIN001-102 AKT1 6 23 2.32630161961136 NA 0.886456937651271 1.33207722454742 -0.445620286896147 1.21083604797509 0.84023551713303 0.484266841789009 0.368026941088653 0.530351642854433 0.335443988402233 NA NA 0.63332076137602 0.426544895653463 90.6527999345367 a626 ARID1A_mut 1529 MLN4924 NEDD8-activating enzyme 3 24 0 NA 1.2818753938071 0.309574907827396 0.972300485979703 1.32894683503697 1.5212911219057 0.645271911133694 0.731632342502743 0.639128482365503 0.335820044235354 NA NA 0.549658450902873 0.333182576696901 90.6527999345367 a627 TP53_mut 56 WH-4-023 SRC family, ABL 15 10 1.63315443905142 NA 1.5091762057789 2.23027688116049 -0.7211006753816 2.0196933178541 2.30689818213958 0.337486452310284 0.357034738396699 0.312584526254557 0.336110025462685 NA NA 0.581105027062543 0.432044189224048 90.6527999345367 a628 loss_cnaDLBC2 6 PHA-665752 MET 4 23 0.693147180559945 NA 2.86579447881801 2.54095477222475 0.324839706593266 0.354975573594688 0.730972350301177 0.466287379344586 0.915104392405795 0.444393972575603 0.337112299260124 NA NA 0.358823937841855 0.200570541278803 90.6527999345367 a629 ARID1A_mut 208 SB-715992 KIF11 3 26 -2.05572501506252 NA -2.8756675919522 -3.56700061695019 0.69133302499799 1.57305359396654 1.06167533552793 0.624126333014164 0.439484724264707 0.651171786574675 0.337190018121277 NA NA 0.731210016718084 0.528795926792538 90.6527999345367 a630 loss_cnaDLBC4_(CDKN2A) 173 FH535 unknown 8 21 3.46573590279973 NA 2.32458315196209 2.0025216706421 0.322061481319989 0.430388171057522 0.752249884788191 0.471183635411623 0.748304676981805 0.42813098125056 0.33755655171239 NA NA 0.340479035985161 0.164122262038213 90.6527999345367 a631 PTEN_mut 345 KIN001-270 CDK9 6 23 2.99573227355399 NA 4.03354146282998 3.52571691197965 0.507824550850332 1.14593258859132 1.06287139713212 0.470758998210259 0.443153948064775 0.477785508407285 0.337912393304072 NA NA 0.799181612482519 0.357530469198763 90.6527999345367 a632 TP53_mut 1194 SB-505124 TGFR1 (ALK5) 19 11 2.30258509299405 NA 3.5986702849692 3.3542210434628 0.244449241506393 0.52430894065715 0.559049793685299 0.455234382585695 0.466231304772354 0.437258441497609 0.337941603559576 NA NA 0.237360587460894 0.251722864028701 90.6527999345367 a633 TP53_mut 196 Phenformin AAPK1 (AMPK) agonist 17 12 8.29404964010203 NA 5.64875587501615 6.22913989177997 -0.580384016763824 1.41047275070879 1.73401045496591 0.374331244209327 0.41148190666723 0.33470618075093 0.338000533240965 NA NA 0.91626569803135 0.349540397311565 90.6527999345367 a634 loss_cnaDLBC2 155 AP-24534 ABL 4 25 -0.669430653942629 NA 0.0422609265747809 -0.736815313869573 0.779076240444354 0.425618762507292 1.85760806827078 0.44338586487342 1.83045558390064 0.419397532639693 0.338095976363388 NA NA 0.226577912352556 0.0820063698627013 90.6527999345367 a635 ARID1A_mut 41 S-Trityl-L-cysteine KIF11 3 22 1.63315443905142 NA -0.254504792953564 0.635174338346834 -0.889679131300398 0.624663762383819 1.31972080049544 0.698105434403593 1.42425282988281 0.674141932874285 0.338785196601196 NA NA 0.0250163715643425 0.109379897439948 90.6527999345367 a636 loss_cnaDLBC2 293 MP470 PDGFR 3 25 2.99573227355399 NA 3.17401435535663 2.17307713713062 1.00093721822601 1.30111954589835 1.83997883852076 0.554766086945053 0.76928920281105 0.543993874967992 0.339282602971268 NA NA 0.485043832362757 0.315880239144865 90.6527999345367 a637 loss_cnaDLBC4_(CDKN2A) 1502 Bicalutamide ANDR (androgen receptor) 6 22 2.30258509299405 NA 3.96820886238686 3.63260670965783 0.335602152729032 0.444367208968026 0.718930607133528 0.497290253372446 0.755236088433293 0.466807435097418 0.341198794038734 NA NA 0.471558523256799 0.18095180549756 90.6527999345367 a638 EP300_mut 154 CHIR-99021 GSK3B 6 24 0.940007258491471 NA 2.51079729279216 2.81925770022384 -0.308460407431688 1.20527133653048 0.786902331219762 0.351969655014079 0.255926112305655 0.391993256588209 0.34225341813481 NA NA 0.391246567421113 0.572624937470388 90.6527999345367 a639 ARID1A_mut 56 WH-4-023 SRC family, ABL 3 22 1.63315443905142 NA 2.85292640027911 1.65371057715687 1.19921582312224 1.22720873799416 2.19648496067264 0.56306918299882 0.977189768940475 0.54597042301396 0.342414692717724 NA NA 0.581313068222923 0.229877402732279 90.6527999345367 a640 ARID1A_mut 154 CHIR-99021 GSK3B 3 27 0.940007258491471 NA 3.18125283925317 2.71048926090243 0.470763578350735 0.529617341199129 0.894485183809255 0.538944164436424 0.888874932389599 0.526295557346116 0.342808576725196 NA NA 0.391264830944948 0.261385904749464 90.6527999345367 a641 ARID1A_mut 200 LAQ824 HDAC 3 26 0.0237165266173161 NA -4.09482041140475 -3.35467127455693 -0.740149136847819 0.490180190754671 1.28929153082027 0.593175701999337 1.50995317805132 0.574074302944443 0.342846031247622 NA NA 0.940775324141417 0.0978154910941594 90.6527999345367 a642 PTEN_mut 190 Bleomycin DNA damage 5 24 4.15888308335967 NA 2.15341616408385 1.1767166882847 0.976699475799155 2.29665210436748 1.63267305516555 0.559060555464077 0.425270973318855 0.598221102938531 0.34402031359399 NA NA 0.438878788775153 0.408180902093741 90.6527999345367 a643 loss_cnaDLBC4_(CDKN2A) 34 Imatinib ABL, KIT, PDGFR 8 19 0.693147180559945 NA 2.81196254046651 2.64133149550429 0.170631044962223 0.338172556795231 0.580103266634416 0.325786495317022 0.504567983219118 0.294139086566729 0.344216957270089 NA NA 0.357222196464946 0.350581515833497 90.6527999345367 a644 CREBBP_mut 37 Crizotinib MET, ALK 7 19 0.693147180559945 NA 2.24118264200577 1.91829445525781 0.322888186747962 0.568205697055032 1.0195548857657 0.348111784808401 0.56825932654577 0.316695247363234 0.344442465455317 NA NA 0.368896659898295 0.321668648069656 90.6527999345367 a645 loss_cnaDLBC4_(CDKN2A) 329 QL-XI-92 DDR1 7 22 2.32630161961136 NA 2.01597491091937 2.63557414720665 -0.61959923628728 1.30391636104787 1.26472559436611 0.486517722408658 0.475183266961501 0.489908039378161 0.344643215155086 NA NA 0.286343692697561 0.296204807988248 90.6527999345367 a646 CREBBP_mut 282 EKB-569 EGFR 6 23 0.916290731874155 2.99573227355399 -0.168126890035104 0.439967515879511 -0.608094405914615 1.1118758515575 1.37431414398141 0.457341666591235 0.546908546545738 0.442471183591952 0.345830149979187 NA NA 0.840384514094724 0.285254506202386 90.6527999345367 a647 loss_cnaDLBC2 1023 GW 441756 NTRK1 3 27 0.693147180559945 NA 2.69968012522521 1.67543984366619 1.02424028155901 0.467431600928037 2.00487423096626 0.529055190992674 2.19120889457514 0.51087507921401 0.346340811686185 NA NA 0.35184945370201 0.0472021434202318 90.6527999345367 a648 loss_cnaDLBC4_(CDKN2A) 253 XMD14-99 EPHB3, CAMK1 7 22 2.32630161961136 NA 3.41528785358237 3.11137856938919 0.303909284193186 0.726866559848453 0.935172577977989 0.3402892593651 0.418108771239317 0.324976684891994 0.346473090860516 NA NA 0.312488975011294 0.386961226349121 90.6527999345367 a649 PTEN_mut 333 T0901317 LXR 6 23 2.32630161961136 NA 3.388778508583 2.78277505346117 0.606003455121829 0.856795098468502 1.42188898119483 0.453796959793599 0.707290991982848 0.426196041418505 0.346613604953963 NA NA 0.873534599689838 0.208720521244335 90.6527999345367 a650 EP300_mut 185 OSI-906 IGF1R 5 24 0.940007258491471 NA 2.9294903855457 2.10439614404036 0.825094241505338 0.597692236398607 1.5291398767999 0.57700556770731 1.38046672059343 0.53958061915961 0.346895602809215 NA NA 0.33329904568264 0.0609398090483821 90.6527999345367 a651 ARID1A_mut 186 Bexarotene Retinioic acid X family agonist 3 26 2.07944154167984 NA 3.6765016890846 3.12153359854434 0.554968090540259 0.708358839183185 0.86267099127643 0.651218714860953 0.783456152223918 0.643313726962251 0.346906276524286 NA NA 0.183658461044243 0.30629737098546 90.6527999345367 a652 MLL2_mut 157 JNK-9L JNK 9 21 1.63315443905142 NA -0.784895162692984 -0.530803766717707 -0.254091395975277 0.423016341908524 0.87508949781863 0.328547519928549 0.60066567364488 0.290360467824903 0.34703754680215 NA NA 0.49272983004513 0.293776227080411 90.6527999345367 a653 TP53_mut 288 KIN001-055 JAK3, MNK1 17 12 2.32630161961136 NA 3.89022687267355 3.60542312533063 0.284803747342923 0.590766185473625 1.09521162029174 0.341505520724429 0.482092161579275 0.26004449009321 0.347723141185474 NA NA 0.863902113487254 0.424348466987134 90.6527999345367 a654 CREBBP_mut 1377 Afatinib (rescreen) ERBB2, EGFR 6 24 2.30258509299405 NA 3.77419497363208 3.28043696511966 0.493758008512418 0.433825257602404 1.03491175269242 0.516636856812972 1.13814951955827 0.477101556947112 0.347991203803302 NA NA 0.139227114805296 0.0881393794950839 90.6527999345367 a655 ARID1A_mut 202 GSK-1904529A IGF1R 3 26 0.0237165266173161 NA 2.2991666258052 1.86295640406517 0.436210221740038 0.282206650564132 0.790877899148174 0.570292413224544 1.54571205486495 0.551551917444986 0.348297471895697 NA NA 0.746238810916766 0.0947567065219447 90.6527999345367 a656 PTEN_mut 135 Gemcitabine DNA replication 5 23 0.0237165266173161 NA -2.3275928315232 -3.71635977226643 1.38876694074323 3.29769605612685 2.10144945634126 0.597092033199403 0.42113248677452 0.660861452818925 0.348797810925386 NA NA 0.242130772818671 0.410300997105132 90.6527999345367 a657 TP53_mut 202 GSK-1904529A IGF1R 16 13 0.0237165266173161 NA 1.79830871693978 2.04318668554411 -0.244877968604326 0.899104909914104 0.559190141822038 0.319323881865091 0.272357503450538 0.43791538922061 0.349137430213269 NA NA 0.746253480446486 0.378279826156992 90.6527999345367 a658 PTEN_mut 1021 Axitinib PDGFR, KIT, VEGFR 4 26 0.693147180559945 NA 1.28493022997867 1.76027631981402 -0.475346089835349 0.972853911746732 0.888908124272202 0.529175028744642 0.488609938343033 0.534752779118248 0.349969018106507 NA NA 0.845056966716583 0.412045963815807 90.6527999345367 a659 EP300_mut 206 Ruxolitinib JAK1, JAK2, TYK2 6 23 1.65632149833295 0.0237165266173161 3.37870204627227 2.79014283089778 0.58855921537449 0.658843358112475 1.57957574541003 0.404855234853237 0.893321922620055 0.37260588299405 0.350503146705523 NA NA 0.757667664538344 0.181097527920942 90.6527999345367 a660 ARID1A_mut 256 JW-7-24-1 LCK 3 26 2.32630161961136 NA -0.515820960559016 0.124199953345826 -0.640020913904842 0.351826228326505 1.04358281739713 0.634473653357088 1.81913928631519 0.613291923971268 0.350582591139845 NA NA 0.341321294855465 0.0593908528434406 90.6527999345367 a661 MLL2_mut 295 NVP-BHG712 EPHB4 9 20 2.32630161961136 NA 0.82188687484948 1.51214818217803 -0.690261307328548 1.21811164088903 1.61684797508788 0.457210557148251 0.566665061032311 0.426917878467226 0.352120021193595 NA NA 0.272605647035999 0.218554459318061 90.6527999345367 a662 loss_cnaDLBC4_(CDKN2A) 304 SB52334 ALK5 7 22 2.99573227355399 NA 3.41671134794636 3.85320433591729 -0.436492987970938 1.25016982234945 0.764886188382628 0.487296933982516 0.349146956011653 0.570663968836872 0.352287186315147 NA NA 0.225698665648248 0.409686683110081 90.6527999345367 a663 EP300_mut 295 NVP-BHG712 EPHB4 6 23 2.32630161961136 NA 0.908472551204533 1.39952653086864 -0.491053979664106 1.98697098619983 1.40792765479151 0.320581034301707 0.247136965297751 0.348777849481778 0.352365244515533 NA NA 0.272613740063887 0.588695612298369 90.6527999345367 a664 MLL2_mut 202 GSK-1904529A IGF1R 9 20 0.0237165266173161 NA 2.09546969685525 1.82375695557063 0.271712741284619 0.675592382983486 0.801269426505537 0.354631211076587 0.402184435657353 0.339102843933035 0.352522329534656 NA NA 0.746312105390873 0.357409073043318 90.6527999345367 a665 loss_cnaDLBC4_(CDKN2A) 1053 MK-2206 AKT1, AKT2 8 24 1.38629436111989 0.693147180559945 1.31438876829639 0.507037954268412 0.80735081402798 1.17256347354726 1.91976741821867 0.455153233155523 0.688534848851778 0.420546159063952 0.353035264484169 NA NA 0.22481544701917 0.172231216880181 90.6527999345367 a666 loss_cnaDLBC4_(CDKN2A) 159 HG-6-64-1 BRAFV600E, TAK, MAP4K5 8 22 1.63315443905142 NA 0.0374894733848097 0.758801871072811 -0.721312397688002 1.23113671358431 1.7446298971865 0.442121713847062 0.58589138779558 0.413447229610839 0.35459164932494 NA NA 0.426791924856304 0.224007158258169 90.6527999345367 a667 PTEN_mut 328 SNX-2112 HSP90 6 22 0.940007258491471 NA -3.13275033524368 -2.57967015343341 -0.553080181810268 0.593017895250169 1.42401307338703 0.423511327932469 0.932653443075182 0.388395438319089 0.354810581710786 NA NA 0.910991272855934 0.169164059205593 90.6527999345367 a668 MLL2_mut 256 JW-7-24-1 LCK 9 20 2.32630161961136 NA -0.250861988622681 0.196974690145928 -0.447836678768609 0.688018426876733 1.11317823523994 0.445115737276344 0.650907971755303 0.40230455877722 0.355969611221057 NA NA 0.341500607893051 0.198273913909667 90.6527999345367 a669 MLL2_mut 222 BX-912 PDPK1 (PDK1) 9 20 2.32630161961136 NA 0.557269771791349 1.22954557066843 -0.672275798877077 1.64558316400431 1.41829781420244 0.451415317331207 0.408533469217796 0.474001857822168 0.357169838883929 NA NA 0.285632429553448 0.307154916066267 90.6527999345367 a670 MLL2_mut 206 Ruxolitinib JAK1, JAK2, TYK2 9 20 1.65632149833295 0.0237165266173161 3.31115544339641 2.73225491988575 0.57890052351066 0.821687581823291 1.64202415185352 0.399726180710274 0.704526314278845 0.352552989465591 0.357668633983265 NA NA 0.757785086140392 0.217306613843169 90.6527999345367 a671 ARID1A_mut 136 Mitomycin C DNA crosslinker 3 26 2.77258872223978 NA -1.99302025419431 -1.23199745858652 -0.761022795607789 1.82680612750125 1.15995584689858 0.622820672762222 0.416586513561093 0.656079106495794 0.357798924538226 NA NA 0.380365873077018 0.548097578987039 90.6527999345367 a672 CREBBP_mut 88 MS-275 HDAC 7 22 1.6094379124341 NA 0.310181284044563 -0.0921928629734706 0.402374147018033 1.35069847085809 1.51627442796525 0.271676118387329 0.297900794070203 0.265370265168949 0.358118946365706 NA NA 0.0907437023068634 0.518888154944705 90.6527999345367 a673 TP53_mut 207 AS601245 JNK 16 13 2.07944154167984 NA 1.86693387330655 2.1357756143149 -0.268841741008356 0.609653901822635 0.883473293623211 0.361394828267707 0.440974363002715 0.304300925618034 0.359593056238193 NA NA 0.853706410463717 0.362302693883918 90.6527999345367 a674 loss_cnaDLBC2 238 CAL-101 PI3Kdelta 4 25 2.99573227355399 2.32630161961136 3.56349130896993 2.6115697480933 0.951921560876623 0.294899227769151 2.09900235202576 0.480429183334436 3.22795542083207 0.453511431255861 0.359727283858456 NA NA 0.67157587337732 0.0415960720703829 90.6527999345367 a675 loss_cnaDLBC2 328 SNX-2112 HSP90 4 24 0.940007258491471 NA -2.13582550132264 -2.79191430757111 0.656088806248468 2.20791394656476 1.13605015412695 0.502579640890258 0.2971532505917 0.57751746598958 0.360166532368374 NA NA 0.911025372635314 0.598518246821478 90.6527999345367 a676 TP53_mut 290 KIN001-260 IKK 17 12 2.99573227355399 NA 2.9743948293524 3.27202828412055 -0.297633454768145 0.947551214361616 0.99651322130342 0.307536830481182 0.314108040026804 0.298674867934864 0.360230149454383 NA NA 0.665434224403942 0.427145480774019 90.6527999345367 a677 PTEN_mut 1042 BIRB 0796 p38, JNK2 4 25 2.30258509299405 NA 4.17965171422504 3.66549229455117 0.51415941967387 0.68278803534199 0.902775150949826 0.583576534180296 0.75302933423012 0.569532091277561 0.360297437418588 NA NA 0.550109855013899 0.242046355108735 90.6527999345367 a678 EP300_mut 252 WZ3105 CLK2, CNSK1E, FLT3, ULK1 6 23 0.246860077931526 2.32630161961136 -1.89484660205057 -1.33574720870333 -0.559099393347239 0.539477372758244 1.28083347710261 0.474114952878306 1.03637227728138 0.436512164416552 0.360755149401206 NA NA 0.598276294960376 0.12160456602646 90.6527999345367 a679 MLL2_mut 184 BMS-754807 IGF1R 9 20 0.940007258491471 NA 0.712280620159849 1.30153450692785 -0.589253886768002 1.1307055872003 1.58335103462319 0.402523723217513 0.521138210899826 0.372156188920061 0.36187388121674 NA NA 0.69464113309102 0.267115680772763 90.6527999345367 a680 CREBBP_mut 202 GSK-1904529A IGF1R 7 22 0.0237165266173161 NA 2.130013523706 1.8374668962349 0.292546627471099 0.38434539680323 0.844236961019944 0.381777642652947 0.76115553849308 0.346521937534772 0.361900509982205 NA NA 0.746470524909776 0.21858878135648 90.6527999345367 a681 loss_cnaDLBC2 1498 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 27 1.38629436111989 NA 2.14596461958283 2.65113551730764 -0.50517089772481 0.337669216001827 0.863238849960896 0.603752277234866 1.49605256797255 0.585204080826175 0.363439685318281 NA NA 0.50966552228812 0.098332314749127 90.6527999345367 a682 loss_cnaDLBC2 310 YM201636 FYV1 4 25 1.63315443905142 NA 1.28824295833954 0.820565930723756 0.467677027615783 0.649778559125647 0.946413102237238 0.509342035195807 0.719748322020809 0.494157389104436 0.363507433490231 NA NA 0.93678533388982 0.265702188550767 90.6527999345367 a683 TP53_mut 269 NSC-207895 MDM4 17 11 2.99573227355399 NA 3.25658881916418 2.6933118149783 0.563277004185885 0.898100935563308 1.74861054302495 0.435567205210272 0.627186746924593 0.322128335799385 0.364898204986552 NA NA 0.341918500913188 0.340852609932618 90.6527999345367 a684 loss_cnaDLBC4_(CDKN2A) 275 I-BET BRD2, BRD3, BRD4 7 22 2.99573227355399 NA 1.81257326750552 1.30703364597435 0.505539621531164 1.8270053576771 1.27709463205146 0.356553626559493 0.276703962255435 0.395851340099278 0.365715794151071 NA NA 0.542643220573148 0.515163676995139 90.6527999345367 a685 loss_cnaDLBC2 329 QL-XI-92 DDR1 4 25 2.32630161961136 NA 2.95852977837101 2.41041346005991 0.548116318311099 1.54195502296668 1.25268289668571 0.425544108677732 0.355468421677137 0.437553925068569 0.366157621944712 NA NA 0.287049821145612 0.539236268305271 90.6527999345367 a686 PTEN_mut 1029 AMG-706 VEGFR, RET, c-KIT, PDGFR 5 27 0.693147180559945 NA 2.48745924096218 2.67454592976937 -0.187086688807192 0.540866642624856 0.595008563105235 0.318132595627194 0.34590169565505 0.314426884599479 0.366664963846769 NA NA 0.349557940315818 0.510899737160572 90.6527999345367 a687 MLL2_mut 292 Masitinib KIT 9 20 2.99573227355399 NA 2.90811251025412 2.62980994076759 0.278302569486526 0.41296343206429 0.765058005824571 0.409260753884807 0.673915770448169 0.363766626017559 0.367656685867999 NA NA 0.581413787391267 0.21629978991604 90.6527999345367 a688 ARID1A_mut 1049 PD-173074 FGFR1, FGFR3 3 29 0.693147180559945 NA 2.36645521690134 1.95910643193744 0.407348784963902 0.477810306533438 0.839346281202055 0.496635524524374 0.852532436814222 0.485316720984961 0.370299426369999 NA NA 0.313318604952001 0.277960819915045 90.6527999345367 a689 PTEN_mut 254 AC220 FLT3 6 23 0.0237165266173161 NA 1.46313778015335 1.71860830974365 -0.255470529590307 0.910377333803501 0.675498509144984 0.352489643113618 0.280620485708895 0.378195549111826 0.37069446379079 NA NA 0.518720967659081 0.54234398684146 90.6527999345367 a690 MLL2_mut 258 STF-62247 stimulates autophagy 9 20 2.32630161961136 NA 2.93046701547652 3.3266172434143 -0.396150227937783 1.18523867586441 1.09813146017094 0.352244817799803 0.334236669798904 0.360749365905714 0.371814694710096 NA NA 0.868480409061922 0.408299709541114 90.6527999345367 a691 CREBBP_mut 197 Bryostatin 1 PRKC 7 22 -4.8283137373023 NA -3.63393207599955 -3.2146025904134 -0.41932948558615 0.639705618665625 1.0395342562755 0.434490586978009 0.655503833874146 0.403382075246414 0.37342512393126 NA NA 0.556753159390765 0.218356204597494 90.6527999345367 a692 CREBBP_mut 1236 UNC0638 G9a(EHMT2), GLP(EHMT1) 6 24 2.99573227355399 NA 1.74396911890249 2.31465684058127 -0.570687721678782 2.95696962057337 0.806011552109781 0.39428025011034 0.192997492334103 0.708039134408154 0.374054887227771 NA NA 0.74258515844022 0.658514417348846 90.6527999345367 a693 CREBBP_mut 1016 Temsirolimus MTOR 7 23 -1.6094379124341 NA -3.96488247835859 -3.17966662959945 -0.78521584875914 1.56010764998182 1.9351905428831 0.42188914266114 0.503308761269321 0.405756348720734 0.374256171939123 NA NA 0.648478574445872 0.292994407913046 90.6527999345367 a694 loss_cnaDLBC2 331 QL-X-138 MNK2, PRKDC (DNAPK), MTOR, BTK, JAK3 4 25 2.32630161961136 NA 0.275289308664462 -0.322558704544313 0.597848013208775 1.62857631412893 1.26308850189928 0.456808974275582 0.367098555973132 0.473322346224992 0.374635532105247 NA NA 0.59199365971846 0.525808061396289 90.6527999345367 a695 ARID1A_mut 305 TPCA-1 IKK 3 26 2.99573227355399 NA 0.39648195974911 1.27143194870031 -0.874949988951197 2.0771919883586 1.46622359760132 0.575652935625161 0.421217679374251 0.596737080471614 0.374743267381984 NA NA 0.764338777542878 0.544737120377961 90.6527999345367 a696 MLL2_mut 87 GW843682X PLK1 8 17 -1.36257783450257 NA -3.31468482447872 -2.54175998416738 -0.772924840311337 1.38695916204435 1.44818397339796 0.540571943521857 0.557280171949734 0.533720062167088 0.375405460168096 NA NA 0.0337330225007725 0.220337672753033 90.6527999345367 a697 loss_cnaDLBC4_(CDKN2A) 254 AC220 FLT3 7 22 0.0237165266173161 NA 1.85559701525868 1.60534721355515 0.250249801703524 0.546744362743645 0.767399175634922 0.345554227622004 0.45770897471669 0.326101212574896 0.375489192060798 NA NA 0.51885035298569 0.358193321739581 90.6527999345367 a698 CREBBP_mut 225 Genentech Cpd 10 AURKA, AURKB 6 23 2.32630161961136 NA 1.02629888133042 1.40840880997951 -0.382109928649098 1.02327071223986 1.10034028882339 0.351695097230997 0.373420175207291 0.347265234700889 0.375689120481765 NA NA 0.377020687127569 0.445055932990796 90.6527999345367 a699 loss_cnaDLBC4_(CDKN2A) 94 TGX221 PI3Kbeta 8 19 2.30258509299405 NA 3.76934318945323 3.35253243459113 0.4168107548621 0.4876335223611 1.31110014982785 0.364971338258934 0.854762307652518 0.317909165761919 0.375985599073054 NA NA 0.846098660117199 0.24059121343084 90.6527999345367 a700 ARID1A_mut 281 CH5424802 ALK 3 26 1.63315443905142 NA 3.60658029944536 2.95479385938861 0.651786440056752 0.161394580265921 1.30644868934822 0.518155229961079 4.03846547376523 0.498899379187961 0.376314935190678 NA NA 0.556545109681 0.024257596216371 90.6527999345367 a701 MLL2_mut 346 THZ-2-102-1 CDK7 9 20 0.916290731874155 2.99573227355399 -4.04481412688012 -3.63458521829312 -0.410228908586995 1.1726581354583 1.51854923306898 0.287911483319466 0.349828220333516 0.270145280543802 0.376752313713958 NA NA 0.373328007756415 0.437550356406925 90.6527999345367 a702 loss_cnaDLBC2 1019 Bosutinib SRC, ABL, TEC 3 27 0.693147180559945 NA 1.62533390312664 1.02920391023199 0.596129992894647 1.7238576209794 1.2352409741166 0.467054532574117 0.345811617873614 0.482602184825499 0.376861689057961 NA NA 0.205770104341617 0.613615493941052 90.6527999345367 a703 MLL2_mut 186 Bexarotene Retinioic acid X family agonist 9 20 2.07944154167984 NA 3.03068153401265 3.24566224116464 -0.214980707151995 0.931146001548195 0.83394547113681 0.248852941028854 0.230877549594319 0.257787486823257 0.377277778661802 NA NA 0.184532441679953 0.562139437163267 90.6527999345367 a704 PTEN_mut 1066 AZD6482 PI3Kbeta 5 23 1.6094379124341 NA 0.971910958921644 1.64409917245154 -0.672188213529898 1.69676287340031 1.42985646698048 0.456008965965486 0.396159194703991 0.47010887389935 0.377354354205227 NA NA 0.890982274450584 0.445127798088396 90.6527999345367 a705 EP300_mut 301 PHA-793887 CDK-pan 6 23 2.32630161961136 NA -0.68661006772048 -0.0179592959704786 -0.668650771750002 1.51958581041342 1.86056842510276 0.370999169622277 0.440021726425628 0.359379833995126 0.377724607646503 NA NA 0.685713307161982 0.383755880348095 90.6527999345367 a706 loss_cnaDLBC2 163 JQ1 BRD4 4 26 0.940007258491471 NA -1.08410243328551 -0.318946113246558 -0.765156320038951 1.12811284994205 1.47638022518087 0.530220175933745 0.678262214705076 0.518265083065043 0.378064720647134 NA NA 0.408823757434543 0.284149041750809 90.6527999345367 a707 loss_cnaDLBC4_(CDKN2A) 328 SNX-2112 HSP90 7 21 0.940007258491471 NA -3.09181556495605 -2.56697792534784 -0.524837639608208 1.01842307484468 1.38049390405085 0.401903444695743 0.515343429044212 0.380181062783509 0.378522996595665 NA NA 0.911137024368534 0.301070217239578 90.6527999345367 a708 PTEN_mut 127 GSK269962A ROCK1, ROCK2 4 24 0.916290731874155 NA 2.09644641123097 1.39183320804721 0.704613203183758 0.878221081066172 1.18792887672067 0.609298131004831 0.802318708096084 0.593144267297275 0.378810154822636 NA NA 0.375924332210589 0.218563511515482 90.6527999345367 a709 TP53_mut 1526 RDEA119 (rescreen) MAP2K1 (MEK1), MAP2K2 (MEK2) 18 9 1.6094379124341 NA 2.99309258909763 2.66743989600131 0.325652693096323 0.534543410734852 1.44228120266646 0.35116911972115 0.609216551091032 0.225790014107002 0.378976406182876 NA NA 0.86892181322091 0.528497669179335 90.6527999345367 a710 MLL2_mut 1026 17-AAG HSP90 9 23 0 NA 1.09443235757992 0.581488317575339 0.512944040004577 0.834248620929692 1.23613496063925 0.448821769882329 0.614857522249121 0.414957958748544 0.379537650985677 NA NA 0.0801163492271131 0.189977036659706 90.6527999345367 a711 EP300_mut 287 KIN001-244 PDPK1 (PDK1) 6 23 2.99573227355399 NA 1.75363516740357 2.14439771836148 -0.390762550957906 0.621084174263966 1.09527798186816 0.381542601256311 0.629161983431618 0.356770205762195 0.381100186592673 NA NA 0.787139947207731 0.271009644963963 90.6527999345367 a712 TP53_mut 230 GSK429286A ROCK2 17 12 2.99573227355399 2.32630161961136 3.63528819323941 3.79471807923324 -0.159429885993837 0.583361348714332 0.995695635532193 0.204873802475501 0.273295250611314 0.160119096945346 0.381389851554089 NA NA 0.186430808069735 0.625372983662415 90.6527999345367 a713 TP53_mut 1042 BIRB 0796 p38, JNK2 18 11 2.30258509299405 NA 3.63996740803156 3.89422735237377 -0.254259944342214 0.875856424738159 0.915846550457958 0.285404123697507 0.290298657589029 0.277622866205125 0.381983527638147 NA NA 0.550672850987374 0.469185510408784 90.6527999345367 a714 ARID1A_mut 341 EX-527 SIRT1 3 26 2.99573227355399 NA 4.9946988245921 4.67838078120046 0.316318043391637 0.050101563965936 0.624566332979999 0.52619354421215 6.31353631209399 0.506460285623123 0.382072292645317 NA NA 0.707476625665455 0.0182758550812424 90.6527999345367 a715 CREBBP_mut 1012 Vorinostat HDAC inhibitor Class I, IIa, IIb, IV 7 23 2.30258509299405 NA 0.104985356731592 -0.116132261139855 0.221117617871447 0.338345177469147 0.704620733813765 0.34339403072188 0.653526731267242 0.313810830792114 0.38240490614545 NA NA 0.549370127125655 0.268568764379001 90.6527999345367 a716 loss_cnaDLBC2 1006 Cytarabine DNA synthesis 3 27 0.693147180559945 NA 0.799647284043664 -0.298556625638878 1.09820390968254 1.48246405519372 1.9502641701509 0.571792920800133 0.740796315320466 0.563105207228192 0.382423060456217 NA NA 0.652000942400422 0.329152063514268 90.6527999345367 a717 CREBBP_mut 276 CAY10603 HDAC6 6 23 2.99573227355399 NA -0.328811047728379 -0.94785333577001 0.619042288041631 1.89886044107014 1.37369567127079 0.416855948514317 0.326007259223726 0.450640051496239 0.382708358291804 NA NA 0.92604738777264 0.480316742543678 90.6527999345367 a718 PTEN_mut 185 OSI-906 IGF1R 5 24 0.940007258491471 NA 2.89004753457104 2.11261340466009 0.777434129910954 0.563990473517833 1.53584456307699 0.542126388943406 1.37845259169324 0.506193236347696 0.383401085184829 NA NA 0.334462232462422 0.0689678449702052 90.6527999345367 a719 CREBBP_mut 29 AZ628 BRAF 7 22 1.38629436111989 NA 1.17954115267329 1.71852344606274 -0.538982293389453 1.42234176553481 1.03490948916251 0.47591493771273 0.378940073651562 0.520801383148607 0.383494567557647 NA NA 0.128721815075182 0.380391139380771 90.6527999345367 a720 loss_cnaDLBC2 294 MPS-1-IN-1 MPS1 4 25 2.99573227355399 NA 2.34159688063218 2.79848325073036 -0.456886370098179 0.167919081399285 0.974545845845576 0.496338335660563 2.72087225758325 0.468819781076339 0.384530161110679 NA NA 0.816462763292138 0.0406204351549035 90.6527999345367 a721 loss_cnaDLBC2 1043 JNK Inhibitor VIII JNK 3 29 2.30258509299405 NA 4.47751699190014 4.14261680406499 0.334900187835147 0.686428081442189 0.649445642614417 0.513669183076632 0.487888238971109 0.515670851969948 0.385896444906358 NA NA 0.632139207936832 0.491546615199604 90.6527999345367 a722 MLL2_mut 170 Shikonin unknown 9 21 2.77258872223978 NA -0.65310480973741 -0.259278400436502 -0.393826409300908 0.893478970019632 1.15419336793282 0.362603208206667 0.440778599738341 0.341213543798347 0.386039642930733 NA NA 0.881998776194304 0.324986353680897 90.6527999345367 a723 PTEN_mut 303 PIK-93 PI4K, PI3K 6 23 2.99573227355399 NA 0.040864035705798 0.746452827802189 -0.705588792096391 0.932067614182109 1.6650714109724 0.453576832533938 0.757014599971426 0.423758877515247 0.386411563214549 NA NA 0.581776850311852 0.19158268465035 90.6527999345367 a724 loss_cnaDLBC2 281 CH5424802 ALK 4 25 1.63315443905142 NA 3.50020327887321 2.94574272507788 0.554460553795328 0.403471325445859 1.32785033688959 0.440358190496823 1.3742254252706 0.4175625357705 0.387063011208839 NA NA 0.556810598585242 0.115523008533521 90.6527999345367 a725 PTEN_mut 165 DMOG Prolyl-4-Hydroxylase 6 24 8.29404964010203 NA 4.65325229442177 5.31101128859654 -0.657758994174772 1.47918633305509 1.62944790792068 0.410164086585611 0.444676224675659 0.40366985098292 0.388363102318704 NA NA 0.90735407987905 0.366914218017044 90.6527999345367 a726 EP300_mut 1013 Nilotinib ABL 5 25 0.693147180559945 NA 2.47060733216655 2.05219790316332 0.418409429003224 0.859714449010581 0.783986098721675 0.526138319019712 0.486684188552093 0.533694959241573 0.388445540729761 NA NA 0.383695130607009 0.35648255582208 90.6527999345367 a727 PTEN_mut 269 NSC-207895 MDM4 6 22 2.99573227355399 NA 2.71653125589818 3.12223874341651 -0.405707487518339 1.82645142325967 1.15768957095731 0.308987316240191 0.222128813474969 0.350445834268726 0.388603186281683 NA NA 0.342669394105586 0.623554248396563 90.6527999345367 a728 PTEN_mut 71 Pyrimethamine Dihydrofolate reductase (DHFR) 4 24 2.99573227355399 NA 3.62470283473308 2.84425529797197 0.780447536761109 0.986238316162873 1.20325499212549 0.661254517258535 0.791337675661977 0.648613587201899 0.389863114433391 NA NA 0.182163907378483 0.220129081778509 90.6527999345367 a729 loss_cnaDLBC2 287 KIN001-244 PDPK1 (PDK1) 4 25 2.99573227355399 NA 1.63040680616316 2.13285325208331 -0.502446445920148 0.895588919377254 1.03622970054629 0.491842536201344 0.561023517653081 0.484879410091475 0.391034279823054 NA NA 0.787267700584231 0.361253877468488 90.6527999345367 a730 loss_cnaDLBC2 299 OSI-027 MTORC1/2 4 25 2.99573227355399 NA -0.722293542814388 -1.4458471953738 0.723553652559408 2.66465112911701 1.556678708365 0.421775065588546 0.271537855238548 0.464806031373916 0.391595360585761 NA NA 0.436166180271971 0.630119671805455 90.6527999345367 a731 MLL2_mut 1016 Temsirolimus MTOR 8 22 -1.6094379124341 NA -2.9129386470527 -3.52650002967617 0.613561382623467 2.02774737052004 1.8167319575082 0.327806631369227 0.302582753425596 0.33772807270095 0.391770937318293 NA NA 0.648823665436876 0.4667871411423 90.6527999345367 a732 ARID1A_mut 193 GW-2580 CSF1R (cFMS) 3 26 2.99573227355399 NA 4.30297683850096 4.64864990191691 -0.345673063415955 0.935265063937728 0.575302507832679 0.567325054525544 0.369599033198754 0.600854435205227 0.392513964037762 NA NA 0.585224469278865 0.590262655334959 90.6527999345367 a733 EP300_mut 163 JQ1 BRD4 6 24 0.940007258491471 NA -0.784083471287643 -0.330187827076112 -0.453895644211532 1.57107446561923 1.42965049445555 0.311760214271566 0.288907785177854 0.317487138270383 0.392732772700172 NA NA 0.409229643398884 0.539411257937067 90.6527999345367 a734 loss_cnaDLBC4_(CDKN2A) 1248 FK866 NAMPT 7 21 0 NA -5.01652866710573 -4.12540122047985 -0.891127446625883 3.10705211681034 3.12701608765323 0.285396374487363 0.286808013874161 0.284976930609481 0.393145521517868 NA NA 0.236946744572006 0.526033143685404 90.6527999345367 a735 ARID1A_mut 303 PIK-93 PI4K, PI3K 3 26 2.99573227355399 NA -0.102385302255754 0.681567506171246 -0.783952808427 1.5277076369759 1.56698746182532 0.501212810695692 0.513156306516106 0.500292968211633 0.393264844305595 NA NA 0.581934157432443 0.473599209245146 90.6527999345367 a736 CREBBP_mut 159 HG-6-64-1 BRAFV600E, TAK, MAP4K5 7 23 1.63315443905142 NA 0.0324109239606809 0.72898610795459 -0.696575183993909 1.94426277253422 1.54177759468521 0.425680692596205 0.358272139874368 0.451800043271567 0.393506743077995 NA NA 0.427902280361472 0.409193215632505 90.6527999345367 a737 EP300_mut 1039 SL 0101-1 RSK, AURKB, PIM3 6 26 2.30258509299405 NA 3.72388523203967 3.99809267316021 -0.274207441120538 0.77480570848131 0.74020085092752 0.367530982716375 0.353904776538121 0.370450048492836 0.394076266333086 NA NA 0.823980548664127 0.455706578001968 90.6527999345367 a738 TP53_mut 261 TL-1-85 MAP3K7 (TAK1) 17 12 2.32630161961136 NA 1.39909832000431 1.74506565977855 -0.345967339774245 1.38256433080381 0.939413919239881 0.283212047080964 0.250235979669099 0.36827998040968 0.39429838000826 NA NA 0.663586146719102 0.429427918287805 90.6527999345367 a739 PTEN_mut 136 Mitomycin C DNA crosslinker 5 24 2.77258872223978 NA -0.783107755854676 -1.42064399610663 0.637536240251957 1.73320924794388 1.10673197156912 0.52256459474672 0.367835701897086 0.576052970935738 0.394313630202519 NA NA 0.381469544714122 0.467658324662241 90.6527999345367 a740 PTEN_mut 255 CP724714 ERBB2 6 23 2.32630161961136 NA 3.48856320258055 3.81340438219457 -0.324841179614017 0.818236266278714 0.866416514882664 0.378735877086787 0.397001688878169 0.374924962802687 0.394381156958738 NA NA 0.854681378606798 0.416657398403719 90.6527999345367 a741 loss_cnaDLBC2 34 Imatinib ABL, KIT, PDGFR 4 23 0.693147180559945 NA 2.87321698810816 2.6603535124296 0.212863475678556 0.452530958095115 0.533131494513905 0.406139415708594 0.47038433917225 0.399270119790313 0.394514148144518 NA NA 0.358926284399595 0.440269304561967 90.6527999345367 a742 MLL2_mut 153 Midostaurin KIT 9 21 -0.669430653942629 NA -0.48770112274864 -0.165271891575968 -0.322429231172672 0.757000361249256 0.934863895674475 0.363222885234552 0.425930088911155 0.344894302437521 0.395095721545833 NA NA 0.800910131337119 0.333080695832309 90.6527999345367 a743 ARID1A_mut 163 JQ1 BRD4 3 27 0.940007258491471 NA -1.16679246215518 -0.338097455225444 -0.828695006929741 0.374460536976588 1.49621782452077 0.573387877548783 2.21303695609867 0.553859868094517 0.39533420246173 NA NA 0.40929936196586 0.0394612436691563 90.6527999345367 a744 PTEN_mut 341 EX-527 SIRT1 6 23 2.99573227355399 NA 4.53957251610471 4.75585050818957 -0.21627799208486 0.726268658173943 0.570737010789725 0.358922613505574 0.297793371159163 0.378945097297261 0.395364990078811 NA NA 0.707703721550663 0.521112374563363 90.6527999345367 a745 MLL2_mut 91 KIN001-135 IKKE 9 18 1.6094379124341 NA 3.49820169137506 3.30912412153992 0.189077569835137 0.557513230589128 0.652009979781987 0.303333840688873 0.339144543054766 0.289991834018182 0.395502750290243 NA NA 0.581133824685539 0.442876768532458 90.6527999345367 a746 loss_cnaDLBC2 200 LAQ824 HDAC 4 25 0.0237165266173161 NA -3.93363574714594 -3.35085485536443 -0.582780891781513 0.700434012778435 1.30492408419082 0.465386156671665 0.832028258407637 0.446601376158135 0.396694721769925 NA NA 0.940985178504522 0.223942059839118 90.6527999345367 a747 EP300_mut 275 I-BET BRD2, BRD3, BRD4 6 23 2.99573227355399 NA 1.05250446122816 1.52729244854806 -0.474787987319898 1.19455313319949 1.46826662041722 0.333990663366192 0.397460752581366 0.323366329192297 0.396973803911934 NA NA 0.543433633513966 0.430078076401105 90.6527999345367 a748 loss_cnaDLBC2 1175 AG-014699 PARP1, PARP2 3 27 1.6094379124341 NA 3.57584909322648 3.27181997096376 0.304029122262717 0.596939467391562 0.639597266167507 0.477548847166168 0.509313152958756 0.47534462441416 0.397201345921003 NA NA 0.409842506508094 0.476940085975745 90.6527999345367 a749 MLL2_mut 1020 Lenalidomide TNFA 8 22 1.6094379124341 NA 3.27399884409885 3.03558804046334 0.238410803635508 0.442460196380061 0.937898948492751 0.283204236057515 0.538829945803124 0.25419668506788 0.39750962865145 NA NA 0.330989627886561 0.356441711610011 90.6527999345367 a750 TP53_mut 1133 JNJ-26854165 MDM2 18 12 2.30258509299405 NA 2.77440356994575 2.45800889729901 0.316394672646742 0.910962579023333 0.836282078116043 0.358570473349004 0.347319066592128 0.378334871601587 0.397514773112767 NA NA 0.626884258627682 0.336773929386046 90.6527999345367 a751 MLL2_mut 35 NVP-TAE684 ALK 8 18 0.693147180559945 NA 1.22392698008837 0.746675801632394 0.47725117845598 1.24562841074152 1.99484361305421 0.26386848149684 0.38314089044571 0.239242402428371 0.398751731994532 NA NA 0.275143848620915 0.467055838886068 90.6527999345367 a752 TP53_mut 1031 Elesclomol HSP70 17 13 -1.6094379124341 NA -2.67444572515332 -3.133868210721 0.459422485567684 1.25868612322795 1.38531385941863 0.349516971257229 0.365001629150783 0.331637832426283 0.399016357822486 NA NA 0.674871998080549 0.358275375589279 90.6527999345367 a753 MLL2_mut 238 CAL-101 PI3Kdelta 9 20 2.99573227355399 2.32630161961136 2.22947680957756 2.97389588260072 -0.744419073023161 3.19585703474073 1.12337365713536 0.376263284350959 0.23293253262925 0.662663814746604 0.399041459307572 NA NA 0.672345987643087 0.513708805327958 90.6527999345367 a754 MLL2_mut 172 Embelin XIAP 9 20 3.46573590279973 NA 2.4151010061173 2.79451155687996 -0.37941055076266 1.16033365601997 1.1607726805881 0.326896966691898 0.32698400912033 0.326860338038308 0.399698809606441 NA NA 0.826254653143778 0.427670209371316 90.6527999345367 a755 TP53_mut 173 FH535 unknown 16 13 3.46573590279973 NA 1.96794161472393 2.24327342027677 -0.275331805552838 0.729901401378562 0.624503324324628 0.401907465336552 0.377217806450049 0.440881248871809 0.399896188783342 NA NA 0.342441385439552 0.283495264382141 90.6527999345367 a756 loss_cnaDLBC2 193 GW-2580 CSF1R (cFMS) 4 25 2.99573227355399 NA 4.35131991745221 4.65474193182135 -0.303422014369134 0.992888067856751 0.542763262646581 0.497884471002709 0.305595388032108 0.559031967067208 0.399908382911438 NA NA 0.585389248106712 0.589037895314063 90.6527999345367 a757 TP53_mut 312 AV-951 VEGFR 17 12 -2.05572501506252 NA -0.422955780799598 -0.31247808457249 -0.110477696227109 0.620702767335958 0.307528303942246 0.21386992386226 0.177988083896059 0.359243994165351 0.400038384989525 NA NA 0.26845396999043 0.533102747070788 90.6527999345367 a758 ARID1A_mut 170 Shikonin unknown 3 27 2.77258872223978 NA 0.130482110169082 -0.433860593604092 0.564342703773174 1.44423299056804 1.05566763543105 0.518681110881523 0.390755998137951 0.534583693609912 0.400377035760724 NA NA 0.882096328205473 0.571865201160185 90.6527999345367 a759 EP300_mut 59 WZ-1-84 BMX 5 20 2.32630161961136 NA 3.13637971395249 3.44803997016744 -0.311660256214948 1.26387210725305 0.796271305811114 0.348102585411283 0.246591608776241 0.391399581952131 0.400617726736549 NA NA 0.52029370656039 0.622216293811886 90.6527999345367 a760 CREBBP_mut 179 5-Fluorouracil DNA antimetabolite 6 23 3.46573590279973 NA 2.16773658903861 1.5307075882179 0.637029000820716 1.50289171905798 1.562062638574 0.410648567866206 0.423868860771959 0.407812711916763 0.401687132236107 NA NA 0.80286262411553 0.385702204278145 90.6527999345367 a761 MLL2_mut 179 5-Fluorouracil DNA antimetabolite 9 20 3.46573590279973 NA 2.04921596596353 1.48848751847858 0.560728447484956 0.919631307275353 1.75000817046427 0.361519836775611 0.609731794740938 0.320414759741492 0.401849960933918 NA NA 0.80286446265076 0.269564532746569 90.6527999345367 a762 loss_cnaDLBC2 136 Mitomycin C DNA crosslinker 4 25 2.77258872223978 NA -1.85027408312804 -1.22439593413282 -0.625878148995219 0.449246439736708 1.28959573610774 0.51090855535374 1.39317330897943 0.485328953462769 0.402898488994306 NA NA 0.381708044825618 0.089845900040806 90.6527999345367 a763 loss_cnaDLBC4_(CDKN2A) 147 NSC-87877 PTPN6 (SHP-1), PTPN11 (SHP-2) 8 22 2.77258872223978 NA 4.63847160883986 4.45721210535376 0.181259503486102 0.435656861748832 0.676274289854603 0.290076694751282 0.41606025154403 0.268026607258827 0.40404324447844 NA NA 0.409737104547561 0.400646052234799 90.6527999345367 a764 EP300_mut 1033 Vismodegib SMO 5 25 2.30258509299405 NA 4.07248701985836 3.74208000699825 0.330407012860106 0.811388159940615 0.676861031424135 0.473586948875709 0.407212021536385 0.488146011545266 0.404596848155436 NA NA 0.594057623480198 0.431304167878194 90.6527999345367 a765 CREBBP_mut 1013 Nilotinib ABL 7 23 0.693147180559945 NA 2.31005096220147 2.06467945671763 0.245371505483837 0.704226538035011 0.829522814792071 0.305067611422489 0.348426951032679 0.295798380838196 0.404764698081193 NA NA 0.384134444004116 0.455030849696457 90.6527999345367 a766 loss_cnaDLBC4_(CDKN2A) 171 AKT inhibitor VIII AKT1, AKT2, AKT3 8 22 0.940007258491471 NA 2.21920202856988 1.96270759577817 0.256494432791718 0.546705205851802 0.9040931810393 0.309285446449858 0.469164057788847 0.2837035365059 0.405646044517907 NA NA 0.574711741767426 0.358119754999845 90.6527999345367 a767 loss_cnaDLBC4_(CDKN2A) 1013 Nilotinib ABL 8 22 0.693147180559945 NA 2.29018887955116 2.06074878197757 0.229440097573587 0.600503525603048 0.862002962216798 0.285147942420428 0.382079517923188 0.266170892247911 0.405809819654195 NA NA 0.384161699898583 0.42453793879933 90.6527999345367 a768 MLL2_mut 283 GSK2126458 PI3K, MTOR 9 20 -2.05572501506252 0.0237165266173161 -4.88750075561616 -4.33522250729097 -0.552278248325181 1.99704769721971 1.64401551470013 0.314503440767205 0.276547349917613 0.335932503913089 0.405996127794254 NA NA 0.751837777025792 0.480446205846018 90.6527999345367 a769 MLL2_mut 1052 RO-3306 CDK1 9 23 1.6094379124341 NA 2.8931175059883 3.23118266462749 -0.33806515863919 0.983816134921245 0.781358303813405 0.402395690072024 0.343626361308103 0.432663423411857 0.406674525536907 NA NA 0.238769240832084 0.373838884474921 90.6527999345367 a770 MLL2_mut 164 JQ12 HDAC 9 21 1.63315443905142 NA 0.104960493386636 0.713436796645812 -0.608476303259176 1.01547674398727 1.72485049058727 0.391167257930342 0.599202598052611 0.352770461312275 0.407649723958978 NA NA 0.418545459026605 0.240693684702508 90.6527999345367 a771 EP300_mut 165 DMOG Prolyl-4-Hydroxylase 6 24 8.29404964010203 NA 4.67389995671148 5.30584937302412 -0.631949416312633 1.34607584241808 1.65644260127686 0.393633325654207 0.469475341877768 0.381509999697844 0.40803828355675 NA NA 0.907457598393442 0.352379618575309 90.6527999345367 a772 PTEN_mut 332 XMD15-27 CAMK2B, CLK2, DYRK1A, MAST1, STK39 6 23 2.32630161961136 NA 4.00277379411742 3.57574586757559 0.427027926541824 0.616659471774722 0.885791270021524 0.506879872394447 0.692485798219971 0.482086402286904 0.408185533005565 NA NA 0.144947275509518 0.19847671299413 90.6527999345367 a773 MLL2_mut 252 WZ3105 CLK2, CNSK1E, FLT3, ULK1 9 20 0.246860077931526 2.32630161961136 -1.69394420286076 -1.34228837933666 -0.351655823524097 1.14781998901359 1.20802059381622 0.295384789485645 0.306368443562568 0.291100851528691 0.408738978454467 NA NA 0.599365167071862 0.463478417885733 90.6527999345367 a774 EP300_mut 1028 VX-702 p38 5 25 0.693147180559945 NA 2.3642497199902 1.9750488072391 0.389200912751098 0.770053223348581 0.797548216471823 0.490375920783941 0.505420795537554 0.487996718835178 0.408804681253784 NA NA 0.4760515020256 0.345615441404506 90.6527999345367 a775 EP300_mut 1268 XAV 939 TNKS1 (tankyrase-1) 6 23 1.6094379124341 NA 2.57197741755776 2.98119171955159 -0.409214301993822 0.887766600565657 0.865370950246873 0.470598290629223 0.460948070960412 0.472877327205266 0.409287034653801 NA NA 0.323732287774942 0.342922409720565 90.6527999345367 a776 PTEN_mut 1037 BX-795 TBK1, PDPK1, IKK, AURKB, AURKC 5 27 1.6094379124341 NA 0.826032510406341 1.3349261668337 -0.50889365642736 1.13792533345256 1.21060077813403 0.423666806307642 0.447211817389928 0.420364554210636 0.410797739868674 NA NA 0.850935122756441 0.399350369363848 90.6527999345367 a777 ARID1A_mut 291 KIN001-266 MAP3K8 (COT) 3 26 2.99573227355399 NA 2.44085261021318 2.73915298069362 -0.298300370480439 0.616495194923793 0.552738956560127 0.534864878058075 0.483864875081975 0.539676762312645 0.411173438480639 NA NA 0.747329722693382 0.494757780206958 90.6527999345367 a778 loss_cnaDLBC4_(CDKN2A) 3 Rapamycin MTOR 6 17 -2.30258509299405 NA -3.01266119315191 -3.66155853204938 0.648897338897463 1.49850263009338 2.1827727661244 0.317967066989496 0.433030497155035 0.297281214502967 0.41120654605592 NA NA 0.405409037197776 0.436912520139112 90.6527999345367 a779 ARID1A_mut 275 I-BET BRD2, BRD3, BRD4 3 26 2.99573227355399 NA 0.734838884578219 1.5091629396246 -0.774324055046385 0.665818278653605 1.45788829856792 0.547415325225072 1.16296605225708 0.531127148634777 0.412693004314947 NA NA 0.5437978816604 0.170541548886336 90.6527999345367 a780 loss_cnaDLBC4_(CDKN2A) 37 Crizotinib MET, ALK 8 18 0.693147180559945 NA 2.18098403636335 1.92711115850178 0.253872877861574 0.538451560280742 1.05146526334666 0.272543687109776 0.471486938823629 0.241446756931879 0.412842911462502 NA NA 0.371228102296709 0.424807119097313 90.6527999345367 a781 ARID1A_mut 1029 AMG-706 VEGFR, RET, c-KIT, PDGFR 3 29 0.693147180559945 NA 2.88656516899312 2.62035657936568 0.266208589627445 0.331077671636889 0.600916846592108 0.453660938549949 0.804066877452886 0.443004038141309 0.413317684636445 NA NA 0.350770606573298 0.302807539845112 90.6527999345367 a782 loss_cnaDLBC4_(CDKN2A) 135 Gemcitabine DNA replication 8 20 0.0237165266173161 NA -4.18696758749518 -3.18092491098912 -1.00604267650606 1.65602693806096 2.55047963603338 0.429291930304603 0.607503811311208 0.394452346253862 0.413850354245722 NA NA 0.244095913196671 0.232677358522828 90.6527999345367 a783 loss_cnaDLBC2 1052 RO-3306 CDK1 3 29 1.6094379124341 NA 3.4701256733843 3.10154764897152 0.368578024412781 0.673146718859359 0.858535242701593 0.434931783932228 0.547544857735224 0.429310302105897 0.414966862205614 NA NA 0.238962034826094 0.450739549530871 90.6527999345367 a784 ARID1A_mut 262 VX-11e ERK 3 26 1.63315443905142 NA 1.40709414796559 2.09977014578282 -0.692675997817227 2.39943236295553 1.13303944896346 0.545034384692921 0.288683277141439 0.611343231209564 0.415007966312164 NA NA 0.541117445767751 0.668261872608365 90.6527999345367 a785 MLL2_mut 63 BMS-509744 ITK 8 17 2.32630161961136 NA 2.49338159879997 2.90331251474456 -0.40993091594459 0.535532115942514 0.945117567717325 0.486953184161846 0.765464672876115 0.433735367902077 0.416789227248591 NA NA 0.0872685755340278 0.181854212435787 90.6527999345367 a786 ARID1A_mut 1058 GDC0941 PI3K (class 1) 3 29 1.38629436111989 0.693147180559945 1.20271539248715 0.0993405892099817 1.10337480327717 1.93090519742538 2.04869088580475 0.54059175938782 0.571428781044446 0.538575541543326 0.417508046246621 NA NA 0.44625676671639 0.430568497862667 90.6527999345367 a787 CREBBP_mut 59 WZ-1-84 BMX 6 19 2.32630161961136 NA 3.08923307535658 3.47933155373536 -0.390098478378782 1.10221886248717 0.818418960749473 0.439366800537137 0.353921069267968 0.476648876782555 0.417547765053337 NA NA 0.520766786208344 0.450576712686049 90.6527999345367 a788 loss_cnaDLBC2 1033 Vismodegib SMO 3 27 2.30258509299405 NA 4.09715094893033 3.76381416397989 0.333336784950431 0.582556661409157 0.709954027769135 0.475094696404093 0.572196332188729 0.469518830673958 0.417634497032293 NA NA 0.594318249901681 0.432760548086585 90.6527999345367 a789 PTEN_mut 204 Tipifarnib Farnesyl-transferase (FNTA) 5 24 2.77258872223978 NA 1.50120283569783 0.947796668977948 0.553406166719883 2.03722427177167 1.54678089420544 0.339766362151476 0.271647149696785 0.357779287805438 0.418453065249984 NA NA 0.630374134133533 0.59083573049167 90.6527999345367 a790 TP53_mut 1059 AZD8055 MTORC1/2 19 13 0.693147180559945 NA -1.38646519991292 -1.06131001851413 -0.325155181398793 1.03753415105258 0.933605509326912 0.326047495514814 0.313392268648624 0.348278987377887 0.419455677755215 NA NA 0.67182311394083 0.363226943009983 90.6527999345367 a791 loss_cnaDLBC4_(CDKN2A) 186 Bexarotene Retinioic acid X family agonist 8 21 2.07944154167984 NA 3.44293425412341 3.0783764093533 0.364557844770102 0.660313819180317 0.911453327987371 0.427148404092032 0.552097857383399 0.399974231895232 0.419779819395537 NA NA 0.185603103129269 0.250358372939244 90.6527999345367 a792 PTEN_mut 1020 Lenalidomide TNFA 4 26 1.6094379124341 NA 3.51684551307818 3.03490559964121 0.481939913436972 0.441831979384746 0.866850954537671 0.579417067793987 1.09077643974091 0.555966294913998 0.419969069220388 NA NA 0.331576090488454 0.125704718413355 90.6527999345367 a793 EP300_mut 1012 Vorinostat HDAC inhibitor Class I, IIa, IIb, IV 5 25 2.30258509299405 NA 0.185024931845887 -0.114450766732998 0.299475698578884 0.333233835701857 0.678668302990917 0.467329012403402 0.898695349912858 0.441269611766284 0.420235292294336 NA NA 0.550217238474346 0.163132249579394 90.6527999345367 a794 loss_cnaDLBC4_(CDKN2A) 1494 SN-38 TOP1 7 24 -2.99573227355399 NA -5.11489161027303 -4.5134698878571 -0.601421722415935 2.11588228541883 1.40146721481749 0.381594805822051 0.284241579297917 0.429137204250801 0.422039088845713 NA NA 0.63381054604535 0.50002015590473 90.6527999345367 a795 MLL2_mut 192 LFM-A13 BTK 9 20 2.77258872223978 NA 4.03245769554835 4.33269968596135 -0.300241990413007 0.80060059773949 0.681542000656564 0.417654051279923 0.375020942103648 0.440533364229598 0.422363214556284 NA NA 0.188605125283484 0.345804192684956 90.6527999345367 a796 CREBBP_mut 310 YM201636 FYV1 6 23 1.63315443905142 NA 0.613393327138372 0.955946092983557 -0.342552765845185 1.4152823133952 0.767051254291781 0.371476127890345 0.242038470065676 0.446583932857869 0.422605864103258 NA NA 0.937010800884704 0.589221004845629 90.6527999345367 a797 loss_cnaDLBC4_(CDKN2A) 1046 681640 WEE1, CHEK1 8 24 0.693147180559945 NA 1.57892897872636 1.80966494067591 -0.230735961949551 0.594186364763957 0.819629489134964 0.29852111235447 0.388322545976315 0.281512518776099 0.422674104083244 NA NA 0.595479012555612 0.402445370206669 90.6527999345367 a798 EP300_mut 1050 ZM-447439 AURKB 6 26 1.38629436111989 0.693147180559945 1.9315789981166 1.52153024852744 0.410048749589164 1.23665951083436 1.20674468051919 0.338384979331284 0.331577726930277 0.339797437029302 0.423182698151739 NA NA 0.781740349242701 0.48483971623365 90.6527999345367 a799 CREBBP_mut 172 Embelin XIAP 7 22 3.46573590279973 NA 3.00238428113762 2.57315682839507 0.429227452742547 1.14184067683574 1.1642247271696 0.370250973094675 0.375908356962739 0.368680927939112 0.423572606212175 NA NA 0.826485039035363 0.408227441472769 90.6527999345367 a800 CREBBP_mut 196 Phenformin AAPK1 (AMPK) agonist 6 23 8.29404964010203 NA 6.36225310157525 5.76543521596447 0.596817885610785 1.37439034462665 1.59737652502382 0.382945820423376 0.434241908016976 0.373623798936124 0.4236182879908 NA NA 0.916718585302067 0.384500216032767 90.6527999345367 a801 EP300_mut 331 QL-X-138 MNK2, PRKDC (DNAPK), MTOR, BTK, JAK3 6 23 2.32630161961136 NA -0.571892879378195 -0.153541439246992 -0.418351440131203 1.0589752241013 1.3657949385135 0.318285344728668 0.395053095303753 0.306306187213235 0.425319554293327 NA NA 0.593094784595337 0.438095286457504 90.6527999345367 a802 loss_cnaDLBC4_(CDKN2A) 192 LFM-A13 BTK 8 21 2.77258872223978 NA 4.36196815136815 4.19287465562938 0.169093495738763 0.852556815635182 0.680407651838108 0.231967572191354 0.198336923285028 0.248517921986856 0.426232837079266 NA NA 0.188694481514682 0.625096080860025 90.6527999345367 a803 TP53_mut 304 SB52334 ALK5 17 12 2.99573227355399 NA 3.89750160533249 3.53582896126272 0.361672644069761 0.724207182946406 1.10221258686164 0.402917241408995 0.499404939064966 0.328133291509183 0.426258274174868 NA NA 0.22775374414736 0.333157928057083 90.6527999345367 a804 loss_cnaDLBC4_(CDKN2A) 1241 CHIR-99021 GSK3B 7 22 2.30258509299405 NA 3.47896166870827 3.13926529817639 0.339696370531881 1.45410520436641 1.09268271491173 0.287249387064501 0.233611962540149 0.310882899396211 0.426844407108381 NA NA 0.384531978767605 0.584424432767409 90.6527999345367 a805 loss_cnaDLBC4_(CDKN2A) 1021 Axitinib PDGFR, KIT, VEGFR 8 22 0.693147180559945 NA 1.92649781418094 1.61340557825599 0.313092235924957 0.580160602564653 0.986706592114256 0.346952227018338 0.539664766171477 0.317310372128032 0.428340464018643 NA NA 0.845765470149681 0.298405075669507 90.6527999345367 a806 loss_cnaDLBC4_(CDKN2A) 1149 TW 37 BCL2, BCL2L1 7 23 1.6094379124341 NA -1.19355991345444 -0.941137482652597 -0.252422430801841 0.30960775335689 0.754463264021347 0.369068228328688 0.815297511334833 0.334572195677773 0.428863950829349 NA NA 0.759023685291161 0.209732901795177 90.6527999345367 a807 TP53_mut 211 TL-2-105 CRAF 17 12 2.32630161961136 1.63315443905142 2.84127250077441 2.95826986094048 -0.116997360166069 0.819057666623909 0.610174694391046 0.157870170380088 0.142843861834933 0.191744038619681 0.429094916704673 NA NA 0.138385215640537 0.662972419039921 90.6527999345367 a808 EP300_mut 231 FMK RSK 6 22 2.99573227355399 2.32630161961136 4.44421559758797 4.60077063338469 -0.156555035796716 0.842013567964682 0.663755161014526 0.223152075289364 0.185929350491514 0.235862626751447 0.429747540024797 NA NA 0.148210403250012 0.686657745428803 90.6527999345367 a809 TP53_mut 171 AKT inhibitor VIII AKT1, AKT2, AKT3 17 13 0.940007258491471 NA 1.94458547171561 2.14424848588564 -0.199663014170027 0.9251078057686 0.68656019673406 0.240182288578587 0.215826753298381 0.290816471912901 0.429918022233654 NA NA 0.575202707973106 0.503041029363209 90.6527999345367 a810 MLL2_mut 52 GNF-2 ABL [T315I] 8 17 0.246860077931526 NA 2.35235631724466 2.19203304717521 0.160323270069449 0.597798814797822 0.584730763670346 0.272316511518558 0.268189340796319 0.274183060017403 0.429944477816107 NA NA 0.452636522467964 0.539262411042298 90.6527999345367 a811 EP300_mut 199 Pazopanib VEGFR, PDGFRA, PDGFRB, KIT 5 24 2.07944154167984 NA 3.29836777529591 2.82152855026732 0.476839225028592 1.14954742005092 0.939037603345624 0.490019759833486 0.414806050373694 0.507795665828183 0.4310931577983 NA NA 0.382910189785527 0.423286720729559 90.6527999345367 a812 loss_cnaDLBC4_(CDKN2A) 1498 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 7 23 1.38629436111989 NA 2.35070039166592 2.67668043845189 -0.325980046785963 1.30358022674313 0.658012925869111 0.38841853320118 0.250065197445033 0.495400673710785 0.431286933892324 NA NA 0.511300173061911 0.544292299362986 90.6527999345367 a813 loss_cnaDLBC4_(CDKN2A) 179 5-Fluorouracil DNA antimetabolite 7 22 3.46573590279973 NA 1.27108470506394 1.78705005126344 -0.515965346199502 1.77082267008549 1.49087332102393 0.331290866842384 0.291370420604901 0.346082620785739 0.431370525246067 NA NA 0.803180438306233 0.504017617774167 90.6527999345367 a814 MLL2_mut 163 JQ1 BRD4 9 21 0.940007258491471 NA -0.800323076024593 -0.2583857615872 -0.541937314437392 1.19163928394246 1.53508421020881 0.374962950896265 0.454783021791986 0.353034257556251 0.431768216124827 NA NA 0.410209904416702 0.309728983738254 90.6527999345367 a815 MLL2_mut 1371 PLX4720 (rescreen) BRAF 9 21 2.30258509299405 NA 3.26365779360062 3.4336842026025 -0.170026409001879 0.848269856983879 0.747304025467508 0.218686164311978 0.200439055569448 0.227519728527506 0.432342795735969 NA NA 0.206937821602243 0.61081367924281 90.6527999345367 a816 CREBBP_mut 135 Gemcitabine DNA replication 7 21 0.0237165266173161 NA -3.01052761716384 -3.62097836188557 0.610450744721737 2.0810590590674 2.45594439304488 0.257065331847148 0.293336578826024 0.248560491210838 0.432377955550518 NA NA 0.244576091125779 0.533260159214392 90.6527999345367 a817 loss_cnaDLBC2 1026 17-AAG HSP90 3 29 0 NA 0.331654207146869 0.766522755207291 -0.434868548060423 1.93361096488362 1.08388477841235 0.374866822721051 0.224899711450797 0.401212893401279 0.432387561912729 NA NA 0.0809010667123903 0.736332602541409 90.6527999345367 a818 loss_cnaDLBC4_(CDKN2A) 1026 17-AAG HSP90 8 24 0 NA 1.08585345176353 0.605720621180993 0.480132830582533 0.554238247613046 1.27437957321578 0.418413398960105 0.866293209915294 0.376758103059485 0.433477883789267 NA NA 0.0809157894603318 0.151786095302588 90.6527999345367 a819 EP300_mut 330 XMD13-2 RIPK 6 23 2.32630161961136 NA 2.16726316258422 1.73188240450902 0.435380758075198 0.653150544065192 1.15581918356001 0.402935749096183 0.666585616488044 0.37668587290115 0.433605486246102 NA NA 0.673629479349315 0.245362147935747 90.6527999345367 a820 ARID1A_mut 1067 CCT007093 PPM1D 3 25 1.88706964903238 NA 3.88512647293442 3.57759574433099 0.307530728603423 0.397151245349325 0.658856343458129 0.478631528090995 0.774341594555309 0.466764464904885 0.433752710795812 NA NA 0.818066583965994 0.317855677308174 90.6527999345367 a821 loss_cnaDLBC2 1049 PD-173074 FGFR1, FGFR3 3 29 0.693147180559945 NA 1.60247254485626 2.038139122149 -0.435666577292736 1.81816510723463 0.694527454699412 0.532016402191799 0.239618819852598 0.627284888948401 0.433818458233009 NA NA 0.314903732721879 0.719296011768836 90.6527999345367 a822 CREBBP_mut 1037 BX-795 TBK1, PDPK1, IKK, AURKB, AURKC 7 25 1.6094379124341 NA 0.944741970123839 1.34239901062699 -0.397657040503151 0.493298013237904 1.32368819897787 0.330191915490302 0.806119282526629 0.300415944487694 0.433843991447902 NA NA 0.851100253254649 0.229988410889449 90.6527999345367 a823 MLL2_mut 32 VX-680 AURKA, AURKB, AURKC, FLT3, ABL1, JAK2 8 16 0.693147180559945 NA -0.0715917364761409 0.86339414486711 -0.934985881343251 2.12072076343467 1.76993834457781 0.49506003096429 0.44088118410694 0.528259012076649 0.434043713901651 NA NA 0.0652272886744457 0.303898989644112 90.6527999345367 a824 EP300_mut 106 XMD8-85 MAP2K5 (ERK5) 5 22 2.07944154167984 NA 1.72859359179877 2.05486539590135 -0.326271804102585 1.19968470339315 0.876293050337219 0.348738230226915 0.271964628022486 0.372331840332441 0.434234383808883 NA NA 0.728505195873919 0.590559266658398 90.6527999345367 a825 ARID1A_mut 179 5-Fluorouracil DNA antimetabolite 3 26 3.46573590279973 NA 0.998912901054076 1.73907520615697 -0.740162305102889 2.36898943724261 1.47251681211253 0.475460226548474 0.312437992954668 0.502651174515981 0.434724971344863 NA NA 0.803214267838354 0.645445925645103 90.6527999345367 a826 PTEN_mut 196 Phenformin AAPK1 (AMPK) agonist 6 23 8.29404964010203 NA 5.42819021855307 6.00910379414417 -0.580913575591102 1.87101648787083 1.47964711918612 0.372487834550301 0.310480201193827 0.392602782148918 0.435447836371483 NA NA 0.91677061921902 0.504393016151324 90.6527999345367 a827 MLL2_mut 1498 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 9 21 1.38629436111989 NA 2.75742059310614 2.53341749943332 0.224003093672821 0.747161421925253 0.880615400586433 0.265205387081452 0.299805486605049 0.254371083589555 0.436495652655032 NA NA 0.511409843176448 0.485622862877606 90.6527999345367 a828 PTEN_mut 51 Dasatinib ABL, SRC, KIT, PDGFR 4 20 0.246860077931526 NA 1.06042712079683 -0.546849929479755 1.60727705027659 2.29685256481004 2.63642515763602 0.61991448504396 0.699773714212918 0.609642585764796 0.439500496183865 NA NA 0.172175926510281 0.271141713834428 90.6527999345367 a829 EP300_mut 230 GSK429286A ROCK2 6 23 2.99573227355399 2.32630161961136 3.56191176851483 3.73761067933826 -0.175698910823429 0.695560410935292 0.796679367947914 0.225560206371198 0.252600504659507 0.220539049826273 0.439832011333017 NA NA 0.187847146664588 0.606558479005923 90.6527999345367 a830 PTEN_mut 1219 PFI-1 BRD2, BRD3, BRD4 5 25 2.30258509299405 NA 1.73835798400907 2.16390914648214 -0.42555116247307 0.793447272580498 1.090903032987 0.403915934660301 0.536331999842997 0.390090731811305 0.44060386266052 NA NA 0.837150750412172 0.339117512355353 90.6527999345367 a831 loss_cnaDLBC2 166 FTI-277 Farnesyl transferase (FNTA) 4 26 0.0237165266173161 NA 2.03050141802151 1.81088213079533 0.219619287226183 0.58752642173477 0.603800760888211 0.36476875469556 0.373803252248163 0.36372807298738 0.440809298274011 NA NA 0.355787981679676 0.525854725253517 90.6527999345367 a832 loss_cnaDLBC4_(CDKN2A) 306 TG101348 JAK2 7 22 2.32630161961136 NA 0.522542053860158 0.930384122424257 -0.407842068564099 1.27645411558612 1.09705548904536 0.357955404030293 0.319511734565428 0.3717606562627 0.441747001710572 NA NA 0.807608109486079 0.466293629335823 90.6527999345367 a833 CREBBP_mut 1028 VX-702 p38 7 23 0.693147180559945 NA 2.21728297613489 1.98593425860801 0.23134871752688 0.615840340596446 0.844939141515856 0.288688183264696 0.375663467097359 0.273805184491549 0.44221812349867 NA NA 0.476807398218312 0.441653806358141 90.6527999345367 a834 CREBBP_mut 180 Thapsigargin sarco-endoplasmic reticulum Ca2+-ATPases 7 22 -0.669430653942629 NA -3.63129821729869 -4.32635257726963 0.695054359970941 2.38461867954705 1.68392120757335 0.373172847198859 0.291474006277164 0.412759431287503 0.442689639227731 NA NA 0.625871818709032 0.494116037967387 90.6527999345367 a835 ARID1A_mut 1264 SGC0946 Q8TEK3 (DOT1L) 3 27 -0.693147180559945 NA 1.41855956207063 1.16178608496528 0.256773477105353 0.244492888176141 0.572208446514306 0.462444810954569 1.05022881860009 0.448741151357564 0.443416259936943 NA NA 0.766577239797464 0.210608685311771 90.6527999345367 a836 loss_cnaDLBC4_(CDKN2A) 156 AZD6482 PI3Kbeta 8 22 1.63315443905142 NA 2.05891205570815 1.50463856204649 0.55427349366166 0.782505402299225 2.01322337531402 0.3101935876773 0.708331842864018 0.275316440519276 0.443712093229158 NA NA 0.862470158349518 0.287087846626097 90.6527999345367 a837 PTEN_mut 299 OSI-027 MTORC1/2 6 23 2.99573227355399 NA -1.72723496056634 -1.24660627357411 -0.480628686992229 0.430049998806925 1.89785002414416 0.278932397105474 1.11761118085251 0.253249034896195 0.443945568127348 NA NA 0.437480203377865 0.276736538222165 90.6527999345367 a838 MLL2_mut 1268 XAV 939 TNKS1 (tankyrase-1) 9 20 1.6094379124341 NA 2.75567355549443 2.95991060277916 -0.204237047284725 0.822262141386872 0.904513629586848 0.231838906379026 0.248384349716318 0.225797644838159 0.444234040027212 NA NA 0.324621536809291 0.55670921789518 90.6527999345367 a839 ARID1A_mut 1259 BMN-673 PARP1 3 27 2.30258509299405 NA 1.87239259552915 2.6256740799726 -0.753281484443454 2.40914830920032 1.37280181858027 0.512005008751005 0.312675430386225 0.54871830314334 0.444597882173199 NA NA 0.515782572551381 0.644650571530112 90.6527999345367 a840 CREBBP_mut 261 TL-1-85 MAP3K7 (TAK1) 6 23 2.32630161961136 NA 1.16855522208011 1.63974469673631 -0.471189474656204 1.21109096590134 1.21996642138048 0.386751016130415 0.389062001057473 0.38623151129276 0.444671074095031 NA NA 0.664457366178625 0.42177534924789 90.6527999345367 a841 TP53_mut 119 Lapatinib ERBB2, EGFR 16 12 0.693147180559945 NA 2.45870964348278 2.59811630746309 -0.139406663980311 0.698666091313074 0.718631317574049 0.197129905652791 0.199532603218671 0.193989129851618 0.445640664302014 NA NA 0.340641282921697 0.612019777143586 90.6527999345367 a842 PTEN_mut 177 GSK-650394 SGK3 5 24 2.77258872223978 NA 2.52840845617405 3.01574895641982 -0.487340500245766 1.66278236459504 1.11231845838626 0.402834708409444 0.293087364060692 0.438130372261192 0.445690915208372 NA NA 0.828535070711869 0.559541125384818 90.6527999345367 a843 MLL2_mut 1009 ATRA Retinoic acid and retinoid X receptor agonist 8 22 2.30258509299405 NA 2.99186497716784 3.22189974009797 -0.230034762930138 1.07614548665771 0.889490463493535 0.24481243469985 0.213758052031217 0.258614085671768 0.445912919908898 NA NA 0.308951889329954 0.599526550806422 90.6527999345367 a844 EP300_mut 1023 GW 441756 NTRK1 5 25 0.693147180559945 NA 2.55311253734456 1.6228141387176 0.930298398626961 0.568960840922584 2.0703872185869 0.482311914560015 1.6350833514631 0.449335462601008 0.445932811548065 NA NA 0.354582238563987 0.0673266424431726 90.6527999345367 a845 TP53_mut 180 Thapsigargin sarco-endoplasmic reticulum Ca2+-ATPases 16 13 -0.669430653942629 NA -4.43470237462878 -3.81873894053555 -0.615963434093226 2.20947310213399 1.30010923182453 0.330984635389104 0.278782952142892 0.473778217257023 0.445989494457524 NA NA 0.625928945099213 0.35939809450209 90.6527999345367 a846 PTEN_mut 203 BMS-345541 IKBKB 6 23 2.77258872223978 NA 1.71475882087901 1.90928458641737 -0.19452576553836 0.819494511807867 0.657951495227524 0.281626228273019 0.237372871612308 0.295653656765521 0.446356342174386 NA NA 0.464183304854122 0.60779867845443 90.6527999345367 a847 loss_cnaDLBC2 147 NSC-87877 PTPN6 (SHP-1), PTPN11 (SHP-2) 4 26 2.77258872223978 NA 4.70429491360481 4.47497152054163 0.229323393063178 0.484311474862966 0.639988462350111 0.3668201214934 0.473503943155724 0.35832426137977 0.446370833188813 NA NA 0.410751983215624 0.44043283797136 90.6527999345367 a848 TP53_mut 306 TG101348 JAK2 17 12 2.32630161961136 NA 0.978377224920527 0.624486020558817 0.35389120436171 0.896083126824674 1.42078794850191 0.310593518174074 0.394931222079524 0.249080944651068 0.446685702521393 NA NA 0.807654977822681 0.456189066051809 90.6527999345367 a849 loss_cnaDLBC2 205 BMS-708163 g-secretase 4 25 2.32630161961136 0.940007258491471 4.30712074920178 4.0855689629935 0.221551786208275 0.537963551439309 0.665952875012678 0.339297584793466 0.411834195115112 0.332683879777616 0.446737667824135 NA NA 0.241034882518336 0.496210402239394 90.6527999345367 a850 loss_cnaDLBC2 1069 EHT 1864 Rac GTPases 3 25 2.30258509299405 NA 3.15957000948754 3.56290525017699 -0.403335240689441 1.06324598334416 0.822182086690033 0.478352433974058 0.379343300616906 0.49056680657347 0.446950081335029 NA NA 0.989211587776601 0.583106345051235 90.6527999345367 a851 TP53_mut 1236 UNC0638 G9a(EHMT2), GLP(EHMT1) 19 11 2.99573227355399 NA 2.03202415755687 2.49155635398045 -0.459532196423579 1.57628106096975 1.18442487722979 0.317235398939834 0.29152935209465 0.387979183195108 0.447067786000927 NA NA 0.743574649070793 0.374240593506201 90.6527999345367 a852 EP300_mut 211 TL-2-105 CRAF 6 23 2.32630161961136 1.63315443905142 2.77091659089198 2.92066831735212 -0.149751726460138 1.09806913975224 0.632093520064271 0.202138272666204 0.136377320005485 0.236913876992303 0.447861892677361 NA NA 0.138750043873373 0.759658320671817 90.6527999345367 a853 ARID1A_mut 1268 XAV 939 TNKS1 (tankyrase-1) 3 26 1.6094379124341 NA 3.30865712467734 2.8489731800385 0.459683944638837 0.660341373532502 0.889317257630767 0.525704702310154 0.696130763668123 0.516895338187277 0.447977938261572 NA NA 0.324710495977653 0.355124602332903 90.6527999345367 a854 ARID1A_mut 249 XL-184 VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL 3 26 1.63315443905142 NA 2.58549634195606 2.06858940803259 0.516906933923468 1.34653564061048 1.12681298906108 0.451630042229502 0.383879132741795 0.458733559997549 0.448004076882708 NA NA 0.690938684606545 0.579561296752061 90.6527999345367 a855 TP53_mut 1016 Temsirolimus MTOR 17 13 -1.6094379124341 NA -3.55661728158458 -3.10953969556612 -0.447077586018451 1.77853299236885 2.00454423319334 0.237968336597738 0.251374356245696 0.223032038213611 0.449511640804794 NA NA 0.649816830697742 0.53116225706618 90.6527999345367 a856 MLL2_mut 1219 PFI-1 BRD2, BRD3, BRD4 9 21 2.30258509299405 NA 1.8777660174583 2.18522021071306 -0.307454193254763 0.731278819503013 1.1610508476365 0.291079321272872 0.420433608980653 0.264806828986547 0.449686613595946 NA NA 0.83722115365499 0.390666379078952 90.6527999345367 a857 loss_cnaDLBC2 17 Cyclopamine SMO 3 24 2.77258872223978 NA 4.45560780616482 3.99309538820253 0.462512417962285 0.89735785492897 1.07928129093622 0.433929198509855 0.515415801423942 0.428537418230497 0.450368667784958 NA NA 0.539627696195446 0.475842985935454 90.6527999345367 a858 MLL2_mut 1013 Nilotinib ABL 8 22 0.693147180559945 NA 2.27145685145321 2.06756042855864 0.203896422894564 0.568768865808618 0.870924922961318 0.252949640093384 0.358487313831224 0.234114810035836 0.451029755330501 NA NA 0.385248886836793 0.46526141704205 90.6527999345367 a859 TP53_mut 295 NVP-BHG712 EPHB4 17 12 2.32630161961136 NA 1.18176089585912 1.46250085730007 -0.280739961440958 1.66095479291113 1.34173241320241 0.182427155225346 0.169023240511507 0.209236922860718 0.451681384886001 NA NA 0.275356552139068 0.619574362821671 90.6527999345367 a860 MLL2_mut 1018 ABT-888 PARP1, PARP2 8 22 1.6094379124341 NA 3.64080565754823 3.49289392450581 0.147911733042421 0.608216310557058 0.584421303026026 0.250502562401087 0.243189356278443 0.253090933332787 0.451901732094289 NA NA 0.372421998548686 0.562763093350142 90.6527999345367 a861 EP300_mut 1133 JNJ-26854165 MDM2 6 24 2.30258509299405 NA 2.92559889288436 2.57840740288773 0.347191489996629 1.05410546253808 0.844084534817494 0.392195888942776 0.329370734082583 0.411323126624631 0.452288734371348 NA NA 0.627860007779352 0.479349316290213 90.6527999345367 a862 EP300_mut 193 GW-2580 CSF1R (cFMS) 6 23 2.99573227355399 NA 4.80576327364776 4.5625760140633 0.243187259584461 0.480593228487183 0.636356036572485 0.398330232056879 0.506014744215121 0.382155971827197 0.453142800309925 NA NA 0.586454181446369 0.328425032949782 90.6527999345367 a863 CREBBP_mut 287 KIN001-244 PDPK1 (PDK1) 6 23 2.99573227355399 NA 1.76359547444028 2.14179937739538 -0.378203902955103 1.02930505228642 1.02401356131423 0.36898102735055 0.36743616687297 0.369334857704143 0.454167971210042 NA NA 0.787979785356774 0.446094055592838 90.6527999345367 a864 PTEN_mut 286 KIN001-236 TIE2 6 23 2.32630161961136 NA 2.73178336462893 3.05771107110131 -0.325927706472379 0.386591076757453 1.06362828425834 0.334486222317598 0.84308129718386 0.306430085863735 0.454476079457174 NA NA 0.890671532749744 0.243127769471486 90.6527999345367 a865 TP53_mut 164 JQ12 HDAC 17 13 1.63315443905142 NA 0.393537101868386 0.710514341406093 -0.316977239537707 1.70725423334794 1.37564006273496 0.201419882813176 0.185664931060744 0.230421640169096 0.454578750303419 NA NA 0.419641290061376 0.577954537675784 90.6527999345367 a866 MLL2_mut 196 Phenformin AAPK1 (AMPK) agonist 9 20 8.29404964010203 NA 5.56886604565745 6.03293670828586 -0.464070662628409 1.65171491241443 1.52372741166979 0.296959079242509 0.28096293079418 0.304562784048002 0.454782936750119 NA NA 0.916851103162543 0.484986296503423 90.6527999345367 a867 loss_cnaDLBC2 71 Pyrimethamine Dihydrofolate reductase (DHFR) 3 25 2.99573227355399 NA 2.38449694914603 3.02429790571286 -0.639800956566831 0.563070292898812 1.23449884714715 0.534814195574333 1.13627190891743 0.518267763510167 0.455261112947069 NA NA 0.18373087957879 0.179757438452293 90.6527999345367 a868 TP53_mut 135 Gemcitabine DNA replication 15 13 0.0237165266173161 NA -3.03939442566717 -3.96333250267202 0.923938077004855 2.59325101477864 2.00997629605129 0.394480064385461 0.356285632104042 0.459676106041639 0.455764253249716 NA NA 0.245139538807397 0.298794135577536 90.6527999345367 a869 CREBBP_mut 1038 NU-7441 PRKDC (DNAPK) 7 25 0.693147180559945 NA 1.47770860571088 1.83560533644234 -0.357896730731464 1.14434261644506 0.992913496039119 0.349170737154872 0.312753126195093 0.360451068657207 0.456625451910132 NA NA 0.681200004575502 0.471908544593338 90.6527999345367 a870 EP300_mut 1241 CHIR-99021 GSK3B 6 23 2.30258509299405 NA 3.61509698782318 3.11852114408259 0.496575843740595 1.06560014403769 1.19699324809362 0.423060100234267 0.466005796375937 0.414852668994968 0.456793934256669 NA NA 0.385244932771409 0.349099907992356 90.6527999345367 a871 CREBBP_mut 1031 Elesclomol HSP70 7 23 -1.6094379124341 NA -3.23263883246219 -2.76423444520626 -0.468404387255929 0.838584869754797 1.42279897953295 0.354968240829767 0.55856527365309 0.329213328090584 0.456890667717786 NA NA 0.675780148193897 0.295297109822751 90.6527999345367 a872 ARID1A_mut 134 Etoposide TOP2 3 27 2.77258872223978 NA -0.313994201850961 0.641821432615656 -0.955815634466618 1.80859107056745 1.94956726769754 0.492729785005208 0.528486317344655 0.490270661753285 0.456942387297949 NA NA 0.60751626028292 0.462434568414063 90.6527999345367 a873 loss_cnaDLBC2 1013 Nilotinib ABL 3 27 0.693147180559945 NA 2.41896908373944 2.08892877735917 0.330040306380278 0.958454932722455 0.791923816349354 0.410007184720352 0.344346192097746 0.416757647095036 0.457347074916996 NA NA 0.385387494740736 0.616307955785409 90.6527999345367 a874 EP300_mut 271 VNLG/124 HDAC, RAR 6 23 1.63315443905142 NA 2.97552330914514 2.76772460238857 0.207798706756569 0.698164467783894 0.97237099397707 0.223986930347516 0.297635752527139 0.213703111305961 0.457710168156495 NA NA 0.228437246691144 0.564788438356704 90.6527999345367 a875 loss_cnaDLBC2 88 MS-275 HDAC 4 25 1.6094379124341 NA -0.616163035771524 0.104307125839267 -0.720470161610791 0.506032154085702 1.54823573063017 0.490314468079669 1.42376360038333 0.465349137316151 0.457834708971514 NA NA 0.0925089495547378 0.0922426029794475 90.6527999345367 a876 loss_cnaDLBC2 265 Tubastatin A HDAC6 4 24 2.99573227355399 NA 3.33319675718916 2.85204976101458 0.481146996174585 1.49911987172793 1.08144951029214 0.422987761725243 0.32095298397986 0.444909347681528 0.45817789932094 NA NA 0.864975957093775 0.575420462387041 90.6527999345367 a877 CREBBP_mut 1057 NVP-BEZ235 PI3K (Class 1) and MTORC1/2 7 25 -1.38629436111989 0.693147180559945 -3.38717388748821 -3.09567355209838 -0.291500335389838 0.745172616142789 1.06250254389084 0.289454497792236 0.391184980600496 0.274352599968727 0.45857602362545 NA NA 0.592316923167949 0.422879213601626 90.6527999345367 a878 PTEN_mut 1067 CCT007093 PPM1D 5 23 1.88706964903238 NA 3.43063993853138 3.64965536236614 -0.219015423834763 0.598075944777335 0.652240721672524 0.339978275358328 0.366200021497777 0.335789251663325 0.458776786773367 NA NA 0.818299139316417 0.491847977014731 90.6527999345367 a879 CREBBP_mut 1194 SB-505124 TGFR1 (ALK5) 6 24 2.30258509299405 NA 3.62439749858521 3.48019924587476 0.144198252710452 0.522359694916055 0.552691248000196 0.26342479501796 0.276051644324558 0.260902001311228 0.459134584146775 NA NA 0.240556566704927 0.566464778001934 90.6527999345367 a880 PTEN_mut 186 Bexarotene Retinioic acid X family agonist 5 24 2.07944154167984 NA 3.32011150387175 3.14953421291866 0.170577290953088 0.864445341101415 0.867968604802917 0.196642773815058 0.197325710305467 0.196524724522518 0.459663015392378 NA NA 0.186472196187302 0.702664090999854 90.6527999345367 a881 loss_cnaDLBC2 291 KIN001-266 MAP3K8 (COT) 4 25 2.99573227355399 NA 2.89579445622962 2.6782943001502 0.21750015607942 0.648162844352874 0.548254994487269 0.388229249736036 0.335564060751697 0.396713496942837 0.460295636802688 NA NA 0.747950770821142 0.561946966225945 90.6527999345367 a882 CREBBP_mut 1069 EHT 1864 Rac GTPases 6 22 2.30258509299405 NA 3.75121325552747 3.45654826135102 0.294664994176445 0.884343150842273 0.833829088586904 0.349220904047377 0.333202099089927 0.353387760405212 0.460503689762325 NA NA 0.989219003423398 0.485963813757879 90.6527999345367 a883 ARID1A_mut 252 WZ3105 CLK2, CNSK1E, FLT3, ULK1 3 26 0.246860077931526 2.32630161961136 -1.91066630087415 -1.39843332730222 -0.512232973571937 0.110408900433456 1.23781007036782 0.42991958515583 4.63941739806258 0.413821947190755 0.46065859776221 NA NA 0.600347842861622 0.0511617309182493 90.6527999345367 a884 TP53_mut 175 PAC-1 CASP3 agonist 16 13 0.940007258491471 NA 1.26246417273988 1.00125545684599 0.261208715893882 1.09309192450954 0.987823585275633 0.249337100715966 0.23896317412745 0.2644285070608 0.461355109343845 NA NA 0.786808429487026 0.505474527779251 90.6527999345367 a885 PTEN_mut 1004 Vinblastine Microtubules 4 26 -2.30258509299405 NA -5.36015675976069 -4.91136050693562 -0.448796252825068 1.32411588932111 1.22441086821771 0.363257038015232 0.33894031213172 0.366540566140473 0.461517516914859 NA NA 0.865316268267341 0.560020718522922 90.6527999345367 a886 loss_cnaDLBC2 176 IPA-3 PAK1, PAK2, PAK3 4 25 3.46573590279973 NA 3.151500700775 2.80192260671875 0.34957809405625 1.5262611959142 1.28423698267635 0.266176297256082 0.229042116114902 0.272206842484577 0.461571295461395 NA NA 0.0547224869282686 0.688207712267186 90.6527999345367 a887 MLL2_mut 177 GSK-650394 SGK3 9 20 2.77258872223978 NA 2.69517786544093 3.03817082229888 -0.342992956857949 1.20779590988544 1.21608893804878 0.282615619421554 0.283982545437235 0.282045947567193 0.462952379317433 NA NA 0.828676638979271 0.490602276144374 90.6527999345367 a888 MLL2_mut 178 BAY 61-3606 SYK 9 20 2.07944154167984 NA 0.798947597649034 1.20760656070036 -0.408658963051327 0.866438327955991 1.39583225390367 0.323732169774512 0.471653838323833 0.29277082680132 0.463207760160541 NA NA 0.745344757023634 0.346179288203315 90.6527999345367 a889 CREBBP_mut 41 S-Trityl-L-cysteine KIF11 6 19 1.63315443905142 NA 0.0534609815302776 0.67839764082042 -0.624936659290143 0.850208701579285 1.37537481228242 0.488355674203811 0.735039124075426 0.454375530007756 0.464544704396723 NA NA 0.0261797617082665 0.20402785412831 90.6527999345367 a890 EP300_mut 63 BMS-509744 ITK 5 20 2.32630161961136 NA 2.66381315543362 2.79921498819446 -0.135401832760838 0.464912952131892 0.925537198708669 0.156847916617981 0.291241257400861 0.146295397904865 0.46459949916602 NA NA 0.0881273248724206 0.651948835911266 90.6527999345367 a891 loss_cnaDLBC4_(CDKN2A) 331 QL-X-138 MNK2, PRKDC (DNAPK), MTOR, BTK, JAK3 7 22 2.32630161961136 NA -0.597462180470221 -0.126389777984474 -0.471072402485747 0.730126094107642 1.43264283539161 0.359730892524188 0.645193215647896 0.328813568077475 0.464662558929238 NA NA 0.593821525568539 0.265472716996058 90.6527999345367 a892 CREBBP_mut 173 FH535 unknown 7 22 3.46573590279973 NA 2.29251768855687 2.02736347633103 0.265154212225843 0.659156149676735 0.698121392847513 0.384474968384309 0.402263124383926 0.379811039945826 0.464770447864016 NA NA 0.344061281265665 0.381098718569576 90.6527999345367 a893 CREBBP_mut 165 DMOG Prolyl-4-Hydroxylase 7 23 8.29404964010203 NA 5.58636442937382 5.05561885596656 0.530745573407256 1.77860595233834 1.56076323853072 0.329670542929608 0.298405373438385 0.340055147574395 0.465208805866908 NA NA 0.907719875976646 0.495310231575588 90.6527999345367 a894 EP300_mut 134 Etoposide TOP2 6 24 2.77258872223978 NA 1.14197443845988 0.397306226846274 0.744668211613603 2.51470425131961 1.78823898949377 0.384237639328379 0.296125562766609 0.416425442006725 0.465969805352044 NA NA 0.607663589899816 0.518579213749896 90.6527999345367 a895 loss_cnaDLBC4_(CDKN2A) 1230 IOX2 EGLN1 7 23 -2.30258509299405 NA -0.395061027644088 -0.737258880357569 0.342197852713481 0.673484722645495 1.323403139165 0.281924450672722 0.508100393679762 0.258574158233742 0.466363360930009 NA NA 0.573156326507518 0.37256954839323 90.6527999345367 a896 ARID1A_mut 1012 Vorinostat HDAC inhibitor Class I, IIa, IIb, IV 3 27 2.30258509299405 NA 0.179036035814135 -0.0916019487606636 0.270637984574799 0.474901581618553 0.657010163121344 0.419133751653967 0.569882255713731 0.41192358926237 0.466545271403877 NA NA 0.551109576495108 0.437530910609936 90.6527999345367 a897 CREBBP_mut 1026 17-AAG HSP90 7 25 0 NA 1.09037123798704 0.623660954261712 0.466710283725325 0.899791161261824 1.20480775806849 0.405731620992628 0.518687339705397 0.387373239091306 0.466548628189504 NA NA 0.0813374499296522 0.283499274245686 90.6527999345367 a898 ARID1A_mut 286 KIN001-236 TIE2 3 26 2.32630161961136 NA 2.58437387672762 3.03711281511234 -0.452738938384728 0.390080473900599 1.00570071045002 0.465043003429348 1.16062958460232 0.45017263454268 0.466627901674616 NA NA 0.89073434804391 0.181510620574812 90.6527999345367 a899 EP300_mut 1029 AMG-706 VEGFR, RET, c-KIT, PDGFR 6 26 0.693147180559945 NA 2.5316982091269 2.67153257899318 -0.139834369866278 0.513464292729207 0.603628103248759 0.237184627905318 0.272335139651131 0.231656493648459 0.467294334685866 NA NA 0.351942816828553 0.576369081196893 90.6527999345367 a900 loss_cnaDLBC2 135 Gemcitabine DNA replication 4 24 0.0237165266173161 NA -4.41158328177758 -3.31116274135973 -1.10042054041784 2.1629705332831 2.3809702303559 0.466903932213336 0.508754291140321 0.462173162179082 0.467374698172141 NA NA 0.24540286211797 0.402336817128224 90.6527999345367 a901 EP300_mut 172 Embelin XIAP 5 24 3.46573590279973 NA 2.99676350192728 2.6100967784591 0.386666723468179 1.16964331999479 1.16421336125737 0.331897241039868 0.330585159474002 0.332127027859027 0.467464630634303 NA NA 0.82686058318728 0.526921013634231 90.6527999345367 a902 ARID1A_mut 257 NPK76-II-72-1 PLK3 3 26 2.32630161961136 NA 0.569663249693682 1.12887109239624 -0.559207842702562 1.83417228337457 1.37717814423288 0.394893968751337 0.304882942442961 0.406053381724304 0.467473416443863 NA NA 0.357509854470775 0.6543908007527 90.6527999345367 a903 EP300_mut 45 Z-LLNle-CHO g-secretase 5 20 0.940007258491471 NA 0.010412586415162 0.131583103471566 -0.121170517056404 0.891628171168335 0.72360618786766 0.160381055503545 0.135898035722256 0.167453677273646 0.467474902527466 NA NA 0.0967202375047109 0.788751239950956 90.6527999345367 a904 loss_cnaDLBC4_(CDKN2A) 1072 BMS-708163 g-secretase 7 21 1.6094379124341 NA 3.48553921635519 3.32438700049714 0.161152215858051 0.779317362046325 0.651291943127398 0.235958081860148 0.206786379601372 0.247434683567902 0.467736516763193 NA NA 0.267177898199607 0.63402468649726 90.6527999345367 a905 TP53_mut 29 AZ628 BRAF 16 13 1.38629436111989 NA 1.79343728353793 1.33610056503742 0.457336718500503 1.07630533673285 1.20056012156548 0.403575266662691 0.424913547199125 0.380936123302309 0.468551650589215 NA NA 0.130404359028382 0.29582942310135 90.6527999345367 a906 loss_cnaDLBC2 1022 AZD7762 CHEK1, CHEK2 3 27 0.693147180559945 NA -1.13769454998508 -1.6340340580567 0.496339508071625 1.6481055999674 1.16861012538643 0.410475418795527 0.301157588495205 0.42472634567281 0.469512358324418 NA NA 0.496197366025189 0.657528034051442 90.6527999345367 a907 ARID1A_mut 1046 681640 WEE1, CHEK1 3 29 0.693147180559945 NA 2.08500301752891 1.71753039149814 0.367472626030765 0.851257913402179 0.765918088071838 0.476061860969783 0.431681891287337 0.479780581962569 0.469573363880025 NA NA 0.596248328674127 0.537371001774435 90.6527999345367 a908 PTEN_mut 1049 PD-173074 FGFR1, FGFR3 5 27 0.693147180559945 NA 2.32115735456457 1.93732094089136 0.383836413673209 0.571492620044376 0.848206966119396 0.469957814713882 0.671638443281043 0.452526834847026 0.469819250573736 NA NA 0.315655842479675 0.242429755291948 90.6527999345367 a909 loss_cnaDLBC2 165 DMOG Prolyl-4-Hydroxylase 4 26 8.29404964010203 NA 4.63267395137636 5.26358034182086 -0.630906390444493 0.730651727643241 1.68644643527519 0.391529513450157 0.863484429824751 0.37410401969959 0.470087207910822 NA NA 0.907739905602045 0.231819759888052 90.6527999345367 a910 PTEN_mut 154 CHIR-99021 GSK3B 6 24 0.940007258491471 NA 2.58242839175666 2.80134992548272 -0.218921533726059 1.1384444819472 0.81432097301889 0.248494950911822 0.192298822821482 0.268839365532319 0.470118247528584 NA NA 0.394594936910071 0.672129085379287 90.6527999345367 a911 TP53_mut 154 CHIR-99021 GSK3B 17 13 0.940007258491471 NA 2.68583547754366 2.85136657260639 -0.16553109506273 0.933724962627417 0.806780038920773 0.187770390679406 0.177280357373054 0.205175000715387 0.470274418747762 NA NA 0.394598164955498 0.607257543006787 90.6527999345367 a912 MLL2_mut 1060 PD-0325901 MAP2K1 (MEK1), MAP2K2 (MEK2) 9 23 -1.38629436111989 0.693147180559945 0.232124617907501 0.00302537681902482 0.229099241088476 1.0771887031784 0.856031279672477 0.248961827330888 0.212682550803295 0.267629520706453 0.472254497049056 NA NA 0.576139697989087 0.578162887208958 90.6527999345367 a913 CREBBP_mut 45 Z-LLNle-CHO g-secretase 6 19 0.940007258491471 NA -0.150530424826819 0.188784607919371 -0.33931503274619 0.402935876572227 0.811392628292036 0.457311276312655 0.842106777963632 0.418188458848142 0.472432730682863 NA NA 0.0968051347761926 0.188913263112943 90.6527999345367 a914 MLL2_mut 194 AUY922 HSP90 9 20 -1.36257783450257 NA -3.35016727199974 -2.9677168215999 -0.38245045039984 0.652516822438849 1.35367571657441 0.321438023829496 0.586115847512393 0.282527377655604 0.472432872980926 NA NA 0.705115355955552 0.314049351214104 90.6527999345367 a915 CREBBP_mut 230 GSK429286A ROCK2 6 23 2.99573227355399 2.32630161961136 3.44893611098664 3.76708258999778 -0.318146479011145 0.662100114128536 0.793603401974467 0.412670715077194 0.480511137548877 0.400888502014487 0.472926292925799 NA NA 0.188530240908325 0.341244327865913 90.6527999345367 a916 loss_cnaDLBC2 1047 Nutlin-3a MDM2 3 29 2.07944154167984 1.38629436111989 1.97192505073874 2.58019203477375 -0.608266984035006 0.672844018923514 1.20913136651452 0.515052814016235 0.90402376617418 0.503061123778814 0.473027848098364 NA NA 0.0686270994316015 0.255407445637089 90.6527999345367 a917 loss_cnaDLBC4_(CDKN2A) 140 Vinorelbine Microtubules 8 22 -2.74887219562247 NA -4.78691383075103 -4.37916271782311 -0.407751112927925 0.816015737849567 1.52520523581062 0.29494890047301 0.499685354111508 0.267341799879943 0.473045367433952 NA NA 0.921262058365055 0.357810610633954 90.6527999345367 a918 TP53_mut 224 AS605240 PI3Kgamma 17 12 2.99573227355399 2.32630161961136 2.45114625074619 1.98511172491709 0.466034525829103 0.953193241685001 1.62636859656828 0.366599725638316 0.48891925104848 0.286549141942645 0.473127691159652 NA NA 0.262683455607635 0.386122359324801 90.6527999345367 a919 MLL2_mut 197 Bryostatin 1 PRKC 9 20 -4.8283137373023 NA -3.53996496870295 -3.21495484013826 -0.325010128564693 1.43086005056367 0.690073551084353 0.334914284730004 0.227143198551569 0.470978967465114 0.474278619969119 NA NA 0.558902180115717 0.531783059284558 90.6527999345367 a920 loss_cnaDLBC4_(CDKN2A) 326 GSK690693 AKT 7 21 2.32630161961136 NA 1.53059470364506 0.706366594161343 0.824228109483713 1.35195303253764 2.80878346682461 0.323526374806393 0.609657354691252 0.293446653762713 0.474279212040182 NA NA 0.951612236800764 0.312875109650412 90.6527999345367 a921 CREBBP_mut 194 AUY922 HSP90 7 22 -1.36257783450257 NA -2.82376576498746 -3.16997643295833 0.346210667970871 1.73171551692376 0.988044718337075 0.289952131990055 0.199923523573828 0.350399796229426 0.474301615939952 NA NA 0.705139218280555 0.629469695198135 90.6527999345367 a922 EP300_mut 1052 RO-3306 CDK1 6 26 1.6094379124341 NA 2.99358585633473 3.16899014239687 -0.175404286062139 1.1086273173099 0.790408800052518 0.205935976823848 0.158217539224778 0.221915907376644 0.474952266290334 NA NA 0.240201942589025 0.726026178120976 90.6527999345367 a923 CREBBP_mut 1049 PD-173074 FGFR1, FGFR3 7 25 0.693147180559945 NA 2.15574071772465 1.95293068611269 0.202810031611967 0.438866200233502 0.895666313115641 0.24588991779769 0.462122695947104 0.226434810198988 0.47516452263213 NA NA 0.315759769957401 0.415473482979763 90.6527999345367 a924 ARID1A_mut 175 PAC-1 CASP3 agonist 3 26 0.940007258491471 NA 0.740585242751475 1.19207661440698 -0.451491371655506 0.979210350407127 1.05177357221697 0.431400585712337 0.46107700094039 0.429266701105482 0.475434698147199 NA NA 0.786943951603988 0.515929996874234 90.6527999345367 a925 loss_cnaDLBC2 223 ZSTK474 PI3K 4 25 1.63315443905142 2.32630161961136 -0.0867415632268506 -0.803999935776098 0.717258372549247 0.86971629531839 1.93305459318539 0.388670512281047 0.824703844702219 0.371049206306849 0.475613765195586 NA NA 0.921187574078312 0.24919298183251 90.6527999345367 a926 MLL2_mut 345 KIN001-270 CDK9 9 20 2.99573227355399 NA 3.83445829526145 3.53913065475793 0.295327640503518 1.0797844139535 1.09490352121407 0.270832061349823 0.273506115375578 0.269729373210936 0.476323531416261 NA NA 0.800757241632688 0.507369340515378 90.6527999345367 a927 EP300_mut 62 BMS-536924 IGF1R 5 20 1.63315443905142 NA 2.60760914393966 1.79731323158475 0.810295912354908 1.64842916314116 1.438529135279 0.548543346955966 0.491556404407971 0.563280848807942 0.476470062215211 NA NA 0.0582311943348749 0.355079862664615 90.6527999345367 a928 CREBBP_mut 221 TAK-715 p38a 6 23 2.99573227355399 2.32630161961136 2.87021165787392 2.77062524092505 0.0995864169488754 0.66756506253599 0.606757795382956 0.161020709858479 0.149178593275328 0.164128780390899 0.47684663175367 NA NA 0.0244945139904919 0.749613267386946 90.6527999345367 a929 TP53_mut 86 A-443654 AKT1, AKT2, AKT3 15 10 0.0237165266173161 NA -1.34851184029081 -1.25806471437604 -0.0904471259147679 1.61912538653011 0.485385955475574 0.0696174110234473 0.0558617181023899 0.186340632427548 0.47685336823203 NA NA 0.0429313164719251 0.84139902814979 90.6527999345367 a930 MLL2_mut 9 MG-132 Proteasome 9 18 0 NA -0.893251650219862 -0.423349875890883 -0.469901774328979 0.778931801181241 1.23260066356379 0.424165052140014 0.603264334074406 0.381227909589437 0.476946806727089 NA NA 0.0795297975601343 0.23990256922106 90.6527999345367 a931 ARID1A_mut 60 BI-2536 PLK1, PLK2, PLK3 3 22 -1.36257783450257 NA -2.92116260102336 -2.21289445866146 -0.7082681423619 1.12100086893319 1.30380812728708 0.549495957861124 0.631817656872944 0.543230347731949 0.478685793955634 NA NA 0.0352959418644881 0.393555426257783 90.6527999345367 a932 MLL2_mut 1062 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 9 23 1.38629436111989 0.693147180559945 3.04917312062859 2.77832117815432 0.270851942474267 0.942838318547937 0.892612404214353 0.298861812960366 0.287272947170205 0.303437349957803 0.47954624881311 NA NA 0.802865185306087 0.470650667702003 90.6527999345367 a933 MLL2_mut 1243 piperlongumine Increases ROS levels 9 21 2.30258509299405 NA 1.54353236253238 1.79466916658671 -0.251136804054333 0.673568800004286 1.26770490410048 0.222189427299075 0.37284506653624 0.198103520182035 0.480321869743772 NA NA 0.405654273228783 0.487059452465551 90.6527999345367 a934 ARID1A_mut 1004 Vinblastine Microtubules 3 27 -2.30258509299405 NA -4.49210876293824 -5.02443236779831 0.532323604860066 0.978223504443354 1.25205538966105 0.431201664807767 0.544173803268996 0.425159788660927 0.48101535034318 NA NA 0.865431031973406 0.454154787503021 90.6527999345367 a935 loss_cnaDLBC2 159 HG-6-64-1 BRAFV600E, TAK, MAP4K5 4 26 1.63315443905142 NA 1.04970255378872 0.492105643674056 0.557596910114664 1.21345245553616 1.69806273923815 0.337334400366232 0.459512779071589 0.328372384146909 0.481767378362322 NA NA 0.429909258021187 0.456860131466469 90.6527999345367 a936 CREBBP_mut 177 GSK-650394 SGK3 7 22 2.77258872223978 NA 2.65882439673213 3.01855665717368 -0.359732260441547 0.974985281991335 1.274440521134 0.296248144271677 0.368961734177998 0.282266810004955 0.482035439250509 NA NA 0.828823549584055 0.445935661150213 90.6527999345367 a937 PTEN_mut 157 JNK-9L JNK 6 24 1.63315443905142 NA -0.846248824957136 -0.547226775648579 -0.299022049308557 0.84319103365737 0.756705526995212 0.386903506437956 0.354631438633234 0.395163030585937 0.482050118291946 NA NA 0.49587855034596 0.453527068647176 90.6527999345367 a938 PTEN_mut 229 LY317615 PRKCB (PKCbeta) 6 23 2.99573227355399 2.32630161961136 2.06583555260953 2.2531862247984 -0.187350672188872 1.39120714230784 0.881379256070596 0.188162451462753 0.134667704392375 0.212565329735723 0.482080887686183 NA NA 0.168818591482542 0.764116550646472 90.6527999345367 a939 CREBBP_mut 1033 Vismodegib SMO 7 23 2.30258509299405 NA 3.94408140835865 3.75242893111902 0.191652477239628 0.705597680455429 0.703863484549578 0.272142612542868 0.271617215515683 0.272286432591786 0.483365988936298 NA NA 0.59546348158464 0.543166995372579 90.6527999345367 a940 EP300_mut 157 JNK-9L JNK 6 24 1.63315443905142 NA -0.845648620549216 -0.547376826750559 -0.298271793798657 0.803816623738615 0.766025190272892 0.385907938376563 0.371069451651013 0.389375959937295 0.483380474128862 NA NA 0.495902680781835 0.437388856362587 90.6527999345367 a941 CREBBP_mut 157 JNK-9L JNK 7 23 1.63315443905142 NA -0.399163614108739 -0.670295228980327 0.271131614871589 1.30501637570562 0.545268733035433 0.350453106480355 0.207761082480661 0.497244016472828 0.484937746403052 NA NA 0.495930787555262 0.609646652237236 90.6527999345367 a942 CREBBP_mut 295 NVP-BHG712 EPHB4 6 23 2.32630161961136 NA 0.823310056413065 1.42174283385772 -0.598432777444653 2.03023340543158 1.3847227458046 0.392410501419628 0.294760580652273 0.432167940663767 0.485036353377882 NA NA 0.276082299711573 0.519742651963942 90.6527999345367 a943 TP53_mut 256 JW-7-24-1 LCK 17 12 2.32630161961136 NA -0.0166803362161674 0.16377513508244 -0.180455471298608 1.16466246946355 0.777165873450803 0.176116219337054 0.154942291032806 0.232196854575384 0.485478053843597 NA NA 0.344898576358489 0.620954164628746 90.6527999345367 a944 ARID1A_mut 64 CMK RSK 3 22 1.38629436111989 NA 1.68509433436079 1.28398674229794 0.401107592062849 0.516840900489101 1.2695215460074 0.328075788636088 0.776075561518583 0.315951779884571 0.485583084287534 NA NA 0.162703261206238 0.356440755213518 90.6527999345367 a945 EP300_mut 1024 CEP-701 FLT3, JAK2, NTRK1, RET 5 25 0.693147180559945 NA -1.37796364217837 -1.83962094771148 0.46165730553311 1.03617249792388 1.30034369868017 0.364662707066038 0.44554097552107 0.355027140902582 0.48570121825742 NA NA 0.853475924463149 0.414554885842457 90.6527999345367 a946 MLL2_mut 29 AZ628 BRAF 9 20 1.38629436111989 NA 1.28514919720924 1.72489805536051 -0.439748858151268 1.02513785638295 1.182442783221 0.386387624996806 0.428965582934241 0.371898635935165 0.485975474551238 NA NA 0.130692650346406 0.322436756988122 90.6527999345367 a947 loss_cnaDLBC4_(CDKN2A) 164 JQ12 HDAC 8 22 1.63315443905142 NA 0.800513716360562 0.432850338143513 0.367663378217049 1.1517753131596 1.6903806655529 0.233716978003544 0.319214497841995 0.217503303078063 0.486427936944236 NA NA 0.42028913813794 0.507340672454423 90.6527999345367 a948 ARID1A_mut 1371 PLX4720 (rescreen) BRAF 3 27 2.30258509299405 NA 3.72533632698879 3.34460294133673 0.380733385652065 0.77816222462354 0.772245164563564 0.492750751899748 0.489272511058034 0.493021391551525 0.487053067959787 NA NA 0.208048609935984 0.491482666745323 90.6527999345367 a949 ARID1A_mut 157 JNK-9L JNK 3 27 1.63315443905142 NA -0.881480789749558 -0.57653678503926 -0.304944004710297 0.268541580869888 0.802846237285038 0.392481538212838 1.1355560048559 0.379828652795979 0.487372914275527 NA NA 0.495974439531297 0.204069251398066 90.6527999345367 a950 EP300_mut 1526 RDEA119 (rescreen) MAP2K1 (MEK1), MAP2K2 (MEK2) 6 21 1.6094379124341 NA 3.11039536813067 2.82001206947549 0.290383298655187 0.365737684827454 1.02647203323994 0.311382871843255 0.793966032765211 0.282894505891822 0.488029044982286 NA NA 0.869728812914179 0.29175787641024 90.6527999345367 a951 ARID1A_mut 87 GW843682X PLK1 3 22 -1.36257783450257 NA -3.48063992637142 -2.69479447943459 -0.785845446936823 1.45755563713675 1.45392781419499 0.540380873813769 0.539152967416428 0.540498255322207 0.488442720559441 NA NA 0.0348873693980343 0.454907109322963 90.6527999345367 a952 TP53_mut 305 TPCA-1 IKK 17 12 2.99573227355399 NA 1.3631978021179 0.922692825787582 0.440504976330318 1.28877279557182 1.82143318164494 0.288220928249158 0.341801889242138 0.241845257223489 0.490083003839798 NA NA 0.765729017130248 0.480413609715429 90.6527999345367 a953 EP300_mut 1 Erlotinib EGFR 5 22 0.693147180559945 NA 2.55645809386868 2.14901484147541 0.407443252393266 0.874549378142971 0.825319354968227 0.488897715245604 0.465889362654898 0.493679507139332 0.490239216657316 NA NA 0.18651289052301 0.380368235536739 90.6527999345367 a954 PTEN_mut 211 TL-2-105 CRAF 6 23 2.32630161961136 1.63315443905142 2.78887601956352 2.91598324900303 -0.127107229439509 0.713149197254911 0.747894999346259 0.171399771348027 0.178233713125916 0.169953308352929 0.49068400011175 NA NA 0.139500344912309 0.710222689120266 90.6527999345367 a955 MLL2_mut 176 IPA-3 PAK1, PAK2, PAK3 9 20 3.46573590279973 NA 2.48812807411032 3.0130457652038 -0.524917691093472 1.12893422576505 1.35890798700833 0.405331765464248 0.464967470303904 0.386279053557623 0.490788244925241 NA NA 0.0550204408925013 0.291729366620919 90.6527999345367 a956 ARID1A_mut 153 Midostaurin KIT 3 27 -0.669430653942629 NA -0.618969102141668 -0.222337500792892 -0.396631601348775 0.724689708781017 0.903915692123653 0.444500544837432 0.547312313867324 0.438792693616074 0.491205390462181 NA NA 0.801823655550938 0.451222390505281 90.6527999345367 a957 loss_cnaDLBC2 1053 MK-2206 AKT1, AKT2 3 29 1.38629436111989 0.693147180559945 1.48839330459276 0.628235901208095 0.860157403384662 2.28284007821354 1.75120005862163 0.48011706820571 0.376792667867381 0.49118168946482 0.491599682516228 NA NA 0.227907836045376 0.584723634157217 90.6527999345367 a958 PTEN_mut 294 MPS-1-IN-1 MPS1 6 23 2.99573227355399 NA 2.5167738876763 2.79251415064042 -0.275740262964124 0.571525037615954 0.990939333572122 0.297233801322594 0.482464012625484 0.278261497573358 0.491689854793572 NA NA 0.817460329648887 0.391276737937151 90.6527999345367 a959 EP300_mut 293 MP470 PDGFR 6 22 2.99573227355399 NA 2.82424400049275 2.1319776132445 0.692266387248254 1.12406479941578 1.93643144161717 0.382728067566965 0.615859857552745 0.357495944535027 0.492028686102071 NA NA 0.488925110377371 0.28074011468406 90.6527999345367 a960 ARID1A_mut 225 Genentech Cpd 10 AURKA, AURKB 3 26 2.32630161961136 NA 0.964316418413279 1.37147102547198 -0.407154607058701 1.06385114478644 1.0928357276983 0.373291424719286 0.382717647157709 0.372567071829028 0.492142774659982 NA NA 0.3799015798775 0.583544702865848 90.6527999345367 a961 PTEN_mut 288 KIN001-055 JAK3, MNK1 6 23 2.32630161961136 NA 3.97395613809403 3.71979119612408 0.254164941969956 0.476608728849497 0.902165379822079 0.302653324727333 0.533277983774016 0.281727660642532 0.492299976522038 NA NA 0.864981095700118 0.361968549078335 90.6527999345367 a962 loss_cnaDLBC4_(CDKN2A) 303 PIK-93 PI4K, PI3K 7 22 2.99573227355399 NA 1.00384516083081 0.472121960357704 0.531723200473103 1.45444392319162 1.59632320596523 0.339562699977764 0.365585219199303 0.333092445493576 0.493954094401963 NA NA 0.583850270543029 0.428289554020375 90.6527999345367 a963 MLL2_mut 254 AC220 FLT3 9 20 0.0237165266173161 NA 1.78011278210848 1.61429013830239 0.165822643806089 0.769917885835128 0.710085523423294 0.227676328273235 0.215377051055544 0.233524890081781 0.494347078621921 NA NA 0.52143353966036 0.591098015256063 90.6527999345367 a964 TP53_mut 301 PHA-793887 CDK-pan 17 12 2.32630161961136 NA 0.0636395237403314 -0.467883009769127 0.531522533509459 1.96322389872428 1.5425969152858 0.294678488523134 0.270739640982797 0.344563461940401 0.494367800664956 NA NA 0.687517157658514 0.422138197218834 90.6527999345367 a965 loss_cnaDLBC4_(CDKN2A) 1059 AZD8055 MTORC1/2 8 24 0.693147180559945 NA -1.02164432601296 -1.3319464346219 0.310302108608935 0.864089601334785 1.03939385535342 0.309918221506924 0.35910871757929 0.298541411430053 0.49454964794233 NA NA 0.672822594158528 0.417792844244703 90.6527999345367 a966 TP53_mut 271 VNLG/124 HDAC, RAR 17 12 1.63315443905142 NA 2.67425122967753 3.00404456710748 -0.329793337429953 1.03861711189321 0.701884504193468 0.359844594502591 0.317531199566699 0.469868383558228 0.494683105939955 NA NA 0.229192731715475 0.316716080823373 90.6527999345367 a967 loss_cnaDLBC4_(CDKN2A) 221 TAK-715 p38a 7 22 2.99573227355399 2.32630161961136 2.85060395399139 2.77233740048091 0.0782665535104816 0.406074885445398 0.667365440326384 0.126458997243328 0.192739212188993 0.117276905247302 0.494989282681094 NA NA 0.0245974509754124 0.713017181609014 90.6527999345367 a968 TP53_mut 1262 UNC1215 LMBL3 18 12 0 NA 1.69993640067121 1.79962221092354 -0.0996858102523273 0.454527366860361 0.530463301690227 0.205208973895794 0.219317509836438 0.187922161504285 0.495451873051333 NA NA 0.561104357990885 0.599322799063909 90.6527999345367 a969 MLL2_mut 1175 AG-014699 PARP1, PARP2 8 22 1.6094379124341 NA 3.40851363799335 3.26357169962519 0.144941938368164 0.615278430994583 0.648266000745869 0.226408637209703 0.2355712975894 0.223584050685058 0.495812601108279 NA NA 0.41204632064925 0.583362425347602 90.6527999345367 a970 PTEN_mut 265 Tubastatin A HDAC6 6 22 2.99573227355399 NA 2.62220659219851 3.00221553363252 -0.380008941434008 0.942576683900367 1.18144453290137 0.333515488888969 0.403159708832959 0.321647720947837 0.496570587059074 NA NA 0.865215933702151 0.428362210524129 90.6527999345367 a971 TP53_mut 192 LFM-A13 BTK 16 13 2.77258872223978 NA 4.19898239753871 4.28941497065714 -0.0904325731184255 0.673729449354996 0.798194647604422 0.12359816992252 0.134226837204463 0.113296391287308 0.496788050483746 NA NA 0.190131596389822 0.747972017330432 90.6527999345367 a972 PTEN_mut 272 AR-42 HDAC 6 22 1.63315443905142 NA -2.14388534074335 -1.71473826938822 -0.429147071355129 1.01292848766766 1.41138541309693 0.319314120718905 0.423669663337508 0.304060866275694 0.496832126025398 NA NA 0.985837015269768 0.419315498235627 90.6527999345367 a973 PTEN_mut 1239 YK 4-279 RNA helicase A 5 22 2.30258509299405 NA 2.00927597726658 1.64455910476061 0.364716872505966 1.98780115391699 1.45279654299645 0.235172253694526 0.183477543408849 0.251044700143438 0.49735724548884 NA NA 0.400380893834859 0.714335266525683 90.6527999345367 a974 EP300_mut 1170 CCT018159 HSP90 6 24 2.30258509299405 NA 3.09312087281034 2.77798954517144 0.3151313276389 1.25806068652182 0.786670356620044 0.354333143480191 0.250489766523226 0.400588791718138 0.497594578189412 NA NA 0.657022770023217 0.579433420524158 90.6527999345367 a975 loss_cnaDLBC2 346 THZ-2-102-1 CDK7 4 25 0.916290731874155 2.99573227355399 -3.2426819660008 -3.84497214575121 0.60229017975041 2.507397166976 1.22044065732784 0.423503902281563 0.240205336307687 0.493502224900576 0.497713008396329 NA NA 0.376291786967821 0.667274243115746 90.6527999345367 a976 PTEN_mut 252 WZ3105 CLK2, CNSK1E, FLT3, ULK1 6 23 0.246860077931526 2.32630161961136 -1.79258482765267 -1.36242419332887 -0.4301606343238 0.328575934736292 1.30756724287795 0.361862002144211 1.30916658479276 0.328977830139748 0.498800524592999 NA NA 0.600964251310609 0.168314063181485 90.6527999345367 a977 CREBBP_mut 186 Bexarotene Retinioic acid X family agonist 7 22 2.07944154167984 NA 3.42663948850314 3.10013191863112 0.326507569872017 0.866302732677554 0.855457486518436 0.380598454433076 0.376897772055795 0.38167597457221 0.498999837318981 NA NA 0.187220960053257 0.404051252721312 90.6527999345367 a978 EP300_mut 1219 PFI-1 BRD2, BRD3, BRD4 6 24 2.30258509299405 NA 2.33987959506346 2.03126004215492 0.30861955290854 1.12523237557383 1.04354199492726 0.291537769669117 0.27427183896229 0.29574234138038 0.499848660213935 NA NA 0.837572265991711 0.560665680676605 90.6527999345367 a979 PTEN_mut 34 Imatinib ABL, KIT, PDGFR 4 23 0.693147180559945 NA 2.91444055140133 2.65318419707427 0.261256354327062 0.278487940629812 0.545916608655466 0.501333901898355 0.938124479416306 0.478564583280418 0.501273158839441 NA NA 0.361663966618137 0.185002218818587 90.6527999345367 a980 ARID1A_mut 1031 Elesclomol HSP70 3 27 -1.6094379124341 NA -3.40038222332542 -2.81498953322234 -0.585392690103077 0.923587872197194 1.34880835660665 0.44248181140607 0.633824574493862 0.434007312629511 0.501800855351966 NA NA 0.676368203153805 0.395363388423887 90.6527999345367 a981 CREBBP_mut 281 CH5424802 ALK 6 23 1.63315443905142 NA 3.29733885937991 2.95044991678958 0.346888942590329 0.419699250754763 1.38845211043062 0.27394722351302 0.826517898153269 0.249838608032901 0.502203750764536 NA NA 0.559094340989796 0.311957779838597 90.6527999345367 a982 TP53_mut 37 Crizotinib MET, ALK 15 11 0.693147180559945 NA 2.14386782652565 1.81616870418672 0.327699122338934 0.710155267465817 1.15928163632147 0.354573120743036 0.461447147337687 0.282674297661404 0.502819308196336 NA NA 0.373540960402248 0.419075388124077 90.6527999345367 a983 MLL2_mut 88 MS-275 HDAC 9 20 1.6094379124341 NA -0.384635186397531 0.180237134023668 -0.5648723204212 1.1178564912553 1.59125263525545 0.385052586828075 0.505317386301417 0.354985944975682 0.502989695018933 NA NA 0.0931306642531698 0.284955400269744 90.6527999345367 a984 CREBBP_mut 1043 JNK Inhibitor VIII JNK 7 25 2.30258509299405 NA 4.30820250503696 4.13644083033306 0.171761674703903 0.37643754778722 0.708447719906208 0.261976876237672 0.456281993423754 0.242447918001123 0.503264085605303 NA NA 0.633943210249021 0.402931438318429 90.6527999345367 a985 loss_cnaDLBC2 156 AZD6482 PI3Kbeta 4 26 1.63315443905142 NA 2.20884730464167 1.56684444585082 0.642002858790847 1.06993974708623 1.85838456132712 0.358542254129463 0.600036460500896 0.345462867132504 0.503361064925045 NA NA 0.862826058177639 0.358026579762831 90.6527999345367 a986 TP53_mut 258 STF-62247 stimulates autophagy 17 12 2.32630161961136 NA 3.31540188457774 3.04539299747944 0.270008887098293 1.17406191372039 1.0684218125069 0.238478708836581 0.229978405689598 0.252717497843624 0.503875785714412 NA NA 0.869373179928556 0.525896121117852 90.6527999345367 a987 MLL2_mut 1012 Vorinostat HDAC inhibitor Class I, IIa, IIb, IV 8 22 2.30258509299405 NA -0.215759848569263 -0.00954844184279109 -0.206211406726472 0.476988307212469 0.691098211301556 0.320066702556571 0.432319626306097 0.298382202926139 0.504603450672237 NA NA 0.55174277089022 0.369168107162005 90.6527999345367 a988 EP300_mut 54 CGP-082996 CDK4 5 20 1.63315443905142 NA 1.97115859119469 2.19560056598453 -0.224441974789838 0.876795833311706 1.07791182317058 0.214629683550038 0.255979746096771 0.208219234602755 0.505529586717703 NA NA 0.314229716084459 0.639979145142229 90.6527999345367 a989 loss_cnaDLBC2 1494 SN-38 TOP1 3 28 -2.99573227355399 NA -5.27742530018934 -4.58197295285406 -0.695452347335277 0.730245803479887 1.62867186970966 0.439279666049076 0.95235377460739 0.427005807780824 0.505833241961025 NA NA 0.635049359531495 0.244910929073521 90.6527999345367 a990 loss_cnaDLBC4_(CDKN2A) 59 WZ-1-84 BMX 8 17 2.32630161961136 NA 3.17594584884066 3.48441948131682 -0.308473632476163 0.841230927885485 0.91356432012052 0.345756236972496 0.366693166229089 0.337659457229534 0.506223807777002 NA NA 0.522831147831351 0.418677092625337 90.6527999345367 a991 TP53_mut 219 AT-7519 CDK9 17 12 2.32630161961136 NA -1.26063616771913 -0.934244596066479 -0.326391571652651 1.28264061770732 1.05358285407237 0.273214645561845 0.254468451370319 0.309792030490115 0.506267081397343 NA NA 0.811650222236451 0.459785912077502 90.6527999345367 a992 EP300_mut 207 AS601245 JNK 5 24 2.07944154167984 NA 2.17734530318463 1.94788743512814 0.229457868056494 0.654575075817913 0.766928415973256 0.30539640479372 0.350544767947021 0.299190724032966 0.50650304750202 NA NA 0.854829986372012 0.513273830776038 90.6527999345367 a993 PTEN_mut 175 PAC-1 CASP3 agonist 5 24 0.940007258491471 NA 1.40116263992542 1.09208060430037 0.309082035625052 1.46692069669256 0.958235229727902 0.294567443180237 0.210701257622128 0.322553404462929 0.506615390435001 NA NA 0.787221619689913 0.671546464529819 90.6527999345367 a994 CREBBP_mut 136 Mitomycin C DNA crosslinker 7 22 2.77258872223978 NA -1.63716366970264 -1.20685677263246 -0.430306897070175 1.26043654424572 1.22190567435216 0.349680289079635 0.341395129357888 0.352160486772696 0.507636974599077 NA NA 0.384103880253433 0.446696393916015 90.6527999345367 a995 CREBBP_mut 331 QL-X-138 MNK2, PRKDC (DNAPK), MTOR, BTK, JAK3 6 23 2.32630161961136 NA -0.598320129259911 -0.146647374060457 -0.451672755199453 1.07351423682914 1.36091099788422 0.344145764108541 0.420742212542582 0.331890003021256 0.508115734687623 NA NA 0.594516835766908 0.407905792820293 90.6527999345367 a996 TP53_mut 1010 Gefitinib EGFR 17 13 -0.693147180559945 NA 0.939279315108424 1.1004376873122 -0.161158372203775 0.546663424929105 0.795460568259376 0.242419346029462 0.294803648560674 0.202597562512019 0.508313851885835 NA NA 0.982018941580231 0.538235385012859 90.6527999345367 a997 TP53_mut 89 Parthenolide NFKB1 16 11 1.6094379124341 NA 2.4742666063185 1.94482037999197 0.529446226326526 1.27685723250961 1.25818082249812 0.417077386152514 0.41464794406648 0.420802969540823 0.508638687058767 NA NA 0.0648824824657089 0.297222046117421 90.6527999345367 a998 ARID1A_mut 1020 Lenalidomide TNFA 3 27 1.6094379124341 NA 3.36649130098368 3.06946124963086 0.297030051352817 0.698609871309696 0.854001351176936 0.351993294166867 0.425172995045103 0.34780981428597 0.508782015026638 NA NA 0.333492171791378 0.548884888352384 90.6527999345367 a999 loss_cnaDLBC2 11 Paclitaxel Microtubules 4 21 -2.27886856637673 NA -4.32329166098603 -3.54117124690329 -0.782120414082747 1.40029437421893 1.65320820867805 0.482059311033137 0.558539995934072 0.473092505818217 0.508927771700573 NA NA 0.042387484938861 0.368520066541208 90.6527999345367 a1000 loss_cnaDLBC4_(CDKN2A) 252 WZ3105 CLK2, CNSK1E, FLT3, ULK1 7 22 0.246860077931526 2.32630161961136 -1.68231218230513 -1.37795818801564 -0.304353994289488 0.630166929714728 1.31221145019605 0.254736236620463 0.482973605782942 0.231939748920813 0.509042693752323 NA NA 0.601116474708699 0.416364337057042 90.6527999345367 a1001 CREBBP_mut 273 CUDC-101 HDAC, EGFR 6 22 1.63315443905142 NA -1.77182454198241 -2.2243014890657 0.452476947083291 1.68370216741312 1.45420647355671 0.301436734035027 0.26873930309093 0.311150414546443 0.509120530313783 NA NA 0.889923515959252 0.566939342794801 90.6527999345367 a1002 TP53_mut 152 CP466722 ATM 17 12 2.77258872223978 NA 1.66266653404244 1.34699055317302 0.315675980869422 1.06971971941604 1.08813228935205 0.293036255587761 0.295101581414007 0.290108090678383 0.509612749009494 NA NA 0.624303916203508 0.446134187136687 90.6527999345367 a1003 MLL2_mut 155 AP-24534 ABL 9 20 -0.669430653942629 NA -1.05587691148062 -0.437422346855732 -0.618454564624886 1.8961734281405 1.69077316066599 0.352568191757838 0.326159282398224 0.365782104313319 0.509728374367997 NA NA 0.230862097799565 0.415180642251476 90.6527999345367 a1004 ARID1A_mut 283 GSK2126458 PI3K, MTOR 3 26 -2.05572501506252 0.0237165266173161 -5.12586747109919 -4.43516748204105 -0.690699989058134 1.30350312948457 1.79410520884236 0.391896775883054 0.529879808828117 0.384982990771097 0.512110902296129 NA NA 0.753059294210832 0.467513099564933 90.6527999345367 a1005 loss_cnaDLBC2 332 XMD15-27 CAMK2B, CLK2, DYRK1A, MAST1, STK39 4 25 2.32630161961136 NA 3.85728368985052 3.63318651838164 0.224097171468876 0.618072533106585 0.882979251143382 0.261308664930689 0.362574227886343 0.253796644914011 0.512121775121568 NA NA 0.146876202228807 0.555533826730387 90.6527999345367 a1006 loss_cnaDLBC2 1030 KU-55933 ATM 3 29 2.30258509299405 NA 3.47829951801773 3.0884322831342 0.389867234883527 0.470517699747426 0.924727984789175 0.432419657776575 0.828592070166135 0.421602072497472 0.512249202735625 NA NA 0.614579211381006 0.293837288581194 90.6527999345367 a1007 PTEN_mut 1011 ABT-263 BCL2, BCL2L1, BCL2L2 5 27 0.693147180559945 NA 1.10010449959654 0.266821931075339 0.833282568521198 1.44298679562439 1.72070869432265 0.494141487805595 0.577470681677743 0.484267076275346 0.512323451288116 NA NA 0.124739997453532 0.292260693371778 90.6527999345367 a1008 MLL2_mut 59 WZ-1-84 BMX 8 17 2.32630161961136 NA 3.17849100786315 3.48322175942389 -0.304730751560733 1.0284218045067 0.825992144168355 0.34144457236651 0.296309111908516 0.368926936790119 0.512490610798849 NA NA 0.522954497720599 0.477703249571694 90.6527999345367 a1009 TP53_mut 35 NVP-TAE684 ALK 15 11 0.693147180559945 NA 1.17099871014119 0.515145419815664 0.655853290325521 1.46946182365269 2.16361334299859 0.366055243770832 0.446322102261386 0.303128695544354 0.512707606800068 NA NA 0.278091436523146 0.397235718615081 90.6527999345367 a1010 MLL2_mut 308 XL-880 MET 9 20 1.63315443905142 NA -0.567021769899933 -0.331431537625816 -0.235590232274117 0.756757458787862 0.893205543345979 0.275528172418866 0.311315375274231 0.263758139466519 0.512983219517354 NA NA 0.907300192641155 0.473376076846259 90.6527999345367 a1011 TP53_mut 1268 XAV 939 TNKS1 (tankyrase-1) 18 11 1.6094379124341 NA 2.78674867254411 3.07616344993083 -0.289414777386719 0.994390655580815 0.618940890521716 0.331009471868039 0.291047362284066 0.467596796105629 0.51359535497176 NA NA 0.326097500240897 0.342627152359624 90.6527999345367 a1012 loss_cnaDLBC4_(CDKN2A) 1014 RDEA119 MAP2K1 (MEK1), MAP2K2 (MEK2) 8 24 1.6094379124341 NA 3.01219770459309 2.69905566932993 0.313142035263161 1.23007616612755 1.19500839088275 0.260239877735716 0.254571256549888 0.262041704185728 0.513972794479835 NA NA 0.863471873517739 0.542025712911842 90.6527999345367 a1013 loss_cnaDLBC4_(CDKN2A) 166 FTI-277 Farnesyl transferase (FNTA) 8 22 0.0237165266173161 NA 1.93163137721721 1.80690409341031 0.124727283806904 0.636179238438073 0.59332866632749 0.206390652529558 0.196056828438996 0.210216176775893 0.514831855823331 NA NA 0.357305275396396 0.637747794912772 90.6527999345367 a1014 loss_cnaDLBC2 186 Bexarotene Retinioic acid X family agonist 4 25 2.07944154167984 NA 2.97816791401908 3.21106827893321 -0.232900364914136 0.722773791328016 0.882296057674237 0.268930722176405 0.32223133670385 0.263970764561807 0.515104181017329 NA NA 0.187499995897161 0.589881936715108 90.6527999345367 a1015 EP300_mut 192 LFM-A13 BTK 5 24 2.77258872223978 NA 4.5189606891005 4.18130456390249 0.33765612519801 0.648064151823767 0.733098911086287 0.468229275107452 0.521022686176648 0.460587405180673 0.515374333062265 NA NA 0.190456417217272 0.338445833624868 90.6527999345367 a1016 MLL2_mut 1059 AZD8055 MTORC1/2 9 23 0.693147180559945 NA -1.04799439958125 -1.33512693229556 0.287132532714312 0.956381597788761 1.01805179335156 0.286565816606709 0.300227998299202 0.282041183552199 0.515980922460815 NA NA 0.673063366361779 0.464631835475544 90.6527999345367 a1017 ARID1A_mut 301 PHA-793887 CDK-pan 3 26 2.32630161961136 NA -0.851760613008324 -0.0760554759468816 -0.775705137061442 0.477286616921419 1.87357371954877 0.429154152620037 1.62523965592179 0.414024347677263 0.516652798844058 NA NA 0.687785642821486 0.11636325112181 90.6527999345367 a1018 CREBBP_mut 164 JQ12 HDAC 7 23 1.63315443905142 NA 0.807467781578488 0.446719247782277 0.360748533796211 1.30063706180103 1.64089645663501 0.229164923630677 0.277362951119256 0.219848444633733 0.516822909255277 NA NA 0.420844915104132 0.557800166500387 90.6527999345367 a1019 loss_cnaDLBC2 277 ABT-869 VEGFR and PDGFR family 4 25 0.0237165266173161 NA 2.07489999798145 1.78267866751177 0.292221330469679 0.538823183935611 0.850067072792154 0.355790520780415 0.542332511261429 0.343762674526189 0.517044747127229 NA NA 0.967628686321706 0.395828467033485 90.6527999345367 a1020 ARID1A_mut 178 BAY 61-3606 SYK 3 26 2.07944154167984 NA 0.598770575191812 1.13639799489512 -0.537627419703306 0.660805128678574 1.30246137014187 0.424621783667118 0.813594502177082 0.412778015554309 0.517062631660829 NA NA 0.745913477559044 0.304728952030257 90.6527999345367 a1021 PTEN_mut 1072 BMS-708163 g-secretase 5 23 1.6094379124341 NA 3.26162988408798 3.38707617845593 -0.125446294367946 0.811146854050792 0.659459484305747 0.183137053908997 0.154652999936422 0.190225931013808 0.517282215132252 NA NA 0.268206399689341 0.758993041734952 90.6527999345367 a1022 CREBBP_mut 1059 AZD8055 MTORC1/2 7 25 0.693147180559945 NA -1.45500383363174 -1.19819368814428 -0.256810145487456 0.972440691913052 1.01278439141237 0.25557183830143 0.264088234504298 0.253568427460975 0.517859339687949 NA NA 0.67308364076582 0.554279595422656 90.6527999345367 a1023 loss_cnaDLBC2 35 NVP-TAE684 ALK 4 22 0.693147180559945 NA 0.242709385089039 1.01185194226063 -0.769142557171594 2.03904459336269 1.76334444832208 0.427273494182299 0.37720732527147 0.43618395595 0.518928669095729 NA NA 0.278221635255041 0.519435494634566 90.6527999345367 a1024 MLL2_mut 94 TGX221 PI3Kbeta 9 18 2.30258509299405 NA 3.25916903386489 3.58446335933741 -0.32529432547252 1.42372645635666 0.992127179605853 0.283349884389702 0.228480916414908 0.327875631430389 0.519091902060196 NA NA 0.847283122819362 0.550112723325481 90.6527999345367 a1025 loss_cnaDLBC4_(CDKN2A) 228 KIN001-102 AKT1 7 22 2.32630161961136 NA 1.41746373558577 1.1833759836999 0.234087751885874 0.72330665226557 0.985065960510551 0.250827027899825 0.323635557826898 0.237636626652441 0.520211229092692 NA NA 0.636717127585161 0.50835159252461 90.6527999345367 a1026 EP300_mut 60 BI-2536 PLK1, PLK2, PLK3 5 20 -1.36257783450257 NA -1.75430821182959 -2.43378124172371 0.679473029894111 1.72042951935386 1.16640717809961 0.530796617161897 0.3949438336476 0.582535020918813 0.520394888471804 NA NA 0.0356389121375193 0.44137584557044 90.6527999345367 a1027 EP300_mut 254 AC220 FLT3 6 23 0.0237165266173161 NA 1.5293655849753 1.70133149109445 -0.171965906119147 0.961312338269173 0.665095264565945 0.235864622900286 0.178886610806191 0.258558307780728 0.52065875662023 NA NA 0.521874537253002 0.693186989658534 90.6527999345367 a1028 MLL2_mut 1527 GDC0941 (rescreen) PI3K 9 18 1.38629436111989 NA 1.17961151508187 0.625774551340047 0.553836963741826 0.998682721445222 1.66165245346616 0.37367734366162 0.554567483595143 0.33330493544937 0.521252784836999 NA NA 0.160708412214798 0.292019894986884 90.6527999345367 a1029 TP53_mut 273 CUDC-101 HDAC, EGFR 17 11 1.63315443905142 NA -2.26752181812428 -1.9107008275661 -0.356820990558183 1.61294987722055 1.30661590063974 0.237478772241615 0.22122261553041 0.273087898580965 0.521419256057354 NA NA 0.889978799076329 0.526382110266984 90.6527999345367 a1030 loss_cnaDLBC2 298 OSI-930 KIT, VEGFR, PDGFR 4 25 2.32630161961136 NA 3.32276529119569 2.9270362624326 0.395729028763096 0.950779262325078 1.11380141576334 0.360775318820492 0.416215460774105 0.355295857198999 0.522396357641046 NA NA 0.90675564629608 0.489033034940461 90.6527999345367 a1031 loss_cnaDLBC4_(CDKN2A) 274 PXD101, Belinostat HDAC 6 22 2.99573227355399 NA -1.11787324426518 -1.5393560392106 0.421482794945423 1.17920171983611 1.46250342657261 0.298407086900007 0.357430614164982 0.288192688842563 0.522530335991927 NA NA 0.966397103106773 0.479873402083741 90.6527999345367 a1032 loss_cnaDLBC2 286 KIN001-236 TIE2 4 25 2.32630161961136 NA 3.28068259193045 2.94381297821528 0.336869613715167 1.14382033982925 0.953615703147635 0.344948066333784 0.294512697479619 0.353255103290822 0.522653826064259 NA NA 0.890992130287648 0.60840188547204 90.6527999345367 a1033 loss_cnaDLBC4_(CDKN2A) 310 YM201636 FYV1 7 22 1.63315443905142 NA 0.690101449068687 0.947109543544147 -0.25700809447546 1.27648092416217 0.798522728969225 0.277456798110316 0.20134111651073 0.321854450914904 0.522871341059399 NA NA 0.937299462827692 0.629740047158863 90.6527999345367 a1034 EP300_mut 305 TPCA-1 IKK 6 23 2.99573227355399 NA 1.57365384790951 1.0784675416521 0.495186306257418 1.31520448591937 1.57563988191493 0.323490977633765 0.376508985149383 0.314276321601864 0.52375299167794 NA NA 0.766039670826053 0.451361080261435 90.6527999345367 a1035 CREBBP_mut 272 AR-42 HDAC 6 22 1.63315443905142 NA -1.48800344299621 -1.89361515059198 0.405611707595777 1.44992312162261 1.31915446038096 0.301505070172007 0.279747044203183 0.307478555224413 0.524024220876462 NA NA 0.985853108457662 0.554478445187601 90.6527999345367 a1036 loss_cnaDLBC2 275 I-BET BRD2, BRD3, BRD4 4 25 2.99573227355399 NA 1.81397812517112 1.3674736233316 0.44650450183952 1.88753851667351 1.35799128250537 0.312991596587858 0.236553849309742 0.328797767402277 0.524044784852142 NA NA 0.545873143727528 0.676000635299371 90.6527999345367 a1037 EP300_mut 1031 Elesclomol HSP70 5 25 -1.6094379124341 NA -3.16195979159009 -2.81584260436116 -0.346117187228928 0.753108885465249 1.40185612829745 0.260490250050599 0.459584522117419 0.246899221854732 0.524572920369234 NA NA 0.67663346570483 0.446920995039439 90.6527999345367 a1038 MLL2_mut 1017 Olaparib PARP1, PARP2 8 22 1.6094379124341 NA 2.79269420133569 3.08354501414155 -0.290850812805865 0.894710246479685 0.870413145645964 0.331812932540323 0.325078218283788 0.334152596684434 0.524801042079173 NA NA 0.314236670455913 0.442931539911449 90.6527999345367 a1039 loss_cnaDLBC2 211 TL-2-105 CRAF 4 25 2.32630161961136 1.63315443905142 3.04837916575738 2.86429416725685 0.184084998500532 0.452203762102663 0.769066137263566 0.248567141365957 0.407084181795771 0.239361726620196 0.525329852902407 NA NA 0.140033245199764 0.524930622434306 90.6527999345367 a1040 CREBBP_mut 274 PXD101, Belinostat HDAC 6 22 2.99573227355399 NA -1.12049037867985 -1.53864227527933 0.418151896599478 1.47191538385141 1.39813371086809 0.296011213790579 0.284086912323277 0.299078616979954 0.525817663541905 NA NA 0.966401507424941 0.551153199790874 90.6527999345367 a1041 TP53_mut 257 NPK76-II-72-1 PLK3 17 12 2.32630161961136 NA 1.1622501570594 0.941782123447798 0.220468033611603 1.54980449209069 1.21403667863779 0.154974444403566 0.142255384299597 0.18159915387316 0.526100009392968 NA NA 0.358677969519906 0.67137731416379 90.6527999345367 a1042 TP53_mut 309 Y-39983 ROCK 17 12 2.99573227355399 NA 2.52905788067057 2.81254367098553 -0.283485790314968 1.09422399562994 1.32061027010254 0.237891818562042 0.259074733735635 0.214662718239316 0.526132294121597 NA NA 0.979163764108862 0.548253123777964 90.6527999345367 a1043 TP53_mut 274 PXD101, Belinostat HDAC 17 11 2.99573227355399 NA -1.58399402626996 -1.2404703528759 -0.343523673394063 1.49810080662536 1.26531745901394 0.243096908752791 0.229306113363552 0.271492083624429 0.526633479439779 NA NA 0.966402592779816 0.520567773277106 90.6527999345367 a1044 TP53_mut 286 KIN001-236 TIE2 17 12 2.32630161961136 NA 2.89825074036121 3.12064935308027 -0.222398612719059 0.940552093540805 1.02865020067407 0.227540356906429 0.236455390665089 0.216204315687998 0.526645958276575 NA NA 0.891008674486434 0.558498555107246 90.6527999345367 a1045 TP53_mut 328 SNX-2112 HSP90 16 12 0.940007258491471 NA -2.55541795893011 -2.88854650367627 0.333128544746161 1.50314635127246 1.00597374546362 0.253150423179854 0.221620831839931 0.331150336923188 0.526730834673456 NA NA 0.911811002511746 0.489318847231708 90.6527999345367 a1046 MLL2_mut 1015 CI-1040 MAP2K1 (MEK1), MAP2K2 (MEK2) 8 22 2.30258509299405 NA 2.77687141315133 2.61990375316992 0.156967659981403 1.36573658742025 0.872947038358844 0.154079802340318 0.114932602250849 0.179813497364634 0.527158733266583 NA NA 0.135024590638896 0.768412194468503 90.6527999345367 a1047 PTEN_mut 224 AS605240 PI3Kgamma 6 23 2.99573227355399 2.32630161961136 2.65399182167093 2.15508156659412 0.498910255076808 0.760372801628037 1.36657431692985 0.390925963708941 0.656139007087825 0.365080953809862 0.527666517823581 NA NA 0.263740891189417 0.255308685709536 90.6527999345367 a1048 MLL2_mut 303 PIK-93 PI4K, PI3K 9 20 2.99573227355399 NA 0.368346848343388 0.704923880929732 -0.336577032586344 1.6188508494756 1.55662371296583 0.213656610798911 0.207911082540663 0.216222475465869 0.528679760580621 NA NA 0.584370324202279 0.607856526769173 90.6527999345367 a1049 ARID1A_mut 1495 AZD-2281 PARP1, PARP2 3 27 2.30258509299405 NA 3.77125674612854 3.46689270408803 0.304364042040508 0.865232810158669 0.882377096858367 0.34541151425193 0.351771267186103 0.344936471180147 0.528817240294459 NA NA 0.433761081745188 0.612035876875654 90.6527999345367 a1050 MLL2_mut 1023 GW 441756 NTRK1 8 22 0.693147180559945 NA 1.3163617759806 1.94568281576445 -0.629321039783849 2.85972598322423 1.51511925708928 0.324280385320135 0.220063405891188 0.415360729420632 0.528859456357249 NA NA 0.356228965169805 0.568727510979209 90.6527999345367 a1051 loss_cnaDLBC2 1057 NVP-BEZ235 PI3K (Class 1) and MTORC1/2 3 29 -1.38629436111989 0.693147180559945 -2.77958328457576 -3.19873469521206 0.419151410636295 0.936670211231797 1.0116802237958 0.416298340545436 0.447490915810247 0.41431215197985 0.530428371321722 NA NA 0.593322522827841 0.526410901973503 90.6527999345367 a1052 loss_cnaDLBC2 1025 SB 216763 GSK3A, GSK3B 3 27 2.30258509299405 NA 4.35672785672754 4.10149658275892 0.255231273968628 0.712742464264465 0.732545249807307 0.349082649660278 0.358097471057825 0.348417075990548 0.531044787328501 NA NA 0.486792410152604 0.606163501375047 90.6527999345367 a1053 PTEN_mut 119 Lapatinib ERBB2, EGFR 4 24 0.693147180559945 NA 2.80710510246318 2.47034706564287 0.336758036820309 0.396162987933604 0.73058531230369 0.480947063162061 0.850049214786186 0.460942796342894 0.531180375249909 NA NA 0.342474675050886 0.216154108775994 90.6527999345367 a1054 TP53_mut 1218 JQ1 BRD2, BRD3, BRD4 18 11 0 NA 0.860918766475822 0.517949237763563 0.342969528712259 1.31058709830872 1.82243079536274 0.225580727866895 0.2616915191328 0.188193444483577 0.531439644930237 NA NA 0.851579828344362 0.593723171313561 90.6527999345367 a1055 EP300_mut 1069 EHT 1864 Rac GTPases 6 22 2.30258509299405 NA 3.71316925348763 3.46692389827098 0.246245355216648 0.888659564222852 0.836258539193232 0.290868136335598 0.277097513075205 0.294460796124378 0.531792671538851 NA NA 0.989252757358071 0.560177641030432 90.6527999345367 a1056 PTEN_mut 1495 AZD-2281 PARP1, PARP2 5 25 2.30258509299405 NA 3.34381404406598 3.5280321211373 -0.184218077071316 1.5659876756394 0.708285159665783 0.208541509207807 0.117636990339722 0.260090268103658 0.532168989675583 NA NA 0.433816084921908 0.808331814459935 90.6527999345367 a1057 loss_cnaDLBC4_(CDKN2A) 54 CGP-082996 CDK4 8 17 1.63315443905142 NA 2.27574730422112 2.09187210834676 0.183875195874355 1.38026667539941 0.859966753068947 0.175775042471878 0.133217152273236 0.213816633280488 0.532790604973632 NA NA 0.314825884580193 0.736420940811964 90.6527999345367 a1058 PTEN_mut 54 CGP-082996 CDK4 4 21 1.63315443905142 NA 2.5750413864499 2.06988755856497 0.505153827884926 1.11574737501223 1.01883467454663 0.489494075008902 0.452749286440748 0.495815307924925 0.532900166344993 NA NA 0.314828171270917 0.447455888028181 90.6527999345367 a1059 EP300_mut 274 PXD101, Belinostat HDAC 6 22 2.99573227355399 NA -1.76714222968254 -1.36228267955132 -0.404859550131217 1.01131188083299 1.49317214824188 0.286459175740284 0.400331052966318 0.271140571840905 0.53421867712744 NA NA 0.966412540074518 0.452796184717877 90.6527999345367 a1060 PTEN_mut 1046 681640 WEE1, CHEK1 5 27 0.693147180559945 NA 1.90620643783558 1.72342067469833 0.182785763137256 0.851559967500804 0.764613915007953 0.235315402502292 0.214648140017319 0.23905628651207 0.534535509259739 NA NA 0.597127456778121 0.672185373078695 90.6527999345367 a1061 TP53_mut 1014 RDEA119 MAP2K1 (MEK1), MAP2K2 (MEK2) 19 13 1.6094379124341 NA 2.67422667258878 2.9280469939597 -0.253820321370923 1.12358706048384 1.31667684622659 0.21071918257202 0.225901783936193 0.192773437232026 0.534903169455922 NA NA 0.863568779197733 0.575618074087727 90.6527999345367 a1062 loss_cnaDLBC4_(CDKN2A) 273 CUDC-101 HDAC, EGFR 6 22 1.63315443905142 NA -1.79381474077281 -2.21830416212287 0.424489421350061 1.17274411827677 1.57090169616142 0.282512797088855 0.36196252424937 0.270220232359111 0.535063335347997 NA NA 0.890037463694981 0.483419581252812 90.6527999345367 a1063 EP300_mut 1054 PD-0332991 CDK4, CDK6 6 26 1.38629436111989 0.693147180559945 1.05316391453593 1.54069256894471 -0.487528654408788 1.71933113385045 1.46793979870265 0.322281363200956 0.283557160578465 0.332117607847175 0.535476742200446 NA NA 0.677011606004746 0.541566773966727 90.6527999345367 a1064 CREBBP_mut 1007 Docetaxel Microtubules 6 23 -4.38202663467388 NA -4.62475447885025 -4.33260021955332 -0.29215425929693 1.0102292107332 1.09073077089791 0.271448835363478 0.289196012343469 0.267851854089001 0.535804614162252 NA NA 0.782081080042206 0.551643093613172 90.6527999345367 a1065 loss_cnaDLBC2 158 PF-562271 FAK 4 26 0.940007258491471 NA 1.41873460299013 1.70330817869682 -0.284573575706693 0.814208723049604 0.889413601055301 0.322769167551022 0.349509367377971 0.319956402026056 0.536311368032618 NA NA 0.766995921407608 0.554042100034031 90.6527999345367 a1066 CREBBP_mut 286 KIN001-236 TIE2 6 23 2.32630161961136 NA 2.76002187700626 3.05034450265505 -0.290322625648799 0.983276600811478 0.974824545659551 0.297341289170336 0.295260382896533 0.297820389260276 0.538479061746263 NA NA 0.891056404617298 0.537343152458785 90.6527999345367 a1067 EP300_mut 299 OSI-027 MTORC1/2 6 23 2.99573227355399 NA -1.63383574690915 -1.2709712858325 -0.362864461076651 1.22575494295919 1.82315152212917 0.209969912688049 0.296033447110261 0.199031433576558 0.53859580025961 NA NA 0.439324847335752 0.574734499828309 90.6527999345367 a1068 TP53_mut 83 JW-7-52-1 MTOR 15 10 0.182321556793955 NA -2.19320717737167 -1.98942118685033 -0.203785990521341 1.95538737250841 1.47210237099967 0.114360936961587 0.104217708156681 0.138431942326779 0.538954680745184 NA NA 0.198477464246445 0.769376723501016 90.6527999345367 a1069 PTEN_mut 59 WZ-1-84 BMX 4 21 2.32630161961136 NA 3.70884210914037 3.32415854935951 0.38468355978085 1.16363435467107 0.844558427684568 0.430936619739527 0.330588004931833 0.455484839379905 0.539962117365842 NA NA 0.523465133287256 0.566005887342904 90.6527999345367 a1070 loss_cnaDLBC2 170 Shikonin unknown 4 26 2.77258872223978 NA -0.0655230442513074 -0.425411443069154 0.359888398817846 1.0995317863554 1.09418274986354 0.328738123911289 0.327310591002342 0.328910685955094 0.540086628476808 NA NA 0.882826370904183 0.575141041428883 90.6527999345367 a1071 EP300_mut 87 GW843682X PLK1 5 20 -1.36257783450257 NA -2.19190870998267 -2.9383927388381 0.746484028855422 1.85061791394931 1.34444675684449 0.51650236147074 0.403370151790213 0.555235099534527 0.540404904115022 NA NA 0.0352907625729057 0.434494417507873 90.6527999345367 a1072 CREBBP_mut 1054 PD-0332991 CDK4, CDK6 7 25 1.38629436111989 0.693147180559945 1.16394044315087 1.52917628710888 -0.365235843958007 1.436634530647 1.53700684192709 0.240688372159687 0.254230172090823 0.237627988369965 0.540698779302961 NA NA 0.677063515563263 0.571040895370774 90.6527999345367 a1073 PTEN_mut 150 Bicalutamide ANDR (androgen receptor) 5 24 0.0237165266173161 NA 2.16983800649207 1.97439199705007 0.195446009441999 0.445767921220822 0.514567705810448 0.38704711308056 0.43844790111126 0.379825642447129 0.540861325009157 NA NA 0.464203309201576 0.41687056521207 90.6527999345367 a1074 loss_cnaDLBC2 268 YM155 BIRC5 (Survivin) 4 25 1.63315443905142 NA -4.50466069496126 -4.88921427621629 0.384553581255032 1.26438938139212 1.06982474191337 0.351783385077291 0.304141735856426 0.35945474636085 0.541137492687976 NA NA 0.814459612602426 0.59754215358921 90.6527999345367 a1075 loss_cnaDLBC4_(CDKN2A) 1377 Afatinib (rescreen) ERBB2, EGFR 7 23 2.30258509299405 NA 3.6414026518294 3.29938428008081 0.34201837174859 0.590583198078138 1.04500360225971 0.354130303894446 0.579119712280299 0.327289179682262 0.541340147890859 NA NA 0.142883288702401 0.287081713007591 90.6527999345367 a1076 loss_cnaDLBC4_(CDKN2A) 165 DMOG Prolyl-4-Hydroxylase 8 22 8.29404964010203 NA 4.88547761655553 5.28636198910925 -0.400884372553714 0.973163099807332 1.77967132381594 0.24803743650742 0.411939553229136 0.225257533337192 0.542192844746321 NA NA 0.907999848741781 0.441792709852226 90.6527999345367 a1077 loss_cnaDLBC4_(CDKN2A) 312 AV-951 VEGFR 7 22 -2.05572501506252 NA -0.30351325150365 -0.400699660360795 0.0971864088571447 0.17753429692853 0.579459984465017 0.187675369465704 0.547423289688467 0.167718930491588 0.54335640667497 NA NA 0.27156121557702 0.495289759972585 90.6527999345367 a1078 CREBBP_mut 1025 SB 216763 GSK3A, GSK3B 7 23 2.30258509299405 NA 3.9531984059758 4.17992184621055 -0.226723440234752 0.896267431727107 0.675830750203805 0.311133010050597 0.252964050917097 0.335473696878073 0.543444217139414 NA NA 0.486981325834487 0.55340436543709 90.6527999345367 a1079 CREBBP_mut 64 CMK RSK 6 19 1.38629436111989 NA 0.972400582866362 1.44571514928625 -0.473314566419892 1.17942445052792 1.22082858359625 0.390540319938093 0.401309779704866 0.387699446736107 0.543527656469446 NA NA 0.163800478468431 0.418306147326412 90.6527999345367 a1080 CREBBP_mut 344 THZ-2-49 CDK9 6 23 2.99573227355399 NA 0.137182482801101 0.565476598261845 -0.428294115460744 1.35863263110356 1.70144858960077 0.260619657610197 0.315239090873932 0.251723218719903 0.543545170000933 NA NA 0.724054472722271 0.530690002437463 90.6527999345367 a1081 PTEN_mut 1378 Bleomycin (50 uM) DNA damage 5 26 3.91202300542815 NA 2.87311660155158 3.48354486836258 -0.610428266811 1.79413564297259 1.54237953490995 0.38647125628258 0.340235293358098 0.395770465695812 0.543655599826314 NA NA 0.448129979346532 0.507190479856192 90.6527999345367 a1082 loss_cnaDLBC2 266 Zibotentan, ZD4054 Endothelin A Receptor 4 25 2.99573227355399 NA 4.95371268356653 4.74822727798752 0.205485405579008 0.371397010418919 0.666816149837249 0.320693356830043 0.553276951118238 0.308159011489391 0.544691952666522 NA NA 0.821657048874671 0.400044496698932 90.6527999345367 a1083 TP53_mut 1192 GSK269962A ROCK1, ROCK2 19 11 1.6094379124341 NA 1.79319287363377 1.47248308028444 0.320709793349325 1.28400648253326 1.83681208336223 0.213105963168925 0.249772721331271 0.174601308568417 0.545086179039321 NA NA 0.82091259671786 0.616254211210566 90.6527999345367 a1084 CREBBP_mut 1243 piperlongumine Increases ROS levels 6 24 2.30258509299405 NA 2.01729728080609 1.6448358365115 0.372461444294598 1.10657467103073 1.13021704983492 0.330773526237811 0.336589526260948 0.329548598075918 0.545688634811101 NA NA 0.406817008810533 0.484185465242827 90.6527999345367 a1085 CREBBP_mut 178 BAY 61-3606 SYK 7 22 2.07944154167984 NA 0.802577938768074 1.16930063733964 -0.366722698571562 1.58854108850264 1.15893943076028 0.289428641662171 0.230855028696321 0.316429563821974 0.545728249174434 NA NA 0.746175973580093 0.587420144826577 90.6527999345367 a1086 PTEN_mut 1058 GDC0941 PI3K (class 1) 5 27 1.38629436111989 0.693147180559945 -0.460642125515837 0.325638292301115 -0.786280417816953 1.77491708948664 2.08545278098815 0.384156329084564 0.442995575666223 0.377031033732823 0.545787558423034 NA NA 0.44856300261409 0.409444191162876 90.6527999345367 a1087 CREBBP_mut 71 Pyrimethamine Dihydrofolate reductase (DHFR) 7 21 2.99573227355399 NA 3.10561119107869 2.90579334060518 0.199817850473515 1.11325341022081 1.23815665269622 0.165073605680253 0.179489996292832 0.16138333549183 0.546083422577219 NA NA 0.185400344126402 0.69684695667358 90.6527999345367 a1088 TP53_mut 1114 Cetuximab EGFR 18 10 4.18661983833127 NA 6.01228761692691 6.10406536876554 -0.0917777518386291 0.584633445957905 0.507887352598113 0.16410552345079 0.156983409815451 0.18070493657528 0.54622859325733 NA NA 0.385493970923514 0.66892075055519 90.6527999345367 a1089 TP53_mut 292 Masitinib KIT 17 12 2.99573227355399 NA 2.63780309311626 2.82721323538855 -0.189410142272294 0.415002273750982 0.951458663995574 0.276026108717131 0.456407480759846 0.199073432656424 0.547007943669364 NA NA 0.58470906126903 0.527797847240878 90.6527999345367 a1090 loss_cnaDLBC4_(CDKN2A) 302 PI-103 PI3Ka, PRKDC (DNAPK) 7 21 2.32630161961136 NA -1.03142302250479 -1.47649452794817 0.445071505443373 2.290253425752 2.02826402554996 0.212786128505195 0.194332863096683 0.219434698755599 0.547136535972823 NA NA 0.468292137898429 0.657552746831347 90.6527999345367 a1091 loss_cnaDLBC2 1268 XAV 939 TNKS1 (tankyrase-1) 3 26 1.6094379124341 NA 3.23302658658065 2.85769978058812 0.375326805992536 1.05824064507462 0.86241385630287 0.427275889482815 0.35467056358062 0.435204981053464 0.54754995190402 NA NA 0.326702565058589 0.60650052601039 90.6527999345367 a1092 loss_cnaDLBC4_(CDKN2A) 235 QL-XII-47 BTK, BMX 7 21 2.32630161961136 NA -0.00601088045055913 0.403063718532053 -0.409074598982612 1.19584828569851 1.24579156693167 0.33138326639163 0.342079011087654 0.328365201564292 0.548027002759474 NA NA 0.344861642565601 0.454789147244657 90.6527999345367 a1093 CREBBP_mut 1372 Trametinib MAP2K1 (MEK1), MAP2K2 (MEK2) 6 24 0 NA 1.01977776765626 0.537224208093962 0.482553559562299 1.30028045086851 1.74407494706918 0.288353350478361 0.371114984648107 0.27668166461149 0.548042018722781 NA NA 0.896757009623885 0.467558580404456 90.6527999345367 a1094 ARID1A_mut 1023 GW 441756 NTRK1 3 27 0.693147180559945 NA 1.04064887092649 1.85977664969938 -0.819127778772887 2.7595270944266 1.86810688752275 0.421064528243448 0.296836287792671 0.438480144923139 0.548306253033738 NA NA 0.356552389557434 0.661577283460461 90.6527999345367 a1095 CREBBP_mut 306 TG101348 JAK2 6 23 2.32630161961136 NA 0.562249477073619 0.902293400344045 -0.340043923270426 0.832527726106797 1.20449352948717 0.297042271133206 0.408447565897409 0.282312785370631 0.548443207306632 NA NA 0.808461733944258 0.437787080674564 90.6527999345367 a1096 loss_cnaDLBC4_(CDKN2A) 268 YM155 BIRC5 (Survivin) 7 22 1.63315443905142 NA -5.0427737376457 -4.7704356146242 -0.272338123021496 0.971848589398884 1.12786737317748 0.248683560815507 0.280226905705491 0.24146289670057 0.549050903791423 NA NA 0.814511026417749 0.547009461834047 90.6527999345367 a1097 loss_cnaDLBC4_(CDKN2A) 199 Pazopanib VEGFR, PDGFRA, PDGFRB, KIT 8 21 2.07944154167984 NA 3.03708176015818 2.8529461905538 0.184135569604387 0.635632337391151 1.08358869938241 0.186529214517043 0.28968880085639 0.169931238401927 0.550140248708409 NA NA 0.385323931098557 0.578216085880045 90.6527999345367 a1098 TP53_mut 104 Bortezomib Proteasome 16 12 -3.91202300542815 NA -6.12887548802382 -6.06317762399565 -0.0656978640281674 1.24645833537088 0.972576608450155 0.057697848595689 0.0527076294199749 0.0675503229846951 0.550417361184547 NA NA 0.086002862593787 0.876747339628348 90.6527999345367 a1099 ARID1A_mut 63 BMS-509744 ITK 3 22 2.32630161961136 NA 2.41882786444044 2.82031281580618 -0.401484951365739 0.427411486915271 0.884328388105236 0.469928737554204 0.939340573795406 0.453999845267844 0.551750829572946 NA NA 0.0893809240561727 0.254128316078832 90.6527999345367 a1100 TP53_mut 1502 Bicalutamide ANDR (androgen receptor) 18 10 2.30258509299405 NA 3.74740450648604 3.62733196700447 0.120072539481578 0.556343009951786 0.883042680651655 0.17471769307909 0.215824657331425 0.135975918392719 0.55206638446902 NA NA 0.476488438393478 0.703384378224294 90.6527999345367 a1101 MLL2_mut 1032 Afatinib ERBB2, EGFR 8 22 -0.693147180559945 NA 1.18514636565449 1.05318981611406 0.131956549540433 0.746222269733184 0.6771674247189 0.189845159274306 0.176832768053967 0.194865471556328 0.552137617103341 NA NA 0.407711293981263 0.66898024163398 90.6527999345367 a1102 CREBBP_mut 153 Midostaurin KIT 7 23 -0.669430653942629 NA -0.452421950597912 -0.204046355375987 -0.248375595221925 0.596924080026155 0.9593979203254 0.277768715429651 0.416092437100279 0.258886943529837 0.552539373501132 NA NA 0.802265933833199 0.421935082666806 90.6527999345367 a1103 ARID1A_mut 282 EKB-569 EGFR 3 26 0.916290731874155 2.99573227355399 -0.147910122200335 0.367470072754582 -0.515380194954918 1.24463562710961 1.35174834260965 0.38343693031414 0.414081184669101 0.381269337427068 0.552845987255773 NA NA 0.842030826232117 0.556364040494512 90.6527999345367 a1104 PTEN_mut 1023 GW 441756 NTRK1 4 26 0.693147180559945 NA 2.54698048084192 1.6595382396652 0.887442241176719 0.572961376979889 2.04021534024446 0.458171063647883 1.54886922021599 0.43497479097985 0.552884389107197 NA NA 0.356625469166939 0.0881605746381735 90.6527999345367 a1105 EP300_mut 294 MPS-1-IN-1 MPS1 6 23 2.99573227355399 NA 2.95370769845347 2.67853141739421 0.275176281059266 0.628671636862543 0.983076791755857 0.296616421123745 0.437710666306762 0.279913312334206 0.553004398607162 NA NA 0.817884278818747 0.418175565955009 90.6527999345367 a1106 MLL2_mut 180 Thapsigargin sarco-endoplasmic reticulum Ca2+-ATPases 9 20 -0.669430653942629 NA -4.4220928249455 -4.04000043982566 -0.382092385119846 0.757372239876017 2.18531217038247 0.203351150717415 0.504497478257713 0.174845676649013 0.553538014790376 NA NA 0.627474981311508 0.493387472581919 90.6527999345367 a1107 MLL2_mut 62 BMS-536924 IGF1R 8 17 1.63315443905142 NA 2.03531858840005 1.9236330378937 0.111685550506349 1.19111086342732 1.63581928495769 0.0737509149759708 0.093765873467885 0.0682749931690887 0.555321151645797 NA NA 0.0590917911538738 0.849029214022408 90.6527999345367 a1108 MLL2_mut 86 A-443654 AKT1, AKT2, AKT3 8 17 0.0237165266173161 NA -1.66870143213687 -1.14463019358986 -0.524071238547007 1.00288875834035 1.37697170975412 0.411102552713078 0.522561684123648 0.38059695405114 0.55667856610563 NA NA 0.0436429185625292 0.295760395464544 90.6527999345367 a1109 PTEN_mut 276 CAY10603 HDAC6 6 23 2.99573227355399 NA -1.153551223547 -0.732703724686892 -0.420847498860106 1.18518979726058 1.55943770995723 0.281088367186527 0.355088695357355 0.269871310776272 0.556943946954982 NA NA 0.926647574015991 0.486774371467199 90.6527999345367 a1110 PTEN_mut 173 FH535 unknown 5 24 3.46573590279973 NA 2.19077253615172 2.07065656743426 0.120115968717463 0.714988943297702 0.695031402854585 0.172079977972675 0.167996959734033 0.172820923233297 0.557352438316469 NA NA 0.34582781084507 0.743645256019647 90.6527999345367 a1111 loss_cnaDLBC4_(CDKN2A) 110 Roscovitine CDKs 8 20 2.77258872223978 NA 3.4803585477312 3.29145472633068 0.188903821400521 1.07308882765248 0.927637420422739 0.19495771003876 0.176037450519146 0.20363971659793 0.557942187418258 NA NA 0.493119189196998 0.670336280567993 90.6527999345367 a1112 MLL2_mut 1066 AZD6482 PI3Kbeta 6 22 1.6094379124341 NA 1.8562624886081 1.43346640133387 0.422796087274234 1.46538596333799 1.49237835053257 0.284285114719254 0.288521998880861 0.28330355175908 0.559392790684665 NA NA 0.891946997027537 0.54986433379223 90.6527999345367 a1113 loss_cnaDLBC2 134 Etoposide TOP2 4 26 2.77258872223978 NA -0.0431887044635094 0.63692118818938 -0.680109892652889 0.733352158005805 2.0456087962142 0.34917414680827 0.92739877455642 0.332473097452243 0.560212956629903 NA NA 0.608957138114478 0.233980865422137 90.6527999345367 a1114 EP300_mut 1001 AICAR AAPK1 (AMPK) agonist 5 25 7.60090245954208 NA 6.83193979342601 6.56306609481681 0.268873698609202 0.366377925168601 0.876173657040462 0.326733575707739 0.733869810757485 0.306872611894545 0.560282197795752 NA NA 0.731855148163264 0.279908550282412 90.6527999345367 a1115 TP53_mut 253 XMD14-99 EPHB3, CAMK1 17 12 2.32630161961136 NA 3.29757429128735 3.02488171247948 0.272692578807868 0.841034422302704 0.962263687410312 0.305567250410767 0.324234741856644 0.283386541938157 0.560909937608966 NA NA 0.317588082838556 0.437349087620582 90.6527999345367 a1116 EP300_mut 190 Bleomycin DNA damage 5 24 4.15888308335967 NA 1.89535216345353 1.23048002174935 0.664872141704184 2.24998219136571 1.67171100606358 0.375772636438349 0.295501068522065 0.397719545598839 0.561167437200831 NA NA 0.443814606267569 0.559128580847569 90.6527999345367 a1117 MLL2_mut 34 Imatinib ABL, KIT, PDGFR 8 19 0.693147180559945 NA 2.75586404373492 2.66495191518074 0.0909121285541792 0.498196197180518 0.539437073932223 0.172112207385234 0.182482582301281 0.168531480217842 0.561391973316219 NA NA 0.362817108655374 0.679087205309145 90.6527999345367 a1118 ARID1A_mut 328 SNX-2112 HSP90 3 25 0.940007258491471 NA -3.13516186076705 -2.64575039218784 -0.489411468579216 0.954939203047025 1.34348922771384 0.371420534200518 0.51250536894663 0.364283879977234 0.561743407023263 NA NA 0.911925585484688 0.482366844832269 90.6527999345367 a1119 CREBBP_mut 1067 CCT007093 PPM1D 6 22 1.88706964903238 NA 3.74068089702599 3.5750539838601 0.165626913165892 0.55629612057983 0.665844770232842 0.25630049039504 0.297731562451413 0.248747036201807 0.562851021715109 NA NA 0.819076488596585 0.551095857333829 90.6527999345367 a1120 CREBBP_mut 1170 CCT018159 HSP90 6 24 2.30258509299405 NA 3.01282719212367 2.79806296534311 0.214764226780556 0.906277701391467 0.891889212046008 0.240100720773933 0.236973972161971 0.240796977785934 0.563902162803218 NA NA 0.657788693490384 0.617282603767483 90.6527999345367 a1121 CREBBP_mut 166 FTI-277 Farnesyl transferase (FNTA) 7 23 0.0237165266173161 NA 1.92765854229701 1.81353614246458 0.114122399832431 0.510674472481632 0.628219951540006 0.188645344330881 0.223473868348756 0.181659941796935 0.565813115220566 NA NA 0.358148731504272 0.633427354259305 90.6527999345367 a1122 CREBBP_mut 1019 Bosutinib SRC, ABL, TEC 7 23 0.693147180559945 NA 0.768639610168131 1.18626217454203 -0.417622564373901 1.25871714375259 1.28154723134315 0.327113667423167 0.331784282471001 0.325873720577746 0.566672209757625 NA NA 0.209537284477251 0.461557183317816 90.6527999345367 a1123 EP300_mut 286 KIN001-236 TIE2 6 23 2.32630161961136 NA 2.79411519558272 3.04145059346119 -0.247335397878475 0.488454427229101 1.05867482978516 0.252775375836017 0.506363304518616 0.233627352724225 0.566689546069954 NA NA 0.891162669981623 0.41635307609143 90.6527999345367 a1124 loss_cnaDLBC4_(CDKN2A) 152 CP466722 ATM 7 22 2.77258872223978 NA 1.29741347652406 1.60669651732405 -0.309283040799994 1.22403864443906 1.03593897336557 0.286221519897857 0.252674245380325 0.298553340256319 0.566792270152951 NA NA 0.625025506026718 0.56134848453979 90.6527999345367 a1125 ARID1A_mut 206 Ruxolitinib JAK1, JAK2, TYK2 3 26 1.65632149833295 0.0237165266173161 2.46462442832429 2.96352400397345 -0.498899575649164 1.53310878039116 1.46068170066603 0.340274176804581 0.325416944987996 0.341552560986887 0.566908506192186 NA NA 0.76015314752069 0.636750462039999 90.6527999345367 a1126 TP53_mut 1022 AZD7762 CHEK1, CHEK2 17 13 0.693147180559945 NA -1.6629176056677 -1.48172337854887 -0.181194227118837 1.27242829205637 1.13495629540175 0.149079863640022 0.142400344483075 0.159648638324614 0.56758332790841 NA NA 0.497777662337593 0.684259976569083 90.6527999345367 a1127 loss_cnaDLBC2 172 Embelin XIAP 4 25 3.46573590279973 NA 3.00735653115676 2.62386856272112 0.383487968435643 1.22960639818553 1.15869992776643 0.328668880020733 0.311878637750697 0.330964004783252 0.567788734548189 NA NA 0.827531979804934 0.591502778905109 90.6527999345367 a1128 PTEN_mut 155 AP-24534 ABL 5 24 -0.669430653942629 NA -0.0228631524769773 -0.755709307418971 0.732846154941994 1.57070945582899 1.78596655088066 0.417399524047599 0.466570155430312 0.410335879236162 0.568131228090816 NA NA 0.231829920636386 0.388208726553241 90.6527999345367 a1129 CREBBP_mut 312 AV-951 VEGFR 6 23 -2.05572501506252 NA -0.299567326005803 -0.397503536192532 0.0979362101867284 0.243124984207418 0.56203073588051 0.189064361590391 0.402822484517575 0.174254189200695 0.568736586446243 NA NA 0.271970161235977 0.53094248739281 90.6527999345367 a1130 CREBBP_mut 206 Ruxolitinib JAK1, JAK2, TYK2 6 23 1.65632149833295 0.0237165266173161 3.24467470018492 2.82510648639883 0.419568213786088 0.540050517600345 1.60133622738042 0.286581914787252 0.776905493305317 0.262011316931516 0.56904404243705 NA NA 0.760169515389398 0.304515802773126 90.6527999345367 a1131 loss_cnaDLBC2 271 VNLG/124 HDAC, RAR 4 25 1.63315443905142 NA 2.62408213267945 2.8405790871636 -0.216496954484153 0.67421712737506 0.955650615946692 0.233142913668793 0.32110865430999 0.226544043263851 0.570107431930044 NA NA 0.230469972821677 0.59971189168711 90.6527999345367 a1132 loss_cnaDLBC2 1502 Bicalutamide ANDR (androgen receptor) 3 25 2.30258509299405 NA 3.94683068613836 3.67544434913514 0.271386337003221 1.01090640690453 0.64971850487162 0.396587198874153 0.268458420235188 0.417698333922082 0.570227172008314 NA NA 0.476767299789849 0.690761490273125 90.6527999345367 a1133 EP300_mut 281 CH5424802 ALK 6 23 1.63315443905142 NA 3.33889337093606 2.93960960942711 0.399283761508945 0.598020318049875 1.37043686685851 0.316004492843101 0.667675912435544 0.291355093521554 0.570723887773102 NA NA 0.560079243960516 0.300932888589506 90.6527999345367 a1134 EP300_mut 273 CUDC-101 HDAC, EGFR 6 22 1.63315443905142 NA -2.42504878239041 -2.04614942349988 -0.378899358890529 0.913324556071118 1.61394043122673 0.251800915552031 0.414857299491053 0.234766631753896 0.57075280434343 NA NA 0.890178527291934 0.46703410209969 90.6527999345367 a1135 ARID1A_mut 1030 KU-55933 ATM 3 29 2.30258509299405 NA 3.43292126612826 3.0931265850538 0.339794681074458 0.870062362138245 0.905765280499718 0.376116648141128 0.390540604743994 0.375146506926155 0.571907747564731 NA NA 0.615258415605557 0.575690359474362 90.6527999345367 a1136 ARID1A_mut 1175 AG-014699 PARP1, PARP2 3 27 1.6094379124341 NA 3.0753188420031 3.32743444332191 -0.252115601318811 0.650276580959995 0.637938636129077 0.39465344696371 0.387705183764447 0.395203530622654 0.571973585466033 NA NA 0.413304140471163 0.577901879295362 90.6527999345367 a1137 loss_cnaDLBC2 178 BAY 61-3606 SYK 4 25 2.07944154167984 NA 0.718578894880904 1.138733760533 -0.420154865652092 0.350410698725241 1.33983529011816 0.331196353843421 1.19903549515061 0.313586952628363 0.572143505494964 NA NA 0.746396036385623 0.204373975202145 90.6527999345367 a1138 MLL2_mut 1 Erlotinib EGFR 8 19 0.693147180559945 NA 2.02466319514744 2.30859533792753 -0.283932142780088 0.596847947193689 0.915679394040973 0.338532728298155 0.475719392376407 0.310078117546219 0.572442287695332 NA NA 0.18793613484667 0.351638019604618 90.6527999345367 a1139 loss_cnaDLBC2 301 PHA-793887 CDK-pan 4 25 2.32630161961136 NA 0.29170956839258 -0.227982499488568 0.519692067881149 2.53572208227175 1.70306112894303 0.286403215693701 0.204948354362067 0.305151740621128 0.572491484108693 NA NA 0.688374905034686 0.715465863601837 90.6527999345367 a1140 EP300_mut 298 OSI-930 KIT, VEGFR, PDGFR 6 23 2.32630161961136 NA 2.74400865836124 3.04360503371436 -0.299596375353121 0.958589667657852 1.1282254759756 0.272660496847836 0.312538707083223 0.265546543428347 0.572493449853171 NA NA 0.906920365252886 0.528155892919515 90.6527999345367 a1141 loss_cnaDLBC2 180 Thapsigargin sarco-endoplasmic reticulum Ca2+-ATPases 4 25 -0.669430653942629 NA -4.61220648665374 -4.08600073097631 -0.526205755677426 2.01030169943101 1.86136745068456 0.28012034202529 0.261754619133219 0.28269848357126 0.573420434723969 NA NA 0.627703439099415 0.65001125451597 90.6527999345367 a1142 loss_cnaDLBC2 263 FR-180204 ERK 4 25 2.99573227355399 NA 4.76610659478345 4.56721943399219 0.198887160791261 0.60089049808686 0.78753292069871 0.258619110125952 0.330987361964428 0.252544567425582 0.574582533368188 NA NA 0.430334748164232 0.584002856852445 90.6527999345367 a1143 MLL2_mut 309 Y-39983 ROCK 9 20 2.99573227355399 NA 2.45697491570632 2.73158668909346 -0.274611773387138 0.806995440196494 1.32245107418558 0.230153345802454 0.340289126441995 0.207653635546598 0.575259563346622 NA NA 0.979199625798607 0.49865502840847 90.6527999345367 a1144 PTEN_mut 257 NPK76-II-72-1 PLK3 6 23 2.32630161961136 NA 0.68883557214347 1.17072281384881 -0.481887241705338 1.61600281438321 1.36219422125954 0.341125185121982 0.298197031228106 0.35375810158684 0.57582788815684 NA NA 0.359501699402223 0.523887009961529 90.6527999345367 a1145 ARID1A_mut 211 TL-2-105 CRAF 3 26 2.32630161961136 1.63315443905142 3.05668917276762 2.87041551254415 0.186273660223469 0.830350490279229 0.733570272224865 0.251322889908247 0.224331366578503 0.253927493079177 0.576249017999851 NA NA 0.14071235114114 0.740419335722222 90.6527999345367 a1146 TP53_mut 91 KIN001-135 IKKE 16 11 1.6094379124341 NA 3.32952326627775 3.43415246815001 -0.104629201872263 0.690157436902694 0.520762894136469 0.166631523250141 0.151601933526676 0.200915240026384 0.576265494067241 NA NA 0.584397137456823 0.657703557163655 90.6527999345367 a1147 loss_cnaDLBC4_(CDKN2A) 32 VX-680 AURKA, AURKB, AURKC, FLT3, ABL1, JAK2 8 16 0.693147180559945 NA 0.0436755471342552 0.805760503061912 -0.762084955927656 1.63679516433162 2.02128122970787 0.399547448930299 0.46559580119413 0.377030640134029 0.576450177279588 NA NA 0.0670554461356319 0.335047726252203 90.6527999345367 a1148 TP53_mut 178 BAY 61-3606 SYK 16 13 2.07944154167984 NA 1.21647803659666 0.913770077484762 0.302707959111901 1.36676041303875 1.13222348380209 0.238749512040483 0.221478436325854 0.267357075208672 0.576967130252419 NA NA 0.746434099805468 0.519734729304233 90.6527999345367 a1149 PTEN_mut 159 HG-6-64-1 BRAFV600E, TAK, MAP4K5 6 24 1.63315443905142 NA 1.00031758024533 0.457985477883682 0.542332102361643 2.15619167694598 1.51690553245917 0.328817995894549 0.251523140618834 0.357525297888807 0.576974629439233 NA NA 0.431488046011473 0.581314808557177 90.6527999345367 a1150 EP300_mut 170 Shikonin unknown 6 24 2.77258872223978 NA -0.140058287917277 -0.436768332054149 0.296710044136872 1.73868833253575 0.896103806021842 0.270921549722008 0.170651656530151 0.331111241959885 0.577043909295888 NA NA 0.882967418732846 0.700434084222034 90.6527999345367 a1151 EP300_mut 1062 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 6 26 1.38629436111989 0.693147180559945 3.0242384365296 2.81532748323189 0.20891095329771 0.745755630231518 0.940664369551747 0.229300382248469 0.280133256564022 0.222088727988349 0.577785719144428 NA NA 0.803507163234406 0.571570605458214 90.6527999345367 a1152 EP300_mut 276 CAY10603 HDAC6 6 23 2.99573227355399 NA -1.13645815471157 -0.73716278612222 -0.399295368589355 1.09797489853971 1.57509529014297 0.266508353760812 0.363665297922941 0.253505531435569 0.57809654197223 NA NA 0.926698739458629 0.48728529781341 90.6527999345367 a1153 PTEN_mut 1028 VX-702 p38 4 26 0.693147180559945 NA 2.32116086602225 1.99664712757075 0.324513738451502 0.626252363136649 0.817983653443364 0.405823299681939 0.518183654950445 0.396723989636513 0.578238458232055 NA NA 0.479122089352499 0.400832020395223 90.6527999345367 a1154 PTEN_mut 274 PXD101, Belinostat HDAC 6 22 2.99573227355399 NA -1.73280733154872 -1.37164674267873 -0.361160588869997 1.14646769535702 1.47229088433025 0.255152532686165 0.315020292619346 0.245305185757698 0.578939240454729 NA NA 0.966466195124943 0.535984872403182 90.6527999345367 a1155 TP53_mut 263 FR-180204 ERK 17 12 2.99573227355399 NA 4.682671496597 4.46995806556579 0.212713431031212 0.610127540721715 0.945334180059589 0.278186743527861 0.348637648416255 0.225014006176951 0.579171970692159 NA NA 0.430401715090347 0.502242587198898 90.6527999345367 a1156 CREBBP_mut 3 Rapamycin MTOR 5 18 -2.30258509299405 NA -3.15046075070752 -3.58723102501185 0.436770274304323 2.38731976241729 1.96712956995846 0.21266400932102 0.182954240642682 0.222034318925695 0.579266711829008 NA NA 0.409754174430716 0.721270105353314 90.6527999345367 a1157 EP300_mut 1011 ABT-263 BCL2, BCL2L1, BCL2L2 6 26 0.693147180559945 NA 0.260647045950789 0.428493552358158 -0.167846506407369 1.218479994544 1.79643162565078 0.0979441477931285 0.137750728086581 0.0934332840786883 0.579297471904797 NA NA 0.125515189186991 0.788272450690225 90.6527999345367 a1158 EP300_mut 288 KIN001-055 JAK3, MNK1 6 23 2.32630161961136 NA 3.9332721392316 3.73040441321863 0.202867726012978 0.618539089156341 0.885238593245324 0.240865293696427 0.32797882877488 0.229167286154183 0.579552402525423 NA NA 0.86541149183199 0.529854988811787 90.6527999345367 a1159 CREBBP_mut 32 VX-680 AURKA, AURKB, AURKC, FLT3, ABL1, JAK2 6 18 0.693147180559945 NA -0.0203606718695014 0.742429803182313 -0.762790475051815 2.06461968203005 1.8661571166249 0.398725652532168 0.369458104895036 0.408749332120215 0.581055052918934 NA NA 0.0671014127530353 0.445775544392245 90.6527999345367 a1160 MLL2_mut 1030 KU-55933 ATM 9 23 2.30258509299405 NA 3.28866232042405 3.0609336470056 0.227728673418454 1.0176549558988 0.857559469672643 0.252182540633491 0.223777884732377 0.265554380159064 0.581304772288999 NA NA 0.615353274967506 0.563019290569829 90.6527999345367 a1161 loss_cnaDLBC4_(CDKN2A) 41 S-Trityl-L-cysteine KIF11 8 17 1.63315443905142 NA 0.172537076296189 0.695883791435302 -0.523346715139113 0.672032872276009 1.47465250817588 0.407398041181032 0.778751660416055 0.354894941172604 0.581724846136801 NA NA 0.026907283839622 0.235262992396177 90.6527999345367 a1162 EP300_mut 176 IPA-3 PAK1, PAK2, PAK3 5 24 3.46573590279973 NA 2.81525081908234 2.85740891148571 -0.0421580924033749 1.5042749485344 1.28424296672206 0.0319583305775653 0.028025523156155 0.0328271935263002 0.582138056699676 NA NA 0.0557868556177678 0.955581321997144 90.6527999345367 a1163 CREBBP_mut 152 CP466722 ATM 6 23 2.77258872223978 NA 1.28443926013096 1.59663400678312 -0.31219474665216 1.58735005396478 0.928634090977032 0.288713958542424 0.19667668506539 0.336187040391436 0.582469591907851 NA NA 0.625199818578822 0.660842543556019 90.6527999345367 a1164 TP53_mut 5 Sunitinib PDGFRA, PDGFRB, KDR, KIT, FLT3 15 10 2.07944154167984 NA 2.111408615489 1.57341124517024 0.537997370318761 1.39213319598596 0.987986479615818 0.430517449954147 0.386455385066608 0.544539203135618 0.582634731183589 NA NA 0.0190014552023648 0.270340181890048 90.6527999345367 a1165 CREBBP_mut 1021 Axitinib PDGFR, KIT, VEGFR 7 23 0.693147180559945 NA 1.8739259174193 1.64301842665844 0.230907490760862 0.698256348395575 0.957389192730348 0.254273396088445 0.330691573791534 0.241184559544008 0.582881405659859 NA NA 0.84669780943199 0.49705450377569 90.6527999345367 a1166 loss_cnaDLBC4_(CDKN2A) 1268 XAV 939 TNKS1 (tankyrase-1) 7 22 1.6094379124341 NA 2.78161091923418 2.93309080092699 -0.151479881692816 0.530689641528776 0.961173373684588 0.171392198926344 0.285439680443814 0.15759891590851 0.583016677654997 NA NA 0.327264180725126 0.603398107493687 90.6527999345367 a1167 ARID1A_mut 147 NSC-87877 PTPN6 (SHP-1), PTPN11 (SHP-2) 3 27 2.77258872223978 NA 4.67080707994851 4.48718584995023 0.183621229998286 0.419660044421973 0.640983275807744 0.292498773991648 0.437547563650478 0.286468051396338 0.583535836095653 NA NA 0.413184325153368 0.545649262206055 90.6527999345367 a1168 loss_cnaDLBC4_(CDKN2A) 1373 Dabrafenib BRAF 7 23 2.30258509299405 NA 2.60089363897573 2.99491370370898 -0.394020064733252 2.06280419962666 1.28984929114402 0.264507227647143 0.191011858907677 0.305477599157169 0.584013832913146 NA NA 0.714603736600487 0.646472470491536 90.6527999345367 a1169 TP53_mut 265 Tubastatin A HDAC6 17 11 2.99573227355399 NA 3.00985778323549 2.78312717982756 0.226730603407931 1.01518661816605 1.32672823562155 0.19800321126888 0.223338841697424 0.170894533876948 0.584013995559197 NA NA 0.865657473249413 0.635318757208442 90.6527999345367 a1170 EP300_mut 262 VX-11e ERK 6 23 1.63315443905142 NA 2.34156604962003 1.94634391028391 0.395222139336119 1.38086337986404 1.25448813026398 0.309048939853759 0.286213788488643 0.315046535556261 0.584024136037983 NA NA 0.543981868519018 0.544204097274064 90.6527999345367 a1171 CREBBP_mut 229 LY317615 PRKCB (PKCbeta) 6 23 2.99573227355399 2.32630161961136 2.33884036348668 2.18196757848263 0.156872785004055 1.18953388741239 0.94730484973243 0.157405786399485 0.131877525023943 0.165599051929655 0.585605216732654 NA NA 0.170406327637221 0.773769986917133 90.6527999345367 a1172 MLL2_mut 111 Salubrinal GADD34-PP1C 9 18 2.77258872223978 NA 2.73361805608756 3.02967684833973 -0.296058792252168 0.702605921614375 1.05748161569954 0.308932821257685 0.42137246946612 0.279965899980513 0.586181606316629 NA NA 0.294627822076473 0.395758525326977 90.6527999345367 a1173 CREBBP_mut 329 QL-XI-92 DDR1 6 23 2.32630161961136 NA 2.15953504121526 2.57118458120392 -0.411649539988661 1.00804600698976 1.34743587549184 0.318778713934218 0.408363841664266 0.305505848163943 0.58640650987511 NA NA 0.291865773847931 0.427563913021501 90.6527999345367 a1174 EP300_mut 1114 Cetuximab EGFR 6 22 4.18661983833127 NA 5.97004966578568 6.0655242180739 -0.0954745522882208 0.655375020332958 0.534329878892522 0.170598490187729 0.145679266566668 0.178680916152595 0.586709666389469 NA NA 0.386148883757614 0.752377462251008 90.6527999345367 a1175 EP300_mut 171 AKT inhibitor VIII AKT1, AKT2, AKT3 6 24 0.940007258491471 NA 1.90025844366442 2.06381802807051 -0.16355958440609 0.872457237739445 0.826436249171892 0.195917196790385 0.187470029854845 0.197909499456225 0.587475944413927 NA NA 0.577553738015517 0.68988181577918 90.6527999345367 a1176 CREBBP_mut 150 Bicalutamide ANDR (androgen receptor) 7 22 0.0237165266173161 NA 2.08029536165661 1.98511501954844 0.0951803421081681 0.519777017102168 0.505857261351277 0.187000862274185 0.183117642713047 0.188156520386633 0.587930278449189 NA NA 0.464899533085793 0.680135655499903 90.6527999345367 a1177 loss_cnaDLBC4_(CDKN2A) 1069 EHT 1864 Rac GTPases 7 21 2.30258509299405 NA 3.67319616221804 3.46852229273148 0.204673869486561 0.668547775333949 0.894948792930671 0.241336819091478 0.306146960678051 0.228698972615315 0.589106832706761 NA NA 0.989274491255254 0.532073170533245 90.6527999345367 a1178 TP53_mut 252 WZ3105 CLK2, CNSK1E, FLT3, ULK1 17 12 0.246860077931526 2.32630161961136 -1.57479398616779 -1.27664730396897 -0.298146682198819 1.29720215977977 1.02182558789117 0.249973852210393 0.229838256089118 0.291778446079169 0.589527141865238 NA NA 0.602143812243652 0.495354427312727 90.6527999345367 a1179 PTEN_mut 163 JQ1 BRD4 6 24 0.940007258491471 NA -0.618032347452008 -0.371700608035021 -0.246331739416987 1.67541350542456 1.4144237789812 0.168208323121343 0.14702742852402 0.174156955699951 0.590045772009569 NA NA 0.413065154590894 0.749904782393067 90.6527999345367 a1180 PTEN_mut 1050 ZM-447439 AURKB 5 27 1.38629436111989 0.693147180559945 1.29628529811825 1.65436422073414 -0.358078922615888 1.74273868926508 1.11256203565391 0.294567360096916 0.205469084276135 0.321850747320734 0.590865970818487 NA NA 0.783050046751363 0.677702527190612 90.6527999345367 a1181 PTEN_mut 106 XMD8-85 MAP2K5 (ERK5) 4 23 2.07944154167984 NA 1.80741325173921 2.02697189834203 -0.219558646602819 0.873488930988361 0.95019485165412 0.233245435156173 0.251358247155332 0.23106697139077 0.591867315155385 NA NA 0.73029250542901 0.669096418071097 90.6527999345367 a1182 TP53_mut 41 S-Trityl-L-cysteine KIF11 15 10 1.63315443905142 NA 0.741652758376496 0.208552968912221 0.533099789464275 1.51986838239137 0.774582180123816 0.416171802551566 0.350753917668512 0.688241742637379 0.592052923801909 NA NA 0.0269590796400527 0.261597557581309 90.6527999345367 a1183 PTEN_mut 1218 JQ1 BRD2, BRD3, BRD4 5 24 0 NA 1.03504808891116 0.667447456975341 0.367600631935817 1.23378725343709 1.56826444832186 0.241310144470921 0.297944909798472 0.234399646264488 0.592141993327356 NA NA 0.851880202379821 0.582464368069243 90.6527999345367 a1184 EP300_mut 257 NPK76-II-72-1 PLK3 6 23 2.32630161961136 NA 1.2491462050138 1.02455482266524 0.224591382348556 1.20824770595749 1.46854310367893 0.157725905317627 0.185881902561178 0.152934824851868 0.594840627061901 NA NA 0.359781334756794 0.707595124342285 90.6527999345367 a1185 TP53_mut 185 OSI-906 IGF1R 16 13 0.940007258491471 NA 2.17755901676741 2.33169347049375 -0.154134453726344 1.72243848448301 1.05490265198429 0.105295144462495 0.089486187817388 0.146112490509351 0.59495709430723 NA NA 0.338900656227244 0.769592929844748 90.6527999345367 a1186 PTEN_mut 1242 (5Z)-7-Oxozeaenol MAP3K7 (TAK1) 5 24 2.30258509299405 NA 1.00019435069506 1.25060950682876 -0.2504151561337 1.5163656492118 0.830374869817927 0.25994562166418 0.165141670324611 0.301568803724283 0.595075351179926 NA NA 0.987235632801762 0.736299923500328 90.6527999345367 a1187 TP53_mut 1 Erlotinib EGFR 15 12 0.693147180559945 NA 2.19905000185666 2.25623891282938 -0.0571889109727164 0.978335652526163 0.647941033184924 0.0673639687777759 0.0584553070564778 0.0882625239701319 0.595678273184205 NA NA 0.188271716927998 0.857135425876883 90.6527999345367 a1188 TP53_mut 294 MPS-1-IN-1 MPS1 17 12 2.99573227355399 NA 2.82044227887233 2.61507917082983 0.205363108042497 0.758800673791716 1.13173335076256 0.221061219566939 0.270641704910857 0.181458916894271 0.596126239633704 NA NA 0.818133178591397 0.590697204403643 90.6527999345367 a1189 ARID1A_mut 192 LFM-A13 BTK 3 26 2.77258872223978 NA 4.400651917513 4.22092912410089 0.179722793412103 0.933241458366176 0.712290598255575 0.24587517821307 0.192579092796352 0.252316672229355 0.596338127673128 NA NA 0.191656315176055 0.774065528282831 90.6527999345367 a1190 TP53_mut 341 EX-527 SIRT1 17 12 2.99573227355399 NA 4.66927960359425 4.77035362699052 -0.101074023396273 0.506615303179068 0.72912201379966 0.166461926140567 0.199508429299356 0.138624292619486 0.596959775993856 NA NA 0.71010851646951 0.683168612734713 90.6527999345367 a1191 TP53_mut 208 SB-715992 KIF11 17 12 -2.05572501506252 NA -3.60220741770343 -3.3442910596336 -0.257916358069821 0.926235165820564 1.35575643171952 0.230022438477253 0.278456668011875 0.190237974930867 0.597226526184576 NA NA 0.734435845980771 0.57466404752812 90.6527999345367 a1192 MLL2_mut 1029 AMG-706 VEGFR, RET, c-KIT, PDGFR 9 23 0.693147180559945 NA 2.7078818235559 2.62083043028613 0.087051393269773 0.619262896434438 0.580196362236764 0.147328307506897 0.140572596503025 0.150037812946937 0.597374183472323 NA NA 0.354017368152481 0.721476791810853 90.6527999345367 a1193 MLL2_mut 1248 FK866 NAMPT 8 20 0 NA -4.64100826608696 -4.23105300855606 -0.409955257530902 3.03978970612237 3.17899094433207 0.130470894103796 0.134863032368727 0.128957667608908 0.597704291635376 NA NA 0.241146697929656 0.755231837287088 90.6527999345367 a1194 loss_cnaDLBC2 60 BI-2536 PLK1, PLK2, PLK3 4 21 -1.36257783450257 NA -2.74880924693294 -2.21199661456621 -0.53681263236673 1.23304748341975 1.30396302881387 0.414548437270197 0.435354387876392 0.411677801060843 0.598415315827607 NA NA 0.0361679138825809 0.469771489250612 90.6527999345367 a1195 loss_cnaDLBC4_(CDKN2A) 261 TL-1-85 MAP3K7 (TAK1) 7 22 2.32630161961136 NA 1.73091485435473 1.48222978986057 0.248685064494159 0.809585689890304 1.32507362886963 0.202290727931419 0.307175716665465 0.187676412144964 0.598539506408337 NA NA 0.6663416643654 0.55826592531631 90.6527999345367 a1196 MLL2_mut 1241 CHIR-99021 GSK3B 9 20 2.30258509299405 NA 3.34108430771393 3.16734047357066 0.173743834143275 1.21356424650415 1.17882869832626 0.146098187131053 0.143168220919303 0.147386837790734 0.598703180763318 NA NA 0.387784241053343 0.723946548264462 90.6527999345367 a1197 PTEN_mut 194 AUY922 HSP90 5 24 -1.36257783450257 NA -3.29710741468527 -3.04251270027372 -0.254594714411545 1.05575150770112 1.22303542124983 0.212210831695751 0.241150225743861 0.208166264024776 0.600287626531563 NA NA 0.706440817548869 0.649277235415283 90.6527999345367 a1198 PTEN_mut 158 PF-562271 FAK 6 24 0.940007258491471 NA 1.47558322450727 1.71281048795976 -0.237227263452497 1.05146842521382 0.840494203217274 0.269002457327234 0.225615204188615 0.282247352265405 0.60045033169042 NA NA 0.767456136967583 0.624340691609723 90.6527999345367 a1199 MLL2_mut 1529 MLN4924 NEDD8-activating enzyme 8 19 0 NA 0.707384803861667 0.295597133599234 0.411787670262433 1.69735563353033 1.45604049759175 0.269590440704751 0.242605416406434 0.282813335853993 0.601649340777998 NA NA 0.555143139196992 0.560346869813029 90.6527999345367 a1200 ARID1A_mut 199 Pazopanib VEGFR, PDGFRA, PDGFRB, KIT 3 26 2.07944154167984 NA 3.1442396571651 2.87599250428461 0.268247152880489 1.11999213976401 0.975819779397125 0.271719313019061 0.239508067384303 0.27489415417078 0.601829064341575 NA NA 0.386102400454604 0.723892289299729 90.6527999345367 a1201 MLL2_mut 1372 Trametinib MAP2K1 (MEK1), MAP2K2 (MEK2) 9 21 0 NA 0.892024052932045 0.523039577324012 0.368984475608033 0.977033488414382 1.88465125974026 0.220124730149528 0.377657961557545 0.195783954034491 0.601929846793148 NA NA 0.896928675701721 0.487917523734847 90.6527999345367 a1202 loss_cnaDLBC4_(CDKN2A) 178 BAY 61-3606 SYK 8 21 2.07944154167984 NA 0.85715046034185 1.1659740909578 -0.308823630615946 1.12777717619056 1.31539394152875 0.243279704910701 0.273833907207716 0.234776534136254 0.602081586420939 NA NA 0.746622266070005 0.539236707470766 90.6527999345367 a1203 ARID1A_mut 180 Thapsigargin sarco-endoplasmic reticulum Ca2+-ATPases 3 26 -0.669430653942629 NA -3.56472328797291 -4.22710285988861 0.662379571915703 1.02306023029688 1.92829343788659 0.353028708416078 0.647449243260573 0.343505588361941 0.602536218839536 NA NA 0.628010823485021 0.399402351649242 90.6527999345367 a1204 ARID1A_mut 167 OSU-03012 PDPK1 (PDK1) 3 26 2.77258872223978 NA 1.14485298667076 1.36833221091686 -0.223479224246105 0.0734571154845874 0.586898444010732 0.395470514658711 3.04230873717053 0.380780059185194 0.602723331229227 NA NA 0.153782795017999 0.0799070939751993 90.6527999345367 a1205 MLL2_mut 1049 PD-173074 FGFR1, FGFR3 9 23 0.693147180559945 NA 2.08009242628502 1.96489653653585 0.115195889749164 0.597229254623101 0.896825048033217 0.139191686857663 0.192883869732506 0.128448564189631 0.602746961231352 NA NA 0.317753946765788 0.677276062730121 90.6527999345367 a1206 CREBBP_mut 184 BMS-754807 IGF1R 7 22 0.940007258491471 NA 1.34647976791826 1.04617533384399 0.300304434074271 1.09077488107644 1.57960949698716 0.202231740622173 0.275312935129119 0.190113084687735 0.603518207382078 NA NA 0.697809710477145 0.581122737812741 90.6527999345367 a1207 loss_cnaDLBC2 305 TPCA-1 IKK 4 25 2.99573227355399 NA 0.778918384516395 1.24524012029559 -0.466321735779194 1.51489719335242 1.53838642816632 0.303635551739564 0.307824014610021 0.303123927279459 0.604453376438908 NA NA 0.766653051092475 0.598515991543742 90.6527999345367 a1208 EP300_mut 1377 Afatinib (rescreen) ERBB2, EGFR 6 24 2.30258509299405 NA 3.4525397681273 3.36085076649585 0.0916890016314418 0.861236272970018 0.999918004817376 0.093886044450586 0.106462076098174 0.0916965203043702 0.60479481883211 NA NA 0.143646384377818 0.826761790470698 90.6527999345367 a1209 EP300_mut 249 XL-184 VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL 6 23 1.63315443905142 NA 1.93737513425118 2.17024186213949 -0.232866727888311 1.27252422711537 1.12276092039715 0.20214744179126 0.182995909175094 0.207405444612322 0.604913615527138 NA NA 0.69269883401371 0.694714828224041 90.6527999345367 a1210 CREBBP_mut 341 EX-527 SIRT1 6 23 2.99573227355399 NA 4.81556409059251 4.68385270614927 0.131711384443238 0.246974369292815 0.661907825621506 0.21703608855206 0.533299810909043 0.19898750149927 0.604939528410427 NA NA 0.710173422151496 0.448806993094781 90.6527999345367 a1211 TP53_mut 59 WZ-1-84 BMX 15 10 2.32630161961136 NA 3.33320996483077 3.46445485006497 -0.131244885234203 1.01769620957629 0.684892673074918 0.145470542554174 0.128962733671619 0.1916283972567 0.605450598605745 NA NA 0.524504630263969 0.703468012898071 90.6527999345367 a1212 loss_cnaDLBC4_(CDKN2A) 294 MPS-1-IN-1 MPS1 7 22 2.99573227355399 NA 2.88527849300363 2.68779633362555 0.197482159378072 0.878761560885262 0.945105722648232 0.212170434716351 0.22472780805197 0.208952453303021 0.605732894343591 NA NA 0.818183709079261 0.621425395578935 90.6527999345367 a1213 TP53_mut 205 BMS-708163 g-secretase 17 12 2.32630161961136 0.940007258491471 4.09233934036416 4.1498281904545 -0.0574888500903485 0.741688796490626 0.509583263448575 0.0874887708418017 0.0775107435387493 0.112815420391353 0.606603278660811 NA NA 0.243855907173461 0.806473786378066 90.6527999345367 a1214 CREBBP_mut 262 VX-11e ERK 6 23 1.63315443905142 NA 2.23111649289245 1.97515683812589 0.255959654766565 1.6188521533799 1.19628845824361 0.19917996091968 0.158111816593111 0.213961484793028 0.607031911904468 NA NA 0.544258156271746 0.728594413146914 90.6527999345367 a1215 PTEN_mut 6 PHA-665752 MET 4 23 0.693147180559945 NA 2.83560298963848 2.5462054659951 0.289397523643375 0.435919345264394 0.727298162738047 0.414148233657289 0.663878597697584 0.397907678680068 0.607889342738507 NA NA 0.365426508941297 0.315066659146465 90.6527999345367 a1216 CREBBP_mut 151 QS11 ARFGAP 7 22 2.32630161961136 NA 2.18967227169154 2.47791477478651 -0.288242503094962 1.02368992444072 1.10843705735891 0.264400494149496 0.281572081753603 0.260044087466512 0.607899058645283 NA NA 0.574201844170014 0.538074101209043 90.6527999345367 a1217 TP53_mut 332 XMD15-27 CAMK2B, CLK2, DYRK1A, MAST1, STK39 17 12 2.32630161961136 NA 3.77479140030605 3.50727865947835 0.267512740827703 0.795166758322105 0.924947981858444 0.314559990558425 0.336423445809262 0.289219227539916 0.60806213487869 NA NA 0.148146584355532 0.425605782209513 90.6527999345367 a1218 ARID1A_mut 273 CUDC-101 HDAC, EGFR 3 25 1.63315443905142 NA -2.56896002513144 -2.07434799743782 -0.494612027693621 1.29113918398147 1.52150039086245 0.328638741236038 0.383081881357199 0.325081761834616 0.610041279835442 NA NA 0.890314896512701 0.586609704183983 90.6527999345367 a1219 TP53_mut 159 HG-6-64-1 BRAFV600E, TAK, MAP4K5 17 13 1.63315443905142 NA 0.482589749918558 0.676117784774219 -0.193528034855661 1.75928440682798 1.52160696423486 0.116471531732842 0.110003836846707 0.127186612183375 0.610221358969515 NA NA 0.431928565181915 0.749531611511825 90.6527999345367 a1220 loss_cnaDLBC4_(CDKN2A) 1007 Docetaxel Microtubules 7 22 -4.38202663467388 NA -4.1935680821105 -4.45651615218429 0.262948070073793 0.837688243157617 1.13609076792655 0.244160345918719 0.313897290813854 0.231449878387527 0.61031805922115 NA NA 0.782594664481253 0.520411102517349 90.6527999345367 a1221 CREBBP_mut 35 NVP-TAE684 ALK 7 19 0.693147180559945 NA 1.07565377108311 0.826421256447808 0.249232514635297 1.08114783174208 2.00612120773976 0.136977919151743 0.230525842366721 0.124236020073832 0.612025259311018 NA NA 0.279874243976152 0.689793353499152 90.6527999345367 a1222 TP53_mut 1001 AICAR AAPK1 (AMPK) agonist 17 13 7.60090245954208 NA 6.55207334240264 6.68085419359273 -0.128780851190092 0.962487955502203 0.59987341215773 0.15575997347343 0.133799961291876 0.21468004512297 0.613024380741866 NA NA 0.73225968454158 0.656830076448795 90.6527999345367 a1223 loss_cnaDLBC4_(CDKN2A) 1199 Tamoxifen ER 7 23 1.6094379124341 NA 3.05343633236737 2.81620637719671 0.237229955170664 0.533297906485946 1.05398739279514 0.245496810210108 0.44483571430805 0.225078551026628 0.613100267333576 NA NA 0.720539280135963 0.435321962454572 90.6527999345367 a1224 loss_cnaDLBC4_(CDKN2A) 308 XL-880 MET 7 22 1.63315443905142 NA -0.264278044939029 -0.449176380320115 0.184898335381085 0.833827708901356 0.865511207446248 0.215355785846046 0.221746451223965 0.213629048116709 0.613387042520118 NA NA 0.907612015442116 0.623148020919758 90.6527999345367 a1225 loss_cnaDLBC4_(CDKN2A) 151 QS11 ARFGAP 8 21 2.32630161961136 NA 2.20959064115564 2.48405265799518 -0.274462016839541 0.49639262473839 1.23225212778492 0.251740986426258 0.552913164219932 0.222732029144807 0.61516803252319 NA NA 0.57428036798647 0.400273491589418 90.6527999345367 a1226 MLL2_mut 53 CGP-60474 CDK1,CDK2,CDK5,CDK7,CDK9 8 17 -1.36257783450257 NA -3.03398651517093 -2.65345443666004 -0.380532078510899 0.570796178218463 1.3329821979313 0.329317201617165 0.666668931979528 0.285474238966927 0.615389284058663 NA NA 0.183114227250209 0.32846449196865 90.6527999345367 a1227 PTEN_mut 1018 ABT-888 PARP1, PARP2 4 26 1.6094379124341 NA 3.73860272403554 3.50060387320659 0.237998850828942 0.523967337338137 0.59566312502016 0.404485174655073 0.454224593536738 0.399552768724582 0.615448675386361 NA NA 0.375206614972971 0.450376988586262 90.6527999345367 a1228 loss_cnaDLBC4_(CDKN2A) 176 IPA-3 PAK1, PAK2, PAK3 8 21 3.46573590279973 NA 2.91146097448509 2.82678000834229 0.0846809661427996 1.58300183020206 1.21262858415539 0.0642165539640618 0.0534939155010266 0.0698325664175077 0.616594736004893 NA NA 0.0560203736674578 0.893837489132922 90.6527999345367 a1229 MLL2_mut 171 AKT inhibitor VIII AKT1, AKT2, AKT3 9 21 0.940007258491471 NA 1.89053884570565 2.09134922496799 -0.200810379262338 0.783420783148358 0.850858781440668 0.241315515399338 0.256325060021174 0.236009057722043 0.616671550791827 NA NA 0.577865744813626 0.539448822603237 90.6527999345367 a1230 ARID1A_mut 344 THZ-2-49 CDK9 3 26 2.99573227355399 NA 0.0457992948633705 0.526602260470728 -0.480802965607357 1.3217606805303 1.66942913877677 0.292069109642767 0.363759470749619 0.288004416862912 0.616714823218582 NA NA 0.724667168547967 0.605902236031705 90.6527999345367 a1231 MLL2_mut 173 FH535 unknown 9 20 3.46573590279973 NA 2.02921374987158 2.11933482751683 -0.0901210776452483 0.573299465585755 0.744641479103601 0.129063273780537 0.157197212024556 0.121026131600587 0.617516134417451 NA NA 0.346709966047707 0.725908071044186 90.6527999345367 a1232 ARID1A_mut 1114 Cetuximab EGFR 3 25 4.18661983833127 NA 6.17306130473295 6.02970587512564 0.143355429607313 0.594901382794866 0.55615380847689 0.256344442791454 0.240973434847007 0.25776220071191 0.617712423815801 NA NA 0.386591872831404 0.723428989808248 90.6527999345367 a1233 TP53_mut 30 Sorafenib PDGFRA, PDGFRB, KDR, KIT, FLT3 16 12 1.38629436111989 NA 1.78737593129003 1.44613469915641 0.341241232133623 1.01874908131716 0.761391104003666 0.371436077626367 0.334961020718099 0.448181270229262 0.617991246248096 NA NA 0.0330301271612229 0.319765676985659 90.6527999345367 a1234 CREBBP_mut 275 I-BET BRD2, BRD3, BRD4 6 23 2.99573227355399 NA 1.64699806909711 1.37220715953877 0.274790909558339 1.33224876026527 1.45229419070567 0.192050860753937 0.20626096098121 0.189211601421348 0.618230768591809 NA NA 0.547103458493266 0.6700519767508 90.6527999345367 a1235 loss_cnaDLBC4_(CDKN2A) 38 AZD-0530 SRC, ABL1 8 19 0.693147180559945 NA 1.89869508447714 2.22051284888159 -0.321817764404444 1.11073819622765 1.04619173889301 0.302273011378627 0.289733229214067 0.307608779959365 0.618596636655942 NA NA 0.232619231688823 0.497184432714898 90.6527999345367 a1236 CREBBP_mut 224 AS605240 PI3Kgamma 6 23 2.99573227355399 2.32630161961136 1.95237118327225 2.33811303748073 -0.385741854208489 1.83334269617815 1.12101967573241 0.300627763867063 0.210403573217719 0.344099093494027 0.618636196177823 NA NA 0.265121944027396 0.640206803617108 90.6527999345367 a1237 PTEN_mut 346 THZ-2-102-1 CDK7 6 23 0.916290731874155 2.99573227355399 -4.11179749358266 -3.67061941505598 -0.441178078526683 0.970616934198352 1.51091047467215 0.309298897639378 0.454533671299542 0.291994850735556 0.619117796569203 NA NA 0.378251001227584 0.400295640836781 90.6527999345367 a1238 EP300_mut 153 Midostaurin KIT 6 24 -0.669430653942629 NA -0.0816733317808252 -0.307082493214506 0.225409161433681 1.21745125320439 0.809292120088609 0.25159496707449 0.18514840807005 0.278526326697708 0.620374934365868 NA NA 0.802657572839444 0.681601872882489 90.6527999345367 a1239 PTEN_mut 151 QS11 ARFGAP 5 24 2.32630161961136 NA 2.25024666947038 2.44127489999134 -0.191028230520959 1.19714375040859 1.07635704976953 0.174440292525918 0.159570001894726 0.177476638037407 0.621566437979353 NA NA 0.574347825037535 0.753678766335769 90.6527999345367 a1240 loss_cnaDLBC2 1036 PLX4720 BRAF 3 29 2.30258509299405 NA 3.15420026450585 3.37272331436839 -0.218523049862549 0.711936929120088 0.817644765686424 0.269440141715173 0.306941585587687 0.267259155850029 0.621626344509286 NA NA 0.50184755950921 0.657355540734055 90.6527999345367 a1241 loss_cnaDLBC2 290 KIN001-260 IKK 4 25 2.99573227355399 NA 2.84880311063886 3.13735356263528 -0.288550451996419 0.300519368780529 1.02782513172296 0.296190180022819 0.960172561147461 0.280738856339032 0.623308741228579 NA NA 0.669073968216555 0.272663981359214 90.6527999345367 a1242 EP300_mut 309 Y-39983 ROCK 6 23 2.99573227355399 NA 2.43307689777251 2.70200202767787 -0.268925129905359 1.32966783908445 1.16233377310961 0.2250248986587 0.202249856693931 0.231366528381859 0.623543215058817 NA NA 0.979229380904772 0.664450551914105 90.6527999345367 a1243 ARID1A_mut 184 BMS-754807 IGF1R 3 26 0.940007258491471 NA 0.681100853289813 1.1691505061587 -0.488049652868888 1.29925428662556 1.49665428194453 0.329110958999282 0.37563828566343 0.326093780478675 0.623561494728985 NA NA 0.697971563468617 0.59242791069176 90.6527999345367 a1244 PTEN_mut 330 XMD13-2 RIPK 6 23 2.32630161961136 NA 2.05157640203017 1.76206155943616 0.289514842594002 0.528005275922838 1.17999308402474 0.265826779635121 0.548318086572135 0.245352999533286 0.623654108924557 NA NA 0.675859957265138 0.387112050257594 90.6527999345367 a1245 TP53_mut 308 XL-880 MET 17 12 1.63315443905142 NA -0.466845989561481 -0.316287071589213 -0.150558917972268 0.818895892902112 0.914308287607224 0.175262563742753 0.183855993511821 0.16466975090676 0.623677575151328 NA NA 0.907638219925676 0.652978613132303 90.6527999345367 a1246 EP300_mut 1018 ABT-888 PARP1, PARP2 5 25 1.6094379124341 NA 3.70118657090472 3.4985671497996 0.202619421105116 0.504130190317678 0.60217326175697 0.343908384825837 0.401918839610529 0.336480269007513 0.624255641973789 NA NA 0.375316543630654 0.455819202590833 90.6527999345367 a1247 ARID1A_mut 1066 AZD6482 PI3Kbeta 3 25 1.6094379124341 NA 1.94300568806053 1.47379274787248 0.469212940188044 2.07032475950128 1.43161243345194 0.314803785241471 0.226637361136072 0.327751372664924 0.625324257319103 NA NA 0.892170835943212 0.73592360188293 90.6527999345367 a1248 loss_cnaDLBC4_(CDKN2A) 5 Sunitinib PDGFRA, PDGFRB, KDR, KIT, FLT3 8 17 2.07944154167984 NA 1.56342491825111 2.05281425517814 -0.489389336927038 1.10072514767705 1.31980417241357 0.389276734291638 0.444606301545702 0.370804508090071 0.626036372342317 NA NA 0.01916027162549 0.345558238205803 90.6527999345367 a1249 CREBBP_mut 1133 JNJ-26854165 MDM2 6 24 2.30258509299405 NA 2.78773002261806 2.61287462045431 0.174855402163757 0.775663801629426 0.917612075860057 0.195605451989515 0.225426791602807 0.190554818058458 0.626202809708793 NA NA 0.629971320597592 0.646078041592797 90.6527999345367 a1250 ARID1A_mut 110 Roscovitine CDKs 3 25 2.77258872223978 NA 3.0479235673531 3.38112768825616 -0.333204120903059 0.25939178018919 1.00379084964195 0.344542790534607 1.28455928965842 0.331945764420858 0.626246560577856 NA NA 0.494045739503212 0.20748702113024 90.6527999345367 a1251 EP300_mut 1004 Vinblastine Microtubules 5 25 -2.30258509299405 NA -4.70424757728744 -5.02459049331727 0.320342916029832 1.24227210877327 1.23890250127579 0.258469371624997 0.257868556950995 0.258569916276666 0.626925965406609 NA NA 0.866083607576384 0.618275337977977 90.6527999345367 a1252 CREBBP_mut 1498 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 6 24 1.38629436111989 NA 2.72512061296839 2.56949288117686 0.155627731791533 0.850145594904789 0.848574126580353 0.183338425590759 0.183060093146706 0.183399100817147 0.627450470844952 NA NA 0.514327612027318 0.699170444800237 90.6527999345367 a1253 CREBBP_mut 1373 Dabrafenib BRAF 6 24 2.30258509299405 NA 2.6074910909874 2.97684683800884 -0.36935574702144 1.46898495947459 1.49668300382698 0.247594868840394 0.251436030463884 0.246782883267202 0.629049086357445 NA NA 0.71494471597418 0.598473047613051 90.6527999345367 a1254 loss_cnaDLBC4_(CDKN2A) 1016 Temsirolimus MTOR 8 22 -1.6094379124341 NA -3.12646791537808 -3.4488530230124 0.322385107634315 1.85044526901134 1.89890836815243 0.170853527218984 0.174220287966993 0.169773914866668 0.629224394247738 NA NA 0.651891796827152 0.68216146550282 90.6527999345367 a1255 PTEN_mut 164 JQ12 HDAC 6 24 1.63315443905142 NA 0.348631817172796 0.576459427791875 -0.227827610619079 2.14790452942665 1.42596491476204 0.144260835110707 0.106069710034968 0.159770838861837 0.629405806271008 NA NA 0.422465942832423 0.81325811908005 90.6527999345367 a1256 loss_cnaDLBC4_(CDKN2A) 301 PHA-793887 CDK-pan 7 22 2.32630161961136 NA -0.48643964933613 -0.0512566667404992 -0.435182982595631 1.16725944703882 1.95971716865745 0.239930510172035 0.372824553872433 0.222064178216984 0.630139219823259 NA NA 0.688874593742748 0.483286719050419 90.6527999345367 a1257 loss_cnaDLBC4_(CDKN2A) 260 NG-25 MAP3K7 (TAK1) 7 22 2.32630161961136 NA 0.986427719009578 0.780213851805721 0.206213867203857 1.09139985443749 1.56422442515336 0.140059209391846 0.188944378511155 0.131831381666118 0.630500304576693 NA NA 0.315383540322208 0.703064300806387 90.6527999345367 a1258 EP300_mut 1262 UNC1215 LMBL3 6 24 0 NA 1.67541882689268 1.75590869924201 -0.0804898723493244 0.395226069132042 0.505055067885514 0.165188158879384 0.20365527133898 0.159368507450696 0.631143578466972 NA NA 0.562820947042343 0.683498614665013 90.6527999345367 a1259 ARID1A_mut 1053 MK-2206 AKT1, AKT2 3 29 1.38629436111989 0.693147180559945 1.28400595696878 0.649379419927817 0.634626537040961 1.68617319739774 1.80792450444439 0.352557769559114 0.37637090781681 0.351024910321682 0.631342128901057 NA NA 0.229840723325722 0.589179973075018 90.6527999345367 a1260 ARID1A_mut 330 XMD13-2 RIPK 3 26 2.32630161961136 NA 1.50554920710991 1.85847025607242 -0.352921048962517 1.10946332732014 1.08864002826706 0.323722528198887 0.318100689109736 0.324185258486509 0.631462798365457 NA NA 0.675923750282058 0.644421375606625 90.6527999345367 a1261 ARID1A_mut 308 XL-880 MET 3 26 1.63315443905142 NA -0.640117185727715 -0.377364427862792 -0.262752757864923 0.955976899998389 0.850199661131762 0.306066675468464 0.274852622344082 0.309048297567132 0.632532800228947 NA NA 0.907660005286493 0.686860669571418 90.6527999345367 a1262 MLL2_mut 1236 UNC0638 G9a(EHMT2), GLP(EHMT1) 9 21 2.99573227355399 NA 2.42115397700565 2.10596157591974 0.315192401085906 0.483803339021229 1.69890084668575 0.21604270892221 0.651488684893255 0.185527249398215 0.632947167368476 NA NA 0.745200012914239 0.442661878224086 90.6527999345367 a1263 TP53_mut 1020 Lenalidomide TNFA 17 13 1.6094379124341 NA 3.06680525029093 3.14147987600296 -0.0746746257120283 0.724601350343672 0.98888689083848 0.0880583678568084 0.103056150359933 0.0755138190260683 0.633561133209196 NA NA 0.335367563901444 0.820876338134692 90.6527999345367 a1264 loss_cnaDLBC4_(CDKN2A) 255 CP724714 ERBB2 7 22 2.32630161961136 NA 3.8760714329806 3.70487181704973 0.171199615930866 0.930907240766756 0.845419747515553 0.197884936852314 0.183906202931513 0.202502504151307 0.633923330142396 NA NA 0.856078432475427 0.674765334733226 90.6527999345367 a1265 EP300_mut 41 S-Trityl-L-cysteine KIF11 5 20 1.63315443905142 NA 1.00172501126856 0.410084800421343 0.591640210847216 1.7966799209215 1.15011627295073 0.460016972290653 0.329296389389029 0.51441773737303 0.634238038968267 NA NA 0.0271528383858408 0.515329422157311 90.6527999345367 a1266 ARID1A_mut 173 FH535 unknown 3 26 3.46573590279973 NA 2.30757692229332 2.06641882816542 0.241158094127898 0.40907363713258 0.713414656246381 0.346763875309814 0.589522453263688 0.338033557365849 0.634979754448156 NA NA 0.346933015786684 0.434179097492757 90.6527999345367 a1267 MLL2_mut 83 JW-7-52-1 MTOR 8 17 0.182321556793955 NA -2.00801847075204 -2.16048069194483 0.152462221192781 1.50641056192551 1.89194240423541 0.0854871910419874 0.101208943329435 0.0805850224887768 0.635545700884319 NA NA 0.200014919466043 0.83087089437375 90.6527999345367 a1268 TP53_mut 1241 CHIR-99021 GSK3B 18 11 2.30258509299405 NA 3.17257862222089 3.30092300371478 -0.128344381493898 1.10568223449854 1.32200026686792 0.107816880679652 0.116077094746942 0.09708347623709 0.635968797763872 NA NA 0.388269259148611 0.790545262637324 90.6527999345367 a1269 loss_cnaDLBC4_(CDKN2A) 1371 PLX4720 (rescreen) BRAF 7 23 2.30258509299405 NA 3.551386004719 3.33132984191413 0.220056162804874 0.610511566096391 0.814964058535203 0.283686245187369 0.360445526383574 0.270019469570717 0.636297303734459 NA NA 0.210212226437823 0.456055753985434 90.6527999345367 a1270 EP300_mut 272 AR-42 HDAC 6 22 1.63315443905142 NA -2.04213169298591 -1.74248926423116 -0.29964242875475 0.883821877197801 1.43927133454721 0.221905269048299 0.339030336864687 0.20819036797465 0.636761426499081 NA NA 0.985905814539295 0.537785983790193 90.6527999345367 a1271 TP53_mut 1024 CEP-701 FLT3, JAK2, NTRK1, RET 17 13 0.693147180559945 NA -1.84958078830974 -1.64903603864719 -0.200544749662546 1.22896710659575 1.33235562370625 0.157375906185361 0.163181543742092 0.150518935105843 0.63743176333544 NA NA 0.854194949184962 0.676360709995096 90.6527999345367 a1272 ARID1A_mut 1069 EHT 1864 Rac GTPases 3 25 2.30258509299405 NA 3.74460760808607 3.49270073834516 0.251906869740911 1.0743097913089 0.827699524446732 0.296634657152061 0.234482522433307 0.304345794942066 0.637527636231692 NA NA 0.989289743371704 0.728270599131616 90.6527999345367 a1273 PTEN_mut 1038 NU-7441 PRKDC (DNAPK) 5 27 0.693147180559945 NA 1.60241244343951 1.78600116421619 -0.183588720776674 1.252674067169 0.996140712380773 0.177546990327416 0.146557453042497 0.184299987436411 0.638017021824342 NA NA 0.682949284500073 0.769067653730331 90.6527999345367 a1274 TP53_mut 32 VX-680 AURKA, AURKB, AURKC, FLT3, ABL1, JAK2 14 10 0.693147180559945 NA 0.851725311985671 0.131741805826524 0.719983506159147 2.07061454412909 1.6456735684711 0.377300984544374 0.347714888896414 0.437500802074645 0.638174519697422 NA NA 0.06761544889714 0.353688795210468 90.6527999345367 a1275 ARID1A_mut 1047 Nutlin-3a MDM2 3 29 2.07944154167984 1.38629436111989 2.12791794186035 2.56405483914048 -0.436136897280123 1.93633887356636 1.11533695974369 0.36716265784494 0.225237897784308 0.391035994521647 0.638875930610256 NA NA 0.0699862755809067 0.736070211263155 90.6527999345367 a1276 ARID1A_mut 35 NVP-TAE684 ALK 3 23 0.693147180559945 NA 0.316876497933416 0.968736990273471 -0.651860492340056 0.527855892038188 1.88399352436936 0.360101879853643 1.23492131502607 0.345999327443685 0.639132403870142 NA NA 0.280263243164711 0.215790187467326 90.6527999345367 a1277 loss_cnaDLBC4_(CDKN2A) 1031 Elesclomol HSP70 8 22 -1.6094379124341 NA -3.09241483368566 -2.79393388170428 -0.298480951981386 1.31550843790041 1.33266752639783 0.224692322670362 0.226893985155862 0.223972555846823 0.639283662706732 NA NA 0.677694262375525 0.593490484000038 90.6527999345367 a1278 PTEN_mut 1069 EHT 1864 Rac GTPases 5 23 2.30258509299405 NA 3.68012835447776 3.48481302219559 0.195315332282177 0.852815886985154 0.848915727175086 0.229913411165504 0.229024031168849 0.230076232575079 0.640184514906293 NA NA 0.989290505791326 0.659032530538562 90.6527999345367 a1279 CREBBP_mut 1029 AMG-706 VEGFR, RET, c-KIT, PDGFR 7 25 0.693147180559945 NA 2.71218584570857 2.62658941554496 0.0855964301636138 0.357423745853056 0.636269910020135 0.144804018274296 0.239481654917254 0.13452848989968 0.640766746030656 NA NA 0.354526594876072 0.650215207268035 90.6527999345367 a1280 CREBBP_mut 253 XMD14-99 EPHB3, CAMK1 6 23 2.32630161961136 NA 2.98593920916782 3.23659601072312 -0.250656801555305 0.693375915011386 0.937189981163622 0.279422563209553 0.361502031046448 0.267455699050568 0.641208628532472 NA NA 0.318713614813662 0.482314836480908 90.6527999345367 a1281 ARID1A_mut 223 ZSTK474 PI3K 3 26 1.63315443905142 2.32630161961136 -0.229554174849743 -0.759934697029254 0.530380522179511 2.29523113682399 1.81583300910734 0.285827547507316 0.231079351299417 0.292086617832906 0.641300213783061 NA NA 0.921635661906833 0.732008556269887 90.6527999345367 a1282 PTEN_mut 1375 Temozolomide DNA akylating agent 5 25 3.40119738166216 NA 4.35626817478018 4.65045902836627 -0.294190853586092 1.08416625608126 0.802709841340278 0.346656523326239 0.27135215833912 0.366497130637995 0.642031347584401 NA NA 0.307499077153682 0.589976282361426 90.6527999345367 a1283 PTEN_mut 300 CX-5461 RNA Pol I 6 23 2.32630161961136 NA 1.96995042243697 1.55091454226636 0.419035880170608 1.74717496853714 1.41754333945032 0.282346327565914 0.239836242915873 0.29560710315432 0.642533405982411 NA NA 0.45656777964344 0.604596373812358 90.6527999345367 a1284 loss_cnaDLBC4_(CDKN2A) 157 JNK-9L JNK 8 22 1.63315443905142 NA -0.690956311082651 -0.576512958029431 -0.11444335305322 0.486901856350226 0.856837130661887 0.146542220532318 0.235043985888814 0.133564885271504 0.642838827377261 NA NA 0.498125065775874 0.652858591409034 90.6527999345367 a1285 EP300_mut 222 BX-912 PDPK1 (PDK1) 6 23 2.32630161961136 NA 0.88533920817987 1.05627409175702 -0.170934883577149 1.63184271440909 1.49597944479807 0.112305358913677 0.104749607341321 0.114262855797609 0.643954964950642 NA NA 0.291496748784665 0.822585593976018 90.6527999345367 a1286 EP300_mut 308 XL-880 MET 6 23 1.63315443905142 NA -0.54269564845025 -0.368506643083227 -0.174189005367023 0.624857416934802 0.904228507827544 0.202693216379628 0.278766004285419 0.192638258868348 0.644782636210116 NA NA 0.907689007103127 0.593702994918345 90.6527999345367 a1287 PTEN_mut 180 Thapsigargin sarco-endoplasmic reticulum Ca2+-ATPases 5 24 -0.669430653942629 NA -3.89729725553662 -4.21301491430582 0.315717658769195 2.34619957160391 1.79128569855954 0.167592802882175 0.13456555980588 0.176251984272011 0.645453788220793 NA NA 0.62840985220607 0.787656272727567 90.6527999345367 a1288 CREBBP_mut 53 CGP-60474 CDK1,CDK2,CDK5,CDK7,CDK9 6 19 -1.36257783450257 NA -3.05474962855452 -2.68695367227689 -0.367795956277631 0.842374750581646 1.2322751094453 0.317413294127515 0.436617973204531 0.298469029730862 0.645848964851382 NA NA 0.183517339779192 0.424244978452746 90.6527999345367 a1289 loss_cnaDLBC4_(CDKN2A) 63 BMS-509744 ITK 8 17 2.32630161961136 NA 2.79559675741797 2.76109361657139 0.0345031408465797 0.767418191718812 0.90431890632217 0.0398903158061728 0.0449600246891488 0.0381537316154349 0.646089343901875 NA NA 0.0903828992376286 0.922440596775528 90.6527999345367 a1290 ARID1A_mut 345 KIN001-270 CDK9 3 26 2.99573227355399 NA 3.89760008623621 3.5999975959155 0.297602490320708 1.19259598305087 1.08744665563975 0.271638809397422 0.249541751397978 0.273670886546271 0.646993535123982 NA NA 0.801890473079334 0.713726383177518 90.6527999345367 a1291 loss_cnaDLBC4_(CDKN2A) 201 Epothilone B Microtubules 8 21 -3.44201937618241 NA -5.07376495049764 -4.84018362492067 -0.233581325576963 0.818810798709659 1.54867690152891 0.167253335257122 0.28526898514902 0.150826376596928 0.649595625854037 NA NA 0.738005990858138 0.604522418396564 90.6527999345367 a1292 PTEN_mut 35 NVP-TAE684 ALK 4 22 0.693147180559945 NA 1.51544333267077 0.780445769973045 0.73499756269773 1.01216714450259 1.88819071956343 0.407849739092215 0.726162241769794 0.3892602347223 0.649689871743622 NA NA 0.280404743108836 0.290427719898662 90.6527999345367 a1293 PTEN_mut 223 ZSTK474 PI3K 6 23 1.63315443905142 2.32630161961136 -1.00104011719062 -0.627857562789832 -0.373182554400786 1.77177836096955 1.87526138932173 0.201010450462001 0.210625980439547 0.199002953148715 0.649954358200432 NA NA 0.921652635655979 0.661718207109178 90.6527999345367 a1294 CREBBP_mut 255 CP724714 ERBB2 6 23 2.32630161961136 NA 3.88340938758012 3.71040102958598 0.173008357994136 0.803382587897097 0.878920965176379 0.1999102949051 0.215349897546318 0.196841769452407 0.650520279293959 NA NA 0.856138471241479 0.656824539111248 90.6527999345367 a1295 CREBBP_mut 346 THZ-2-102-1 CDK7 6 23 0.916290731874155 2.99573227355399 -3.93352329702219 -3.71712572720219 -0.216397569820003 1.27473468864184 1.46956744299715 0.150748879052986 0.169758908852291 0.147252561188117 0.651320750368273 NA NA 0.378645707116134 0.728523120357535 90.6527999345367 a1296 loss_cnaDLBC4_(CDKN2A) 1036 PLX4720 BRAF 8 24 2.30258509299405 NA 3.49070396539681 3.30608104945944 0.184622915937371 0.801962154934239 0.811767292604609 0.228073113284283 0.230214000500448 0.227433302153622 0.651426131775888 NA NA 0.502141353716793 0.584202526968046 90.6527999345367 a1297 PTEN_mut 184 BMS-754807 IGF1R 5 24 0.940007258491471 NA 1.4476034789019 1.05013326356192 0.397470215339971 1.22574578554809 1.5230489739913 0.268059197920574 0.324268066042947 0.260970081807915 0.652032809254426 NA NA 0.698182247966509 0.548645813240974 90.6527999345367 a1298 MLL2_mut 288 KIN001-055 JAK3, MNK1 9 20 2.32630161961136 NA 3.67344244644832 3.81689761606916 -0.14345516962084 1.1127975492869 0.700178790087349 0.170022605496239 0.128913987735476 0.20488362637055 0.652879297858047 NA NA 0.865684592090906 0.728378694258116 90.6527999345367 a1299 CREBBP_mut 127 GSK269962A ROCK1, ROCK2 7 21 0.916290731874155 NA 1.26299555930648 1.56899112966245 -0.305995570355966 1.36107530860302 1.11504098068618 0.260113132667102 0.224818985710668 0.274425402883094 0.652915248141807 NA NA 0.381404493362695 0.60403544536148 90.6527999345367 a1300 loss_cnaDLBC4_(CDKN2A) 1037 BX-795 TBK1, PDPK1, IKK, AURKB, AURKC 8 24 1.6094379124341 NA 1.09682026552691 1.30827528884693 -0.211455023320025 0.502272798833775 1.35682209903886 0.174389013667307 0.420996366538266 0.155845798406302 0.653529793784475 NA NA 0.852156896136701 0.52538014964462 90.6527999345367 a1301 CREBBP_mut 1072 BMS-708163 g-secretase 6 22 1.6094379124341 NA 3.21398151142562 3.40577329347148 -0.191791782045859 0.63745034431488 0.692093253234162 0.281250494604291 0.300873289592451 0.277118410199222 0.654206353757287 NA NA 0.270290550165827 0.538312240767804 90.6527999345367 a1302 PTEN_mut 282 EKB-569 EGFR 6 23 0.916290731874155 2.99573227355399 0.112642990537602 0.36672319920837 -0.254080208670768 1.09699515454374 1.40079603573343 0.188248612192924 0.231614704603179 0.181382729668946 0.655030930140281 NA NA 0.842496217931213 0.645101295570874 90.6527999345367 a1303 EP300_mut 202 GSK-1904529A IGF1R 5 24 0.0237165266173161 NA 2.07301535999265 1.87372039929778 0.199294960694874 0.446477414377159 0.816848202242574 0.257735251154112 0.446371875210961 0.243980411718762 0.655380906420815 NA NA 0.749481249158063 0.460285512704571 90.6527999345367 a1304 EP300_mut 221 TAK-715 p38a 6 23 2.99573227355399 2.32630161961136 2.79638207794879 2.7898851313403 0.00649694660848876 1.158375013356 0.408180844303692 0.0104810576570334 0.00560867295442265 0.0159168336759452 0.655399824330059 NA NA 0.0252843345844413 0.989703856563175 90.6527999345367 a1305 PTEN_mut 1526 RDEA119 (rescreen) MAP2K1 (MEK1), MAP2K2 (MEK2) 5 22 1.6094379124341 NA 2.70069644719707 2.92632470144472 -0.225628254247649 0.879362472432796 0.9470431414161 0.24091607263978 0.256581627395854 0.238244958841336 0.656243229968964 NA NA 0.870502595685825 0.627153747519983 90.6527999345367 a1306 loss_cnaDLBC4_(CDKN2A) 1012 Vorinostat HDAC inhibitor Class I, IIa, IIb, IV 8 22 2.30258509299405 NA -0.171698621367563 -0.0255707062797729 -0.146127915087791 0.573920477965048 0.670503699274669 0.225607184634161 0.254613523472654 0.217937522560826 0.657397461159412 NA NA 0.553592681154014 0.565114110535642 90.6527999345367 a1307 ARID1A_mut 45 Z-LLNle-CHO g-secretase 3 22 0.940007258491471 NA -0.141252281829672 0.141249174863461 -0.282501456693133 0.103190540603835 0.78544065576915 0.376101373264515 2.73766815291435 0.359672566753616 0.657623107168686 NA NA 0.0991503135906876 0.125729070629112 90.6527999345367 a1308 EP300_mut 180 Thapsigargin sarco-endoplasmic reticulum Ca2+-ATPases 5 24 -0.669430653942629 NA -3.91013347960922 -4.21034070095736 0.300207221348134 2.33715966061943 1.79381887736273 0.159326515561174 0.128449599061011 0.16735648461315 0.657625485974492 NA NA 0.628512116902891 0.797112414519414 90.6527999345367 a1309 PTEN_mut 1236 UNC0638 G9a(EHMT2), GLP(EHMT1) 5 25 2.99573227355399 NA 1.88970669484334 2.26268181652595 -0.372975121682606 0.57008655859364 1.55916733788959 0.255549640776078 0.654242967248179 0.239214298952314 0.658303005473572 NA NA 0.74535043557976 0.366606432723251 90.6527999345367 a1310 CREBBP_mut 330 XMD13-2 RIPK 6 23 2.32630161961136 NA 1.61977821807572 1.87470456394602 -0.254926345870299 0.815996391190256 1.14389187602669 0.233741526718047 0.312411119243371 0.222858778187836 0.65844286069308 NA NA 0.676130661893144 0.546723327930393 90.6527999345367 a1311 loss_cnaDLBC2 111 Salubrinal GADD34-PP1C 3 24 2.77258872223978 NA 2.64159649378182 2.9671648455649 -0.325568351783076 0.117889469021268 1.00380238447476 0.337940123815964 2.76164066634604 0.324335105015146 0.658450933131477 NA NA 0.295640885147066 0.144179114079763 90.6527999345367 a1312 PTEN_mut 63 BMS-509744 ITK 4 21 2.32630161961136 NA 3.11762467492361 2.70632699244585 0.411297682477753 0.832583776205648 0.853395851555385 0.483475720565689 0.494001557839824 0.481954161984885 0.658898030363055 NA NA 0.0904951543212331 0.414834476793506 90.6527999345367 a1313 MLL2_mut 262 VX-11e ERK 9 20 1.63315443905142 NA 2.14576858608666 1.97516944797351 0.17059913811315 1.23709528634432 1.30738034370245 0.132560258961984 0.137902989362509 0.130489294056556 0.658913769723645 NA NA 0.544803850132298 0.740039557023305 90.6527999345367 a1314 TP53_mut 1170 CCT018159 HSP90 18 12 2.30258509299405 NA 2.91318671785355 2.73275944996774 0.180427267885812 0.910534559808252 0.868393683816033 0.201771439739725 0.198155320896121 0.207771280754772 0.659122671356301 NA NA 0.658621275298319 0.589497167191048 90.6527999345367 a1315 CREBBP_mut 1008 Methotrexate Dihydrofolate reductase (DHFR) 7 23 -1.6094379124341 NA -2.66847247085271 -2.53939215132768 -0.129080319525026 1.1232249362903 1.40263483400499 0.0957819999020885 0.114919385560779 0.092027031124315 0.659427390061019 NA NA 0.158283282151027 0.806427084382841 90.6527999345367 a1316 MLL2_mut 127 GSK269962A ROCK1, ROCK2 9 19 0.916290731874155 NA 1.29509539381738 1.5859960049316 -0.290900611114227 1.3456508662221 1.09214474831382 0.247368328945489 0.216178370197113 0.266357194468363 0.660151805367846 NA NA 0.381489670127703 0.580762794466273 90.6527999345367 a1317 CREBBP_mut 1061 SB590885 BRAF 7 25 1.6094379124341 NA 3.35556997063612 3.20545170521881 0.150118265417303 0.472669176231635 0.873030245239426 0.185567696418645 0.317596900678237 0.171950818698307 0.660281762101714 NA NA 0.924423638608197 0.555106661005812 90.6527999345367 a1318 loss_cnaDLBC4_(CDKN2A) 1061 SB590885 BRAF 8 24 1.6094379124341 NA 3.34522328068424 3.20264567414372 0.142577606540522 0.880285717368515 0.786013896529786 0.176240657549639 0.161967420040321 0.181393238936353 0.660440164789458 NA NA 0.924423892540952 0.691694876996807 90.6527999345367 a1319 CREBBP_mut 252 WZ3105 CLK2, CNSK1E, FLT3, ULK1 6 23 0.246860077931526 2.32630161961136 -1.61299207469354 -1.40927447670952 -0.20371759798402 0.929360656311534 1.25260456431371 0.169858715277821 0.219201874536564 0.162635203309861 0.661068525941294 NA NA 0.602843262439113 0.667407067856043 90.6527999345367 a1320 MLL2_mut 1377 Afatinib (rescreen) ERBB2, EGFR 9 21 2.30258509299405 NA 3.33334964961368 3.39883381705434 -0.0654841674406614 0.816363045629304 1.03408453397208 0.0670365543257215 0.0802145170475987 0.0633257391338467 0.661680680109799 NA NA 0.144201030521588 0.854988173409966 90.6527999345367 a1321 EP300_mut 1371 PLX4720 (rescreen) BRAF 6 24 2.30258509299405 NA 3.43223241960309 3.37028724497665 0.0619451746264428 0.826786659029033 0.770984329173251 0.0792906949160281 0.0749228037849454 0.0803455690115886 0.661786739348338 NA NA 0.210481724347871 0.872388835998974 90.6527999345367 a1322 TP53_mut 88 MS-275 HDAC 16 13 1.6094379124341 NA 0.210062979015379 -0.247537050873114 0.457600029888493 1.41148950652295 1.54651525659046 0.310652257433734 0.324196551071599 0.295891054380766 0.661849293187484 NA NA 0.094700720801712 0.417898326839028 90.6527999345367 a1323 MLL2_mut 301 PHA-793887 CDK-pan 9 20 2.32630161961136 NA -0.416229043968126 -0.0393331408965379 -0.376895903071588 1.62018917018213 1.89110362918912 0.207650058265011 0.232624628042181 0.199299444649258 0.661992592351999 NA NA 0.689109377981733 0.589441115628042 90.6527999345367 a1324 TP53_mut 1375 Temozolomide DNA akylating agent 18 12 3.40119738166216 NA 4.62736066912989 4.5625270448933 0.0648336242365914 0.610270575693422 1.13477832498955 0.0757778144623337 0.10623750647477 0.0571332945024205 0.662226376840942 NA NA 0.307725175439971 0.858580241531489 90.6527999345367 a1325 PTEN_mut 290 KIN001-260 IKK 6 23 2.99573227355399 NA 3.28397094035892 3.04892286375148 0.235048076607442 0.566109195505999 1.04548665018118 0.241157390327328 0.415199185021808 0.224821690995967 0.662901202271422 NA NA 0.669385299721532 0.470725807924938 90.6527999345367 a1326 EP300_mut 52 GNF-2 ABL [T315I] 5 20 0.246860077931526 NA 2.18053402809813 2.25903710997227 -0.0785030818741395 0.419152465895084 0.623425437210178 0.13238822130525 0.187290039452587 0.125922166771763 0.663252411285888 NA NA 0.457122009836904 0.744479920365242 90.6527999345367 a1327 ARID1A_mut 332 XMD15-27 CAMK2B, CLK2, DYRK1A, MAST1, STK39 3 26 2.32630161961136 NA 3.3999423526654 3.69457579465181 -0.294633441986407 0.647756837286961 0.870820409523936 0.34408047936166 0.454851921317323 0.338340074215162 0.663760878468554 NA NA 0.148712101827254 0.526795648603962 90.6527999345367 a1328 loss_cnaDLBC2 1012 Vorinostat HDAC inhibitor Class I, IIa, IIb, IV 3 27 2.30258509299405 NA -0.241144445710914 -0.0449152285912136 -0.196229217119701 0.167777441608392 0.671158041556713 0.302684295559212 1.16958045872292 0.2923740832555 0.663779913072083 NA NA 0.55365017385579 0.246817323902729 90.6527999345367 a1329 TP53_mut 282 EKB-569 EGFR 17 12 0.916290731874155 2.99573227355399 0.415658560660161 0.17035799948295 0.24530056117721 1.2554885835893 1.47247274654636 0.181958591524107 0.195382550174948 0.166590900750153 0.663986761615931 NA NA 0.842529401321771 0.64373402460499 90.6527999345367 a1330 loss_cnaDLBC4_(CDKN2A) 281 CH5424802 ALK 7 22 1.63315443905142 NA 3.16743748318798 2.976014493642 0.191422989545978 0.617104734259103 1.40382877684108 0.150515991243366 0.310195302221755 0.136357789998237 0.664499408335409 NA NA 0.561097389492468 0.618588567773763 90.6527999345367 a1331 EP300_mut 1527 GDC0941 (rescreen) PI3K 6 21 1.38629436111989 NA 0.894472192210579 0.786362495552106 0.108109696658473 1.39720460871201 1.53203156608799 0.0717844565663858 0.07737570860014 0.070566233132212 0.664562334815491 NA NA 0.162620660457406 0.873820007004429 90.6527999345367 a1332 loss_cnaDLBC2 231 FMK RSK 4 24 2.99573227355399 2.32630161961136 4.65250742299793 4.55300907616663 0.099498346831294 0.580877292113045 0.718279049818856 0.141373974380437 0.171289785609196 0.138523247832979 0.664764998587722 NA NA 0.151684410686538 0.772861387918687 90.6527999345367 a1333 CREBBP_mut 176 IPA-3 PAK1, PAK2, PAK3 7 22 3.46573590279973 NA 2.54675152496254 2.94667305892414 -0.399921533961604 1.10583548819712 1.35936981496178 0.30591761724084 0.361646500071731 0.294196273567283 0.665673467401057 NA NA 0.0563079371784874 0.446531338849536 90.6527999345367 a1334 loss_cnaDLBC2 5 Sunitinib PDGFRA, PDGFRB, KDR, KIT, FLT3 4 21 2.07944154167984 NA 1.49676911362492 1.97229358235893 -0.475524468734015 0.873549357594696 1.31539252324524 0.375453771576654 0.544359016007251 0.361507656711349 0.665720866985172 NA NA 0.019286082956661 0.398079169375907 90.6527999345367 a1335 loss_cnaDLBC2 119 Lapatinib ERBB2, EGFR 4 24 0.693147180559945 NA 2.34058055721739 2.54810115651717 -0.207520599299776 0.62751064657286 0.716484743554002 0.293609834713497 0.330704507458394 0.28963715022096 0.666923879253004 NA NA 0.344475205839636 0.578252664772825 90.6527999345367 a1336 CREBBP_mut 235 QL-XII-47 BTK, BMX 6 22 2.32630161961136 NA 0.431884908089789 0.26504329443093 0.16684161365886 1.40859071009482 1.20409876511118 0.133898204913872 0.118445771694483 0.138561402513734 0.667726861308116 NA NA 0.346568463550855 0.798564498241726 90.6527999345367 a1337 CREBBP_mut 203 BMS-345541 IKBKB 6 23 2.77258872223978 NA 1.95223873069699 1.84733330559529 0.104905425101704 0.747338538432854 0.681468459320044 0.151130421718592 0.140372026473689 0.153940250156811 0.667817367677226 NA NA 0.467607234036913 0.763958002730308 90.6527999345367 a1338 loss_cnaDLBC2 157 JNK-9L JNK 4 26 1.63315443905142 NA -0.738652926672125 -0.586781686870008 -0.151871239802117 0.212204116896515 0.8231371344942 0.194485586164428 0.715684700293442 0.184502962432182 0.668173405370251 NA NA 0.498376580112804 0.440951673440964 90.6527999345367 a1339 EP300_mut 208 SB-715992 KIF11 6 23 -2.05572501506252 NA -3.70005257722555 -3.44211753709601 -0.257935040129541 1.37875471329376 1.05726790832708 0.22952799121211 0.187078265366977 0.24396374665119 0.668578157263931 NA NA 0.734914914115235 0.683145673659444 90.6527999345367 a1340 TP53_mut 71 Pyrimethamine Dihydrofolate reductase (DHFR) 16 12 2.99573227355399 NA 2.93733220009468 2.98030194072872 -0.0429697406340437 1.10415311461117 1.3486114744124 0.0354067728540522 0.0389164691612319 0.0318622089825878 0.668664753310419 NA NA 0.186971520725954 0.929112308337012 90.6527999345367 a1341 loss_cnaDLBC4_(CDKN2A) 35 NVP-TAE684 ALK 8 18 0.693147180559945 NA 1.00617023407334 0.843456577639075 0.162713656434269 0.855163611874772 2.09350070331566 0.0893311069704844 0.190271959862221 0.0777232394412692 0.669387683751068 NA NA 0.280654414917784 0.78099487472496 90.6527999345367 a1342 EP300_mut 197 Bryostatin 1 PRKC 5 24 -4.8283137373023 NA -3.42877092674837 -3.29228862030624 -0.136482306442127 0.721367743337011 1.01988473635483 0.139068088823369 0.189199347631995 0.133821305072108 0.669991192474554 NA NA 0.561426034548484 0.731668003000484 90.6527999345367 a1343 loss_cnaDLBC4_(CDKN2A) 226 GSK1070916 AURKB 7 18 0.940007258491471 2.32630161961136 -0.0559589046216087 0.641389944279017 -0.697348848900626 3.2595838734583 2.30210350592969 0.269633517817155 0.213937998214712 0.302918112545511 0.670080131358885 NA NA 0.344446050965201 0.617751250177965 90.6527999345367 a1344 EP300_mut 1014 RDEA119 MAP2K1 (MEK1), MAP2K2 (MEK2) 6 26 1.6094379124341 NA 2.9835207672864 2.72976127295941 0.253759494326988 0.924454444492154 1.25599355421706 0.210226365646231 0.274496483670853 0.202038850816533 0.670378915296289 NA NA 0.864050883319701 0.586028630107249 90.6527999345367 a1345 TP53_mut 157 JNK-9L JNK 17 13 1.63315443905142 NA -0.574636617948692 -0.64939331232161 0.0747566943729178 0.949623553544626 0.472950945818585 0.0956245069515045 0.0787224517482492 0.15806437228607 0.670662085212775 NA NA 0.498400018602153 0.780266904486437 90.6527999345367 a1346 CREBBP_mut 185 OSI-906 IGF1R 7 22 0.940007258491471 NA 2.37930269116063 2.20444729757149 0.174855393589137 1.28124378279156 1.51208266864548 0.11944211521699 0.136473164543413 0.115638779026396 0.670817297635547 NA NA 0.339849551847965 0.768961674945533 90.6527999345367 a1347 PTEN_mut 140 Vinorelbine Microtubules 6 24 -2.74887219562247 NA -4.71565299023621 -4.43095718736248 -0.284695802873729 1.53970132584851 1.35526977413033 0.204817138454322 0.184903265389368 0.210065780487444 0.670974498745264 NA NA 0.921755477002691 0.690768182297644 90.6527999345367 a1348 MLL2_mut 1149 TW 37 BCL2, BCL2L1 8 22 1.6094379124341 NA -1.10050280387959 -0.963502684734278 -0.137000119145307 0.599649095860909 0.717557071148141 0.198559056645476 0.228467148689048 0.190925746054035 0.671450567819914 NA NA 0.760977324353876 0.608000333546085 90.6527999345367 a1349 loss_cnaDLBC4_(CDKN2A) 266 Zibotentan, ZD4054 Endothelin A Receptor 7 22 2.99573227355399 NA 4.86036255812716 4.74990885350291 0.110453704624252 0.982291568369468 0.505996992352231 0.171756012296076 0.112444927942929 0.218289251307177 0.671499029694878 NA NA 0.822298277854582 0.783340211370684 90.6527999345367 a1350 PTEN_mut 266 Zibotentan, ZD4054 Endothelin A Receptor 6 23 2.99573227355399 NA 4.68716965292424 4.79989194636559 -0.112722293441354 0.564851200980519 0.659721353689802 0.175249766641318 0.199561040581449 0.170863490791834 0.671526162686925 NA NA 0.822298385840017 0.684544821066657 90.6527999345367 a1351 EP300_mut 1061 SB590885 BRAF 6 26 1.6094379124341 NA 3.11739622534621 3.26618865664792 -0.148792431301714 0.558072595166433 0.850669093199553 0.183857090666671 0.266618415938055 0.174912233783025 0.671538658993932 NA NA 0.924441310101211 0.608566542634966 90.6527999345367 a1352 TP53_mut 155 AP-24534 ABL 16 13 -0.669430653942629 NA -0.663228217434502 -0.587668281652935 -0.0755599357815667 1.95715436334243 1.52631519540574 0.0424827732927704 0.0386070394838584 0.0495048047801689 0.672385540528867 NA NA 0.233139007276826 0.907895380667976 90.6527999345367 a1353 loss_cnaDLBC4_(CDKN2A) 295 NVP-BHG712 EPHB4 7 22 2.32630161961136 NA 0.998753471282875 1.39312141901026 -0.394367947727386 1.69411701233071 1.48726928045902 0.256809294293553 0.232786723028552 0.265162437568583 0.672393698117944 NA NA 0.278923952927704 0.594224194707803 90.6527999345367 a1354 CREBBP_mut 1018 ABT-888 PARP1, PARP2 7 23 1.6094379124341 NA 3.58933606742952 3.51498952728291 0.0743465401466086 0.443213162023113 0.628203139066159 0.12528126696138 0.16774443206344 0.118347928437809 0.672632453164556 NA NA 0.37586139755947 0.731779517518133 90.6527999345367 a1355 PTEN_mut 193 GW-2580 CSF1R (cFMS) 6 23 2.99573227355399 NA 4.54239588194193 4.63128055103004 -0.0888846690881122 0.519168650359496 0.638174832119707 0.143856957014993 0.171205771046777 0.139279496173299 0.67345579267045 NA NA 0.589257230901405 0.7303124845153 90.6527999345367 a1356 CREBBP_mut 1526 RDEA119 (rescreen) MAP2K1 (MEK1), MAP2K2 (MEK2) 5 22 1.6094379124341 NA 3.055929791916 2.84558985037224 0.210339941543757 0.704614681730114 0.975144569767974 0.224452940754532 0.298517682071693 0.215701289905973 0.674139072107886 NA NA 0.870560760899937 0.592743370416955 90.6527999345367 a1357 PTEN_mut 1014 RDEA119 MAP2K1 (MEK1), MAP2K2 (MEK2) 5 27 1.6094379124341 NA 2.59141992261503 2.81177104028103 -0.220351117666005 1.1151567589821 1.22232214853183 0.182321937308478 0.197596540478433 0.180272539387981 0.674888180346319 NA NA 0.864063207793885 0.703428769413584 90.6527999345367 a1358 EP300_mut 344 THZ-2-49 CDK9 6 23 2.99573227355399 NA 0.182038777755315 0.553774956099876 -0.37173617834456 0.980412444095343 1.76232142054678 0.225870558102217 0.379163055898962 0.210935516081524 0.676190691147817 NA NA 0.725059828972241 0.504581426019877 90.6527999345367 a1359 CREBBP_mut 1023 GW 441756 NTRK1 7 23 0.693147180559945 NA 1.41908623803115 1.88705706471499 -0.467970826683833 1.9269618996227 1.95776578498577 0.239836722856616 0.242854218744783 0.239033101034214 0.677926575000141 NA NA 0.358229645469839 0.587370601178514 90.6527999345367 a1360 EP300_mut 290 KIN001-260 IKK 6 23 2.99573227355399 NA 3.27659840844079 3.05084613294751 0.225752275493278 0.961694372387653 0.978064711424597 0.231527995267974 0.234744303361982 0.230815275161558 0.677989695826904 NA NA 0.669492334872001 0.623757949963238 90.6527999345367 a1361 PTEN_mut 167 OSU-03012 PDPK1 (PDK1) 5 24 2.77258872223978 NA 1.33129302723567 1.34811380448635 -0.0168207772506739 0.881492569620587 0.495504944667331 0.0295389483023986 0.019082154325945 0.0339467394456919 0.678303625863968 NA NA 0.154550311839912 0.96878745250267 90.6527999345367 a1362 loss_cnaDLBC4_(CDKN2A) 1495 AZD-2281 PARP1, PARP2 7 23 2.30258509299405 NA 3.34093891792253 3.54492612275238 -0.203987204829848 0.807810384423331 0.900808797709637 0.231354940732358 0.252518671167452 0.226448948265713 0.67834537064987 NA NA 0.435685817565426 0.580787566500528 90.6527999345367 a1363 MLL2_mut 1025 SB 216763 GSK3A, GSK3B 8 22 2.30258509299405 NA 4.0092640047149 4.16983996667974 -0.160575961964841 0.971789821298294 0.631784237767571 0.219441158623055 0.165237336763123 0.25416265928419 0.67924792727136 NA NA 0.488593875913656 0.673458271183195 90.6527999345367 a1364 CREBBP_mut 226 GSK1070916 AURKB 5 20 0.940007258491471 2.32630161961136 -0.133045078859052 0.590926602948316 -0.723971681807368 3.20364999778322 2.44028457397328 0.279605513993633 0.225983388418936 0.296675104833612 0.679341904269868 NA NA 0.344562970877041 0.655846614608921 90.6527999345367 a1365 EP300_mut 306 TG101348 JAK2 6 23 2.32630161961136 NA 1.02672852062059 0.781124954201358 0.245603566419228 0.849120513950518 1.20682490659736 0.213751250375044 0.289244650652193 0.203512179005078 0.679438108672231 NA NA 0.809156894084181 0.57796914536074 90.6527999345367 a1366 CREBBP_mut 268 YM155 BIRC5 (Survivin) 6 23 1.63315443905142 NA -4.99098692536673 -4.79578600578487 -0.195200919581858 1.19385646667126 1.07590957556381 0.177664172678498 0.163504512503184 0.181428740867528 0.679509044131362 NA NA 0.8151815133413 0.726350531880683 90.6527999345367 a1367 loss_cnaDLBC4_(CDKN2A) 155 AP-24534 ABL 8 21 -0.669430653942629 NA -0.955023066851883 -0.50529307645834 -0.449729990393543 1.51458328910946 1.84694302232139 0.254546462991963 0.296933152258649 0.243499655895332 0.680265945573287 NA NA 0.233219195767414 0.512115903153475 90.6527999345367 a1368 CREBBP_mut 332 XMD15-27 CAMK2B, CLK2, DYRK1A, MAST1, STK39 6 23 2.32630161961136 NA 3.47508711222937 3.71340326285074 -0.238316150621372 0.843011410203905 0.858308677950927 0.27857057747648 0.282696233688852 0.277657859862623 0.680746678718844 NA NA 0.148862773919511 0.556173436121283 90.6527999345367 a1369 EP300_mut 1049 PD-173074 FGFR1, FGFR3 6 26 0.693147180559945 NA 2.18441803593008 1.95411322928112 0.23030480664896 0.569470588885696 0.866111808119633 0.279455343996514 0.404419141468932 0.265906554430844 0.681651137073527 NA NA 0.318609879304957 0.440523477580929 90.6527999345367 a1370 MLL2_mut 1239 YK 4-279 RNA helicase A 9 18 2.30258509299405 NA 1.61289540568038 1.7617011966635 -0.14880579098312 1.72066022613923 1.47233472704942 0.0956263890296225 0.0864817985111482 0.101067908166052 0.684022345255204 NA NA 0.403290316700435 0.827528186874457 90.6527999345367 a1371 MLL2_mut 203 BMS-345541 IKBKB 9 20 2.77258872223978 NA 1.76479013690755 1.91594935903528 -0.151159222127734 0.571932541083854 0.736387012343458 0.218517821683492 0.264295544088602 0.205271439601697 0.684503987524536 NA NA 0.467771906503374 0.555291078200577 90.6527999345367 a1372 EP300_mut 1218 JQ1 BRD2, BRD3, BRD4 6 23 0 NA 0.93720051917661 0.676990273778449 0.260210245398161 0.973339238107723 1.62587545165225 0.170492019604366 0.267337671400198 0.160043160214843 0.684768894959568 NA NA 0.852230296471812 0.626486449771154 90.6527999345367 a1373 MLL2_mut 255 CP724714 ERBB2 9 20 2.32630161961136 NA 3.83629419771489 3.70565161132622 0.130642586388668 1.04176241195131 0.780570315108197 0.150820812357438 0.125405356240454 0.167368120283385 0.685548618646176 NA NA 0.856253551228273 0.742462438976325 90.6527999345367 a1374 PTEN_mut 221 TAK-715 p38a 6 23 2.99573227355399 2.32630161961136 2.80487443037439 2.78766973505536 0.017204695319033 1.02782019907584 0.481066008037481 0.0277567157317424 0.0167390126546477 0.0357636894554657 0.68556806013674 NA NA 0.0253761805344112 0.969577324568787 90.6527999345367 a1375 EP300_mut 1060 PD-0325901 MAP2K1 (MEK1), MAP2K2 (MEK2) 6 26 -1.38629436111989 0.693147180559945 0.244729434429986 0.0265511008240448 0.218178333605941 0.745514616829421 0.953573427425332 0.236594205277952 0.292654669245556 0.228800769118564 0.686144077884525 NA NA 0.5784869041886 0.556099288938029 90.6527999345367 a1376 loss_cnaDLBC4_(CDKN2A) 256 JW-7-24-1 LCK 7 22 2.32630161961136 NA 0.144591910513105 0.0304360241692136 0.114155886343892 0.413941139782621 1.14390017579744 0.111098037858279 0.275778064494483 0.0997953219688163 0.686849836506643 NA NA 0.347909313445548 0.696776611331867 90.6527999345367 a1377 EP300_mut 328 SNX-2112 HSP90 6 22 0.940007258491471 NA -2.88250025246087 -2.64792017601054 -0.234580076450336 0.777907561659841 1.42259655984474 0.177276976908769 0.301552636858043 0.164895714689439 0.687570770321931 NA NA 0.912238092121656 0.600916336848038 90.6527999345367 a1378 loss_cnaDLBC4_(CDKN2A) 180 Thapsigargin sarco-endoplasmic reticulum Ca2+-ATPases 8 21 -0.669430653942629 NA -4.3411472510904 -4.08903172439521 -0.25211552669519 1.38960526699248 2.02911346586559 0.133799920845445 0.181429599242124 0.124249102347582 0.688199067503542 NA NA 0.628749133071603 0.707363703268621 90.6527999345367 a1379 loss_cnaDLBC4_(CDKN2A) 238 CAL-101 PI3Kdelta 7 22 2.99573227355399 2.32630161961136 2.96793979138268 2.67125592720607 0.29668386417661 1.82373655044935 2.05520842762795 0.147892361670695 0.162679123858931 0.144357068698396 0.688288077289491 NA NA 0.675648505588219 0.723133661156884 90.6527999345367 a1380 EP300_mut 159 HG-6-64-1 BRAFV600E, TAK, MAP4K5 6 24 1.63315443905142 NA 0.422140155139996 0.602529834160015 -0.180389679020019 2.23315550926838 1.51068012033281 0.108480476077595 0.0807779298268027 0.119409580222898 0.689104951532219 NA NA 0.432785130476083 0.857312681578787 90.6527999345367 a1381 ARID1A_mut 53 CGP-60474 CDK1,CDK2,CDK5,CDK7,CDK9 3 22 -1.36257783450257 NA -3.11711466175989 -2.72860334360493 -0.388511318154965 0.285886570272777 1.2137292654468 0.334111757263404 1.35897016003329 0.320097182473347 0.689685235468496 NA NA 0.184023763595398 0.224665045893195 90.6527999345367 a1382 EP300_mut 329 QL-XI-92 DDR1 6 23 2.32630161961136 NA 2.7718886037349 2.4114401735901 0.360448430144799 0.904724312273724 1.36713216916796 0.278547597480476 0.398406923805254 0.263652950514776 0.689793458567675 NA NA 0.293131343272532 0.455005714802265 90.6527999345367 a1383 TP53_mut 1371 PLX4720 (rescreen) BRAF 18 12 2.30258509299405 NA 3.39551513900483 3.36341799124759 0.0320971477572436 0.625078421354589 0.975060721290682 0.0410715833329288 0.0513489934393941 0.0329181014642419 0.691457445539135 NA NA 0.210764625329381 0.920707892628405 90.6527999345367 a1384 CREBBP_mut 1005 Cisplatin DNA crosslinker 7 23 1.79175946922805 2.30258509299405 2.78789508625193 2.72081178989699 0.0670832963549324 1.13169431645744 0.991926152274043 0.0655440249997146 0.0592768695392272 0.0676293252286376 0.691486477082013 NA NA 0.11501121962634 0.890828362629876 90.6527999345367 a1385 PTEN_mut 1025 SB 216763 GSK3A, GSK3B 4 26 2.30258509299405 NA 4.32879456003335 4.09597742555923 0.232817134474121 0.454205211387611 0.757291546927991 0.318554518014001 0.512581380919999 0.307433953830016 0.692013305382401 NA NA 0.488708137274838 0.423931534219381 90.6527999345367 a1386 TP53_mut 34 Imatinib ABL, KIT, PDGFR 15 12 0.693147180559945 NA 2.67801948220666 2.70922554210113 -0.0312060598944734 0.605668863573835 0.413368492661824 0.0589095845017555 0.0515233022056601 0.0754921104255593 0.69355048593487 NA NA 0.364642605442838 0.875254258518708 90.6527999345367 a1387 MLL2_mut 230 GSK429286A ROCK2 9 20 2.99573227355399 2.32630161961136 3.73241193314323 3.68724044187899 0.0451714912642451 1.0312399246709 0.649249189441606 0.05775449991855 0.0438030861524883 0.0695749675145461 0.69398525389526 NA NA 0.191557067129355 0.905837387663035 90.6527999345367 a1388 TP53_mut 204 Tipifarnib Farnesyl-transferase (FNTA) 16 13 2.77258872223978 NA 1.11749868987679 0.951781168917786 0.165717520959008 1.58742311477756 1.70540733093775 0.10099134205779 0.104394045554911 0.0971718122425832 0.69425811880107 NA NA 0.633699397798103 0.790598713607032 90.6527999345367 a1389 CREBBP_mut 265 Tubastatin A HDAC6 6 22 2.99573227355399 NA 3.09703880897061 2.87271583814922 0.224322970821385 1.27699450916232 1.11364400358336 0.195596510123909 0.175664788855307 0.201431489865328 0.695438365493365 NA NA 0.866054489570845 0.706669490783943 90.6527999345367 a1390 loss_cnaDLBC2 45 Z-LLNle-CHO g-secretase 4 21 0.940007258491471 NA 0.16434506212709 0.0964926072856559 0.0678524548414338 0.516698462980416 0.786474524404215 0.089661773191561 0.131319250400026 0.0862741929153201 0.695701473466212 NA NA 0.0994711841303528 0.834019347097171 90.6527999345367 a1391 loss_cnaDLBC4_(CDKN2A) 62 BMS-536924 IGF1R 8 17 1.63315443905142 NA 1.63286629253343 2.11302235359564 -0.480156061062204 0.87314938537718 1.69968063146623 0.320695294305107 0.549912843212719 0.282497812926183 0.697140972789576 NA NA 0.0601655540038611 0.360989921046994 90.6527999345367 a1392 loss_cnaDLBC4_(CDKN2A) 292 Masitinib KIT 7 22 2.99573227355399 NA 2.82446160213148 2.6817263723963 0.14273522973518 0.237804562729688 0.772087912901893 0.206837546538897 0.600220736291872 0.184869141648274 0.699818980230014 NA NA 0.586273526523252 0.453224758685505 90.6527999345367 a1393 CREBBP_mut 271 VNLG/124 HDAC, RAR 6 23 1.63315443905142 NA 2.99688485907828 2.76215202414514 0.234732834933141 0.896478255875455 0.933303043076738 0.253328663853449 0.261838849291345 0.251507628389722 0.699889578132094 NA NA 0.232016816348835 0.58657526303821 90.6527999345367 a1394 PTEN_mut 202 GSK-1904529A IGF1R 5 24 0.0237165266173161 NA 2.05383896420007 1.87771548175456 0.176123482445509 0.447723480343178 0.817687130469625 0.227515577686131 0.393375577064914 0.215392264207895 0.700083326539253 NA NA 0.749721771199747 0.51373181272271 90.6527999345367 a1395 loss_cnaDLBC2 64 CMK RSK 4 21 1.38629436111989 NA 1.44297495849331 1.31100435712685 0.131970601366461 0.515593191385566 1.30284972262898 0.107371643231419 0.255958774420224 0.10129380163674 0.700711668413766 NA NA 0.165879387240572 0.736866346842397 90.6527999345367 a1396 loss_cnaDLBC4_(CDKN2A) 332 XMD15-27 CAMK2B, CLK2, DYRK1A, MAST1, STK39 7 22 2.32630161961136 NA 3.49521681122598 3.71783091092551 -0.222614099699539 0.844003744823782 0.858948679377984 0.260169535359477 0.263759611334447 0.259170431300677 0.702120206524636 NA NA 0.149038845291032 0.55815485721343 90.6527999345367 a1397 TP53_mut 1004 Vinblastine Microtubules 17 13 -2.30258509299405 NA -5.03897830790935 -4.88256684499309 -0.156411462916259 1.18970177146441 1.3105717682998 0.125839580235826 0.131471152407995 0.119345973032191 0.702362477587468 NA NA 0.866309080325669 0.738958455262263 90.6527999345367 a1398 PTEN_mut 1015 CI-1040 MAP2K1 (MEK1), MAP2K2 (MEK2) 4 26 2.30258509299405 NA 2.69538429125145 2.65658910422858 0.0387951870228749 0.846323482654745 1.04019156261148 0.0379904744371577 0.0458396674770057 0.0372961946792537 0.702658483052173 NA NA 0.136824756492548 0.937707591703485 90.6527999345367 a1399 EP300_mut 152 CP466722 ATM 6 23 2.77258872223978 NA 1.72212020353542 1.48245636937327 0.239663834162152 1.46974332874702 0.976079685287948 0.220972649066963 0.16306509407086 0.245537160310278 0.703357421380019 NA NA 0.626260048369397 0.717856618335173 90.6527999345367 a1400 MLL2_mut 231 FMK RSK 8 20 2.99573227355399 2.32630161961136 4.59161521558826 4.55746628976424 0.0341489258240237 0.926656770357532 0.602405485949998 0.0484697948649321 0.0368517523600978 0.0566876076338691 0.704312489897989 NA NA 0.152035226205822 0.9252111024937 90.6527999345367 a1401 EP300_mut 53 CGP-60474 CDK1,CDK2,CDK5,CDK7,CDK9 5 20 -1.36257783450257 NA -2.46483272534395 -2.85282269589342 0.387989970549466 1.9920605288149 0.889189295877904 0.3347613354223 0.194768163385218 0.436341251911271 0.704651385344984 NA NA 0.18417798069807 0.690741634326598 90.6527999345367 a1402 loss_cnaDLBC2 288 KIN001-055 JAK3, MNK1 4 25 2.32630161961136 NA 3.93174327782115 3.74687844912534 0.184864828695814 0.736797852298907 0.856411591989311 0.219044858656454 0.250903050435083 0.215859792680295 0.704848793456098 NA NA 0.865837807113577 0.670593008247083 90.6527999345367 a1403 loss_cnaDLBC2 1054 PD-0332991 CDK4, CDK6 3 29 1.38629436111989 0.693147180559945 1.80175561712473 1.41281804925531 0.388937567869426 0.581681017620286 1.5666434996406 0.255719323811544 0.668644078262358 0.248261693205028 0.705140317903561 NA NA 0.678292680932858 0.415638207804227 90.6527999345367 a1404 loss_cnaDLBC2 173 FH535 unknown 4 25 3.46573590279973 NA 2.00177771082909 2.10570037823458 -0.103922667405489 0.534618396199859 0.716485216313484 0.148754275887072 0.194386628189726 0.14504509658999 0.70516954915838 NA NA 0.347696883209952 0.746014945100535 90.6527999345367 a1405 TP53_mut 45 Z-LLNle-CHO g-secretase 15 10 0.940007258491471 NA 0.112425664170005 0.0997340038957059 0.0126916602742989 0.833503500232577 0.620043465191783 0.0167618225333942 0.0152268829954014 0.0204689848160457 0.705847035776967 NA NA 0.099548985534865 0.965610805650988 90.6527999345367 a1406 loss_cnaDLBC4_(CDKN2A) 1060 PD-0325901 MAP2K1 (MEK1), MAP2K2 (MEK2) 8 24 -1.38629436111989 0.693147180559945 0.151278997768587 0.0395197185773496 0.111759279191237 1.01956506401576 0.894233815905383 0.120821112686003 0.109614661325341 0.124977692862223 0.706097089586903 NA NA 0.578626635153959 0.78729600483783 90.6527999345367 a1407 loss_cnaDLBC4_(CDKN2A) 1066 AZD6482 PI3Kbeta 7 21 1.6094379124341 NA 1.72224382563016 1.45800614198012 0.264237683650042 1.3171097017542 1.54232477902074 0.176940564354677 0.200619343474667 0.171324280880589 0.706701646706937 NA NA 0.892382351885466 0.667959549537241 90.6527999345367 a1408 CREBBP_mut 260 NG-25 MAP3K7 (TAK1) 6 23 2.32630161961136 NA 0.552926131083237 0.902267042882326 -0.349340911799089 1.63877873209961 1.42616431825668 0.237992914098494 0.213171494696853 0.244951375747585 0.707014190417058 NA NA 0.316221772774636 0.647578398065349 90.6527999345367 a1409 ARID1A_mut 1372 Trametinib MAP2K1 (MEK1), MAP2K2 (MEK2) 3 27 0 NA 0.290415957794614 0.67188147136329 -0.381465513568675 1.34981843790978 1.70402004745938 0.226901198660198 0.282605054765279 0.223862104285348 0.707336733985417 NA NA 0.897181853204103 0.684885740576454 90.6527999345367 a1410 PTEN_mut 1371 PLX4720 (rescreen) BRAF 5 25 2.30258509299405 NA 3.17067098126939 3.42507733962844 -0.254406358359048 0.922454255185643 0.748178950649628 0.328064340271025 0.275792926238764 0.340034102988533 0.708211635915656 NA NA 0.210910449934859 0.586730231557086 90.6527999345367 a1411 CREBBP_mut 328 SNX-2112 HSP90 6 22 0.940007258491471 NA -2.52395708256151 -2.74570467689218 0.221747594330675 1.72243079163855 1.20946403161424 0.167528420742089 0.128741076510671 0.183343686570583 0.709378169786797 NA NA 0.912278786025466 0.776538944089267 90.6527999345367 a1412 PTEN_mut 1032 Afatinib ERBB2, EGFR 4 26 -0.693147180559945 NA 1.28440428284293 1.05822037493744 0.226183907905496 0.665428923805107 0.696391231299763 0.326317783132795 0.339906937937283 0.32479430776769 0.7095465014219 NA NA 0.409585674836667 0.562897274514587 90.6527999345367 a1413 MLL2_mut 263 FR-180204 ERK 9 20 2.99573227355399 NA 4.4841050734996 4.64439832837211 -0.16029325487251 1.0237600192182 0.63080761888289 0.208585054577118 0.156573075587499 0.254107988036633 0.71032487105542 NA NA 0.431915394813791 0.672735424789284 90.6527999345367 a1414 loss_cnaDLBC4_(CDKN2A) 87 GW843682X PLK1 8 17 -1.36257783450257 NA -3.11419902188407 -2.63610624421192 -0.478092777672151 0.996635604435507 1.62162903484757 0.327457235561904 0.479706700768474 0.294822531786434 0.71089150582372 NA NA 0.03621337776818 0.37552368760271 90.6527999345367 a1415 PTEN_mut 1062 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 5 27 1.38629436111989 0.693147180559945 2.69306942956914 2.88439251982819 -0.191323090259048 0.903170454832346 0.913519490366046 0.209750419010748 0.211834974489464 0.209435148649522 0.71120347800136 NA NA 0.804088928854785 0.680209890016567 90.6527999345367 a1416 loss_cnaDLBC4_(CDKN2A) 86 A-443654 AKT1, AKT2, AKT3 8 17 0.0237165266173161 NA -1.33490992498854 -1.30170854989496 -0.0332013750935836 0.459486445358865 1.52863351627291 0.02554102362351 0.0722575724027133 0.0217196435510159 0.711610458428222 NA NA 0.044580244459031 0.935405857911507 90.6527999345367 a1417 loss_cnaDLBC4_(CDKN2A) 1526 RDEA119 (rescreen) MAP2K1 (MEK1), MAP2K2 (MEK2) 6 21 1.6094379124341 NA 2.76581650443221 2.91846317338933 -0.152646668957128 1.64276641154988 0.653187428863766 0.162624041296962 0.0929204955031387 0.233695050167546 0.711887121104407 NA NA 0.87067090460988 0.831912549359064 90.6527999345367 a1418 loss_cnaDLBC4_(CDKN2A) 104 Bortezomib Proteasome 8 20 -3.91202300542815 NA -6.0826801532338 -6.10793490352293 0.0252547502891263 1.18843308113451 1.12036585988818 0.0221709517617831 0.0212504605349908 0.022541520759698 0.712140354819383 NA NA 0.0873384967246933 0.959656720548611 90.6527999345367 a1419 loss_cnaDLBC2 32 VX-680 AURKA, AURKB, AURKC, FLT3, ABL1, JAK2 4 20 0.693147180559945 NA 0.0266494284369036 0.656748735615851 -0.630099307178947 1.92740310285066 1.92854934966823 0.326748375422873 0.326916204631517 0.326721899694888 0.712960400835613 NA NA 0.0681468394502611 0.580685108976239 90.6527999345367 a1420 loss_cnaDLBC4_(CDKN2A) 1243 piperlongumine Increases ROS levels 7 23 2.30258509299405 NA 1.62747480571907 1.74728348352517 -0.119808677806102 1.31839338501548 1.08003393253424 0.105527476218847 0.0908747564784657 0.110930475605499 0.713327571191538 NA NA 0.40882638645284 0.831684348078746 90.6527999345367 a1421 PTEN_mut 271 VNLG/124 HDAC, RAR 6 23 1.63315443905142 NA 2.60850096267097 2.86346956233835 -0.254968599667381 0.928893467089324 0.924912674603155 0.275447828989274 0.274486374057858 0.275667754014484 0.714248255507053 NA NA 0.232146040176103 0.565962289382595 90.6527999345367 a1422 TP53_mut 221 TAK-715 p38a 17 12 2.99573227355399 2.32630161961136 2.80747540831871 2.7682140455918 0.0392613627269132 0.743303473418098 0.372213924780264 0.0633700499912414 0.0528200985613169 0.105480639258972 0.714605861875629 NA NA 0.0254551092537573 0.853122100590139 90.6527999345367 a1423 CREBBP_mut 1022 AZD7762 CHEK1, CHEK2 7 23 0.693147180559945 NA -1.77390447537197 -1.5267248647775 -0.247179610594469 0.837184974892833 1.29809972716109 0.203582014152033 0.295250891986099 0.190416503002465 0.714629152812289 NA NA 0.499328203159764 0.561227999618573 90.6527999345367 a1424 MLL2_mut 1061 SB590885 BRAF 9 23 1.6094379124341 NA 3.14997664575895 3.27284750491707 -0.122870859158121 0.909909338549219 0.769739062690202 0.151787142776911 0.135036375551469 0.159626638576316 0.714826137194407 NA NA 0.92450246109009 0.726155484096375 90.6527999345367 a1425 ARID1A_mut 258 STF-62247 stimulates autophagy 3 26 2.32630161961136 NA 3.44591651024686 3.17572301833978 0.270193491907081 0.740156703089128 1.16331157595656 0.237558102751672 0.365049037290885 0.232262359879733 0.71529261535027 NA NA 0.870166510723449 0.612816221908338 90.6527999345367 a1426 PTEN_mut 1024 CEP-701 FLT3, JAK2, NTRK1, RET 4 26 0.693147180559945 NA -1.94299361090605 -1.73493721000211 -0.208056400903945 1.1372857573317 1.29203366261682 0.163008731929735 0.182941182163476 0.161030170438871 0.716129232139196 NA NA 0.85443905186929 0.753933749751457 90.6527999345367 a1427 TP53_mut 127 GSK269962A ROCK1, ROCK2 16 12 0.916290731874155 NA 1.6032274201576 1.34484532629461 0.258382093862987 1.08115536568392 1.29621171205876 0.219536011500132 0.238987015246916 0.199336336386438 0.716338950810354 NA NA 0.382076023269729 0.581500838124798 90.6527999345367 a1428 MLL2_mut 298 OSI-930 KIT, VEGFR, PDGFR 9 20 2.32630161961136 NA 2.87605634952959 3.02912302899157 -0.153066679461986 1.30091425927977 1.00892824120696 0.138706842875115 0.117660851489728 0.151712156732648 0.716609354198852 NA NA 0.907258898628365 0.759326040760329 90.6527999345367 a1429 loss_cnaDLBC2 37 Crizotinib MET, ALK 4 22 0.693147180559945 NA 1.79959467320273 2.04261338414217 -0.243018710939444 0.623901168523117 0.971343494085605 0.259912874892457 0.389514755221106 0.250188231474402 0.716789003895068 NA NA 0.376850075831129 0.540125392707212 90.6527999345367 a1430 CREBBP_mut 1024 CEP-701 FLT3, JAK2, NTRK1, RET 7 23 0.693147180559945 NA -1.92986001486177 -1.71179659998464 -0.218063414877129 0.826929974899225 1.37189354144449 0.171046287438443 0.263702394998686 0.158950682607287 0.717278186015201 NA NA 0.854442080605386 0.613406958001731 90.6527999345367 a1431 TP53_mut 201 Epothilone B Microtubules 16 13 -3.44201937618241 NA -4.8400069589871 -4.98414341411705 0.144136455129946 1.54096330691163 1.19755674850121 0.103044000440682 0.0935365913538986 0.120358768225671 0.717541448774195 NA NA 0.73837870106963 0.77905885827732 90.6527999345367 a1432 TP53_mut 225 Genentech Cpd 10 AURKA, AURKB 17 12 2.32630161961136 NA 1.3555845950188 1.29218815018265 0.0633964448361499 0.792481668771596 1.42987527992015 0.0577495509881255 0.079997364398875 0.0443370451440284 0.717725430597899 NA NA 0.383038578694897 0.891027636405411 90.6527999345367 a1433 TP53_mut 268 YM155 BIRC5 (Survivin) 17 12 1.63315443905142 NA -4.78355401469224 -4.91071511962369 0.127161104931456 1.08580420071549 1.11995526112008 0.115617231931244 0.117112371500924 0.113541236284993 0.717984527454997 NA NA 0.815324490945603 0.763100954916033 90.6527999345367 a1434 MLL2_mut 150 Bicalutamide ANDR (androgen receptor) 9 20 0.0237165266173161 NA 2.0399175276324 1.99376701064852 0.0461505169838738 0.518074586197312 0.506921032253182 0.090446659142265 0.0890808354886126 0.0910408407769989 0.718132952123583 NA NA 0.466312904400984 0.826189602900998 90.6527999345367 a1435 CREBBP_mut 1149 TW 37 BCL2, BCL2L1 6 24 1.6094379124341 NA -1.10320440364748 -0.974243961387747 -0.128960442259732 0.832817060896143 0.655812373055147 0.186694915837698 0.154848463504057 0.196642283003843 0.718408196863739 NA NA 0.7611949392468 0.735085398092894 90.6527999345367 a1436 TP53_mut 1054 PD-0332991 CDK4, CDK6 19 13 1.38629436111989 0.693147180559945 1.34899382629702 1.59585442924113 -0.24686060294411 1.63054985465797 1.33801895610493 0.162375488329719 0.15139715123638 0.184497089385594 0.719020940787089 NA NA 0.678365680151179 0.642945613998169 90.6527999345367 a1437 loss_cnaDLBC2 208 SB-715992 KIF11 4 25 -2.05572501506252 NA -3.28355059670556 -3.52939265718957 0.245842060484014 1.03236483530503 1.13665474352896 0.21842060442126 0.238134864804239 0.216285606410923 0.719062796887536 NA NA 0.735183631092061 0.684131149165791 90.6527999345367 a1438 ARID1A_mut 290 KIN001-260 IKK 3 26 2.99573227355399 NA 2.87986979395445 3.12267085102208 -0.242801057067628 1.27759916843363 0.948454555237366 0.248606734483478 0.190044783267438 0.255996511089415 0.719556659175035 NA NA 0.669756318408801 0.776701966513461 90.6527999345367 a1439 loss_cnaDLBC2 282 EKB-569 EGFR 4 25 0.916290731874155 2.99573227355399 0.530518123954346 0.27953676116803 0.250981362786316 1.09252280120612 1.37984316597733 0.185782797944813 0.229726429974036 0.18189122428892 0.719622328268621 NA NA 0.842711534118946 0.699799483948881 90.6527999345367 a1440 PTEN_mut 305 TPCA-1 IKK 6 23 2.99573227355399 NA 1.01226491528909 1.22491682842264 -0.212651913133555 1.17246968649366 1.61449628062109 0.137886200025161 0.181370926330304 0.131714092925472 0.720352089379657 NA NA 0.767273828627678 0.723468157371477 90.6527999345367 a1441 loss_cnaDLBC4_(CDKN2A) 29 AZ628 BRAF 8 21 1.38629436111989 NA 1.37940656658146 1.66805006425913 -0.288643497677667 1.13682744395475 1.1541989280313 0.251055382127808 0.253902647418104 0.25008123874279 0.720409109140193 NA NA 0.133283425640447 0.553411952360106 90.6527999345367 a1442 TP53_mut 1046 681640 WEE1, CHEK1 19 13 0.693147180559945 NA 1.6982488823757 1.83051243391497 -0.132263551539269 0.84253528615421 0.666424052007811 0.170246086542149 0.156982803821774 0.198467554015771 0.720479099611874 NA NA 0.598774661410842 0.624608129732361 90.6527999345367 a1443 CREBBP_mut 299 OSI-027 MTORC1/2 6 23 2.99573227355399 NA -1.64163360050233 -1.26893706315602 -0.372696537346313 1.74312196029588 1.72430463817223 0.215705234572456 0.213809788319717 0.216143092754986 0.720837041923691 NA NA 0.441543256204976 0.65301745909277 90.6527999345367 a1444 CREBBP_mut 193 GW-2580 CSF1R (cFMS) 6 23 2.99573227355399 NA 4.67691376441141 4.59618892951626 0.0807248348951477 0.621708253881657 0.617234930015291 0.130608811130938 0.129843595273409 0.130784618578128 0.721102806528365 NA NA 0.589621090940171 0.784064359774989 90.6527999345367 a1445 MLL2_mut 1192 GSK269962A ROCK1, ROCK2 9 21 1.6094379124341 NA 1.84451703058067 1.60320596223545 0.241311068345223 1.19506092577206 1.61770251318792 0.159906626372908 0.20192365354873 0.149169001332441 0.72160429181793 NA NA 0.821704632258776 0.655056402987129 90.6527999345367 a1446 MLL2_mut 1008 Methotrexate Dihydrofolate reductase (DHFR) 8 22 -1.6094379124341 NA -2.61793502911391 -2.55190211561793 -0.0660329134959805 1.36026123339212 1.34454678043644 0.0489679478881129 0.0485442883138795 0.0491116519386155 0.722083368878024 NA NA 0.158795714218116 0.908012017991359 90.6527999345367 a1447 PTEN_mut 1036 PLX4720 BRAF 5 27 2.30258509299405 NA 3.41343164178088 3.34090439634432 0.0725272454365671 0.768393780279725 0.81991628302456 0.0891835992602643 0.0943881214267044 0.0884568911950668 0.722493696394477 NA NA 0.502721395661136 0.854407032518121 90.6527999345367 a1448 CREBBP_mut 154 CHIR-99021 GSK3B 7 23 0.940007258491471 NA 2.82461054515436 2.73716064113238 0.0874499040219816 0.889451747007655 0.883543176120266 0.0988343769560321 0.0983188849942514 0.0989763787277308 0.72259036845327 NA NA 0.398072822252332 0.824195727382582 90.6527999345367 a1449 MLL2_mut 1373 Dabrafenib BRAF 9 21 2.30258509299405 NA 2.72649271984291 2.97861124664526 -0.252118526802354 1.53572479822436 1.47813634520629 0.168661846209223 0.164169079703512 0.170565136037683 0.723517705755659 NA NA 0.715499278093677 0.682933506530289 90.6527999345367 a1450 EP300_mut 1032 Afatinib ERBB2, EGFR 5 25 -0.693147180559945 NA 1.0464391632173 1.09676604254635 -0.0503268793290415 0.877045160818746 0.66277105212934 0.0721611014146792 0.0573823123111014 0.0759340335812074 0.723620127908748 NA NA 0.409704991023901 0.908025559438927 90.6527999345367 a1451 TP53_mut 254 AC220 FLT3 17 12 0.0237165266173161 NA 1.72288264599579 1.58481773525797 0.138064910737815 0.726869333717903 0.732713061257053 0.189323029715415 0.189944608106687 0.188429711490265 0.723664733584326 NA NA 0.524198746332148 0.62070053288998 90.6527999345367 a1452 loss_cnaDLBC2 192 LFM-A13 BTK 4 25 2.77258872223978 NA 4.07226712759977 4.26628177875052 -0.194014651150757 0.971032363122736 0.693847750054011 0.265823341560661 0.199802456147627 0.279621359492273 0.724512882119805 NA NA 0.192974899266308 0.722953648558514 90.6527999345367 a1453 loss_cnaDLBC4_(CDKN2A) 184 BMS-754807 IGF1R 8 21 0.940007258491471 NA 0.929424153569522 1.19075345197331 -0.261329298403786 0.829168366084577 1.6554132460561 0.175862066441482 0.315170367193109 0.157863481536338 0.725079201017679 NA NA 0.69862886312123 0.579391269892036 90.6527999345367 a1454 loss_cnaDLBC2 228 KIN001-102 AKT1 4 25 2.32630161961136 NA 1.37234692688432 1.21868520331844 0.153661723565886 0.260677590445306 0.989995822241476 0.163921066536657 0.589470400211201 0.155214517186523 0.726168019855625 NA NA 0.638626209770441 0.524318812293359 90.6527999345367 a1455 ARID1A_mut 309 Y-39983 ROCK 3 26 2.99573227355399 NA 2.87901251120206 2.61951809575461 0.259494415447447 1.01678015361221 1.21091481610949 0.216676142270342 0.255211920222447 0.214296176737823 0.727180452043745 NA NA 0.979277849539129 0.712254856812608 90.6527999345367 a1456 CREBBP_mut 192 LFM-A13 BTK 7 22 2.77258872223978 NA 4.10827122654578 4.28128247242462 -0.173011245878846 0.658887146955175 0.747979999147923 0.237286776941905 0.262580999915326 0.231304641936864 0.727751300349343 NA NA 0.193000426666958 0.569927873128 90.6527999345367 a1457 EP300_mut 1199 Tamoxifen ER 6 24 1.6094379124341 NA 2.96952105710179 2.84706977747855 0.122451279623242 1.06898193000154 0.947822407423121 0.126164561237997 0.114549438289444 0.129192218567774 0.727756590449588 NA NA 0.721216242919583 0.804832079226892 90.6527999345367 a1458 EP300_mut 140 Vinorelbine Microtubules 6 24 -2.74887219562247 NA -4.67608731981505 -4.44084860496777 -0.235238714847281 1.57957725267472 1.34725002392656 0.169043765721883 0.148925109201812 0.174606576856223 0.728342497565772 NA NA 0.921843431892007 0.747132463535491 90.6527999345367 a1459 MLL2_mut 1036 PLX4720 BRAF 9 23 2.30258509299405 NA 3.29756351328851 3.37363066480889 -0.0760671515203728 0.64948952607511 0.864728419250034 0.0935724077934692 0.117118365218373 0.0879665220050761 0.728635527791935 NA NA 0.502764126812128 0.790005454137992 90.6527999345367 a1460 loss_cnaDLBC4_(CDKN2A) 245 UNC0638 G9a(EHMT2), GLP(EHMT1) 7 22 3.68887945411394 NA 1.95040430214181 1.8517672675546 0.0986370345872125 0.560576400944593 0.747532541483361 0.138876033497589 0.175956452003697 0.131950154827351 0.72894544331359 NA NA 0.838085160966637 0.715649828850948 90.6527999345367 a1461 TP53_mut 298 OSI-930 KIT, VEGFR, PDGFR 17 12 2.32630161961136 NA 2.91719427253807 3.07288875770421 -0.155694485166147 1.18479215628402 0.972110841088298 0.141142000551856 0.131410800063419 0.160161247653451 0.729359328649475 NA NA 0.907280724418862 0.701405025551192 90.6527999345367 a1462 MLL2_mut 156 AZD6482 PI3Kbeta 9 21 1.63315443905142 NA 1.46138692264115 1.7343267860437 -0.272939863402546 1.93876981126609 1.74159463772727 0.151621838862918 0.140779922307695 0.156718364589548 0.729912663657174 NA NA 0.863665066237217 0.721323253787342 90.6527999345367 a1463 MLL2_mut 1058 GDC0941 PI3K (class 1) 9 23 1.38629436111989 0.693147180559945 0.47725477977659 0.0953795759374614 0.381875203839128 2.13032915588133 2.03421536949936 0.185350743751388 0.179256432173809 0.187726043940525 0.730052701062023 NA NA 0.450498499220776 0.65136655438534 90.6527999345367 a1464 ARID1A_mut 1059 AZD8055 MTORC1/2 3 29 0.693147180559945 NA -1.03963576635425 -1.27658488758505 0.236949121230801 0.437190316492891 1.03711784875083 0.235001020555167 0.541981632007749 0.228468849047577 0.730369492517712 NA NA 0.674692458511094 0.489791924406183 90.6527999345367 a1465 PTEN_mut 1243 piperlongumine Increases ROS levels 5 25 2.30258509299405 NA 1.7833562520854 1.70652250002742 0.0768337520579825 1.77751325771004 0.989646440387655 0.0676260560165237 0.0432254171521438 0.0776375773431629 0.730421841579339 NA NA 0.408968197223599 0.929298143818961 90.6527999345367 a1466 TP53_mut 62 BMS-536924 IGF1R 15 10 1.63315443905142 NA 2.14874841111961 1.67530841845991 0.473439992659701 1.80585546562006 0.803677660365996 0.316488083823646 0.262169371620857 0.589091890950528 0.731268119664242 NA NA 0.0603499956508326 0.382879066602189 90.6527999345367 a1467 CREBBP_mut 171 AKT inhibitor VIII AKT1, AKT2, AKT3 7 23 0.940007258491471 NA 2.10389868217515 2.00895185045446 0.0949468317206819 0.653914328831436 0.879804754561158 0.113498039341935 0.14519766203985 0.107918070717907 0.731590225245286 NA NA 0.578813033922409 0.76249355755533 90.6527999345367 a1468 EP300_mut 196 Phenformin AAPK1 (AMPK) agonist 6 23 8.29404964010203 NA 6.07492957079136 5.84038918051679 0.234540390274572 1.19501281669346 1.64969883597373 0.148873928388688 0.196266004011182 0.142171640762622 0.73195847072821 NA NA 0.91756473250494 0.70216732498607 90.6527999345367 a1469 PTEN_mut 263 FR-180204 ERK 6 23 2.99573227355399 NA 4.54348792863079 4.60799933291973 -0.0645114042889317 0.29869838600199 0.843119081223884 0.0835815768052085 0.215975068203087 0.0765151752885084 0.73264695223562 NA NA 0.432104970745677 0.765625701218794 90.6527999345367 a1470 EP300_mut 1037 BX-795 TBK1, PDPK1, IKK, AURKB, AURKC 6 26 1.6094379124341 NA 1.39093277833894 1.22413739948108 0.166795378857861 0.925642376698895 1.26422708330651 0.137351386468017 0.180194190603828 0.131934666691064 0.732761428302204 NA NA 0.852374210151939 0.719892412632468 90.6527999345367 a1471 EP300_mut 173 FH535 unknown 5 24 3.46573590279973 NA 2.12241289221893 2.08489815992026 0.0375147322986731 0.825147362900605 0.675207566767388 0.0536344630116378 0.0454642818790563 0.0555602960409315 0.733250407912991 NA NA 0.347947728823368 0.927705340695134 90.6527999345367 a1472 loss_cnaDLBC4_(CDKN2A) 208 SB-715992 KIF11 7 22 -2.05572501506252 NA -3.60376193447415 -3.46103114887466 -0.142730785599496 0.62568207538245 1.23358371629834 0.12662507988302 0.22812030456882 0.115704174523148 0.733814323224622 NA NA 0.735252192146935 0.690644332421086 90.6527999345367 a1473 MLL2_mut 3 Rapamycin MTOR 7 16 -2.30258509299405 NA -3.38404901718084 -3.53963244271781 0.155583425536971 1.67853742673832 2.19551125045751 0.0754863991127368 0.0926898757564768 0.070864326249547 0.734422039994485 NA NA 0.412021402456768 0.855355461658416 90.6527999345367 a1474 CREBBP_mut 258 STF-62247 stimulates autophagy 6 23 2.32630161961136 NA 3.35617996501165 3.16388992250021 0.192290042511443 0.912630376784023 1.18290749730472 0.169014879468619 0.210698709360349 0.162557125514531 0.734891675882098 NA NA 0.870212845694026 0.676151690924746 90.6527999345367 a1475 TP53_mut 1026 17-AAG HSP90 19 13 0 NA 0.607924854821544 0.897965406218671 -0.290040551397128 1.18992972516602 1.10868929116343 0.250441359053213 0.243745950086808 0.261606704158534 0.735145098144164 NA NA 0.0834592365278403 0.486591194367113 90.6527999345367 a1476 loss_cnaDLBC4_(CDKN2A) 291 KIN001-266 MAP3K8 (COT) 7 22 2.99573227355399 NA 2.76263836085428 2.69100303648607 0.0716353243682057 0.650685353183885 0.537626004935391 0.126853329537759 0.110092111367937 0.133243786034521 0.735770083074553 NA NA 0.749997581524547 0.79786968475178 90.6527999345367 a1477 loss_cnaDLBC4_(CDKN2A) 1218 JQ1 BRD2, BRD3, BRD4 7 22 0 NA 0.573882492836753 0.780763725550305 -0.206881232713553 1.7970346231632 1.44110124359948 0.13544821232152 0.115123676554096 0.143557736579853 0.736955685063005 NA NA 0.852378985316777 0.787936213628654 90.6527999345367 a1478 CREBBP_mut 308 XL-880 MET 6 23 1.63315443905142 NA -0.516296333262932 -0.37539342095818 -0.140902912304753 0.934211880112328 0.842782898658293 0.163755393185077 0.150825434041591 0.167187673752125 0.738369151584552 NA NA 0.907870694700001 0.746688773225378 90.6527999345367 a1479 EP300_mut 1007 Docetaxel Microtubules 5 24 -4.38202663467388 NA -4.56916934025987 -4.35635355089702 -0.212815789362846 0.94600536072928 1.10168110407629 0.197045295479109 0.224962561733039 0.193173676643281 0.738428147182541 NA NA 0.783208673826423 0.671343423022794 90.6527999345367 a1480 CREBBP_mut 309 Y-39983 ROCK 6 23 2.99573227355399 NA 2.49645121104629 2.68546959812819 -0.189018387081891 1.32309218861041 1.16743278668816 0.157806507289645 0.142861086104974 0.161909438587989 0.738492523635841 NA NA 0.979282016177422 0.758793597335103 90.6527999345367 a1481 EP300_mut 291 KIN001-266 MAP3K8 (COT) 6 23 2.99573227355399 NA 2.79043054702742 2.686867480283 0.103563066744425 0.124557273927723 0.621905617629996 0.18364549223624 0.831449368460968 0.166525375890784 0.738994066070243 NA NA 0.750011134252696 0.463709787494033 90.6527999345367 a1482 EP300_mut 35 NVP-TAE684 ALK 5 21 0.693147180559945 NA 1.31277895599136 0.793699309053965 0.519079646937399 1.14121286809047 1.91670070157221 0.28667880262484 0.454849100857011 0.270819354587606 0.739823177941437 NA NA 0.28140486002847 0.449286416277322 90.6527999345367 a1483 PTEN_mut 1052 RO-3306 CDK1 5 27 1.6094379124341 NA 3.35041011996952 3.09641512001776 0.253994999951761 0.565731763965661 0.884949716822788 0.29904713733209 0.448967189275902 0.287016307393908 0.740131165665964 NA NA 0.243430466257344 0.428572643306594 90.6527999345367 a1484 TP53_mut 140 Vinorelbine Microtubules 17 13 -2.74887219562247 NA -4.56641145629779 -4.38522274469648 -0.181188711601318 1.46469750265513 1.28842854734294 0.130174614818771 0.123703844154079 0.140627675453927 0.741681320024062 NA NA 0.921861039820345 0.721913117625548 90.6527999345367 a1485 loss_cnaDLBC2 1028 VX-702 p38 3 27 0.693147180559945 NA 1.86383800791092 2.05947980582207 -0.195641797911149 1.41096924160643 0.738607485268473 0.242892539455385 0.138657734089515 0.264879251582505 0.741768316455831 NA NA 0.480767749002844 0.833857683968234 90.6527999345367 a1486 TP53_mut 163 JQ1 BRD4 17 13 0.940007258491471 NA -0.299399219562983 -0.579940149613987 0.280540930051003 1.56135066900769 1.31514113059853 0.192030049828078 0.179678361574789 0.213316216430191 0.742170502727087 NA NA 0.41464863894713 0.597897912741818 90.6527999345367 a1487 MLL2_mut 344 THZ-2-49 CDK9 9 20 2.99573227355399 NA 0.355244223382757 0.531592932319211 -0.176348708936454 1.92359498112073 1.5217017268454 0.106812500194471 0.0916766318623417 0.115889142941329 0.74226004447931 NA NA 0.725401639517127 0.811925316861807 90.6527999345367 a1488 loss_cnaDLBC2 104 Bortezomib Proteasome 4 24 -3.91202300542815 NA -6.3691701705807 -6.05597744225026 -0.313192728330445 0.448863366687802 1.1941649435639 0.276315220407405 0.697746244344951 0.262269236773727 0.742928022141152 NA NA 0.0875125212944995 0.363092941420517 90.6527999345367 a1489 PTEN_mut 1001 AICAR AAPK1 (AMPK) agonist 4 26 7.60090245954208 NA 6.52287003182759 6.62095658500923 -0.0980865531816395 0.465012976163267 0.862100110012276 0.118361024137516 0.210932937809462 0.113776291224743 0.743546936999057 NA NA 0.732979696173055 0.743279965903926 90.6527999345367 a1490 MLL2_mut 1007 Docetaxel Microtubules 7 22 -4.38202663467388 NA -4.49586029048757 -4.36033226770068 -0.135528022786891 1.22018580688192 1.03857921818081 0.125306207359347 0.111071626978863 0.13049367868566 0.743647734205852 NA NA 0.783227567890207 0.797074828276931 90.6527999345367 a1491 EP300_mut 345 KIN001-270 CDK9 6 23 2.99573227355399 NA 3.78241747288801 3.59122751805146 0.191189954836551 1.26015478482674 1.05598717924502 0.174337219451111 0.151719421406505 0.181053291739055 0.743983262718596 NA NA 0.8022815270904 0.742711261664026 90.6527999345367 a1492 PTEN_mut 178 BAY 61-3606 SYK 5 24 2.07944154167984 NA 1.29042422455645 1.03710576958609 0.253318454970361 2.03419127137431 1.08834987712349 0.198899940170162 0.124530302796559 0.232754613470333 0.744068318704054 NA NA 0.747412327557424 0.798759669623204 90.6527999345367 a1493 CREBBP_mut 52 GNF-2 ABL [T315I] 6 19 0.246860077931526 NA 2.2859384109684 2.22988325653293 0.0560551544354708 0.364924827416229 0.6425536442328 0.0944715855667846 0.153607401371831 0.0872380927858559 0.744597700903576 NA NA 0.45798383107993 0.792649281475551 90.6527999345367 a1494 PTEN_mut 312 AV-951 VEGFR 6 23 -2.05572501506252 NA -0.275412374858126 -0.403804827796273 0.128392452938148 0.42413912055939 0.535664631030493 0.248422688761569 0.302713064451148 0.239688128542575 0.744860804457673 NA NA 0.273980710844975 0.547662999590452 90.6527999345367 a1495 CREBBP_mut 303 PIK-93 PI4K, PI3K 6 23 2.99573227355399 NA 0.456308314982735 0.638076059295162 -0.181767744312427 1.79250786116156 1.52977111903313 0.114917618614801 0.101404154620912 0.118820222222074 0.745999603077892 NA NA 0.586504820553344 0.826368657955324 90.6527999345367 a1496 ARID1A_mut 1009 ATRA Retinoic acid and retinoid X receptor agonist 3 27 2.30258509299405 NA 3.37582937691232 3.13663799884301 0.239191378069314 0.748930175215758 0.955869652723382 0.253758071328176 0.319377407914438 0.250234304842539 0.746465716051389 NA NA 0.313218199646051 0.648328292899357 90.6527999345367 a1497 loss_cnaDLBC4_(CDKN2A) 158 PF-562271 FAK 8 22 0.940007258491471 NA 1.76611208081572 1.62872974597964 0.137382334836082 0.804571880471284 0.91036050166732 0.155216822246631 0.170752095829659 0.150909814940858 0.747048732125559 NA NA 0.768179385644617 0.695944583749974 90.6527999345367 a1498 MLL2_mut 166 FTI-277 Farnesyl transferase (FNTA) 9 21 0.0237165266173161 NA 1.86690134933747 1.8287061394632 0.0381952098742722 0.650216897448275 0.588460079309051 0.0629508392491882 0.0587422597354302 0.0649070535406915 0.747122305948099 NA NA 0.36016324458129 0.88166721397564 90.6527999345367 a1499 loss_cnaDLBC4_(CDKN2A) 271 VNLG/124 HDAC, RAR 7 22 1.63315443905142 NA 2.96512581003183 2.76158750179932 0.203538308232506 0.850270420436257 0.948332110834262 0.219463194705338 0.239380676241888 0.214627666728958 0.747729670885289 NA NA 0.232418696588251 0.602400991771317 90.6527999345367 a1500 ARID1A_mut 3 Rapamycin MTOR 3 20 -2.30258509299405 NA -3.24280592214969 -3.52970222186509 0.286896299715404 0.614964833116999 2.15645618049565 0.139272763539879 0.466524725098908 0.133040635052209 0.747740628780385 NA NA 0.4121586415867 0.640533794452035 90.6527999345367 a1501 ARID1A_mut 1 Erlotinib EGFR 3 24 0.693147180559945 NA 2.31003207703813 2.21377169794534 0.0962603790927905 0.917078639619344 0.842694961218752 0.11339618091424 0.104964149129834 0.114229209290125 0.748008905377908 NA NA 0.189890045580092 0.876026546122251 90.6527999345367 a1502 loss_cnaDLBC4_(CDKN2A) 265 Tubastatin A HDAC6 6 22 2.99573227355399 NA 3.06709899836346 2.88088124104208 0.186217757321376 1.19401053840238 1.13689804426274 0.162196195429063 0.155959894265708 0.163794597291383 0.74849047604501 NA NA 0.86619093704388 0.741488400701289 90.6527999345367 a1503 TP53_mut 344 THZ-2-49 CDK9 17 12 2.99573227355399 NA 0.373209033690763 0.623708590340506 -0.250499556649743 1.69048019707965 1.58474915393423 0.151981544123994 0.148182485120197 0.158068900701327 0.748897755385612 NA NA 0.725430961535619 0.686945839619264 90.6527999345367 a1504 PTEN_mut 205 BMS-708163 g-secretase 6 23 2.32630161961136 0.940007258491471 4.24631087065511 4.08216703685713 0.164143833797972 0.650808969476899 0.654888511166054 0.250932672668743 0.252215076153462 0.250643935569595 0.75018844391856 NA NA 0.245331241667626 0.597929734629302 90.6527999345367 a1505 PTEN_mut 1039 SL 0101-1 RSK, AURKB, PIM3 5 27 2.30258509299405 NA 4.06157034661499 3.92540256153068 0.136167785084304 0.573268084128314 0.776402799250516 0.180955509477949 0.237528983130737 0.175382913631624 0.750499308245721 NA NA 0.825867775598243 0.660123809324056 90.6527999345367 a1506 ARID1A_mut 62 BMS-536924 IGF1R 3 22 1.63315443905142 NA 2.03980574282408 1.94840423286005 0.0914015099640331 1.44728054128695 1.52131288789368 0.0603302766204195 0.0631539686720014 0.0600806781375411 0.750735048243266 NA NA 0.0604438926613542 0.92601264192723 90.6527999345367 a1507 ARID1A_mut 1494 SN-38 TOP1 3 28 -2.99573227355399 NA -4.96781690189354 -4.61514528124289 -0.352671620650647 1.37125478425718 1.60898873286447 0.221286625632266 0.257188980997205 0.219188371830789 0.75179852036952 NA NA 0.637143366950468 0.709088640667028 90.6527999345367 a1508 loss_cnaDLBC4_(CDKN2A) 1009 ATRA Retinoic acid and retinoid X receptor agonist 8 22 2.30258509299405 NA 3.11782820053299 3.17609493160155 -0.0582667310685641 0.962410146883599 0.939315170618873 0.0616486644321088 0.0605425153270036 0.0620310763533976 0.751829038707881 NA NA 0.313258721104621 0.885087060104094 90.6527999345367 a1509 ARID1A_mut 1022 AZD7762 CHEK1, CHEK2 3 27 0.693147180559945 NA -1.41255238383131 -1.60349429874045 0.19094191490914 0.512100943661583 1.25547437690711 0.156828244523569 0.372859916140522 0.152087464643867 0.753209934253648 NA NA 0.499607757400492 0.636814203381373 90.6527999345367 a1510 loss_cnaDLBC2 292 Masitinib KIT 4 25 2.99573227355399 NA 2.83823610346759 2.69665067975074 0.141585423716846 1.24914020514009 0.585086561170435 0.204860401926655 0.113346302628188 0.241990558514302 0.753673053231511 NA NA 0.58663972119077 0.837097786637109 90.6527999345367 a1511 loss_cnaDLBC4_(CDKN2A) 223 ZSTK474 PI3K 7 22 1.63315443905142 2.32630161961136 -0.520011295041644 -0.763949344637197 0.243938049595553 1.67714114246327 1.90901630910497 0.13115031523496 0.145448730234638 0.127782066833113 0.754785007197081 NA NA 0.921818390851001 0.751931214414727 90.6527999345367 a1512 loss_cnaDLBC2 225 Genentech Cpd 10 AURKA, AURKB 4 25 2.32630161961136 NA 1.21842523191295 1.34709979959438 -0.128674567681432 0.944490324465542 1.11492534198895 0.117265119728614 0.136237041659738 0.115410927382712 0.754887993600326 NA NA 0.383343761061452 0.816315123716902 90.6527999345367 a1513 ARID1A_mut 1003 Camptothecin TOP1 3 27 -2.30258509299405 NA -5.44289898564903 -5.02271981861515 -0.420179167033878 2.25615548226601 1.50470983059024 0.267569534478105 0.186236795441006 0.279242654292395 0.755354545490025 NA NA 0.139712025791975 0.780214549332694 90.6527999345367 a1514 CREBBP_mut 87 GW843682X PLK1 6 19 -1.36257783450257 NA -3.11886836618424 -2.68495726997736 -0.433911096206873 1.15333078749936 1.54131786681584 0.296036422563548 0.376224324287461 0.281519539576399 0.755781753980867 NA NA 0.0363730344614662 0.476290505590518 90.6527999345367 a1515 EP300_mut 1009 ATRA Retinoic acid and retinoid X receptor agonist 5 25 2.30258509299405 NA 2.94858952412303 3.20295065915532 -0.254361135032291 0.675329701339439 0.977630229804261 0.27047813346729 0.376647339111243 0.260181331630077 0.755841872661606 NA NA 0.313288395396281 0.50008115121882 90.6527999345367 a1516 MLL2_mut 1242 (5Z)-7-Oxozeaenol MAP3K7 (TAK1) 9 20 2.30258509299405 NA 1.12255813980649 1.24562883295535 -0.123070693148858 0.391405283327873 1.12381770295853 0.127334843142754 0.314432886808438 0.109511260433846 0.756288701880961 NA NA 0.987282127472375 0.667380961407863 90.6527999345367 a1517 EP300_mut 164 JQ12 HDAC 6 24 1.63315443905142 NA 0.447314867869019 0.551788665117819 -0.1044737972488 2.26737522993632 1.38825694351698 0.0660599941692997 0.0460769774095726 0.0752553752651354 0.756492552785951 NA NA 0.423647592099835 0.917594007971236 90.6527999345367 a1518 loss_cnaDLBC2 1050 ZM-447439 AURKB 3 29 1.38629436111989 0.693147180559945 1.82646116127317 1.57482334367564 0.251637817597534 1.16510989434471 1.22452638815103 0.206149781841179 0.215977753531191 0.205498076670683 0.756792806513856 NA NA 0.783764374295691 0.750972254974653 90.6527999345367 a1519 MLL2_mut 261 TL-1-85 MAP3K7 (TAK1) 9 20 2.32630161961136 NA 1.40822790937767 1.60257040865084 -0.194342499273162 0.974175276243427 1.32400196332747 0.157904488620508 0.199494386700695 0.146784147347291 0.75679552722651 NA NA 0.667450196719284 0.662866628982417 90.6527999345367 a1520 EP300_mut 166 FTI-277 Farnesyl transferase (FNTA) 6 24 0.0237165266173161 NA 1.81361758062514 1.84680148287557 -0.0331839022504326 0.572048625888051 0.614168527385726 0.0546811734735992 0.0580088837708818 0.0540306133752626 0.756986380991512 NA NA 0.360236494645242 0.903403214528251 90.6527999345367 a1521 TP53_mut 279 BIX02189 MAP2K5 (MEK5) 17 12 2.99573227355399 NA 3.00558530624746 3.04537606830686 -0.0397907620593969 0.885531032153544 0.978558736655103 0.0430374277446258 0.0449343508184335 0.0406626200031786 0.757552348773188 NA NA 0.413509014202802 0.911723910080375 90.6527999345367 a1522 PTEN_mut 206 Ruxolitinib JAK1, JAK2, TYK2 6 23 1.65632149833295 0.0237165266173161 2.7126238229447 2.96390236741802 -0.251278544473323 1.11624478595624 1.54006496885861 0.170842186045283 0.225110609818494 0.163161002655332 0.757721757318792 NA NA 0.761209715913022 0.661255946002981 90.6527999345367 a1523 loss_cnaDLBC4_(CDKN2A) 45 Z-LLNle-CHO g-secretase 8 17 0.940007258491471 NA 0.0984392431816705 0.111541826826692 -0.0131025836450218 0.682423953629356 0.78765449486505 0.0173045059538131 0.0192000640882225 0.0166349379460682 0.758132289586998 NA NA 0.0999016415272207 0.966572520426279 90.6527999345367 a1524 ARID1A_mut 165 DMOG Prolyl-4-Hydroxylase 3 27 8.29404964010203 NA 4.90830275605812 5.20958801572864 -0.301285259670527 0.260038243476485 1.68367330699868 0.185530074218643 1.15861903865603 0.178945201790719 0.75814974827164 NA NA 0.908476546379733 0.407191048639642 90.6527999345367 a1525 PTEN_mut 1129 PF-4708671 RPS6KB1 (p70S6KA) 5 24 2.30258509299405 NA 3.50919049133257 3.57793422951894 -0.0687437381863729 0.859552954385138 0.764785018742802 0.0881836458324717 0.0799761525286679 0.0898863556445939 0.758409863376505 NA NA 0.601313801074782 0.874424751164224 90.6527999345367 a1526 loss_cnaDLBC2 1024 CEP-701 FLT3, JAK2, NTRK1, RET 3 27 0.693147180559945 NA -1.55467837532983 -1.78578913991443 0.231110764584599 1.62807383251652 1.24527773888559 0.181059831964358 0.141953491278322 0.185589734215777 0.758853980600906 NA NA 0.854542106446633 0.831518186563877 90.6527999345367 a1527 loss_cnaDLBC2 1031 Elesclomol HSP70 3 27 -1.6094379124341 NA -2.67281090559563 -2.89583079074787 0.223019885152244 0.94218067383124 1.35905736567143 0.167230329201846 0.236706070657728 0.164098948863769 0.759395389652376 NA NA 0.67841349433885 0.736154697165877 90.6527999345367 a1528 MLL2_mut 1375 Temozolomide DNA akylating agent 9 21 3.40119738166216 NA 4.71700774346058 4.55189270913869 0.16511503432189 0.882989593978221 0.840160581296038 0.19365674628088 0.186995447565787 0.196527947154082 0.759905080834056 NA NA 0.308597222109615 0.641034592495212 90.6527999345367 a1529 CREBBP_mut 1378 Bleomycin (50 uM) DNA damage 6 25 3.91202300542815 NA 3.2634335810166 3.41428592396342 -0.150852342946819 2.06893332135664 1.47759842537914 0.0945623593718993 0.0729131003834877 0.10209292345998 0.760551490583663 NA NA 0.450380949967823 0.871427150074734 90.6527999345367 a1530 CREBBP_mut 30 Sorafenib PDGFRA, PDGFRB, KDR, KIT, FLT3 7 21 1.38629436111989 NA 1.62514758582854 1.64645705665322 -0.0213094708246793 1.11833605921693 0.872830815043963 0.0227854273019072 0.0190546219529042 0.0244142054306435 0.760680227076108 NA NA 0.0335422562448094 0.964391936192618 90.6527999345367 a1531 PTEN_mut 1259 BMN-673 PARP1 5 25 2.30258509299405 NA 2.82919853549638 2.49457541073463 0.334623124761753 2.1115934645933 1.35150233398889 0.225469830529075 0.158469483057527 0.247593449412796 0.76081072480577 NA NA 0.519635829630792 0.748117911305527 90.6527999345367 a1532 loss_cnaDLBC2 41 S-Trityl-L-cysteine KIF11 4 21 1.63315443905142 NA 0.195013512959969 0.59191747680618 -0.39690396384621 1.08046042895812 1.33066664902636 0.305131581878033 0.367347061686415 0.298274525882663 0.760866514089605 NA NA 0.0275826302287205 0.546506877092709 90.6527999345367 a1533 PTEN_mut 179 5-Fluorouracil DNA antimetabolite 6 23 3.46573590279973 NA 1.80910775602761 1.6242629359599 0.184844820067708 1.28508127293281 1.63047130960359 0.117567431934344 0.143839011555943 0.113368949811603 0.761129078206418 NA NA 0.805158951350581 0.773714072748234 90.6527999345367 a1534 ARID1A_mut 1038 NU-7441 PRKDC (DNAPK) 3 29 0.693147180559945 NA 1.9139162640486 1.74111533996168 0.172800924086921 1.02441377569472 1.03576466389613 0.166955509369757 0.168682741473028 0.166834156551463 0.761195781500881 NA NA 0.683624989690574 0.802927963217863 90.6527999345367 a1535 EP300_mut 86 A-443654 AKT1, AKT2, AKT3 5 20 0.0237165266173161 NA -0.939825281643826 -1.40545991699517 0.465634635351346 2.06846364655292 1.04855761046362 0.36223770292046 0.225111345866447 0.44407158052619 0.761215325580412 NA NA 0.0447809543495851 0.648300706442757 90.6527999345367 a1536 TP53_mut 170 Shikonin unknown 17 13 2.77258872223978 NA -0.317976639099784 -0.455168217854377 0.137191578754594 1.19650285476722 0.955782923004653 0.124741420621581 0.114660469223271 0.14353842849934 0.76165300925438 NA NA 0.883446352058353 0.729671386770894 90.6527999345367 a1537 TP53_mut 222 BX-912 PDPK1 (PDK1) 17 12 2.32630161961136 NA 1.00842597332643 1.03859148441178 -0.0301655110853565 1.30141152727895 1.79857116479259 0.0197979618135545 0.0231790716872071 0.0167719307836424 0.761674109679087 NA NA 0.292622766377386 0.960926800341892 90.6527999345367 a1538 TP53_mut 1021 Axitinib PDGFR, KIT, VEGFR 17 13 0.693147180559945 NA 1.64614799661217 1.76326071482095 -0.117112718208772 1.00498643685441 0.770042309302646 0.128449713751997 0.11653164054167 0.152086082535945 0.762360071154014 NA NA 0.847296488052005 0.720531537146402 90.6527999345367 a1539 PTEN_mut 238 CAL-101 PI3Kdelta 6 23 2.99573227355399 2.32630161961136 2.58275011801412 2.78463948826642 -0.201889370252301 1.13314239189406 2.15860868843304 0.100512355128251 0.178167696925398 0.0935275445402079 0.762575064255776 NA NA 0.676064651403915 0.758543458222008 90.6527999345367 a1540 CREBBP_mut 147 NSC-87877 PTPN6 (SHP-1), PTPN11 (SHP-2) 7 23 2.77258872223978 NA 4.54319453340819 4.49409032411497 0.0491042092932146 0.635605726338866 0.628443417411584 0.0779450386468244 0.0772557691952498 0.0781362457346815 0.762595908266726 NA NA 0.415004641109922 0.861224057765324 90.6527999345367 a1541 loss_cnaDLBC4_(CDKN2A) 200 LAQ824 HDAC 8 21 0.0237165266173161 NA -3.54301013127861 -3.38865872964122 -0.154351401637395 0.587166526512032 1.43107389329656 0.121782173965356 0.26287500166996 0.107857045230444 0.76320763076638 NA NA 0.941705366048156 0.683909253295557 90.6527999345367 a1542 TP53_mut 1199 Tamoxifen ER 19 11 1.6094379124341 NA 2.82086481406579 2.9591245031678 -0.138259689102012 1.13545448991515 0.557515528198799 0.142617907851174 0.121765945117134 0.247992534932071 0.763999490134674 NA NA 0.721372267704432 0.659107485215674 90.6527999345367 a1543 PTEN_mut 295 NVP-BHG712 EPHB4 6 23 2.32630161961136 NA 1.58512402315287 1.22300875557777 0.362115267575104 1.65606174306733 1.50997850099819 0.235433603001195 0.218660487201642 0.239814849903971 0.764640415200409 NA NA 0.279745568428481 0.641480973615134 90.6527999345367 a1544 loss_cnaDLBC4_(CDKN2A) 1001 AICAR AAPK1 (AMPK) agonist 8 22 7.60090245954208 NA 6.51822752679008 6.64047868741953 -0.122251160629449 0.432837891242849 0.922299379481607 0.14772928316314 0.282440985650349 0.13255040971421 0.766238479146873 NA NA 0.733069825339981 0.627831663545465 90.6527999345367 a1545 EP300_mut 205 BMS-708163 g-secretase 6 23 2.32630161961136 0.940007258491471 4.10185430724838 4.11985135774585 -0.0179970504974669 0.817246047208075 0.615715194012896 0.0273631488943245 0.0220215815774815 0.0292295052525372 0.766462830552267 NA NA 0.245449879131084 0.961347839400624 90.6527999345367 a1546 MLL2_mut 106 XMD8-85 MAP2K5 (ERK5) 9 18 2.07944154167984 NA 1.89943900119007 2.04194753656183 -0.142508535371766 0.856983815194978 0.979769771252265 0.151247498508925 0.16629081301768 0.145451043248275 0.76661640662201 NA NA 0.731386763553919 0.702545966838059 90.6527999345367 a1547 loss_cnaDLBC4_(CDKN2A) 1170 CCT018159 HSP90 7 23 2.30258509299405 NA 2.73186092985992 2.87423686138945 -0.142375931529523 0.332942044372425 0.996583408855286 0.158773981937384 0.427629775019531 0.14286403954192 0.766640797254191 NA NA 0.659260886839633 0.562607184401982 90.6527999345367 a1548 loss_cnaDLBC2 207 AS601245 JNK 4 25 2.07944154167984 NA 1.88861115839389 2.00326321301692 -0.114652054623029 0.337272195990507 0.792498053254748 0.151739458656041 0.33993924191206 0.144671717680767 0.767691639539148 NA NA 0.855822314935423 0.631348818559778 90.6527999345367 a1549 loss_cnaDLBC2 127 GSK269962A ROCK1, ROCK2 3 25 0.916290731874155 NA 1.6295561505171 1.47604456746022 0.153511583056873 1.15345762191323 1.18583667453062 0.129723264013957 0.133088186458246 0.129454237968847 0.767848521976466 NA NA 0.382505240332136 0.844350869232557 90.6527999345367 a1550 PTEN_mut 207 AS601245 JNK 5 24 2.07944154167984 NA 2.06422492500521 1.97145418058218 0.0927707444230224 0.772598249251311 0.752867460570919 0.122741355101997 0.12007630681654 0.12322320897316 0.768821075515355 NA NA 0.855824748777741 0.814795233080161 90.6527999345367 a1551 PTEN_mut 201 Epothilone B Microtubules 5 24 -3.44201937618241 NA -4.78382951548734 -4.92978450624494 0.145954990757605 2.09857644079571 1.23838941319335 0.104284030676143 0.0695495231530681 0.117858719723096 0.768977902208346 NA NA 0.738598469031253 0.886997020254853 90.6527999345367 a1552 loss_cnaDLBC2 53 CGP-60474 CDK1,CDK2,CDK5,CDK7,CDK9 4 21 -1.36257783450257 NA -3.02269807195008 -2.72808691698989 -0.294611154960183 0.5430772944962 1.23128850071768 0.252925418923899 0.542484758515797 0.239270613498351 0.769037046414624 NA NA 0.184741033250496 0.457944671564791 90.6527999345367 a1553 MLL2_mut 1218 JQ1 BRD2, BRD3, BRD4 9 20 0 NA 0.871199651024094 0.667659127637357 0.203540523386737 1.42922548373846 1.56637166112516 0.133292600358043 0.142413164124622 0.129943951642058 0.769075555748251 NA NA 0.852455090986061 0.73492328510371 90.6527999345367 a1554 CREBBP_mut 1114 Cetuximab EGFR 5 23 4.18661983833127 NA 5.95276177859649 6.06513138692858 -0.112369608332094 0.552658716427746 0.560545360291668 0.200897048838209 0.203325497258823 0.20046479070601 0.77146652172997 NA NA 0.388163317434086 0.695493905716604 90.6527999345367 a1555 loss_cnaDLBC4_(CDKN2A) 111 Salubrinal GADD34-PP1C 8 19 2.77258872223978 NA 2.95750076379378 2.91982840339752 0.0376723603962579 0.648327930244329 1.06810833313168 0.0388745210638816 0.0581069527300184 0.0352701680416657 0.77175730709783 NA NA 0.296757986400313 0.911656541639087 90.6527999345367 a1556 EP300_mut 1502 Bicalutamide ANDR (androgen receptor) 6 22 2.30258509299405 NA 3.59766284558897 3.73366471423907 -0.136001868650105 0.657304196783653 0.694362302957155 0.197852291464511 0.206908565798902 0.195865858602777 0.773122389558106 NA NA 0.478893843233257 0.668520083238708 90.6527999345367 a1557 PTEN_mut 298 OSI-930 KIT, VEGFR, PDGFR 6 23 2.32630161961136 NA 2.85575321340076 3.01445428022579 -0.158701066825035 0.911233873853404 1.14323401515597 0.143756749909438 0.17416063140182 0.138817656508745 0.773894731663274 NA NA 0.907347936938475 0.727243202296755 90.6527999345367 a1558 EP300_mut 5 Sunitinib PDGFRA, PDGFRB, KDR, KIT, FLT3 5 20 2.07944154167984 NA 2.28319422351908 1.7994635283221 0.483730695196981 1.48822922212596 1.21089144762761 0.382848386680302 0.325037761660104 0.399483121418284 0.773953665984513 NA NA 0.0195458621818317 0.528529029912643 90.6527999345367 a1559 loss_cnaDLBC4_(CDKN2A) 55 A-770041 SRC family 8 17 1.63315443905142 NA 1.46879401005125 1.35970504934152 0.109088960709724 2.4575405839974 2.72772431492723 0.0411902982432159 0.0443894849265446 0.0399926635227558 0.774253504112983 NA NA 0.361749570893705 0.921733111868119 90.6527999345367 a1560 TP53_mut 1175 AG-014699 PARP1, PARP2 18 12 1.6094379124341 NA 3.3467475424554 3.23543589429199 0.111311648163413 0.613187584430489 0.682059210263119 0.173618655044887 0.181529520475853 0.163199391619494 0.775102165338708 NA NA 0.415371620618654 0.653060332571942 90.6527999345367 a1561 PTEN_mut 344 THZ-2-49 CDK9 6 23 2.99573227355399 NA 0.261814758267744 0.532963830748807 -0.271149072481063 0.780924603104007 1.78874812491441 0.164407319671909 0.347215430789738 0.151585943657684 0.775426215617382 NA NA 0.725539517142611 0.586752232282821 90.6527999345367 a1562 EP300_mut 1015 CI-1040 MAP2K1 (MEK1), MAP2K2 (MEK2) 5 25 2.30258509299405 NA 2.69688280454927 2.6547375940881 0.0421452104611681 1.21233963080962 0.985678692065922 0.0412725528331124 0.0347635344008534 0.0427575545666249 0.77547799839147 NA NA 0.137282442073189 0.944535092369506 90.6527999345367 a1563 ARID1A_mut 329 QL-XI-92 DDR1 3 26 2.32630161961136 NA 2.21228663564244 2.51759983492517 -0.305313199282734 1.40565711300899 1.29038800329953 0.234986959196032 0.217203183092904 0.236605732928427 0.7755138962261 NA NA 0.293853673677761 0.748612368223396 90.6527999345367 a1564 ARID1A_mut 272 AR-42 HDAC 3 25 1.63315443905142 NA -2.02107137169474 -1.78097359423667 -0.240097777458071 0.910070210456451 1.38473305020689 0.177306397203224 0.263823356373404 0.173389215648603 0.776022049977874 NA NA 0.985946602797241 0.711221803820888 90.6527999345367 a1565 loss_cnaDLBC4_(CDKN2A) 1194 SB-505124 TGFR1 (ALK5) 7 23 2.30258509299405 NA 3.5281795487024 3.50321348050386 0.0249660681985415 0.483672657212207 0.567405577363818 0.0453486608043079 0.0516176960311153 0.0440003926548177 0.778240175516677 NA NA 0.244616205209308 0.910694084866801 90.6527999345367 a1566 EP300_mut 110 Roscovitine CDKs 5 23 2.77258872223978 NA 3.2993756565078 3.35543846199671 -0.0560628054889034 1.04755654188259 0.958499169687717 0.057634429917754 0.0535176892582348 0.0584901972394706 0.778271338823691 NA NA 0.495422875004414 0.916220590761688 90.6527999345367 a1567 EP300_mut 194 AUY922 HSP90 5 24 -1.36257783450257 NA -2.90453158148811 -3.12429933218979 0.21976775070168 0.978269382148757 1.23539329993159 0.183020815934224 0.224649523650595 0.177892943659198 0.778298035907688 NA NA 0.707507877862162 0.676575622464024 90.6527999345367 a1568 loss_cnaDLBC2 1004 Vinblastine Microtubules 3 27 -2.30258509299405 NA -4.7853265092833 -4.99185261820441 0.206526108921116 1.44077611927063 1.22742401472037 0.166034103907582 0.143343650799589 0.168259791599537 0.778314706502829 NA NA 0.866475709555129 0.830601337028424 90.6527999345367 a1569 CREBBP_mut 1495 AZD-2281 PARP1, PARP2 6 24 2.30258509299405 NA 3.55401369960213 3.48315796046457 0.0708557391375657 0.826140784470884 0.898163781855009 0.0799968003359367 0.0857671482505812 0.0788895528510679 0.779850522304843 NA NA 0.436489103297363 0.858024864092751 90.6527999345367 a1570 CREBBP_mut 91 KIN001-135 IKKE 7 20 1.6094379124341 NA 3.41078186780569 3.35862881677271 0.0521530510329797 0.588779071576109 0.642117838386122 0.0828182854262821 0.0885783030524007 0.081220374073487 0.780046849536033 NA NA 0.586255196931209 0.847350081159882 90.6527999345367 a1571 ARID1A_mut 197 Bryostatin 1 PRKC 3 26 -4.8283137373023 NA -3.49784365444493 -3.29481732914449 -0.203026325300434 0.985768637039463 0.980367491064626 0.207007367619448 0.205957379522824 0.207092062059257 0.780119657136241 NA NA 0.562215933454016 0.761918293487752 90.6527999345367 a1572 loss_cnaDLBC2 1021 Axitinib PDGFR, KIT, VEGFR 3 27 0.693147180559945 NA 1.56306970486567 1.71176652298082 -0.148696818115156 1.08853736293986 0.897583426972112 0.162946651615053 0.136602401697599 0.165663506752533 0.780402674068104 NA NA 0.847335461893515 0.838155586287426 90.6527999345367 a1573 ARID1A_mut 1005 Cisplatin DNA crosslinker 3 27 1.79175946922805 2.30258509299405 2.8100236580542 2.7282913258234 0.0817323322308048 1.50854258496735 0.976360784976891 0.0798486064590074 0.0541796652247465 0.0837111992701953 0.780756122884787 NA NA 0.115535162961049 0.934621777124896 90.6527999345367 a1574 PTEN_mut 279 BIX02189 MAP2K5 (MEK5) 6 23 2.99573227355399 NA 2.98434287168105 3.03188720851317 -0.0475443368321149 0.359217622443643 1.00984218146847 0.0514232189740536 0.132355246128199 0.047080957504645 0.781109480747449 NA NA 0.413672394925169 0.854573312658434 90.6527999345367 a1575 loss_cnaDLBC2 279 BIX02189 MAP2K5 (MEK5) 4 25 2.99573227355399 NA 3.10250815147373 3.00917721679977 0.0933309346739546 0.254530670303676 0.976104842553643 0.100987483174803 0.366678540399878 0.0956156865586141 0.782682961756936 NA NA 0.413682647152595 0.693053450275924 90.6527999345367 a1576 TP53_mut 172 Embelin XIAP 16 13 3.46573590279973 NA 2.72001459885982 2.62353127776137 0.0964833210984462 1.29366588171347 1.00393486956235 0.0822002615503179 0.0745813292769638 0.0961051598302456 0.782759613750206 NA NA 0.828362467339383 0.822843579180159 90.6527999345367 a1577 MLL2_mut 1502 Bicalutamide ANDR (androgen receptor) 9 19 2.30258509299405 NA 3.78291486755854 3.66738773572456 0.115527131833984 0.560762031185286 0.736931305603877 0.168027231573242 0.206018106450241 0.156767843834936 0.782881766071737 NA NA 0.478957572501779 0.651532062854743 90.6527999345367 a1578 TP53_mut 63 BMS-509744 ITK 15 10 2.32630161961136 NA 2.7931188337438 2.74065830349004 0.052460530253756 0.953799436193092 0.704027628010403 0.0606691922441162 0.0550016368882982 0.0745148743693633 0.783742855647 NA NA 0.0913362896630198 0.875839430298257 90.6527999345367 a1579 EP300_mut 277 ABT-869 VEGFR and PDGFR family 6 23 0.0237165266173161 NA 1.90865351899374 1.80063676372859 0.108016755265151 0.562064006078895 0.875761645512557 0.130660239730659 0.192178744941708 0.123340358439575 0.7838866732426 NA NA 0.967846482782212 0.718921623448896 90.6527999345367 a1580 PTEN_mut 17 Cyclopamine SMO 4 23 2.77258872223978 NA 4.26432161276777 4.006253316708 0.258068296059768 0.720949633013964 1.11163720515798 0.240668657165056 0.357956068277476 0.232151546261976 0.78473820332257 NA NA 0.54385062380491 0.56962369750603 90.6527999345367 a1581 PTEN_mut 133 Doxorubicin DNA intercalating 5 24 0.0237165266173161 NA -2.16439149835072 -2.45755293543295 0.293161437082235 2.02499871085233 1.10450090601402 0.228454975236443 0.144771172204274 0.265424351837076 0.784959558565069 NA NA 0.421541020375215 0.767431295525274 90.6527999345367 a1582 CREBBP_mut 134 Etoposide TOP2 7 23 2.77258872223978 NA 0.675250364680211 0.506975805317755 0.168274559362456 2.47984500625473 1.79367642816698 0.0858092901628445 0.0678568857884382 0.0938154489404875 0.785229452920983 NA NA 0.61073579284049 0.871702576036352 90.6527999345367 a1583 PTEN_mut 1013 Nilotinib ABL 4 26 0.693147180559945 NA 2.31693778864252 2.09193204174407 0.225005746898451 1.03176418195696 0.776349900576449 0.278614245594632 0.218078656764068 0.289825176420299 0.785884099007118 NA NA 0.38961295410683 0.699810582797954 90.6527999345367 a1584 loss_cnaDLBC2 1001 AICAR AAPK1 (AMPK) agonist 3 27 7.60090245954208 NA 6.71970004574418 6.59545374815992 0.124246297584262 0.954139052655759 0.818066104872248 0.149960457783367 0.130218228924216 0.151878065652977 0.785899389072488 NA NA 0.733140367221471 0.845797474558384 90.6527999345367 a1585 loss_cnaDLBC4_(CDKN2A) 263 FR-180204 ERK 7 22 2.99573227355399 NA 4.63230811827104 4.58267070004733 0.0496374182237105 1.1466343318493 0.624991321543745 0.0642972718838808 0.0432896668492867 0.0794209719602262 0.787047597045988 NA NA 0.432494744966954 0.915826226745615 90.6527999345367 a1586 CREBBP_mut 158 PF-562271 FAK 7 23 0.940007258491471 NA 1.75871153680509 1.63695523045401 0.121756306351073 0.766308305819497 0.915597921865045 0.137464649616513 0.158886841531576 0.132980103431274 0.787547925573325 NA NA 0.7683125162576 0.731815982387752 90.6527999345367 a1587 ARID1A_mut 1011 ABT-263 BCL2, BCL2L1, BCL2L2 3 29 0.693147180559945 NA 0.0279094997535058 0.435206418543321 -0.407296918789815 3.00224853985878 1.57844820574766 0.238095839570648 0.135663957657874 0.258036289886936 0.787555993947221 NA NA 0.127013871888347 0.837274884272045 90.6527999345367 a1588 loss_cnaDLBC4_(CDKN2A) 106 XMD8-85 MAP2K5 (ERK5) 8 19 2.07944154167984 NA 2.05241762430471 1.970035035494 0.0823825888107108 1.01722294624827 0.913933699037205 0.0872701926162168 0.0809877412956077 0.0901406621700215 0.788050237858432 NA NA 0.731473407731443 0.846434246855625 90.6527999345367 a1589 PTEN_mut 29 AZ628 BRAF 4 25 1.38629436111989 NA 1.95603722854958 1.5296061987158 0.426431029833781 0.784282945019043 1.18498324675734 0.371652332559907 0.54372090141961 0.359862496791151 0.788202076895989 NA NA 0.133691085449727 0.391042606066767 90.6527999345367 a1590 loss_cnaDLBC4_(CDKN2A) 89 Parthenolide NFKB1 8 19 1.6094379124341 NA 2.03237848027904 2.3538032651987 -0.321424784919659 1.26308669177182 1.29879320691623 0.249380097597855 0.254475632601887 0.247479570425864 0.788378602872842 NA NA 0.0668369053590151 0.559215478107881 90.6527999345367 a1591 MLL2_mut 71 Pyrimethamine Dihydrofolate reductase (DHFR) 9 19 2.99573227355399 NA 2.95825953142044 2.95455803723556 0.00370149418488142 1.3226535610371 1.16215487852404 0.00304950517540452 0.00279853643759826 0.00318502658577004 0.788573516124736 NA NA 0.187938433285431 0.994368707692363 90.6527999345367 a1592 ARID1A_mut 265 Tubastatin A HDAC6 3 25 2.99573227355399 NA 2.75895189403058 2.94020502444059 -0.181253130410013 1.10862506150515 1.15269550834568 0.157698430443114 0.163493625305502 0.157242853032491 0.788711339712236 NA NA 0.866274669318241 0.809972116169757 90.6527999345367 a1593 MLL2_mut 119 Lapatinib ERBB2, EGFR 9 19 0.693147180559945 NA 2.53452055605043 2.51084552530672 0.0236750307437164 0.890946843899015 0.613836078674306 0.0333120947813788 0.0265728880525669 0.0385689788629678 0.788768324624242 NA NA 0.34557183910262 0.943790064140338 90.6527999345367 a1594 loss_cnaDLBC4_(CDKN2A) 1049 PD-173074 FGFR1, FGFR3 8 24 0.693147180559945 NA 2.02636247325417 1.98760634961902 0.0387561236351501 0.538994462993021 0.899061815432759 0.0467418878456194 0.0719044930813176 0.0431072958164674 0.790083950159336 NA NA 0.319422565712594 0.884957540072462 90.6527999345367 a1595 loss_cnaDLBC4_(CDKN2A) 56 WH-4-023 SRC family, ABL 8 17 1.63315443905142 NA 1.55751903503368 1.91060350694229 -0.35308447190861 2.60127911792418 1.93777283100311 0.163360643104822 0.135734942657892 0.182211488498284 0.790347152068092 NA NA 0.588512998488627 0.739005301472901 90.6527999345367 a1596 loss_cnaDLBC4_(CDKN2A) 53 CGP-60474 CDK1,CDK2,CDK5,CDK7,CDK9 8 17 -1.36257783450257 NA -2.95587796237879 -2.69021140267987 -0.265666559698915 0.729520006853724 1.30835095684141 0.228414411869115 0.364166242464935 0.203054507897698 0.790475625008318 NA NA 0.184894292353315 0.522602460351703 90.6527999345367 a1597 EP300_mut 88 MS-275 HDAC 5 24 1.6094379124341 NA 0.39632126820025 -0.0766075140877361 0.472928782287986 1.33998586525241 1.50331800218331 0.319490718265242 0.352935649958443 0.314589981361988 0.790594934691674 NA NA 0.095442543514833 0.507522618116223 90.6527999345367 a1598 ARID1A_mut 88 MS-275 HDAC 3 26 1.6094379124341 NA -0.330330625691478 0.0436160723065392 -0.373946697998017 0.835415121808294 1.52728507385203 0.251457754718718 0.44761782284787 0.244844072924036 0.79102499791811 NA NA 0.0954443666666833 0.547940450998595 90.6527999345367 a1599 loss_cnaDLBC2 235 QL-XII-47 BTK, BMX 4 24 2.32630161961136 NA 0.391744933776405 0.285636757954732 0.106108175821673 1.99890416454518 1.11264161325526 0.0850592477136905 0.0530831731224173 0.0953659961640583 0.791294714859256 NA NA 0.347672446624244 0.923492767407909 90.6527999345367 a1600 EP300_mut 178 BAY 61-3606 SYK 5 24 2.07944154167984 NA 1.25802790977415 1.04385500183241 0.214172907941748 2.02639059354483 1.09238573407547 0.168018544440701 0.105691819052066 0.196059781138585 0.791905384056811 NA NA 0.747588749217566 0.828557320395003 90.6527999345367 a1601 MLL2_mut 1004 Vinblastine Microtubules 8 22 -2.30258509299405 NA -5.08237578171705 -4.9307724529833 -0.151603328733747 1.0586441116936 1.29940863703417 0.121907299549389 0.143205187710546 0.116671018194686 0.792134736986864 NA NA 0.866500142740906 0.749177808376212 90.6527999345367 a1602 ARID1A_mut 231 FMK RSK 3 25 2.99573227355399 2.32630161961136 4.41454350253394 4.58554468049556 -0.171001177961626 0.836566928865709 0.690243148011743 0.24338978116285 0.204408245247615 0.247740493265595 0.792391793128429 NA NA 0.152635218846415 0.761740871002597 90.6527999345367 a1603 CREBBP_mut 60 BI-2536 PLK1, PLK2, PLK3 6 19 -1.36257783450257 NA -2.56878084898928 -2.21234109472034 -0.356439754268943 0.911099582999799 1.39056336831659 0.27387982283676 0.39121931446326 0.256327588077087 0.79369624155403 NA NA 0.036993244510686 0.479789585592019 90.6527999345367 a1604 MLL2_mut 11 Paclitaxel Microtubules 8 17 -2.27886856637673 NA -3.74443872526858 -3.62954429569203 -0.114894429576549 1.59725807771169 1.6708779234121 0.0696828257985232 0.0719322889517967 0.0687629107828074 0.795143007577964 NA NA 0.0440200603153101 0.871008430191546 90.6527999345367 a1605 loss_cnaDLBC2 152 CP466722 ATM 4 25 2.77258872223978 NA 1.37103001156848 1.55780390682095 -0.186773895252473 0.66828270014411 1.12868016593382 0.171794159614988 0.279483361176635 0.165479912635786 0.795148369563313 NA NA 0.626782299042054 0.659047668820908 90.6527999345367 a1606 TP53_mut 87 GW843682X PLK1 15 10 -1.36257783450257 NA -2.6129810335546 -3.05326828233563 0.440287248781034 1.67291323147201 1.05025108869558 0.301316609917945 0.263185944433963 0.419220940135254 0.795538006615662 NA NA 0.0364895559792293 0.427345415296236 90.6527999345367 a1607 MLL2_mut 332 XMD15-27 CAMK2B, CLK2, DYRK1A, MAST1, STK39 9 20 2.32630161961136 NA 3.54098960095333 3.71949456551816 -0.178504964564831 0.980292399219487 0.799516505223703 0.20827491757528 0.182093592388309 0.223266140721992 0.795630224968536 NA NA 0.149645470823739 0.639718094295026 90.6527999345367 a1608 ARID1A_mut 1375 Temozolomide DNA akylating agent 3 27 3.40119738166216 NA 4.76645200442212 4.5830911322145 0.183360872207619 0.925219722967414 0.848611477526172 0.214630032894423 0.198180894392885 0.216071638274495 0.795742023924207 NA NA 0.308833392577326 0.76930022953958 90.6527999345367 a1609 CREBBP_mut 1060 PD-0325901 MAP2K1 (MEK1), MAP2K2 (MEK2) 7 25 -1.38629436111989 0.693147180559945 0.124057788868996 0.0516120282368843 0.0724457606321121 0.978493723924525 0.912189993692652 0.0782494700590567 0.0740380432299023 0.0794195958441105 0.796642679233686 NA NA 0.579128683901269 0.864380060817505 90.6527999345367 a1610 EP300_mut 255 CP724714 ERBB2 6 23 2.32630161961136 NA 3.8388395535977 3.72202794279879 0.116811610798913 0.738708955758611 0.893695394009904 0.134717322158333 0.158129409273174 0.130706291631193 0.79877559626569 NA NA 0.856528936194386 0.749119710515193 90.6527999345367 a1611 TP53_mut 53 CGP-60474 CDK1,CDK2,CDK5,CDK7,CDK9 15 10 -1.36257783450257 NA -2.66660907590545 -2.93814814060063 0.271539064695179 1.39299190814867 0.657392895943222 0.233683074761701 0.194932262783969 0.413054455517924 0.798851562093672 NA NA 0.184949734759339 0.520360505321738 90.6527999345367 a1612 MLL2_mut 1069 EHT 1864 Rac GTPases 6 22 2.30258509299405 NA 3.44018605472996 3.54137386156852 -0.101187806838563 0.938635370903781 0.829999488842989 0.118769562560994 0.10780310435258 0.121913095367828 0.798857784529793 NA NA 0.989324006811068 0.817145365611911 90.6527999345367 a1613 loss_cnaDLBC4_(CDKN2A) 211 TL-2-105 CRAF 7 22 2.32630161961136 1.63315443905142 2.89494856790055 2.88801049405213 0.00693807384841527 0.776882494551672 0.733675960595813 0.00933170922962395 0.00893066055300826 0.00945659149412626 0.799027182516667 NA NA 0.142565264973424 0.983786345932388 90.6527999345367 a1614 EP300_mut 89 Parthenolide NFKB1 5 22 1.6094379124341 NA 2.60187679348422 2.18054117789029 0.421335615593931 1.57019884539277 1.22528015883126 0.327455552935072 0.268332648970035 0.343868798133337 0.799227495162097 NA NA 0.0668766761742394 0.597405279973599 90.6527999345367 a1615 MLL2_mut 1042 BIRB 0796 p38, JNK2 8 21 2.30258509299405 NA 3.77832236041003 3.72044453987615 0.0578778205338772 1.26103511001201 0.732099137058959 0.0643368635912986 0.0458970730270357 0.079057353852906 0.799239475624851 NA NA 0.556076696075201 0.905460838874171 90.6527999345367 a1616 loss_cnaDLBC4_(CDKN2A) 175 PAC-1 CASP3 agonist 8 21 0.940007258491471 NA 1.07856121237196 1.17082180970763 -0.0922605973356767 0.935918979755245 1.09409201960445 0.087420725786106 0.0985775471289236 0.0843261770331089 0.799986393642235 NA NA 0.788748363418867 0.824213836388924 90.6527999345367 a1617 PTEN_mut 147 NSC-87877 PTPN6 (SHP-1), PTPN11 (SHP-2) 6 24 2.77258872223978 NA 4.48600463258074 4.51043380804238 -0.0244291754616448 0.579525385879381 0.640770594953473 0.0387598215584014 0.0421537624699142 0.0381246824589674 0.800218603052282 NA NA 0.415241101785762 0.930126292872385 90.6527999345367 a1618 EP300_mut 1043 JNK Inhibitor VIII JNK 6 26 2.30258509299405 NA 4.13690223997598 4.18257787898959 -0.0456756390136119 0.481097438298214 0.689628383608027 0.0692613023584409 0.0949405159486618 0.0662322492798864 0.800222871341568 NA NA 0.636213212948897 0.851793659140264 90.6527999345367 a1619 CREBBP_mut 86 A-443654 AKT1, AKT2, AKT3 6 19 0.0237165266173161 NA -1.57229984337669 -1.23023819409802 -0.342061649278671 0.890334367058263 1.38191480481974 0.264944137145186 0.384194592430337 0.247527306376381 0.800915900906722 NA NA 0.0449115042617313 0.490390752747222 90.6527999345367 a1620 EP300_mut 1022 AZD7762 CHEK1, CHEK2 5 25 0.693147180559945 NA -1.37838981776524 -1.6256021651464 0.247212347381154 1.28679001636193 1.20288873861871 0.20342855387799 0.192115531079487 0.205515555549244 0.801110521788447 NA NA 0.499891635551774 0.706787136179657 90.6527999345367 a1621 TP53_mut 147 NSC-87877 PTPN6 (SHP-1), PTPN11 (SHP-2) 17 13 2.77258872223978 NA 4.50017164208296 4.51257855946856 -0.0124069173855998 0.708239267969336 0.508169359061815 0.019683533646987 0.0175179744285755 0.0244149261744265 0.801737617869429 NA NA 0.415249712419124 0.955868428715147 90.6527999345367 a1622 PTEN_mut 1230 IOX2 EGLN1 5 25 -2.30258509299405 NA -0.465550135137927 -0.695785230641723 0.230235095503796 0.630041113743176 1.29215513957436 0.188752248317087 0.365428684702705 0.178179143086206 0.802807181483434 NA NA 0.576514060999287 0.558138085471269 90.6527999345367 a1623 ARID1A_mut 37 Crizotinib MET, ALK 3 23 0.693147180559945 NA 2.08521184274571 1.99479293981311 0.0904189029325992 0.412522856684478 0.972795219272483 0.0962965883584834 0.219185195359386 0.0929475198287057 0.803620345653435 NA NA 0.377576817599379 0.782816145464054 90.6527999345367 a1624 TP53_mut 1037 BX-795 TBK1, PDPK1, IKK, AURKB, AURKC 19 13 1.6094379124341 NA 1.29227173699731 1.20153892719944 0.0907328097978664 1.30141950990023 1.07340713017962 0.0746551689912472 0.0697183414783927 0.0845278620262973 0.804387462138468 NA NA 0.8525154830262 0.831130379251241 90.6527999345367 a1625 loss_cnaDLBC2 1037 BX-795 TBK1, PDPK1, IKK, AURKB, AURKC 3 29 1.6094379124341 NA 1.43432450604119 1.23690329442821 0.197421211612985 0.512647396838176 1.24992670573537 0.162516441370389 0.385101363687026 0.157946230532642 0.805214380858635 NA NA 0.852516832873911 0.621769067076993 90.6527999345367 a1626 PTEN_mut 261 TL-1-85 MAP3K7 (TAK1) 6 23 2.32630161961136 NA 1.47008161064455 1.56108563884993 -0.0910040282053872 1.09000348626126 1.26407104270639 0.0737656783473709 0.0834896670996287 0.0719928114250181 0.805325652763677 NA NA 0.667664855503902 0.864276923118606 90.6527999345367 a1627 CREBBP_mut 1050 ZM-447439 AURKB 7 25 1.38629436111989 0.693147180559945 1.51200797958631 1.62260818373235 -0.110600204146044 0.697151446279778 1.32112826490252 0.0905007462761606 0.158645879222143 0.0837164771084544 0.805443843520899 NA NA 0.783894521972305 0.770104051326288 90.6527999345367 a1628 EP300_mut 119 Lapatinib ERBB2, EGFR 5 23 0.693147180559945 NA 2.65257435595019 2.48929905241437 0.163275303535817 0.630397511128611 0.721013264376319 0.230670923116907 0.259003724877502 0.226452565580816 0.805778062834154 NA NA 0.345681264256058 0.626216514152112 90.6527999345367 a1629 TP53_mut 111 Salubrinal GADD34-PP1C 16 11 2.77258872223978 NA 2.9323343579031 2.92903600440486 0.00329835349824004 1.14508435500901 0.617846836246506 0.00340303323061852 0.00288044586742616 0.00533846465618879 0.806078620564406 NA NA 0.296997791042287 0.992374855605784 90.6527999345367 a1630 EP300_mut 225 Genentech Cpd 10 AURKA, AURKB 6 23 2.32630161961136 NA 1.16215326913738 1.37296853489944 -0.210815265762063 0.607392093290573 1.1776434566167 0.192580326807529 0.347082663885139 0.179014509508441 0.806161519209554 NA NA 0.383686056963366 0.55420014404743 90.6527999345367 a1631 loss_cnaDLBC4_(CDKN2A) 153 Midostaurin KIT 8 22 -0.669430653942629 NA -0.340944875829822 -0.23329367369066 -0.107651202139163 0.821150094226286 0.9240376827959 0.119689597688398 0.131098081697957 0.116500878853163 0.806308627833781 NA NA 0.80333097470251 0.763508040005164 90.6527999345367 a1632 loss_cnaDLBC2 190 Bleomycin DNA damage 4 25 4.15888308335967 NA 1.06936997896222 1.38923205693612 -0.3198620779739 1.72988892042505 1.79146975341609 0.179221312579371 0.184903246790729 0.178547294680229 0.806621195684691 NA NA 0.446265309543187 0.749396213057565 90.6527999345367 a1633 MLL2_mut 110 Roscovitine CDKs 9 19 2.77258872223978 NA 3.37511369351511 3.33136524562249 0.0437484478926216 0.94840237181031 0.98338522824473 0.0449737450777795 0.0461285728431009 0.0444875991992571 0.807179347616923 NA NA 0.495594658229988 0.911685257119314 90.6527999345367 a1634 PTEN_mut 1262 UNC1215 LMBL3 5 25 0 NA 1.71972291734975 1.74382828625662 -0.024105368906864 0.464101826469308 0.492230753720931 0.0493647321375322 0.0519398277103271 0.0489716839605078 0.807228338509365 NA NA 0.564071314989224 0.91987398484468 90.6527999345367 a1635 CREBBP_mut 163 JQ1 BRD4 7 23 0.940007258491471 NA -0.361757948862396 -0.438987088500686 0.0772291396382897 1.55032078473843 1.44422066758843 0.0526226626368829 0.0498149417840127 0.0534746118591747 0.80750289474927 NA NA 0.415073392730214 0.909147148053366 90.6527999345367 a1636 CREBBP_mut 1014 RDEA119 MAP2K1 (MEK1), MAP2K2 (MEK2) 7 25 1.6094379124341 NA 2.86764506389564 2.75205609013574 0.115588973759905 1.13218859632675 1.22917354407656 0.0954966346946789 0.102093391626553 0.0940379609672965 0.807736481835913 NA NA 0.864338397755784 0.819393116121067 90.6527999345367 a1637 EP300_mut 282 EKB-569 EGFR 6 23 0.916290731874155 2.99573227355399 0.213246232988928 0.340478875090633 -0.127232642101705 1.4672510215977 1.32548587387631 0.0940471660497451 0.0867149793926611 0.0959894364846157 0.807781323531916 NA NA 0.842923237771758 0.852333372468508 90.6527999345367 a1638 EP300_mut 279 BIX02189 MAP2K5 (MEK5) 6 23 2.99573227355399 NA 3.15866616352095 2.98641156716363 0.172254596357325 0.708876421193826 0.96383243718533 0.186836610183639 0.242996651048471 0.178718405514924 0.807840265717617 NA NA 0.413835587988065 0.635031502159344 90.6527999345367 a1639 MLL2_mut 219 AT-7519 CDK9 9 20 2.32630161961136 NA -1.19252964535744 -1.0954491597903 -0.0970804855671459 1.5780199806407 1.00793681888215 0.0805448977076694 0.0615204412860032 0.0963160425817293 0.808416993566567 NA NA 0.813031331420945 0.868355571168334 90.6527999345367 a1640 TP53_mut 1060 PD-0325901 MAP2K1 (MEK1), MAP2K2 (MEK2) 19 13 -1.38629436111989 0.693147180559945 0.0512363695333885 0.0911703236054385 -0.03993395407205 0.803394488780432 1.08448520916544 0.0431193651719699 0.0497065322574847 0.0368229587038636 0.809000801884968 NA NA 0.579181513184801 0.910956845952303 90.6527999345367 a1641 ARID1A_mut 1024 CEP-701 FLT3, JAK2, NTRK1, RET 3 27 0.693147180559945 NA -1.94725082154925 -1.74216997922338 -0.205080842325866 1.24944435519116 1.27894660871666 0.1606131724535 0.164137635640837 0.160351371142578 0.809246445583266 NA NA 0.854639605620111 0.808587250660346 90.6527999345367 a1642 EP300_mut 341 EX-527 SIRT1 6 23 2.99573227355399 NA 4.67401250625203 4.72077920641201 -0.0467667001599814 0.35783893102008 0.652810909979345 0.0767848578697889 0.130692040764444 0.0716389684134739 0.80963239347426 NA NA 0.711305304972161 0.818007144811273 90.6527999345367 a1643 CREBBP_mut 170 Shikonin unknown 7 23 2.77258872223978 NA -0.296470240380389 -0.402065131049587 0.105594890669197 1.19535587065811 1.07394166509503 0.0959006203368509 0.0883376183287258 0.0983246056105417 0.810030366645358 NA NA 0.883520982563497 0.83871285235942 90.6527999345367 a1644 EP300_mut 269 NSC-207895 MDM4 6 22 2.99573227355399 NA 3.00951125873216 3.04233510627997 -0.0328238475478106 0.905673922491105 1.40567609907537 0.0247864551092007 0.0362424562888229 0.023350932387199 0.810328597002655 NA NA 0.349296536016896 0.946112271148374 90.6527999345367 a1645 PTEN_mut 1133 JNJ-26854165 MDM2 5 25 2.30258509299405 NA 2.77809988562882 2.62179486393871 0.156305021690112 1.21609604609177 0.829255382688469 0.174678287680495 0.128530161899989 0.188488401707285 0.810479185878522 NA NA 0.631125317188484 0.794893214960266 90.6527999345367 a1646 PTEN_mut 166 FTI-277 Farnesyl transferase (FNTA) 6 24 0.0237165266173161 NA 1.82891650543136 1.84297675167401 -0.0140602462426527 0.523757972722757 0.623614684920564 0.0231639166847609 0.0268449302443272 0.0225463681062027 0.810595179485146 NA NA 0.360578280478704 0.956186305620576 90.6527999345367 a1647 TP53_mut 199 Pazopanib VEGFR, PDGFRA, PDGFRB, KIT 16 13 2.07944154167984 NA 2.90058094630096 2.90763299554461 -0.00705204924365077 1.19406764698865 0.653234849391671 0.00711725299764157 0.00590590429397825 0.010795580257572 0.810875120952766 NA NA 0.388074269417174 0.984054527305153 90.6527999345367 a1648 MLL2_mut 1170 CCT018159 HSP90 8 22 2.30258509299405 NA 2.75564697807618 2.87205902256215 -0.116412044485972 0.349044182218418 1.01633069822771 0.129735381141421 0.333516644643932 0.11454150178576 0.811510149330276 NA NA 0.659448052455912 0.644224406948978 90.6527999345367 a1649 MLL2_mut 1039 SL 0101-1 RSK, AURKB, PIM3 9 23 2.30258509299405 NA 3.99017476672598 3.92965860842911 0.060516158296863 0.987395678680551 0.648155077878772 0.0802921004791523 0.0612886602640699 0.0933667888476863 0.812026482806033 NA NA 0.826001528884847 0.868083606820632 90.6527999345367 a1650 EP300_mut 1036 PLX4720 BRAF 6 26 2.30258509299405 NA 3.23909856680246 3.37834559651486 -0.139247029712401 0.749301645369123 0.823673436084236 0.171538994973542 0.185835745287606 0.169056113275165 0.812138481519889 NA NA 0.503238900869289 0.697771297706769 90.6527999345367 a1651 TP53_mut 158 PF-562271 FAK 17 13 0.940007258491471 NA 1.62179639573784 1.72233941004113 -0.100543014303292 0.896887013912439 0.870870707112809 0.113501383970762 0.112102207684666 0.115451138133491 0.812192624248053 NA NA 0.768381069461205 0.759513880663267 90.6527999345367 a1652 PTEN_mut 1199 Tamoxifen ER 5 25 1.6094379124341 NA 2.93066923036605 2.85973819401063 0.0709310363554212 0.780642792173417 0.999780325017372 0.0730114238534346 0.0908623471151759 0.0709466215532785 0.81226509539506 NA NA 0.721541721931196 0.865096076832882 90.6527999345367 a1653 PTEN_mut 1529 MLN4924 NEDD8-activating enzyme 5 22 0 NA 0.478668607324152 0.403730951484456 0.0749376558396959 2.11598097605523 1.40323290633676 0.0486732064605958 0.0354150895909284 0.0534035764849087 0.812362503453757 NA NA 0.556946095424733 0.942838304692421 90.6527999345367 a1654 PTEN_mut 94 TGX221 PI3Kbeta 4 23 2.30258509299405 NA 3.38013406875548 3.49270980425372 -0.112575735498237 1.44784952766626 1.11298665577122 0.0971910660108734 0.0777537536512471 0.101147426085024 0.812570310601546 NA NA 0.848431363963636 0.890105335102287 90.6527999345367 a1655 EP300_mut 11 Paclitaxel Microtubules 5 20 -2.27886856637673 NA -3.23309053897828 -3.77461550670109 0.541524967722807 2.23480367334481 1.47700598832672 0.331362637927561 0.242314335787856 0.366636947989827 0.812687151816056 NA NA 0.0440705624088668 0.629238668634112 90.6527999345367 a1656 ARID1A_mut 205 BMS-708163 g-secretase 3 26 2.32630161961136 0.940007258491471 4.16174152022537 4.11086471196033 0.0508768082650368 0.640027555062002 0.658940926636368 0.0773722811330005 0.0794915904208346 0.0772099686154611 0.813163625601485 NA NA 0.245741565041552 0.906266725558302 90.6527999345367 a1657 ARID1A_mut 294 MPS-1-IN-1 MPS1 3 26 2.99573227355399 NA 2.6008402058593 2.75099800666191 -0.150157800802607 0.789536924461992 0.944262042483781 0.160823514235065 0.190184646405142 0.159021324639538 0.813224795753672 NA NA 0.818919064410018 0.782148000649448 90.6527999345367 a1658 TP53_mut 1012 Vorinostat HDAC inhibitor Class I, IIa, IIb, IV 17 13 2.30258509299405 NA -0.0255811876434053 -0.115481870704432 0.089900683061027 0.649436913548264 0.649629013823677 0.138411114331857 0.138428662100289 0.13838772768457 0.814030388074428 NA NA 0.554642473900153 0.710224327724673 90.6527999345367 a1659 ARID1A_mut 207 AS601245 JNK 3 26 2.07944154167984 NA 1.89533255386337 1.99807797297724 -0.10274541911387 0.199038222918398 0.783638573795127 0.135906657592319 0.516209487842915 0.131113274090476 0.814615832165887 NA NA 0.855912466789728 0.601842273403052 90.6527999345367 a1660 MLL2_mut 5 Sunitinib PDGFRA, PDGFRB, KDR, KIT, FLT3 8 17 2.07944154167984 NA 1.80295416314556 1.94009461052193 -0.137140447376366 1.27661370338252 1.2782722623448 0.107328152174842 0.107425172558464 0.107285788338083 0.815361482244145 NA NA 0.0196160387359087 0.805923131285422 90.6527999345367 a1661 EP300_mut 292 Masitinib KIT 6 23 2.99573227355399 NA 2.62976714712277 2.73872210977836 -0.108954962655593 0.166035146988568 0.761925831234697 0.157570116195381 0.656216256809141 0.142999434051254 0.815931887783586 NA NA 0.586962618441261 0.533516703579383 90.6527999345367 a1662 EP300_mut 1175 AG-014699 PARP1, PARP2 6 24 1.6094379124341 NA 3.39567654199073 3.27885946848986 0.116817073500874 0.567074633979067 0.656905644732799 0.182018382149727 0.205999469031419 0.177829303854422 0.816107139405805 NA NA 0.41561097793933 0.673002615849812 90.6527999345367 a1663 MLL2_mut 281 CH5424802 ALK 9 20 1.63315443905142 NA 3.06638089373437 3.00234765994153 0.0640332337928458 0.47749544530186 1.48705767561628 0.0502521437994874 0.134102292331533 0.0430603565973382 0.816109573789726 NA NA 0.562118823674924 0.863473187981404 90.6527999345367 a1664 loss_cnaDLBC4_(CDKN2A) 60 BI-2536 PLK1, PLK2, PLK3 8 17 -1.36257783450257 NA -2.53760525090667 -2.18507787566875 -0.352527375237915 0.643909584882027 1.49911344314907 0.27121050938676 0.547479620609317 0.235157236998281 0.816313944026972 NA NA 0.0370507126051836 0.419660054511262 90.6527999345367 a1665 PTEN_mut 1010 Gefitinib EGFR 4 26 -0.693147180559945 NA 0.939979507659209 1.01975077927942 -0.0797712716202124 0.587786053876049 0.678449246319702 0.119182026464742 0.135714808294915 0.117578834456575 0.816443083686718 NA NA 0.982148583023214 0.815977425007517 90.6527999345367 a1666 ARID1A_mut 83 JW-7-52-1 MTOR 3 22 0.182321556793955 NA -2.46920671112328 -2.06294088162312 -0.406265829500167 0.265609120066707 1.86069193835407 0.228280645355555 1.52956280039682 0.218341263873879 0.817016235541135 NA NA 0.201740061543436 0.34962590703272 90.6527999345367 a1667 MLL2_mut 38 AZD-0530 SRC, ABL1 8 19 0.693147180559945 NA 1.98207297201895 2.18540636991662 -0.20333339789767 1.0184702309238 1.09104437334382 0.189814904731698 0.199645892166369 0.186365837050693 0.817327146602976 NA NA 0.234496354447261 0.649954754999308 90.6527999345367 a1668 loss_cnaDLBC4_(CDKN2A) 197 Bryostatin 1 PRKC 8 21 -4.8283137373023 NA -3.27675398018991 -3.33070236569392 0.0539483855040177 0.915218807477718 1.00504025113185 0.0549069518147255 0.0589458881998894 0.0536778357317155 0.817964521235825 NA NA 0.562405914958192 0.892213870803204 90.6527999345367 a1669 CREBBP_mut 54 CGP-082996 CDK4 6 19 1.63315443905142 NA 2.0020538559118 2.19765690211543 -0.195603046203629 1.28703492974657 0.968842434669969 0.186951125972723 0.151979594090849 0.20189355792437 0.818100246433069 NA NA 0.31852163938817 0.741930102198222 90.6527999345367 a1670 CREBBP_mut 1264 SGC0946 Q8TEK3 (DOT1L) 6 24 -0.693147180559945 NA 1.22706572436973 1.17756285975234 0.0495028646173983 0.478681294027637 0.576839790510142 0.0883075359163722 0.103415080628867 0.0858173541974613 0.81820420854984 NA NA 0.76884865372852 0.83305229392527 90.6527999345367 a1671 PTEN_mut 1043 JNK Inhibitor VIII JNK 5 27 2.30258509299405 NA 4.14450723529335 4.17947785618957 -0.0349706208962131 0.549089516938997 0.67499203593033 0.0530183217199979 0.0636883783379501 0.0518089385277171 0.818618550474322 NA NA 0.636280720228785 0.90364389897153 90.6527999345367 a1672 loss_cnaDLBC4_(CDKN2A) 1175 AG-014699 PARP1, PARP2 7 23 1.6094379124341 NA 3.32511848689667 3.29525465597497 0.0298638309216961 0.704734041578493 0.625727178087642 0.0464102880764709 0.0423760300478828 0.0477266002940234 0.818738443955977 NA NA 0.415624564872278 0.921987252316188 90.6527999345367 a1673 MLL2_mut 51 Dasatinib ABL, SRC, KIT, PDGFR 8 16 0.246860077931526 NA -0.332222213817375 -0.252344524741799 -0.0798776890755753 2.631530050958 2.68319535323448 0.02995190611349 0.0303540858469376 0.0297696136732222 0.818793749135434 NA NA 0.177659081131963 0.945439995755994 90.6527999345367 a1674 ARID1A_mut 171 AKT inhibitor VIII AKT1, AKT2, AKT3 3 27 0.940007258491471 NA 1.90122164741531 2.04553771827529 -0.144316070859977 0.159534496933408 0.866826857922942 0.172547878689506 0.904607302082235 0.166487770355641 0.81918902269633 NA NA 0.579278579203971 0.45766311648336 90.6527999345367 a1675 TP53_mut 1019 Bosutinib SRC, ABL, TEC 17 13 0.693147180559945 NA 1.10420373964406 1.06869567013036 0.0355080695136922 1.40128235837472 1.12351511813288 0.0275344680310527 0.0253396963870126 0.0316044430026909 0.820138101211202 NA NA 0.211849176327336 0.939165874130093 90.6527999345367 a1676 PTEN_mut 293 MP470 PDGFR 6 22 2.99573227355399 NA 2.21978158987843 2.29683099795749 -0.0770494080790631 1.27536643152443 1.94154044403827 0.0420497943185073 0.0604135456089799 0.0396846783777554 0.82052145471538 NA NA 0.492610624175919 0.909673399203974 90.6527999345367 a1677 CREBBP_mut 62 BMS-536924 IGF1R 6 19 1.63315443905142 NA 1.90795057758608 1.97561088873036 -0.0676603111442748 1.38690814542373 1.54874683660036 0.0446592148686703 0.048784998031433 0.0436871343626408 0.820623609291566 NA NA 0.0607172561945302 0.921522363610463 90.6527999345367 a1678 loss_cnaDLBC4_(CDKN2A) 1022 AZD7762 CHEK1, CHEK2 8 22 0.693147180559945 NA -1.70926155504453 -1.538995944415 -0.170265610629527 0.268873858437219 1.39605598014196 0.139966808514453 0.633254610988087 0.121961879073225 0.82120832392163 NA NA 0.499990958409401 0.590680118772461 90.6527999345367 a1679 EP300_mut 1067 CCT007093 PPM1D 6 22 1.88706964903238 NA 3.67429242815359 3.59315992991621 0.0811324982373791 0.517329242540097 0.676750127585181 0.124984581248698 0.156829522798705 0.119885456877387 0.82292149287329 NA NA 0.820105357227917 0.757474889001146 90.6527999345367 a1680 EP300_mut 3 Rapamycin MTOR 4 19 -2.30258509299405 NA -3.48762140718842 -3.49326192499985 0.00564051781143338 2.88031149015457 1.89206174775312 0.00273487750067763 0.00195830132633699 0.00298114890707539 0.824100547861516 NA NA 0.412794984798923 0.997208234247302 90.6527999345367 a1681 ARID1A_mut 159 HG-6-64-1 BRAFV600E, TAK, MAP4K5 3 27 1.63315443905142 NA 0.706278900642242 0.550915564768652 0.155363335873591 1.73361256937108 1.65836650960262 0.0933755774387788 0.0896182564769665 0.0936845594589452 0.824305438099361 NA NA 0.433735193632726 0.893838724107993 90.6527999345367 a1682 ARID1A_mut 1001 AICAR AAPK1 (AMPK) agonist 3 27 7.60090245954208 NA 6.69659303884124 6.59802119337135 0.0985718454698903 0.468143589402021 0.850292432831207 0.118924616026094 0.210558998780268 0.115926993659907 0.824500825506481 NA NA 0.733259249022346 0.771853354151525 90.6527999345367 a1683 ARID1A_mut 230 GSK429286A ROCK2 3 26 2.99573227355399 2.32630161961136 3.74284544576656 3.69646076532958 0.0463846804369799 0.890182775928829 0.773010717864631 0.0592932915549433 0.0521069174682485 0.0600052229096036 0.824977375288563 NA NA 0.192449729155478 0.937812295127471 90.6527999345367 a1684 EP300_mut 29 AZ628 BRAF 5 24 1.38629436111989 NA 1.85549475902533 1.53278458695694 0.32271017206839 0.680712877807976 1.21384012772 0.280482621360945 0.474076784190681 0.265858876056888 0.825125546961553 NA NA 0.133861435834089 0.429655606572963 90.6527999345367 a1685 loss_cnaDLBC4_(CDKN2A) 1008 Methotrexate Dihydrofolate reductase (DHFR) 8 22 -1.6094379124341 NA -2.56426488036702 -2.57141853334407 0.00715365297704285 1.07034608298454 1.42965025043169 0.00530360930582256 0.00668349526453696 0.00500377835409939 0.825191910995096 NA NA 0.159384696738021 0.988428436126654 90.6527999345367 a1686 CREBBP_mut 208 SB-715992 KIF11 6 23 -2.05572501506252 NA -3.56777067640709 -3.47662585904865 -0.091144817358435 1.24174472752059 1.10091230964393 0.0807792723880033 0.0734006074987935 0.0827902609136186 0.825287584674431 NA NA 0.735585476527087 0.87440888564975 90.6527999345367 a1687 MLL2_mut 1495 AZD-2281 PARP1, PARP2 9 21 2.30258509299405 NA 3.40874063359091 3.53529559744972 -0.12655496385881 0.774217268900678 0.924513353924962 0.143132192605418 0.163461820011464 0.136888194552873 0.826270184175693 NA NA 0.436745326969005 0.703754218542637 90.6527999345367 a1688 loss_cnaDLBC2 309 Y-39983 ROCK 4 25 2.99573227355399 NA 2.76957273111253 2.62664868395104 0.142924047161488 0.724967870762468 1.24598507157084 0.119170476403338 0.197145353505351 0.114707672204532 0.826561286047426 NA NA 0.979307762449788 0.755717431443156 90.6527999345367 a1689 loss_cnaDLBC4_(CDKN2A) 1219 PFI-1 BRD2, BRD3, BRD4 7 23 2.30258509299405 NA 2.18234711789941 2.06578646768709 0.116560650212321 1.3933540602961 0.956150691723814 0.109441029825765 0.0836547246200658 0.121906150590319 0.826577879375482 NA NA 0.838797256506775 0.84131689574186 90.6527999345367 a1690 CREBBP_mut 201 Epothilone B Microtubules 7 22 -3.44201937618241 NA -4.77803935016675 -4.94489546709764 0.166856116930893 1.73924719776938 1.28507001582319 0.119285106232231 0.0959358262269384 0.129842043527884 0.826753427675144 NA NA 0.738787400337706 0.820508765396941 90.6527999345367 a1691 loss_cnaDLBC4_(CDKN2A) 269 NSC-207895 MDM4 6 22 2.99573227355399 NA 2.86445201188459 3.08189671905658 -0.217444707171999 1.81268434760411 1.17409969858491 0.164593859803683 0.119957292873082 0.185201229021757 0.827344003123801 NA NA 0.349393417298026 0.789814684450416 90.6527999345367 a1692 CREBBP_mut 175 PAC-1 CASP3 agonist 7 22 0.940007258491471 NA 1.23699102935667 1.11621865896997 0.120772370386699 1.05410414358259 1.05508741511941 0.114490397939708 0.114573470868096 0.11446669598749 0.827406532727761 NA NA 0.788815606749208 0.797093186861175 90.6527999345367 a1693 ARID1A_mut 235 QL-XII-47 BTK, BMX 3 25 2.32630161961136 NA 0.387353296564443 0.290408081453034 0.0969452151114083 1.89978442622017 1.17713035587795 0.0777010724473039 0.0510295872381117 0.0823572466951655 0.827679445396668 NA NA 0.34789125082275 0.938400880336583 90.6527999345367 a1694 ARID1A_mut 155 AP-24534 ABL 3 26 -0.669430653942629 NA -0.527181398335926 -0.641145959439708 0.113964561103783 0.935400117792301 1.82941001022567 0.0640731103434395 0.121835093812857 0.0622958005404837 0.827901833918291 NA NA 0.234312180751708 0.868831508270042 90.6527999345367 a1695 loss_cnaDLBC4_(CDKN2A) 288 KIN001-055 JAK3, MNK1 7 22 2.32630161961136 NA 3.71830884845373 3.78958056364736 -0.0712717151936255 1.37867855687497 0.614024022947861 0.0842504728154477 0.0516956725251288 0.116073170641529 0.828040067358949 NA NA 0.86608829971747 0.898323019857389 90.6527999345367 a1696 MLL2_mut 158 PF-562271 FAK 9 21 0.940007258491471 NA 1.62427936934218 1.68297317780944 -0.0586938084672566 0.953616667556585 0.858754276163948 0.0661790733358053 0.0615486394733907 0.068347617119814 0.828405345985706 NA NA 0.768421211541979 0.875914588889851 90.6527999345367 a1697 loss_cnaDLBC4_(CDKN2A) 185 OSI-906 IGF1R 8 21 0.940007258491471 NA 2.26991961684745 2.23779059285322 0.0321290239942327 1.20611258955178 1.54656417988226 0.0219174448710146 0.026638494840828 0.0207744524360305 0.828549418416624 NA NA 0.341093402773991 0.953607046740713 90.6527999345367 a1698 loss_cnaDLBC2 254 AC220 FLT3 4 25 0.0237165266173161 NA 1.56734157680067 1.68149805991286 -0.114156483112187 0.875795016740315 0.711426978251627 0.156054618789822 0.130346120873209 0.160461279375057 0.829468928249853 NA NA 0.524832848711521 0.817460425718746 90.6527999345367 a1699 TP53_mut 1129 PF-4708671 RPS6KB1 (p70S6KA) 18 11 2.30258509299405 NA 3.55464039405347 3.584804261105 -0.0301638670515278 0.777541575580633 0.78380948931558 0.0386781253804277 0.0387938960421542 0.0384836716864283 0.829757477400245 NA NA 0.601656723486972 0.920610509860597 90.6527999345367 a1700 ARID1A_mut 219 AT-7519 CDK9 3 26 2.32630161961136 NA -1.2555433313543 -1.11058153884462 -0.144961792509688 0.509019834413742 1.2443110145067 0.120267614814437 0.284786137413772 0.116499645843894 0.83004590806343 NA NA 0.813077034637232 0.718540938839394 90.6527999345367 a1701 ARID1A_mut 172 Embelin XIAP 3 26 3.46573590279973 NA 2.54963572575485 2.69143203905348 -0.14179631329863 0.486216450257258 1.21223876347389 0.120784673980378 0.291632077079263 0.116970614676838 0.830861931111584 NA NA 0.828463045086813 0.713952291360555 90.6527999345367 a1702 EP300_mut 1373 Dabrafenib BRAF 6 24 2.30258509299405 NA 3.06106108510519 2.8634543394794 0.19760674562579 0.756640172197724 1.61401260416038 0.131970170955915 0.261163433936933 0.122431971792801 0.831308307781167 NA NA 0.715907477610293 0.66696587396263 90.6527999345367 a1703 MLL2_mut 253 XMD14-99 EPHB3, CAMK1 9 20 2.32630161961136 NA 3.08578574189013 3.22926359123137 -0.143477849341241 0.756755521248908 0.954677538679789 0.159317128354978 0.18959603902784 0.150289331767096 0.83149913227579 NA NA 0.320313141896755 0.668953191744588 90.6527999345367 a1704 MLL2_mut 1024 CEP-701 FLT3, JAK2, NTRK1, RET 8 22 0.693147180559945 NA -1.85773615158252 -1.7281114859554 -0.129624665627116 1.01900308080613 1.35219307927155 0.101501500677768 0.127207334372896 0.0958625418323743 0.831754627974365 NA NA 0.854675202281166 0.782244020768527 90.6527999345367 a1705 ARID1A_mut 238 CAL-101 PI3Kdelta 3 26 2.99573227355399 2.32630161961136 2.93743912706073 2.72041890603962 0.217020221021114 0.591951581160178 2.08132206775547 0.108012027296887 0.366618196366284 0.104270369484503 0.831885566651519 NA NA 0.676340319444537 0.692013596409943 90.6527999345367 a1706 loss_cnaDLBC2 1262 UNC1215 LMBL3 3 27 0 NA 1.78289155500723 1.73502396585713 0.0478675891501015 0.869539277835389 0.445515529442545 0.0980543934317699 0.0550493696722498 0.107443143923616 0.833603572437468 NA NA 0.564183832252759 0.933260398396254 90.7118207238641 a1707 TP53_mut 299 OSI-027 MTORC1/2 17 12 2.99573227355399 NA -1.24116670620201 -1.49462667084736 0.253459964645356 1.77103268670232 1.66862821907589 0.146504906385585 0.143114221746692 0.151897206188761 0.833606668662986 NA NA 0.442282477715476 0.697891824296555 90.7118207238641 a1708 loss_cnaDLBC2 306 TG101348 JAK2 4 25 2.32630161961136 NA 0.703054135834996 0.852561141080591 -0.149507005245595 1.38086555694966 1.12056546795579 0.129735917020919 0.108270500696575 0.133421035647596 0.834232326021315 NA NA 0.809621654910501 0.847761162559543 90.7118207238641 a1709 MLL2_mut 229 LY317615 PRKCB (PKCbeta) 9 20 2.99573227355399 2.32630161961136 2.20114620557342 2.22039903179299 -0.0192528262195699 0.732047899872475 1.09171782459861 0.019277022865626 0.0262999541736597 0.0176353502578824 0.834710694591254 NA NA 0.172460676994992 0.956009466818298 90.7118207238641 a1710 CREBBP_mut 301 PHA-793887 CDK-pan 6 23 2.32630161961136 NA -0.333848727430954 -0.109983993437312 -0.223864733993643 1.32462648923432 1.91666525401804 0.122894297954885 0.169002157070741 0.116799077733756 0.835514960948654 NA NA 0.689960587356043 0.745346882401425 90.7118207238641 a1711 TP53_mut 110 Roscovitine CDKs 16 12 2.77258872223978 NA 3.40480353901416 3.26625885701972 0.138544681994441 0.9437037140291 1.00562018007485 0.142773430231513 0.146809512281065 0.137770387607108 0.835749448088996 NA NA 0.495739111992298 0.714503440468651 90.7118207238641 a1712 loss_cnaDLBC4_(CDKN2A) 203 BMS-345541 IKBKB 7 22 2.77258872223978 NA 1.79535029223893 1.89248392578187 -0.0971336335429334 0.644407724232914 0.707781807728017 0.139921918922738 0.150733192496348 0.137236691424343 0.836118302658719 NA NA 0.468827632383526 0.740969581744838 90.7118207238641 a1713 loss_cnaDLBC4_(CDKN2A) 1133 JNJ-26854165 MDM2 7 23 2.30258509299405 NA 2.68822042560266 2.63555774119101 0.0526626844116493 0.522905631787383 0.973882519378742 0.058739305217956 0.100711641279592 0.0540749868323377 0.836689906450568 NA NA 0.631221610117005 0.854491658926124 90.7118207238641 a1714 loss_cnaDLBC4_(CDKN2A) 64 CMK RSK 8 17 1.38629436111989 NA 1.15927617588495 1.41345776038573 -0.254181584500779 1.12724846409312 1.26387506420886 0.207680187685155 0.225488517037165 0.201112904035248 0.836906468735156 NA NA 0.166872757122147 0.620348341496344 90.7118207238641 a1715 MLL2_mut 287 KIN001-244 PDPK1 (PDK1) 9 20 2.99573227355399 NA 1.98974972824074 2.09676054862844 -0.1070108203877 1.446186511316 0.802777134993177 0.103297247452764 0.073995172510856 0.133300782649483 0.837496418918457 NA NA 0.790069219841607 0.839265219058645 90.7118207238641 a1716 loss_cnaDLBC4_(CDKN2A) 345 KIN001-270 CDK9 7 22 2.99573227355399 NA 3.54160036903871 3.65916068951094 -0.117560320472234 1.6858921340429 0.859665118940636 0.107032194320428 0.0697318162285481 0.136751297548403 0.838463679090822 NA NA 0.802528171395119 0.864276623332946 90.7118207238641 a1717 EP300_mut 1010 Gefitinib EGFR 5 25 -0.693147180559945 NA 0.95515515635397 1.01990650040528 -0.0647513440513088 0.398908133511903 0.704506070462114 0.0967238534293297 0.162321443489386 0.0919102712753571 0.838920481094082 NA NA 0.982152811517877 0.781637406481203 90.7118207238641 a1718 ARID1A_mut 1036 PLX4720 BRAF 3 29 2.30258509299405 NA 3.46977134880104 3.34007802978613 0.129693319014909 0.312551998116897 0.837121558897837 0.159572920532771 0.414949575738764 0.154927701522423 0.838967055994271 NA NA 0.503351751380545 0.606227107848213 90.7118207238641 a1719 ARID1A_mut 158 PF-562271 FAK 3 27 0.940007258491471 NA 1.77907888092212 1.65273016353006 0.126348717392069 0.608173982763841 0.904329445826823 0.142531323914296 0.20775094129788 0.13971536365992 0.839394664227878 NA NA 0.76844622966119 0.767739636852969 90.7118207238641 a1720 CREBBP_mut 104 Bortezomib Proteasome 7 21 -3.91202300542815 NA -6.13062018298204 -6.09075228645022 -0.0398678965318124 1.33486588667811 1.07330993247404 0.0350021591846403 0.0298665932882784 0.0371448128127491 0.840396719291885 NA NA 0.0879213541536096 0.944474723658714 90.7118207238641 a1721 TP53_mut 275 I-BET BRD2, BRD3, BRD4 17 12 2.99573227355399 NA 1.50527054133081 1.32109615677922 0.184174384551588 1.31498678518185 1.58772529111821 0.128578818439912 0.140057973682313 0.115998898286666 0.840716834490164 NA NA 0.548723808621383 0.74481181436242 90.7118207238641 a1722 CREBBP_mut 249 XL-184 VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL 6 23 1.63315443905142 NA 2.18401432073737 2.10590120479527 0.0781131159420974 1.32819136583785 1.11269867904052 0.0675929283449764 0.0588116426226139 0.070201499663372 0.841135020557968 NA NA 0.693992937572674 0.898388731106945 90.7118207238641 a1723 PTEN_mut 291 KIN001-266 MAP3K8 (COT) 6 23 2.99573227355399 NA 2.76283624631793 2.69406599351156 0.0687702528063623 0.107096263596001 0.623684877015284 0.121746255524697 0.642134940073952 0.11026442253253 0.841785293485955 NA NA 0.750347391990841 0.620451553614062 90.7118207238641 a1724 CREBBP_mut 6 PHA-665752 MET 7 20 0.693147180559945 NA 2.50817579178188 2.6173953566984 -0.109219564916524 0.818600412475889 0.665310956325625 0.154889276845894 0.133422318449835 0.164163183963964 0.843021954345242 NA NA 0.367671444809871 0.757683425238166 90.7118207238641 a1725 loss_cnaDLBC2 1264 SGC0946 Q8TEK3 (DOT1L) 3 27 -0.693147180559945 NA 1.2413139820311 1.18148003830301 0.0598339437280957 0.559135872736217 0.56075583117267 0.106724305025615 0.107011455793901 0.106702312132839 0.843171178875307 NA NA 0.768906563674031 0.87385393747716 90.7118207238641 a1726 TP53_mut 153 Midostaurin KIT 17 13 -0.669430653942629 NA -0.28176399573782 -0.23615630002232 -0.0456076957155001 0.856862972972755 0.955510713686404 0.0506490564779701 0.0532263584190961 0.047731223797108 0.843378485477793 NA NA 0.80340748707135 0.893389025857031 90.7118207238641 a1727 ARID1A_mut 1037 BX-795 TBK1, PDPK1, IKK, AURKB, AURKC 3 29 1.6094379124341 NA 1.1316662609506 1.26821276805827 -0.136546507107671 0.234253585053105 1.25663961574895 0.112334496279519 0.582900394359881 0.108660036971928 0.844040818218944 NA NA 0.85257333630266 0.618382843756756 90.7118207238641 a1728 MLL2_mut 1022 AZD7762 CHEK1, CHEK2 8 22 0.693147180559945 NA -1.69820514774764 -1.54301645615932 -0.155188691588318 1.63606349041176 1.04029141946622 0.127528537556875 0.094854932279713 0.149178094411224 0.844480360810908 NA NA 0.500091906493159 0.807733702309954 90.7118207238641 a1729 loss_cnaDLBC4_(CDKN2A) 1 Erlotinib EGFR 8 19 0.693147180559945 NA 2.11527122455241 2.27044458870438 -0.155173364151976 0.683047716840773 0.901801975234702 0.183361538145095 0.227177926704275 0.172070330752592 0.845609957392739 NA NA 0.190483704107235 0.631661496656166 90.7118207238641 a1730 PTEN_mut 1248 FK866 NAMPT 5 23 0 NA -4.45806877372299 -4.32429488831313 -0.133773885409855 3.02708520005481 3.16895321573474 0.0425010429050653 0.0441923092906116 0.0422139035520091 0.845721833331601 NA NA 0.243395572236457 0.932095772560547 90.7118207238641 a1731 loss_cnaDLBC4_(CDKN2A) 298 OSI-930 KIT, VEGFR, PDGFR 7 22 2.32630161961136 NA 3.06004814474138 2.95666503238218 0.103383112359194 1.0736345525118 1.11381649073841 0.0935582388814006 0.0962926464292031 0.0928188020368207 0.846217074493673 NA NA 0.907429096555849 0.830192499932487 90.7118207238641 a1732 EP300_mut 253 XMD14-99 EPHB3, CAMK1 6 23 2.32630161961136 NA 3.18725940931733 3.18407769764064 0.0031817116766919 1.02103562267859 0.874210392528614 0.00352269912459888 0.0031161612837219 0.00363952625578946 0.846419340721431 NA NA 0.320385353046663 0.994614158321127 90.7118207238641 a1733 PTEN_mut 1060 PD-0325901 MAP2K1 (MEK1), MAP2K2 (MEK2) 5 27 -1.38629436111989 0.693147180559945 0.0473443463031925 0.0711845739440415 -0.0238402276408489 0.74092119987019 0.951624548388457 0.0257369343496147 0.0321764684895314 0.025052136035395 0.8465462958415 NA NA 0.579320335652657 0.951621708264452 90.7118207238641 a1734 PTEN_mut 52 GNF-2 ABL [T315I] 4 21 0.246860077931526 NA 2.35146545706588 2.22274050055583 0.128724956510052 0.280303292165072 0.625321794850318 0.217500381232335 0.459234550960054 0.20585394203454 0.847131588209319 NA NA 0.458695346793615 0.525304611967917 90.7118207238641 a1735 loss_cnaDLBC2 1373 Dabrafenib BRAF 3 27 2.30258509299405 NA 3.03676410034217 2.8881103095226 0.148653790819575 1.68703151628194 1.4834209792633 0.0991764384313486 0.0881155979511245 0.10021011762514 0.847633857803947 NA NA 0.715950750037591 0.895150463628174 90.7118207238641 a1736 CREBBP_mut 300 CX-5461 RNA Pol I 6 23 2.32630161961136 NA 1.68532360995406 1.62516501508799 0.0601585948660721 2.2479828780347 1.26170441993976 0.0402588082357258 0.026761144603853 0.0476804185792931 0.847885182478533 NA NA 0.458126523470353 0.951854925724997 90.7118207238641 a1737 PTEN_mut 1008 Methotrexate Dihydrofolate reductase (DHFR) 4 26 -1.6094379124341 NA -2.94025910393131 -2.51247270618386 -0.42778639774745 1.78400376346252 1.27685973458414 0.319146861545476 0.239790075844443 0.335030063334854 0.848050444206899 NA NA 0.159476256117385 0.671570826817559 90.7118207238641 a1738 TP53_mut 54 CGP-082996 CDK4 15 10 1.63315443905142 NA 2.16082061609654 2.13554950342159 0.025271112674949 0.934534709791008 1.20746571598237 0.0240718880560465 0.0270413847770303 0.0209290519312085 0.849317829379919 NA NA 0.318706363939929 0.956076354556099 90.752604255914 a1739 ARID1A_mut 1133 JNJ-26854165 MDM2 3 27 2.30258509299405 NA 2.72111200983466 2.63970499989288 0.0814070099417807 1.57615059448511 0.821230513782392 0.09080644087878 0.051649258786959 0.099128087151608 0.84979278305689 NA NA 0.63126407046584 0.937383400511577 90.752604255914 a1740 TP53_mut 64 CMK RSK 15 10 1.38629436111989 NA 1.43614505121654 1.1760815565389 0.260063494677638 1.3530977627223 0.986933954385816 0.212653762366015 0.192198599275204 0.263506482396261 0.850019831768353 NA NA 0.166935241971658 0.5842223855301 90.752604255914 a1741 EP300_mut 1025 SB 216763 GSK3A, GSK3B 5 25 2.30258509299405 NA 4.12171905360013 4.12807984146691 -0.00636078786678151 1.02371907813524 0.675521535626601 0.00864910076145909 0.00621341147453072 0.00941611411526854 0.85038550933953 NA NA 0.489693624006475 0.989912728693452 90.752604255914 a1742 loss_cnaDLBC2 230 GSK429286A ROCK2 4 25 2.99573227355399 2.32630161961136 3.71663746851076 3.69879865447303 0.017838814037729 0.86846563929212 0.770970218641172 0.022800026350934 0.0205406100490853 0.0231381363461351 0.850984589640711 NA NA 0.192564588426017 0.971068565674601 90.7644042382015 a1743 CREBBP_mut 345 KIN001-270 CDK9 6 23 2.99573227355399 NA 3.54215470618378 3.65390476153953 -0.11175005535575 1.04954751861777 1.10944530447545 0.101720464707487 0.106474507703017 0.100726060946814 0.854946707692648 NA NA 0.802558987344289 0.824116919302045 91.1346801243677 a1744 PTEN_mut 208 SB-715992 KIF11 6 23 -2.05572501506252 NA -3.59865950822307 -3.46856790292274 -0.130091605300323 1.35034595141875 1.07059139537487 0.115365620663767 0.0963394640933616 0.121513778143874 0.855613825616069 NA NA 0.735663232201064 0.833342129276083 91.1534959362874 a1745 CREBBP_mut 140 Vinorelbine Microtubules 7 23 -2.74887219562247 NA -4.39661077606037 -4.51567891329105 0.119068137230677 1.98931627500902 1.18066777806001 0.0854138312941095 0.059853799381467 0.10084812971378 0.857150780037546 NA NA 0.921972981044063 0.884429709041561 91.1941066496091 a1746 EP300_mut 111 Salubrinal GADD34-PP1C 5 22 2.77258872223978 NA 2.95720462857404 2.92503284691059 0.032171781663449 1.22340919411364 0.912728869151221 0.0331957465024373 0.0262968284186858 0.0352479063069044 0.857228644261872 NA NA 0.297277974183018 0.957939348538736 91.1941066496091 a1747 loss_cnaDLBC4_(CDKN2A) 229 LY317615 PRKCB (PKCbeta) 7 22 2.99573227355399 2.32630161961136 2.08710912915796 2.25493329917795 -0.167824170019989 0.722063672592834 1.06137244509833 0.168496387107642 0.232422951590065 0.158119961371751 0.857674394854482 NA NA 0.172553033958345 0.642735005132446 91.1941066496091 a1748 loss_cnaDLBC4_(CDKN2A) 51 Dasatinib ABL, SRC, KIT, PDGFR 8 16 0.246860077931526 NA -0.636267495597357 -0.100321883851808 -0.535945611745549 2.41430192107167 2.75883829057474 0.201933565484559 0.221987816464832 0.194264960572915 0.85795831008842 NA NA 0.177866086668055 0.631930880636387 91.1941066496091 a1749 EP300_mut 1149 TW 37 BCL2, BCL2L1 6 24 1.6094379124341 NA -0.939180469819583 -1.01524994484472 0.0760694750251383 0.829645984082962 0.658406451581437 0.109911214183445 0.0916890776120861 0.115535737601638 0.859290568134477 NA NA 0.761624489448637 0.840875529354518 91.237056709953 a1750 TP53_mut 184 BMS-754807 IGF1R 16 13 0.940007258491471 NA 1.18617475406168 1.03557074269298 0.150604011368694 1.78608051389025 1.00009142756036 0.1011518507089 0.0843209531694985 0.150590243270138 0.861720024981233 NA NA 0.699151362232186 0.776920903386405 91.237056709953 a1751 CREBBP_mut 1241 CHIR-99021 GSK3B 6 23 2.30258509299405 NA 3.09278190500968 3.25477725264263 -0.161995347632947 1.65708938523743 1.05567240980946 0.13610776456842 0.0977589676671164 0.153452288918099 0.862056008205108 NA NA 0.390045653894698 0.827314560596259 91.237056709953 a1752 loss_cnaDLBC2 330 XMD13-2 RIPK 4 25 2.32630161961136 NA 1.70846737273156 1.84012019153146 -0.131652818799902 1.51792022532306 1.02983085818494 0.120246098167872 0.0867323701229971 0.127839263849539 0.862449622029999 NA NA 0.677116460648824 0.876376168252657 91.237056709953 a1753 loss_cnaDLBC2 133 Doxorubicin DNA intercalating 4 25 0.0237165266173161 NA -2.35592034738375 -2.41518186210438 0.0592615147206286 0.766642928133352 1.33916929276896 0.0460039602718288 0.0773000213605576 0.044252444437473 0.862588987729496 NA NA 0.421940894459881 0.903012516619243 91.237056709953 a1754 CREBBP_mut 290 KIN001-260 IKK 6 23 2.99573227355399 NA 3.13821026486822 3.08694738779253 0.0512628770756924 1.26226132284366 0.902854275064717 0.0523404277741725 0.0406119368057685 0.0567786834392714 0.863200502998626 NA NA 0.670358110196974 0.928413268316936 91.237056709953 a1755 EP300_mut 167 OSU-03012 PDPK1 (PDK1) 5 24 2.77258872223978 NA 1.46179391549286 1.32092611943277 0.140867796060091 0.603865538215044 0.560110217099147 0.248529266961419 0.233276759717867 0.251500136508233 0.86342448966288 NA NA 0.155658988897714 0.649381011819472 91.237056709953 a1756 CREBBP_mut 1052 RO-3306 CDK1 7 25 1.6094379124341 NA 3.1384866013509 3.13543410523483 0.00305249611607028 0.990136488815306 0.817303476711887 0.00357154639925043 0.00308290437788287 0.00373483804125103 0.864258268612214 NA NA 0.244082952017619 0.994209973366172 91.237056709953 a1757 loss_cnaDLBC4_(CDKN2A) 163 JQ1 BRD4 8 22 0.940007258491471 NA -0.556298131173515 -0.371755619462019 -0.184542511711496 1.31431758596551 1.51261645577702 0.125919511190332 0.140409375695851 0.122002184365169 0.86483895640088 NA NA 0.415337509389692 0.748962178715509 91.237056709953 a1758 MLL2_mut 249 XL-184 VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL 9 20 1.63315443905142 NA 2.15332503796123 2.10799441465322 0.0453306233080126 1.20292155708308 1.13552084483615 0.0392166928306242 0.0376837733442347 0.0399205558525469 0.86499404077802 NA NA 0.694056929015559 0.925197302016436 91.237056709953 a1759 loss_cnaDLBC4_(CDKN2A) 167 OSU-03012 PDPK1 (PDK1) 8 21 2.77258872223978 NA 1.33233766817125 1.35011881421337 -0.0177811460421158 0.321824208727314 0.633622067397653 0.0312266293500599 0.0552511139930494 0.028062700081051 0.865310360072597 NA NA 0.1556653752667 0.921713071184845 91.237056709953 a1760 TP53_mut 272 AR-42 HDAC 17 11 1.63315443905142 NA -1.77278960719797 -1.85910278623958 0.0863131790416005 1.45255409669959 1.18415169356587 0.0636703488013702 0.0594216623241201 0.0728903057864854 0.866692034733045 NA NA 0.98596172338918 0.86478957358483 91.237056709953 a1761 CREBBP_mut 119 Lapatinib ERBB2, EGFR 7 21 0.693147180559945 NA 2.52144416610318 2.51745908678854 0.00398507931464209 0.611341247571787 0.73802121894726 0.00560651703650834 0.00651858406490745 0.00539968121828062 0.86729864377843 NA NA 0.345995739566058 0.988936819553197 91.237056709953 a1762 PTEN_mut 171 AKT inhibitor VIII AKT1, AKT2, AKT3 6 24 0.940007258491471 NA 2.01530296365773 2.03505689807218 -0.019753934414446 0.941383006616958 0.813215884704237 0.0235855885265374 0.0209839505021825 0.0242911320179516 0.868701432394186 NA NA 0.57945589936859 0.963685021703468 91.237056709953 a1763 loss_cnaDLBC4_(CDKN2A) 279 BIX02189 MAP2K5 (MEK5) 7 22 2.99573227355399 NA 2.9325743638327 3.05052011268456 -0.117945748851866 1.16847425176878 0.840217221201152 0.127743082183631 0.100939963951559 0.140375305189834 0.868724866181056 NA NA 0.414123202505284 0.810714549844611 91.237056709953 a1764 TP53_mut 262 VX-11e ERK 17 12 1.63315443905142 NA 2.02370219021158 2.03436408338776 -0.0106618931761799 1.12127509690035 1.50098702879741 0.00826797750334887 0.00950872199485534 0.00710325470615311 0.869494916036115 NA NA 0.546116617791618 0.983585885552161 91.237056709953 a1765 CREBBP_mut 1039 SL 0101-1 RSK, AURKB, PIM3 7 25 2.30258509299405 NA 3.89702826749586 3.9605809208773 -0.0635526533814379 0.853104589843135 0.726773383181301 0.0843169223078117 0.074495734917009 0.0874449379299628 0.869892613609512 NA NA 0.826090706805512 0.861563934075118 91.237056709953 a1766 loss_cnaDLBC4_(CDKN2A) 6 PHA-665752 MET 8 19 0.693147180559945 NA 2.58786019010276 2.58959242924311 -0.00173223914035248 0.900580384560668 0.615327195899699 0.00245048043233966 0.00192346976466461 0.0028151512754441 0.869952693171475 NA NA 0.36779576856837 0.996130782328742 91.237056709953 a1767 CREBBP_mut 1091 BMS-536924 IGF1R 6 24 1.38629436111989 NA 2.30845891749747 2.23592673051524 0.0725321869822229 1.22874011232983 0.934448218281171 0.0730129681287248 0.0590297217893324 0.0776203384663079 0.870286153506496 NA NA 0.962852101281724 0.896568323295232 91.237056709953 a1768 MLL2_mut 294 MPS-1-IN-1 MPS1 9 20 2.99573227355399 NA 2.6818619234288 2.75958557399642 -0.0777236505676258 0.716678864313113 1.01181513452886 0.083203458994758 0.10844975963135 0.0768160585024424 0.870900183742134 NA NA 0.819021527663119 0.815495057454652 91.237056709953 a1769 MLL2_mut 286 KIN001-236 TIE2 9 20 2.32630161961136 NA 2.93865236647628 3.01350917624086 -0.0748568097645848 0.981620688320755 0.984032118256132 0.0761267379645637 0.0762583864166935 0.0760715106507331 0.871133419389028 NA NA 0.891800789413528 0.851891018656327 91.237056709953 a1770 loss_cnaDLBC2 89 Parthenolide NFKB1 3 24 1.6094379124341 NA 2.23922534394232 2.26098391038253 -0.0217585664402047 0.672030485871994 1.33853214124392 0.016764835830893 0.0323773502804294 0.0162555427469856 0.871259059501031 NA NA 0.0670847076063462 0.965443551584216 91.237056709953 a1771 loss_cnaDLBC2 255 CP724714 ERBB2 4 25 2.32630161961136 NA 3.67133402876612 3.75817375563575 -0.0868397268696306 0.866150226377153 0.868138459839342 0.100055247026975 0.100259428705405 0.100029811933112 0.871368236543649 NA NA 0.856636694982374 0.861347876656926 91.237056709953 a1772 loss_cnaDLBC2 245 UNC0638 G9a(EHMT2), GLP(EHMT1) 4 25 3.68887945411394 NA 1.92262395838557 1.86804856670606 0.0545753916795082 0.727504012445936 0.709283300462538 0.0767229341432766 0.075017306771987 0.0769444193087846 0.871513421255839 NA NA 0.838378664519742 0.895636445161788 91.237056709953 a1773 loss_cnaDLBC2 164 JQ12 HDAC 4 26 1.63315443905142 NA 0.3478122722818 0.559060310804407 -0.211248038522607 0.913994183964178 1.64223510232537 0.13367226435308 0.231126239344742 0.128634467880686 0.87169255991499 NA NA 0.424252854856555 0.717530004789001 91.237056709953 a1774 MLL2_mut 55 A-770041 SRC family 8 17 1.63315443905142 NA 1.12526881962222 1.5213639624846 -0.396095142862371 2.78869533876472 2.57509364382785 0.149926338690216 0.142036004204685 0.153817762632345 0.871894688006737 NA NA 0.362365553475338 0.739811271026946 91.237056709953 a1775 PTEN_mut 287 KIN001-244 PDPK1 (PDK1) 6 23 2.99573227355399 NA 2.02268028771101 2.07421203480302 -0.0515317470920063 0.590648229299311 1.11376365833782 0.0496933655705804 0.0872460874946474 0.0462681168542637 0.872017320531054 NA NA 0.790133880186008 0.879648469648299 91.237056709953 a1776 CREBBP_mut 245 UNC0638 G9a(EHMT2), GLP(EHMT1) 6 23 3.68887945411394 NA 1.91041911820054 1.86648675182568 0.0439323663748574 0.406683959989132 0.763839002073973 0.0617583486295794 0.108025815367863 0.0575152175465935 0.872129156280525 NA NA 0.838379452204091 0.851048637519189 91.237056709953 a1777 PTEN_mut 260 NG-25 MAP3K7 (TAK1) 6 23 2.32630161961136 NA 0.853427149993121 0.823875472731921 0.0295516772611998 1.92891870961112 1.35088701913138 0.0200334209736329 0.0153203331555416 0.021875757811487 0.873978459575572 NA NA 0.317302134545759 0.972899794123219 91.237056709953 a1778 TP53_mut 1015 CI-1040 MAP2K1 (MEK1), MAP2K2 (MEK2) 17 13 2.30258509299405 NA 2.74344179555992 2.55494948849464 0.188492307065278 1.04520102319718 0.9773737902225 0.185398662469392 0.180340721910793 0.19285590523393 0.874154292444571 NA NA 0.137683038418634 0.6156946885896 91.237056709953 a1779 CREBBP_mut 219 AT-7519 CDK9 6 23 2.32630161961136 NA -1.18123037518567 -1.11105946751778 -0.0701709076678947 1.28451390183618 1.1872266967029 0.0581927853388999 0.0546283754248103 0.0591048936675445 0.874530511168437 NA NA 0.813152959305609 0.906909634410853 91.237056709953 a1780 loss_cnaDLBC2 151 QS11 ARFGAP 4 25 2.32630161961136 NA 2.45822839814137 2.40035669418314 0.057871703958233 0.475573484302043 1.15181157019986 0.0527329798185051 0.121688247701964 0.0502440724294783 0.87464660336905 NA NA 0.575977006049316 0.864672294720472 91.237056709953 a1781 TP53_mut 200 LAQ824 HDAC 16 13 0.0237165266173161 NA -3.40180119976454 -3.46746885972783 0.0656676599632955 1.52987436572174 0.835272192183195 0.051747480337138 0.0429235638132389 0.078618276267113 0.874915398966048 NA NA 0.941780582214415 0.884473095322222 91.237056709953 a1782 loss_cnaDLBC4_(CDKN2A) 222 BX-912 PDPK1 (PDK1) 7 22 2.32630161961136 NA 1.01701968835355 1.02214552459163 -0.00512583623807572 1.34914981084543 1.57006554735804 0.00336397555248448 0.00379930842140034 0.00326472754382835 0.875058222100341 NA NA 0.293245613365035 0.993437249338885 91.237056709953 a1783 TP53_mut 1069 EHT 1864 Rac GTPases 16 12 2.30258509299405 NA 3.54090780699083 3.49140136425283 0.0495064427379983 0.926287551886761 0.740601592029087 0.0580599918647489 0.0534460844660584 0.066846254816117 0.876560826150165 NA NA 0.989332891907293 0.876403800491268 91.300656216649 a1784 PTEN_mut 277 ABT-869 VEGFR and PDGFR family 6 23 0.0237165266173161 NA 1.87255832910794 1.81005290022054 0.0625054288874045 0.568819477866632 0.875728736561319 0.0755328566893037 0.109886231606963 0.0713753315128627 0.876651000087349 NA NA 0.967878674262236 0.83596711075954 91.300656216649 a1785 ARID1A_mut 310 YM201636 FYV1 3 26 1.63315443905142 NA 0.969543736711601 0.875326495819894 0.0942172408917072 0.850702441448076 0.939070408944392 0.101003487312579 0.11075228693517 0.100330326665938 0.877282028870006 NA NA 0.937769135507448 0.870527411864546 91.30726093655 a1786 TP53_mut 1050 ZM-447439 AURKB 19 13 1.38629436111989 0.693147180559945 1.61508169901157 1.57405447455333 0.0410272244582439 1.16110487798428 1.30996755944934 0.0335511402578232 0.0353346413714743 0.0313192675362817 0.878336400112772 NA NA 0.784031942603011 0.928200458142493 91.30726093655 a1787 loss_cnaDLBC2 333 T0901317 LXR 4 25 2.32630161961136 NA 2.995794222591 2.89413281562963 0.10166140696137 0.866133528192256 1.40846766713193 0.0748093973294212 0.117373827074391 0.072178729646229 0.878389004419482 NA NA 0.875636194078718 0.850555996421258 91.30726093655 a1788 loss_cnaDLBC2 83 JW-7-52-1 MTOR 4 21 0.182321556793955 NA -2.12526275299735 -2.10910802462328 -0.0161547283740688 1.89796694352901 1.76741032777924 0.00905036396226992 0.00851159627892744 0.00914033833578834 0.879279653163255 NA NA 0.202047823353917 0.988162748596166 91.30726093655 a1789 TP53_mut 194 AUY922 HSP90 16 13 -1.36257783450257 NA -3.03716170242037 -3.14701958778997 0.109857885369602 1.24570628488336 1.14626548578412 0.0913559336713601 0.08818923585979 0.0958398265777418 0.88013838257961 NA NA 0.707816070284125 0.806923219680424 91.30726093655 a1790 TP53_mut 276 CAY10603 HDAC6 17 12 2.99573227355399 NA -0.860314768515193 -0.762345162026851 -0.097969606488342 1.66868368490514 1.2338850798129 0.0650197894024171 0.0587107115474143 0.0793992958430113 0.880248038916669 NA NA 0.92710824215353 0.85716762090096 91.30726093655 a1791 TP53_mut 106 XMD8-85 MAP2K5 (ERK5) 16 11 2.07944154167984 NA 1.98427493240093 2.00923706821898 -0.0249621358180439 0.979261118448757 0.890393454440417 0.0264228507796507 0.0254907862139837 0.0280349498230889 0.880565004700627 NA NA 0.731745522556253 0.945819952252714 91.30726093655 a1792 PTEN_mut 197 Bryostatin 1 PRKC 5 24 -4.8283137373023 NA -3.2006124290471 -3.33982164066067 0.139209211613568 0.560563045575866 1.03724642316864 0.141855142544882 0.248338189097996 0.134210355903956 0.881489192366792 NA NA 0.562639916040538 0.679727820818804 91.30726093655 a1793 ARID1A_mut 1021 Axitinib PDGFR, KIT, VEGFR 3 27 0.693147180559945 NA 1.78169649021046 1.68747465794251 0.094221832267946 0.615134953017937 0.932239455270641 0.10317223171981 0.153172619773402 0.101070418909262 0.881979616172147 NA NA 0.847493671690969 0.827444643911134 91.30726093655 a1794 CREBBP_mut 1 Erlotinib EGFR 7 20 0.693147180559945 NA 2.12324995567163 2.25989336460506 -0.136643408933431 0.753337139447579 0.874731852235622 0.161291105750257 0.181384139687618 0.156211767736821 0.882716100329615 NA NA 0.190630662094059 0.699291109895151 91.30726093655 a1795 PTEN_mut 1241 CHIR-99021 GSK3B 5 24 2.30258509299405 NA 3.25156611854145 3.21494740200547 0.0366187165359837 1.0789091704122 1.21065287385941 0.0307189982157717 0.0339404998494855 0.0302470818239151 0.883296728352568 NA NA 0.390124825941124 0.948238299556596 91.30726093655 a1796 TP53_mut 346 THZ-2-102-1 CDK7 17 12 0.916290731874155 2.99573227355399 -3.77544087812217 -3.74271138164221 -0.0327294964799596 1.57702258629082 1.2082995539751 0.022756336542533 0.0207539808018476 0.0270872370781609 0.883605811566714 NA NA 0.380328100001995 0.950055465731952 91.30726093655 a1797 CREBBP_mut 257 NPK76-II-72-1 PLK3 6 23 2.32630161961136 NA 1.06208870094602 1.07335243242205 -0.0112637314760293 1.544631419462 1.39894316205162 0.00789304547988999 0.00729218073263879 0.00805160050928053 0.883841933108765 NA NA 0.362203438892838 0.987500183690877 91.30726093655 a1798 PTEN_mut 275 I-BET BRD2, BRD3, BRD4 6 23 2.99573227355399 NA 1.415961558531 1.43247755359949 -0.0165159950684892 1.7179862062689 1.36309409969006 0.0115057968014787 0.00961357839092229 0.0121165479861182 0.884024923895603 NA NA 0.548872526158467 0.983220392525702 91.30726093655 a1799 TP53_mut 331 QL-X-138 MNK2, PRKDC (DNAPK), MTOR, BTK, JAK3 17 12 2.32630161961136 NA -0.18444272632783 -0.318940335948072 0.134497609620242 1.44564227737224 1.12465501506303 0.101561670767993 0.0930365773922438 0.119590103470711 0.884108649073826 NA NA 0.597502748710137 0.780525311956513 91.30726093655 a1800 EP300_mut 263 FR-180204 ERK 6 23 2.99573227355399 NA 4.59852474540906 4.59364190245583 0.00488284295323282 0.624220586184405 0.80216278097156 0.0063223881816765 0.00782230362359493 0.00608709736859 0.885040305097705 NA NA 0.43295889574433 0.98754036632018 91.30726093655 a1801 loss_cnaDLBC2 94 TGX221 PI3Kbeta 3 24 2.30258509299405 NA 3.55710099480776 3.46589828285142 0.0912027119563419 0.941157106768183 1.17566850177854 0.0787142532322092 0.0969048751802138 0.0775751938734186 0.885068758733463 NA NA 0.848543758108062 0.888206759159615 91.30726093655 a1802 EP300_mut 155 AP-24534 ABL 5 24 -0.669430653942629 NA -0.524301486745111 -0.651242987779777 0.126941501034665 2.48994656417408 1.62303244949779 0.0713822663803 0.0509816165780938 0.078212546566117 0.885954522731596 NA NA 0.234550341964952 0.917472465394318 91.3479192553025 a1803 ARID1A_mut 1378 Bleomycin (50 uM) DNA damage 3 28 3.91202300542815 NA 3.31681766297227 3.39240344986672 -0.0755857868944463 2.20175274476715 1.54201355255382 0.0473508875020049 0.0343298252149743 0.0490175892223933 0.886804743677376 NA NA 0.450972567585294 0.958592722050224 91.3848697761594 a1804 MLL2_mut 228 KIN001-102 AKT1 9 20 2.32630161961136 NA 1.18029307572478 1.26669400544876 -0.0864009297239794 1.24195194708063 0.775329742460137 0.092101481206749 0.0695686575693016 0.111437656770173 0.888323249438682 NA NA 0.639299985816068 0.85088151753434 91.4629067829223 a1805 loss_cnaDLBC2 224 AS605240 PI3Kgamma 4 25 2.99573227355399 2.32630161961136 2.1018510566647 2.28333690940126 -0.181485852736568 1.55397552756314 1.25503603950119 0.140504527746698 0.116788102204649 0.144606088609773 0.890174347492352 NA NA 0.267214785482934 0.835969705048932 91.4629067829223 a1806 CREBBP_mut 305 TPCA-1 IKK 6 23 2.99573227355399 NA 1.07879239133727 1.20756183467094 -0.128769443333668 1.65097233879931 1.51846696316749 0.0834072860094601 0.0779961240460984 0.0848022686414315 0.890778619220397 NA NA 0.767756801945495 0.867367845015076 91.4629067829223 a1807 loss_cnaDLBC2 219 AT-7519 CDK9 4 25 2.32630161961136 NA -1.03231798222329 -1.14049912300519 0.108181140781896 0.962521587825236 1.23259162884152 0.0897340437712393 0.112393469559811 0.0877672200999559 0.890909114764186 NA NA 0.813174948635565 0.849726202278813 91.4629067829223 a1808 PTEN_mut 231 FMK RSK 6 22 2.99573227355399 2.32630161961136 4.60442946387682 4.55707594257864 0.0473535212981808 0.699589464041585 0.705582161612102 0.067222114309712 0.0676875849796475 0.0671126962591972 0.891343398713378 NA NA 0.153042083604518 0.886996062447719 91.4629067829223 a1809 loss_cnaDLBC4_(CDKN2A) 219 AT-7519 CDK9 7 22 2.32630161961136 NA -1.05575582368726 -1.14779360173691 0.0920377780496502 1.10183591151699 1.23352441579464 0.0763479566684901 0.0835312927157495 0.0746136654217414 0.891473649067215 NA NA 0.813175650293091 0.855101466482837 91.4629067829223 a1810 loss_cnaDLBC2 3 Rapamycin MTOR 4 19 -2.30258509299405 NA -3.73203877697624 -3.44180563662347 -0.290233140352778 0.609248563004619 2.21026584269505 0.140942943274595 0.476378867307361 0.131311417272271 0.892310382996261 NA NA 0.413160867670039 0.629383217977937 91.4629067829223 a1811 EP300_mut 64 CMK RSK 5 20 1.38629436111989 NA 1.4199679496169 1.31015757927762 0.10981037033928 1.41712786680029 1.18595146665704 0.0893287981336834 0.0774879761465841 0.0925926342068735 0.892442556465276 NA NA 0.167100242075457 0.878726265874276 91.4629067829223 a1812 CREBBP_mut 231 FMK RSK 6 22 2.99573227355399 2.32630161961136 4.54761186398107 4.57257165164111 -0.0249597876600482 0.746740288158536 0.694242508503298 0.0354219385445095 0.033424991333465 0.0359525487914281 0.892717434928239 NA NA 0.153045878372709 0.943204487376735 91.4629067829223 a1813 loss_cnaDLBC4_(CDKN2A) 1011 ABT-263 BCL2, BCL2L1, BCL2L2 8 24 0.693147180559945 NA 0.208239084220607 0.459950081802166 -0.251710997581558 2.27573212278036 1.4979279224319 0.14708475385159 0.11060660218393 0.168039458916623 0.892903504214501 NA NA 0.127362995669515 0.776502788418144 91.4629067829223 a1814 ARID1A_mut 51 Dasatinib ABL, SRC, KIT, PDGFR 3 21 0.246860077931526 NA -0.31286236475549 -0.274128714863872 -0.0387336498916177 1.82219992614242 2.73730687027758 0.0145226422909294 0.0212565313695389 0.0141502767965836 0.893379068058908 NA NA 0.178008513108306 0.976217696472847 91.4629067829223 a1815 MLL2_mut 45 Z-LLNle-CHO g-secretase 8 17 0.940007258491471 NA 0.0618113130295239 0.128778499839467 -0.0669671868099432 0.690657888080784 0.783573156749503 0.0885219621711984 0.0969614449724641 0.085463860308517 0.894032341947732 NA NA 0.100473696465555 0.831469285039465 91.4629067829223 a1816 EP300_mut 186 Bexarotene Retinioic acid X family agonist 5 24 2.07944154167984 NA 3.11385626760519 3.19250405380753 -0.0786477862023385 1.05227888774207 0.83359365412415 0.0904549520240567 0.0747404391730193 0.0943478705880661 0.894361773566553 NA NA 0.190905885108124 0.881148022452405 91.4629067829223 a1817 loss_cnaDLBC4_(CDKN2A) 11 Paclitaxel Microtubules 8 17 -2.27886856637673 NA -3.918032981196 -3.54785288113795 -0.370180100058048 1.13227734156198 1.81796502068606 0.225731409281995 0.326934123354781 0.20362333479791 0.894926042313547 NA NA 0.0442444427857507 0.540948718829625 91.4629067829223 a1818 loss_cnaDLBC4_(CDKN2A) 1372 Trametinib MAP2K1 (MEK1), MAP2K2 (MEK2) 7 23 0 NA 0.569878192713621 0.653169576139014 -0.0832913834253932 2.26405147707537 1.48843877157338 0.0494319666858842 0.03678864383993 0.0559588913001431 0.895069953312637 NA NA 0.897419824837946 0.929445742534386 91.4629067829223 a1819 loss_cnaDLBC4_(CDKN2A) 1529 MLN4924 NEDD8-activating enzyme 6 21 0 NA 0.541666559169582 0.382163076869586 0.159503482299996 1.48864856820738 1.5505417726801 0.103683947752575 0.107146498983349 0.102869516391226 0.895721381817087 NA NA 0.557272240529998 0.824126676088037 91.4629067829223 a1820 PTEN_mut 273 CUDC-101 HDAC, EGFR 6 22 1.63315443905142 NA -2.1842541540339 -2.11182068577893 -0.0724334682549714 1.08364713877879 1.59839655168897 0.0478719131381462 0.0668423010248518 0.0453163316565175 0.896652771936734 NA NA 0.890854301720055 0.898997777995464 91.4629067829223 a1821 MLL2_mut 1050 ZM-447439 AURKB 9 23 1.38629436111989 0.693147180559945 1.56925171843022 1.60982586889309 -0.0405741504628752 0.814091705920776 1.34095492628668 0.0331797599924268 0.049839778697885 0.0302576542041062 0.897882284271115 NA NA 0.78405763025963 0.917925353658588 91.4629067829223 a1822 EP300_mut 151 QS11 ARFGAP 5 24 2.32630161961136 NA 2.52560993042277 2.38390755395959 0.141702376463178 1.01330541107539 1.11003128275074 0.129262161917347 0.139841724828839 0.127656200924381 0.898072245366227 NA NA 0.576040052689924 0.788842615365716 91.4629067829223 a1823 CREBBP_mut 1006 Cytarabine DNA synthesis 7 23 0.693147180559945 NA -0.0617174457261679 -0.227394126958067 0.165676681231899 1.95426647112241 1.94797418022843 0.0849918540949802 0.0847769143461508 0.0850507583280547 0.898233099423954 NA NA 0.656535657146551 0.848150051508769 91.4629067829223 a1824 loss_cnaDLBC4_(CDKN2A) 283 GSK2126458 PI3K, MTOR 7 22 -2.05572501506252 0.0237165266173161 -4.55331047953156 -4.49176289043836 -0.0615475890931974 1.19211309478175 1.90993398921906 0.0346615127794799 0.0516289850036967 0.0322249823504963 0.898750796048303 NA NA 0.754985377981137 0.920489093177735 91.4629067829223 a1825 PTEN_mut 281 CH5424802 ALK 6 23 1.63315443905142 NA 3.13507633440469 2.99277927113095 0.142297063273746 0.596336118685317 1.38154223107308 0.111762623739563 0.238618890949377 0.102998706860535 0.899466447812864 NA NA 0.562409031397512 0.709954629302614 91.4629067829223 a1826 EP300_mut 332 XMD15-27 CAMK2B, CLK2, DYRK1A, MAST1, STK39 6 23 2.32630161961136 NA 3.7918379990763 3.63077259671675 0.161065402359544 0.910841218735756 0.846362841926556 0.187575734133538 0.176831481762653 0.190303017075885 0.899596210016697 NA NA 0.150037968915496 0.706560708438914 91.4629067829223 a1827 loss_cnaDLBC2 1129 PF-4708671 RPS6KB1 (p70S6KA) 3 26 2.30258509299405 NA 3.49036872793982 3.57481799158838 -0.0844492636485605 1.12859062258249 0.744603929171593 0.108329275318395 0.0748271888484416 0.113415012115924 0.899963978441513 NA NA 0.601872334846605 0.90996300130651 91.4629067829223 a1828 loss_cnaDLBC2 1170 CCT018159 HSP90 3 27 2.30258509299405 NA 2.88357443042167 2.83628707517451 0.0472873552471573 0.404080971336823 0.925934374347807 0.0526137264806305 0.117024454506522 0.051069877690268 0.901149099454426 NA NA 0.659696522759677 0.878478213253206 91.4629067829223 a1829 CREBBP_mut 63 BMS-509744 ITK 6 19 2.32630161961136 NA 2.72256478212596 2.78778825517377 -0.0652234730478041 0.883160672273965 0.859405844088719 0.075435522438924 0.0738523295878501 0.0758936810779598 0.901154002236666 NA NA 0.0917593495929711 0.877714440093388 91.4629067829223 a1830 PTEN_mut 1114 Cetuximab EGFR 5 23 4.18661983833127 NA 6.06396479757526 6.04095681758537 0.0230079799898926 0.607192989665801 0.552240229166578 0.0410091563793969 0.0378923676351339 0.041662991529276 0.901665994684911 NA NA 0.388822150129876 0.940565691207575 91.4629067829223 a1831 loss_cnaDLBC2 226 GSK1070916 AURKB 3 22 0.940007258491471 2.32630161961136 0.473371865610403 0.442417775810902 0.0309540897995013 1.86413642211731 2.66674656180948 0.0118744411001224 0.0166050560636239 0.0116074359081569 0.901801176520159 NA NA 0.346272966473333 0.981194505322074 91.4629067829223 a1832 loss_cnaDLBC4_(CDKN2A) 1058 GDC0941 PI3K (class 1) 8 24 1.38629436111989 0.693147180559945 0.353763106736627 0.152454933777413 0.201308172959215 1.77740324208442 2.14606991222945 0.0974414181399999 0.113259708428986 0.093803175661731 0.901837837178345 NA NA 0.451315062418727 0.796425743417808 91.4629067829223 a1833 loss_cnaDLBC2 1005 Cisplatin DNA crosslinker 3 27 1.79175946922805 2.30258509299405 2.72440242308187 2.73780479637588 -0.0134023732940101 0.554465431312443 1.05136137134644 0.0130895671088203 0.0241717022146648 0.0127476371676525 0.9029766167388 NA NA 0.11594598485976 0.973518565400924 91.5004978838982 a1834 ARID1A_mut 59 WZ-1-84 BMX 3 22 2.32630161961136 NA 3.41138427755948 3.3822065972924 0.0291776802670753 0.626988115770269 0.926757157473798 0.0322532815642237 0.0465362572801398 0.0314836308862285 0.903625512336556 NA NA 0.526909381545744 0.947622833333869 91.5004978838982 a1835 loss_cnaDLBC2 59 WZ-1-84 BMX 4 21 2.32630161961136 NA 3.40139357400252 3.38272017510006 0.0186733989024606 0.938896110164207 0.899421530675906 0.0206411604540188 0.0198886742636464 0.0207615653679401 0.904701238909654 NA NA 0.526912494667804 0.972434028232914 91.5004978838982 a1836 EP300_mut 158 PF-562271 FAK 6 24 0.940007258491471 NA 1.60710910173753 1.6799290186522 -0.0728199169146657 1.03745648473557 0.85054781455847 0.0821136855590047 0.0701908156978999 0.0856153124706663 0.905572458424483 NA NA 0.768560598338617 0.878237049305347 91.5004978838982 a1837 CREBBP_mut 1017 Olaparib PARP1, PARP2 7 23 1.6094379124341 NA 2.92734367388918 3.02991905237284 -0.102575378483661 1.04211761775674 0.837672901332737 0.115843481518803 0.0984297518205903 0.122452783563207 0.905781726477234 NA NA 0.317734439768118 0.817469686962574 91.5004978838982 a1838 TP53_mut 1149 TW 37 BCL2, BCL2L1 18 12 1.6094379124341 NA -1.00520482826296 -0.992282882204793 -0.0129219460581678 0.732612978553816 0.626269158862391 0.0186521844695494 0.0176381615347244 0.020633214769254 0.906189751675189 NA NA 0.761700828813751 0.959171108278562 91.5004978838982 a1839 loss_cnaDLBC4_(CDKN2A) 1242 (5Z)-7-Oxozeaenol MAP3K7 (TAK1) 7 22 2.30258509299405 NA 1.16846808401215 1.21983287860366 -0.0513647945915019 0.593647340355145 1.05079203103171 0.0530603959436798 0.0865240877871588 0.0488819795683734 0.906244356790534 NA NA 0.987302665670044 0.873051598566868 91.5004978838982 a1840 MLL2_mut 56 WH-4-023 SRC family, ABL 8 17 1.63315443905142 NA 1.80127459214727 1.79589500947707 0.00537958267019945 2.08466800688303 2.203734659023 0.0024811407158485 0.00258054647187825 0.00244112087096022 0.90629394749606 NA NA 0.589002088306414 0.995365828284705 91.5004978838982 a1841 PTEN_mut 1006 Cytarabine DNA synthesis 4 26 0.693147180559945 NA -0.41233514294028 -0.154336402629138 -0.257998740311141 2.47682745912185 1.87519334702016 0.132404844012129 0.104165003242743 0.1375851406049 0.906801056612694 NA NA 0.656551667305612 0.852617281992749 91.5004978838982 a1842 loss_cnaDLBC4_(CDKN2A) 262 VX-11e ERK 7 22 1.63315443905142 NA 1.93781966461493 2.05684402645207 -0.119024361837146 1.70771200152618 1.14073066680732 0.0923764133285096 0.0696981468366879 0.104340459409469 0.907133209851215 NA NA 0.54622119702818 0.86740115357691 91.5004978838982 a1843 ARID1A_mut 326 GSK690693 AKT 3 25 2.32630161961136 NA 0.754564779779157 0.931366682542645 -0.176801902763488 2.22754247497397 2.60056829505035 0.0686931020021374 0.0793708334408097 0.0679858718188614 0.908091096416243 NA NA 0.952101422776644 0.907470424252416 91.5398082846868 a1844 TP53_mut 1527 GDC0941 (rescreen) PI3K 18 9 1.38629436111989 NA 0.775600966530711 0.879958684700546 -0.104357718169835 1.50598339483001 1.50568737042279 0.0692997563608828 0.069295397630606 0.0693090213943497 0.908508298911977 NA NA 0.164123533002563 0.867312122813138 91.5398082846868 a1845 MLL2_mut 211 TL-2-105 CRAF 9 20 2.32630161961136 1.63315443905142 2.81156652504567 2.92483860595198 -0.113272080906311 0.962386312210289 0.625606463945142 0.152757724461951 0.117699181159551 0.181059639620737 0.909572342693803 NA NA 0.142955341048457 0.752177110538522 91.5581390898213 a1846 MLL2_mut 154 CHIR-99021 GSK3B 9 21 0.940007258491471 NA 2.74831053410628 2.76153208357946 -0.0132215494731742 0.956275546744902 0.855723415253173 0.0149291734105319 0.0138260875938734 0.015450727697176 0.909781927176145 NA NA 0.399066509330547 0.971963501726654 91.5581390898213 a1847 loss_cnaDLBC4_(CDKN2A) 1010 Gefitinib EGFR 8 22 -0.693147180559945 NA 1.03157378109291 1.00094763832539 0.0306261427675172 0.935713945967646 0.553406979672446 0.0457267270524785 0.0327302407958085 0.0553410851190283 0.910168573643969 NA NA 0.982162433147047 0.932457822943749 91.5581390898213 a1848 CREBBP_mut 1218 JQ1 BRD2, BRD3, BRD4 6 23 0 NA 0.807461926772718 0.710835123970768 0.0966268028019491 1.36638296792 1.56431903801734 0.0631713759856304 0.0707172184303796 0.0617692430083935 0.913018788081896 NA NA 0.852667128504172 0.884514978859618 91.5793524838745 a1849 loss_cnaDLBC2 1009 ATRA Retinoic acid and retinoid X receptor agonist 3 27 2.30258509299405 NA 3.15107585408517 3.16161061249047 -0.0105347584052975 0.820907933831053 0.954423787168529 0.01114185112965 0.0128330571202222 0.0110378204597674 0.913096917635849 NA NA 0.314047719842191 0.98492858759967 91.5793524838745 a1850 ARID1A_mut 298 OSI-930 KIT, VEGFR, PDGFR 3 26 2.32630161961136 NA 3.05496551131552 2.97315658429428 0.0818089270212465 0.842052675579925 1.12408413284084 0.0739908495102557 0.0971541678968058 0.0727782953527643 0.914259612721884 NA NA 0.907476086011255 0.888244774557178 91.5793524838745 a1851 loss_cnaDLBC4_(CDKN2A) 258 STF-62247 stimulates autophagy 7 22 2.32630161961136 NA 3.25405886112699 3.18764254453118 0.0664163165958116 0.924674351878082 1.19464690746921 0.0582501815683444 0.0718267100854643 0.0555949345204524 0.915002379310845 NA NA 0.870472892706323 0.880296776331216 91.5793524838745 a1852 PTEN_mut 249 XL-184 VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL 6 23 1.63315443905142 NA 2.11074095324223 2.12501599631574 -0.0142750430735155 1.12145002583891 1.16381895284542 0.0123476917438893 0.0127290942481693 0.0122656904998964 0.915677543574895 NA NA 0.694157386140063 0.978691768181248 91.5793524838745 a1853 ARID1A_mut 196 Phenformin AAPK1 (AMPK) agonist 3 26 8.29404964010203 NA 5.99011064387925 5.87723833249987 0.112872311379379 0.992728208944827 1.61579575828041 0.0715241140745303 0.113699107532516 0.0698555561870657 0.916443703042961 NA NA 0.917735716891931 0.872967573745579 91.5793524838745 a1854 EP300_mut 147 NSC-87877 PTPN6 (SHP-1), PTPN11 (SHP-2) 6 24 2.77258872223978 NA 4.56784218303049 4.48997442042994 0.0778677626005502 0.553141223751954 0.644936214308461 0.123692547479402 0.140773746842395 0.120737153338559 0.9166695735939 NA NA 0.415702446110071 0.772728101759884 91.5793524838745 a1855 PTEN_mut 1003 Camptothecin TOP1 4 26 -2.30258509299405 NA -4.82306777150669 -5.10191772975113 0.278849958244438 1.97981478454463 1.51652954746546 0.177305545603118 0.140846487470077 0.183873739031642 0.916938331246234 NA NA 0.140330887521771 0.802222347792112 91.5793524838745 a1856 loss_cnaDLBC2 300 CX-5461 RNA Pol I 4 25 2.32630161961136 NA 1.65312698671803 1.63512916239504 0.0179978243229937 1.49775520184092 1.49408813975088 0.0120427380844456 0.012016532675615 0.0120460258295033 0.917370037507907 NA NA 0.458353453023597 0.983255769538825 91.5793524838745 a1857 loss_cnaDLBC4_(CDKN2A) 1050 ZM-447439 AURKB 8 24 1.38629436111989 0.693147180559945 1.65332991474649 1.58010921385171 0.0732207008947718 0.877968569023513 1.30956622310758 0.0598910419813184 0.0833978612425827 0.0559121788595159 0.917617311733297 NA NA 0.784078921144655 0.860116958584312 91.5793524838745 a1858 ARID1A_mut 228 KIN001-102 AKT1 3 26 2.32630161961136 NA 1.27107246112352 1.23628078488953 0.034791676233989 0.564581518310332 0.962636380368709 0.0370535835066102 0.0616238312903208 0.0361420749760809 0.917827328536016 NA NA 0.639359337021065 0.931402403214588 91.5793524838745 a1859 PTEN_mut 1061 SB590885 BRAF 5 27 1.6094379124341 NA 3.28003969575015 3.23055866467305 0.0494810310771028 0.735993339735473 0.822262999391088 0.0609905158588703 0.0672302701745739 0.0601766479991743 0.9186846334986 NA NA 0.924664772192091 0.896648887094803 91.5793524838745 a1860 MLL2_mut 1047 Nutlin-3a MDM2 9 23 2.07944154167984 1.38629436111989 2.45789659025271 2.5487076021035 -0.0908110118507852 1.31011649434639 1.14936188285197 0.0760340096307396 0.069315219098963 0.0790099386500022 0.918763244342175 NA NA 0.0709637920424485 0.858136763977514 91.5793524838745 a1861 loss_cnaDLBC4_(CDKN2A) 1239 YK 4-279 RNA helicase A 6 21 2.30258509299405 NA 1.84179054082801 1.67504461648087 0.166745924347139 0.69107827550085 1.70517763520683 0.107152426550479 0.241283701511659 0.0977880080669209 0.918855329657686 NA NA 0.40481992596636 0.72453204766591 91.5793524838745 a1862 MLL2_mut 205 BMS-708163 g-secretase 9 20 2.32630161961136 0.940007258491471 4.09517816440197 4.12555517960135 -0.0303770151993783 0.696549303131491 0.640482394307612 0.0461942243993242 0.0436107179532184 0.0474283375614362 0.91922501026455 NA NA 0.246152599883594 0.912877125717407 91.5793524838745 a1863 loss_cnaDLBC4_(CDKN2A) 1004 Vinblastine Microtubules 8 22 -2.30258509299405 NA -5.02011179312929 -4.95341390337885 -0.0666978897504373 0.630494777861053 1.39093807323014 0.0535659077072428 0.105786585539549 0.0479517320246662 0.919931894714731 NA NA 0.866648045769672 0.858701067875279 91.5793524838745 a1864 PTEN_mut 1149 TW 37 BCL2, BCL2L1 5 25 1.6094379124341 NA -1.0071437175632 -0.998614516294992 -0.00852920126820889 0.911834852811028 0.649157844632783 0.0123110646830239 0.00935388819797231 0.0131388711370094 0.920398285533996 NA NA 0.761717805538334 0.984893871349806 91.5793524838745 a1865 ARID1A_mut 293 MP470 PDGFR 3 25 2.99573227355399 NA 2.31373704172401 2.27631041476653 0.0374266269574797 1.70085295948667 1.84314491396128 0.0204227857264324 0.0220046222977295 0.020305851522571 0.920818389169527 NA NA 0.492974201845441 0.974095052576434 91.5793524838745 a1866 loss_cnaDLBC4_(CDKN2A) 30 Sorafenib PDGFRA, PDGFRB, KDR, KIT, FLT3 8 20 1.38629436111989 NA 1.5643994625621 1.67182177950103 -0.107422316938925 0.845311417011267 0.964509960694762 0.115023549549106 0.12708016806248 0.111375020804913 0.920930571778498 NA NA 0.0338168577715063 0.774760358156107 91.5793524838745 a1867 EP300_mut 1026 17-AAG HSP90 6 26 0 NA 0.61244536903472 0.751901934932451 -0.139456565897731 0.677087416331937 1.24095728821595 0.119595313576062 0.20596537837496 0.112378215771003 0.922020790098875 NA NA 0.0839993705773016 0.710594890026669 91.5793524838745 a1868 loss_cnaDLBC2 1114 Cetuximab EGFR 3 25 4.18661983833127 NA 6.04927365284756 6.04456039335189 0.00471325949567181 0.48727462248882 0.56683694118786 0.00839977385687905 0.00967269641829121 0.00831501822339724 0.922402570035223 NA NA 0.388877232726633 0.988678813392365 91.5793524838745 a1869 ARID1A_mut 276 CAY10603 HDAC6 3 26 2.99573227355399 NA -0.894286807492717 -0.811178176407783 -0.0831086310849346 0.832627859294414 1.54869857025377 0.0551349555031095 0.0998148574506774 0.0536635292891867 0.922915362913976 NA NA 0.927127237371314 0.891100230621504 91.5793524838745 a1870 PTEN_mut 268 YM155 BIRC5 (Survivin) 6 23 1.63315443905142 NA -4.81605071431316 -4.84142153910319 0.0253708247900288 0.776367622648342 1.16302467363792 0.0230286359934365 0.032678880532761 0.0218145198163933 0.922981488779347 NA NA 0.815754010571452 0.950387311224761 91.5793524838745 a1871 MLL2_mut 293 MP470 PDGFR 8 20 2.99573227355399 NA 2.15968732459368 2.3285736448793 -0.168886320285615 1.75085887420275 1.85954742601142 0.0922412370676062 0.0964591280165381 0.0908211954818829 0.923027425711805 NA NA 0.492978967934753 0.824171396879447 91.5793524838745 a1872 MLL2_mut 260 NG-25 MAP3K7 (TAK1) 9 20 2.32630161961136 NA 0.714949620571413 0.88175760938251 -0.166807988811097 1.23613445571319 1.56202576719407 0.113243606779996 0.134943240227745 0.10678952442042 0.92306998663513 NA NA 0.31744943012098 0.760756567711019 91.5793524838745 a1873 loss_cnaDLBC4_(CDKN2A) 172 Embelin XIAP 8 21 3.46573590279973 NA 2.72451030475908 2.65857417878963 0.0659361259694498 0.970299191853605 1.23792997589185 0.0561437966727698 0.067954427379754 0.0532632113718282 0.923194757094031 NA NA 0.828583159977315 0.881836202815758 91.5793524838745 a1874 EP300_mut 1194 SB-505124 TGFR1 (ALK5) 6 24 2.30258509299405 NA 3.53790230085875 3.50182304530638 0.0360792555523708 0.571494557666031 0.54575763448064 0.0655459976957933 0.0631314070596184 0.0661085677467525 0.924688080401976 NA NA 0.245226979792399 0.892712596540033 91.6381118675102 a1875 EP300_mut 83 JW-7-52-1 MTOR 5 20 0.182321556793955 NA -1.97166443430174 -2.14669986787848 0.175035433576746 2.42334338580151 1.61684513293109 0.098141614501792 0.0722289026814306 0.108257389660712 0.926099741715667 NA NA 0.202193978530141 0.88431053064494 91.6381118675102 a1876 MLL2_mut 1019 Bosutinib SRC, ABL, TEC 8 22 0.693147180559945 NA 0.974214356871525 1.13049056503052 -0.156276208158996 1.07285022194961 1.35178661789949 0.121357949374164 0.145664515849199 0.115607157290719 0.927292956793821 NA NA 0.212212351525018 0.747214750709949 91.6381118675102 a1877 PTEN_mut 200 LAQ824 HDAC 5 24 0.0237165266173161 NA -3.39332935930118 -3.43913614900786 0.0458067897066763 0.89631164755964 1.32351044546886 0.0360874709601301 0.0511058735333776 0.034610070410475 0.927364776613165 NA NA 0.941799341803065 0.926787576965793 91.6381118675102 a1878 loss_cnaDLBC4_(CDKN2A) 204 Tipifarnib Farnesyl-transferase (FNTA) 8 21 2.77258872223978 NA 1.12913619077266 1.01047831941803 0.118657871354634 1.14579483142039 1.78360782454821 0.0722549883391028 0.103559440225035 0.0665268842856139 0.9274951998487 NA NA 0.634667025964959 0.834860336699735 91.6381118675102 a1879 CREBBP_mut 9 MG-132 Proteasome 7 20 0 NA -0.654849927443088 -0.553780656295651 -0.101069271147436 1.48069933883098 0.994699345080981 0.0893978313948794 0.0682577944738135 0.101607859346895 0.9274958289148 NA NA 0.0825467109411683 0.870895110038701 91.6381118675102 a1880 PTEN_mut 262 VX-11e ERK 6 23 1.63315443905142 NA 2.04253931030767 2.0243508857567 0.0181884245509658 1.14168331936736 1.32082497559719 0.0141046978924112 0.0159312343820917 0.0137705031983834 0.927575588741188 NA NA 0.54626296182681 0.973943974276705 91.6381118675102 a1881 loss_cnaDLBC2 1067 CCT007093 PPM1D 3 25 1.88706964903238 NA 3.56963611741667 3.61545458699312 -0.0458184695764556 0.19351501081908 0.67411873141384 0.0705016295911901 0.236769588997373 0.067967951996171 0.927732800100955 NA NA 0.820256139636827 0.798757251577822 91.6381118675102 a1882 CREBBP_mut 1032 Afatinib ERBB2, EGFR 7 23 -0.693147180559945 NA 1.08032659051537 1.09082872809294 -0.0105021375775731 0.691782331382913 0.699278482340657 0.0150529662084423 0.0151812746598757 0.0150185338785485 0.929353447834878 NA NA 0.410726765346627 0.972703149649772 91.6616498294613 a1883 TP53_mut 255 CP724714 ERBB2 17 12 2.32630161961136 NA 3.76391023774047 3.72110049703086 0.0428097407096049 0.821267339872975 0.932251683237499 0.0493087587734146 0.0521264375571373 0.0459207974405971 0.929726115122911 NA NA 0.856687920285935 0.899428185899677 91.6616498294613 a1884 PTEN_mut 134 Etoposide TOP2 6 24 2.77258872223978 NA 0.558337200890645 0.543215536238582 0.0151216646520625 2.64574120727512 1.77945979085628 0.00770568797834895 0.00571547383791044 0.0084978962321964 0.930343796490808 NA NA 0.611181816211252 0.989830785052682 91.6616498294613 a1885 CREBBP_mut 1004 Vinblastine Microtubules 7 23 -2.30258509299405 NA -5.01822693696067 -4.95688746350628 -0.0613394734543933 1.07185170878533 1.28848499107325 0.049259145899001 0.0572275744411563 0.0476058889931658 0.930466118008598 NA NA 0.866654247948663 0.901708503605443 91.6616498294613 a1886 PTEN_mut 1033 Vismodegib SMO 4 26 2.30258509299405 NA 3.82032344540028 3.79358236510181 0.0267410802984771 0.990289118530217 0.667507510764041 0.0377084362626936 0.0270033062043195 0.0400610927476588 0.93059910140562 NA NA 0.598792067411914 0.961253198189268 91.6616498294613 a1887 CREBBP_mut 266 Zibotentan, ZD4054 Endothelin A Receptor 6 23 2.99573227355399 NA 4.74851466104549 4.78388890076875 -0.0353742397232608 0.913107984999334 0.566330820136032 0.0548627631269604 0.0387404779110399 0.0624621483866337 0.931372261097116 NA NA 0.822887429296544 0.930844077831609 91.6616498294613 a1888 EP300_mut 224 AS605240 PI3Kgamma 6 23 2.99573227355399 2.32630161961136 2.32286503862541 2.24146246651904 0.0814025721063727 0.551109437024252 1.4079438045406 0.0629637439493052 0.147706728714193 0.057816634331463 0.931424470112511 NA NA 0.267321565543788 0.827835761020035 91.6616498294613 a1889 MLL2_mut 312 AV-951 VEGFR 9 20 -2.05572501506252 NA -0.418532098344118 -0.358659820168299 -0.0598722781758194 0.500794755948404 0.526253204263278 0.115396372957518 0.119554523014989 0.11377085724283 0.931970368633991 NA NA 0.274887139270168 0.773121468305321 91.6668194604466 a1890 CREBBP_mut 293 MP470 PDGFR 6 22 2.99573227355399 NA 2.15612691439186 2.31419136399928 -0.158064449607418 1.27850724741511 1.93994676411388 0.0863082399217855 0.12363203253403 0.081478756289283 0.932500539999396 NA NA 0.492997860217142 0.816351527437004 91.6704375464522 a1891 loss_cnaDLBC2 1059 AZD8055 MTORC1/2 3 29 0.693147180559945 NA -1.18742916266779 -1.26129591555262 0.073866752884828 0.956666894871142 1.01430541597806 0.0730945000032271 0.0772126152591258 0.0728249615167448 0.933637070270866 NA NA 0.675291706364904 0.908781490512258 91.7123690214728 a1892 TP53_mut 1057 NVP-BEZ235 PI3K (Class 1) and MTORC1/2 19 13 -1.38629436111989 0.693147180559945 -3.16436967586094 -3.15223324411686 -0.0121364317440791 1.05120048403907 0.95737161941526 0.0119604855896193 0.0115453064647066 0.0126768242320487 0.93391430458286 NA NA 0.595810208135321 0.973253392681634 91.7123690214728 a1893 CREBBP_mut 106 XMD8-85 MAP2K5 (ERK5) 7 20 2.07944154167984 NA 2.00189925266887 1.99183559500708 0.0100636576617927 1.21104849780088 0.843426467826232 0.010651710859702 0.00830987171865302 0.0119318731930833 0.934529446750224 NA NA 0.731832128102651 0.984271426729621 91.7220655365457 a1894 MLL2_mut 221 TAK-715 p38a 9 20 2.99573227355399 2.32630161961136 2.73547009545642 2.81632098147059 -0.080850886014173 0.330171000721114 0.705696471572943 0.130685460321102 0.244875794172079 0.114568924843797 0.935607675412749 NA NA 0.0257894284740545 0.677643530443052 91.7220655365457 a1895 loss_cnaDLBC2 258 STF-62247 stimulates autophagy 4 25 2.32630161961136 NA 3.16973315036591 3.20910461624445 -0.0393714658785362 1.3494302197234 1.11160798477508 0.0345217072218535 0.029176362959032 0.0354184806314633 0.935784813559715 NA NA 0.870485218614375 0.958678158302141 91.7220655365457 a1896 ARID1A_mut 190 Bleomycin DNA damage 3 26 4.15888308335967 NA 1.19661808179467 1.362247195918 -0.165629114123333 2.9658074620101 1.65757975494305 0.0926531601329948 0.0558462126233495 0.0999222593238194 0.937098750933174 NA NA 0.446738445225174 0.932425450169612 91.7220655365457 a1897 MLL2_mut 193 GW-2580 CSF1R (cFMS) 9 20 2.99573227355399 NA 4.60913510326569 4.61458060179757 -0.00544549853187792 0.766287915465039 0.545189054355736 0.00879741226167069 0.00710633486706259 0.00998827560526323 0.937500775793209 NA NA 0.590500126355749 0.984971067459234 91.7220655365457 a1898 MLL2_mut 54 CGP-082996 CDK4 8 17 1.63315443905142 NA 2.06412692199782 2.19145817056949 -0.127331248571674 0.780688486451619 1.1455905396467 0.121491173241759 0.163101225112746 0.111149004958564 0.938111148573572 NA NA 0.319036991937326 0.748537336022089 91.7220655365457 a1899 TP53_mut 17 Cyclopamine SMO 16 11 2.77258872223978 NA 4.0827603718469 3.98881334416407 0.0939470276828263 1.09511585146682 1.04526275636871 0.08735585665233 0.085787295980596 0.0898788626213013 0.93845309267463 NA NA 0.544434033444368 0.823996262495048 91.7220655365457 a1900 loss_cnaDLBC2 222 BX-912 PDPK1 (PDK1) 4 25 2.32630161961136 NA 0.993077610439497 1.02536115670931 -0.0322835462698094 1.00749729542414 1.57638625227103 0.021187577526045 0.0320433081224487 0.0204794644861308 0.938624428138075 NA NA 0.293419686037717 0.958530069015914 91.7220655365457 a1901 loss_cnaDLBC2 345 KIN001-270 CDK9 4 25 2.99573227355399 NA 3.57638273098492 3.63948827314288 -0.0631055421579663 0.301310400372777 1.16118106983557 0.0574015759778157 0.209436986177354 0.0543459963284646 0.938666251971959 NA NA 0.802663072712937 0.821983238762703 91.7220655365457 a1902 ARID1A_mut 104 Bortezomib Proteasome 3 25 -3.91202300542815 NA -6.24840312012434 -6.08299719743824 -0.165405922686107 0.574046331451067 1.17272987631332 0.145358697233092 0.288140370600394 0.141043496910038 0.939120297233235 NA NA 0.0881336140683788 0.702726837892602 91.7220655365457 a1903 ARID1A_mut 1017 Olaparib PARP1, PARP2 3 27 1.6094379124341 NA 2.99836602213343 3.00683132797776 -0.00846530584432248 1.32201810514931 0.843850461183137 0.0095480618933577 0.0064033206590362 0.0100317606421089 0.940554126643552 NA NA 0.317810135716226 0.992254873576188 91.7220655365457 a1904 EP300_mut 1042 BIRB 0796 p38, JNK2 6 23 2.30258509299405 NA 3.79970139696555 3.71990025386462 0.0798011431009336 0.575639681006023 0.957818225910602 0.0887289121047252 0.138630371974128 0.0833155404044084 0.940566996240125 NA NA 0.556531256044906 0.799799220141664 91.7220655365457 a1905 PTEN_mut 152 CP466722 ATM 6 23 2.77258872223978 NA 1.60051573110617 1.51417927522437 0.0863364558817983 1.22062575851736 1.05634540999095 0.0793067344264501 0.0707313075112123 0.0817312737530974 0.940663029073811 NA NA 0.627198275807547 0.878513375277373 91.7220655365457 a1906 loss_cnaDLBC2 257 NPK76-II-72-1 PLK3 4 25 2.32630161961136 NA 1.18721086025399 1.0524317884147 0.134779071839292 2.51322318001238 1.2242931061858 0.0944995870304251 0.0536279757847166 0.110087258646082 0.941226196950772 NA NA 0.362350745984445 0.922355649884337 91.7220655365457 a1907 EP300_mut 127 GSK269962A ROCK1, ROCK2 5 23 0.916290731874155 NA 1.62633362583651 1.46339628299454 0.162937342841972 0.548298935675564 1.26421899752185 0.137775298727925 0.297168811099761 0.128883795577638 0.942290450086359 NA NA 0.383288094416354 0.657349027257363 91.7220655365457 a1908 TP53_mut 291 KIN001-266 MAP3K8 (COT) 17 12 2.99573227355399 NA 2.70853444332734 2.7079541493424 0.00058029398493753 0.456314219336137 0.694518168552886 0.00102597457631423 0.00127169822974564 0.000835534635683677 0.942574733252609 NA NA 0.750510981828549 0.998006704072352 91.7220655365457 a1909 MLL2_mut 64 CMK RSK 8 17 1.38629436111989 NA 1.20620256000208 1.39137475609532 -0.185172196093239 1.40294230579883 1.14127437065534 0.150934903640856 0.131988461198911 0.162250376293747 0.943633199967688 NA NA 0.167225723484571 0.750259362815286 91.7220655365457 a1910 loss_cnaDLBC2 202 GSK-1904529A IGF1R 4 25 0.0237165266173161 NA 1.86950178426123 1.9142543698426 -0.0447525855813695 0.401594734582433 0.811827212503253 0.05759544427141 0.111437182133132 0.0551257519976151 0.94428187428616 NA NA 0.750400082320585 0.8668296599201 91.7220655365457 a1911 EP300_mut 1230 IOX2 EGLN1 6 24 -2.30258509299405 NA -0.575253646502509 -0.677952481779903 0.102698835277393 0.724215260500752 1.30563274463395 0.0840234611694563 0.141807057761229 0.0786582871021562 0.944738224275079 NA NA 0.576925431662607 0.800062238723249 91.7220655365457 a1912 EP300_mut 235 QL-XII-47 BTK, BMX 6 22 2.32630161961136 NA 0.353244618824393 0.286490646048765 0.0667539727756274 1.36886200723607 1.21711747045208 0.0535001989070134 0.0487660351611434 0.0548459572688845 0.944780504591195 NA NA 0.348302720747703 0.916639772496286 91.7220655365457 a1913 ARID1A_mut 86 A-443654 AKT1, AKT2, AKT3 3 22 0.0237165266173161 NA -1.41893866469515 -1.29779585245623 -0.121142812238916 0.260349947270416 1.35746806234372 0.0932315528513409 0.465307611962329 0.0892417402658876 0.945533285574599 NA NA 0.0451797458764152 0.714358434152745 91.7220655365457 a1914 loss_cnaDLBC4_(CDKN2A) 276 CAY10603 HDAC6 7 22 2.99573227355399 NA -0.778476203920556 -0.832916344619846 0.0544401406992904 1.12399096181438 1.60016256456808 0.0361152054066291 0.0484346783459999 0.0340216312421887 0.946059666703485 NA NA 0.927134053605442 0.921777816202663 91.7220655365457 a1915 CREBBP_mut 167 OSU-03012 PDPK1 (PDK1) 7 22 2.77258872223978 NA 1.31629558305927 1.35441488011072 -0.038119297051447 0.492156665986456 0.589404072422193 0.0669662927691561 0.0774535827428904 0.0646743021214518 0.946539791581736 NA NA 0.15585462860423 0.867987673795103 91.7220655365457 a1916 EP300_mut 304 SB52334 ALK5 6 23 2.99573227355399 NA 3.84909538086817 3.7214305452433 0.12766483562487 0.637546473838909 0.966847981995978 0.139546812028161 0.200243967872886 0.132042304480293 0.946554428910712 NA NA 0.233339510039035 0.705067463262087 91.7220655365457 a1917 ARID1A_mut 254 AC220 FLT3 3 26 0.0237165266173161 NA 1.61499063717221 1.6716094574426 -0.0566188202703872 0.734012640302967 0.732308585605615 0.077302182859262 0.0771360289476999 0.0773155216029098 0.947797955321399 NA NA 0.525172204824194 0.908836083730448 91.7220655365457 a1918 EP300_mut 258 STF-62247 stimulates autophagy 6 23 2.32630161961136 NA 3.16288857625963 3.21431376304422 -0.0514251867845932 0.886894538686837 1.19047111432397 0.0450953045119193 0.0579834293046103 0.0431973410911326 0.94833184389984 NA NA 0.870490983730185 0.909001800425321 91.7220655365457 a1919 loss_cnaDLBC2 1377 Afatinib (rescreen) ERBB2, EGFR 3 27 2.30258509299405 NA 3.48306544478733 3.36764669149268 0.115418753294654 1.40007783581087 0.936212028997212 0.118174704268458 0.0824373833671954 0.123282707036226 0.948587105738548 NA NA 0.145566104646579 0.900872700469605 91.7220655365457 a1920 loss_cnaDLBC4_(CDKN2A) 83 JW-7-52-1 MTOR 8 17 0.182321556793955 NA -2.28048583605508 -2.03226075533163 -0.248225080723449 1.3323799392206 1.94487554700432 0.139381438564187 0.186302024982944 0.127630316040421 0.948829199694067 NA NA 0.202239295804408 0.713646117680752 91.7220655365457 a1921 PTEN_mut 230 GSK429286A ROCK2 6 23 2.99573227355399 2.32630161961136 3.79246139666148 3.67746729808261 0.114994098578868 0.789389050512804 0.779005053933849 0.147251170711699 0.145674808263637 0.147616627129909 0.950068562524838 NA NA 0.192829345180919 0.758416272064906 91.7220655365457 a1922 MLL2_mut 1378 Bleomycin (50 uM) DNA damage 9 22 3.91202300542815 NA 3.47021596799064 3.35026390333042 0.119952064660214 1.6442894138772 1.57646780608121 0.075183128142483 0.0729507005566434 0.0760891305217271 0.951766952012466 NA NA 0.451107806859407 0.854607636145239 91.7220655365457 a1923 TP53_mut 1091 BMS-536924 IGF1R 19 11 1.38629436111989 NA 2.2600332723151 2.23385116939671 0.0261821029183849 0.945344438698859 1.07548909751561 0.0263458916825689 0.0276958342870468 0.0243443685099792 0.952609418213522 NA NA 0.962868296687248 0.947197505522848 91.7220655365457 a1924 EP300_mut 200 LAQ824 HDAC 5 24 0.0237165266173161 NA -3.47066831830035 -3.42302386588303 -0.0476444524173258 0.96620971157134 1.31491743036784 0.03753552360431 0.0493106743253926 0.0362337978925395 0.953240070028493 NA NA 0.941804889703574 0.927833959819241 91.7220655365457 a1925 EP300_mut 265 Tubastatin A HDAC6 6 22 2.99573227355399 NA 2.93038098110466 2.91816797302175 0.0122130080829095 0.68263727965663 1.2364386711933 0.0106123925688913 0.0178909187160899 0.00987756883333533 0.955406389684373 NA NA 0.866460089045443 0.975019580528967 91.7220655365457 a1926 MLL2_mut 1262 UNC1215 LMBL3 9 21 0 NA 1.73324936874339 1.74262273449875 -0.00937336575536074 0.560209655972239 0.456494113440338 0.0191927777024178 0.0167318889552044 0.0205333770565385 0.956291708170538 NA NA 0.564484182553689 0.965358912433866 91.7220655365457 a1927 CREBBP_mut 111 Salubrinal GADD34-PP1C 7 20 2.77258872223978 NA 2.89209674457774 2.94460342814294 -0.0525066835652055 1.08412696219865 0.929612477864257 0.0541894991837855 0.0484322274014107 0.0564823351831908 0.956392100645591 NA NA 0.297573003013822 0.911450168940333 91.7220655365457 a1928 EP300_mut 312 AV-951 VEGFR 6 23 -2.05572501506252 NA -0.325903972794225 -0.390633106595552 0.0647291338013268 0.450738457743181 0.533204524088181 0.124737522139572 0.14360685823309 0.121396445223375 0.957030036257968 NA NA 0.274927447802473 0.770164832469756 91.7220655365457 a1929 loss_cnaDLBC4_(CDKN2A) 193 GW-2580 CSF1R (cFMS) 7 22 2.99573227355399 NA 4.58453763597565 4.6219120233415 -0.0373743873658476 0.511793443704177 0.646092264677097 0.0604008810749781 0.0730263113480807 0.0578468268530138 0.957090896484938 NA NA 0.590523685351719 0.877417819817378 91.7220655365457 a1930 ARID1A_mut 185 OSI-906 IGF1R 3 26 0.940007258491471 NA 2.13150897698551 2.25993970975926 -0.128430732773745 2.13551459933409 1.39801199955741 0.0876405422087061 0.060140414312219 0.0918666884221337 0.957209505432339 NA NA 0.341502753420944 0.927520973069233 91.7220655365457 a1931 TP53_mut 345 KIN001-270 CDK9 17 12 2.99573227355399 NA 3.65006990987315 3.60346244038902 0.0466074694841292 0.938109096696336 1.29860876201494 0.0423957324740017 0.0496823553340043 0.0358903088038712 0.95721727925641 NA NA 0.802674586916705 0.91648092369765 91.7220655365457 a1932 loss_cnaDLBC2 1378 Bleomycin (50 uM) DNA damage 3 28 3.91202300542815 NA 3.49051497389039 3.37379302369692 0.116721950193469 1.12032681097282 1.62577032166272 0.0731313379260962 0.104185626060413 0.0717948584976593 0.957320783214428 NA NA 0.45111428028466 0.880901698028173 91.7220655365457 a1933 MLL2_mut 1199 Tamoxifen ER 9 21 1.6094379124341 NA 2.90348549912255 2.85787769095205 0.0456078081705003 0.87004179401426 1.00943416270176 0.0469384936470192 0.0524202497906126 0.045181558001198 0.957468440486053 NA NA 0.721810621048084 0.901762064168072 91.7220655365457 a1934 ARID1A_mut 156 AZD6482 PI3Kbeta 3 27 1.63315443905142 NA 1.68919580102164 1.64836138546752 0.0408344155541231 1.76144289326561 1.80802831741176 0.0226261957267878 0.0231823669732593 0.0225850530994884 0.958795445383677 NA NA 0.863961334529371 0.972525599350858 91.7220655365457 a1935 CREBBP_mut 34 Imatinib ABL, KIT, PDGFR 7 20 0.693147180559945 NA 2.65637599021258 2.70431834034127 -0.0479423501286913 0.367314957177682 0.571256597230476 0.0905387210075885 0.130521094204993 0.0839243701711662 0.958973145469 NA NA 0.366172447771181 0.80250390472922 91.7220655365457 a1936 loss_cnaDLBC2 86 A-443654 AKT1, AKT2, AKT3 4 21 0.0237165266173161 NA -1.43542823732584 -1.28888627613425 -0.146541961191596 0.78059121961903 1.35961935183074 0.112827294969346 0.187732013259279 0.107781608870363 0.9590816823914 NA NA 0.0451890295316037 0.773557200637162 91.7220655365457 a1937 EP300_mut 71 Pyrimethamine Dihydrofolate reductase (DHFR) 5 23 2.99573227355399 NA 3.0838765457683 2.92789372875731 0.155982817010992 0.932871949775982 1.25635339583513 0.128675480845235 0.167207103877921 0.124155207864349 0.959326489978333 NA NA 0.188541672802472 0.760081569952601 91.7220655365457 a1938 loss_cnaDLBC2 269 NSC-207895 MDM4 4 24 2.99573227355399 NA 3.00046784683038 3.04110702096795 -0.0406391741375676 1.00040480185939 1.36082847106022 0.0306882825504294 0.0406227299809378 0.029863553711443 0.959345025934287 NA NA 0.349827826261567 0.946090817916387 91.7220655365457 a1939 PTEN_mut 1022 AZD7762 CHEK1, CHEK2 4 26 0.693147180559945 NA -1.49945621644039 -1.59746839814325 0.0980121817028674 1.30712660234918 1.20740225663237 0.0804382393410159 0.0749829293709721 0.081176079607668 0.959867111844127 NA NA 0.50038005893933 0.894972588373985 91.7220655365457 a1940 MLL2_mut 1129 PF-4708671 RPS6KB1 (p70S6KA) 8 21 2.30258509299405 NA 3.53309097718778 3.57864981655311 -0.0455588393653317 0.734801932744188 0.794856252779922 0.058428928263561 0.0620015235877072 0.0573170799197901 0.959936824662979 NA NA 0.601966399147333 0.886169167020591 91.7220655365457 a1941 ARID1A_mut 1054 PD-0332991 CDK4, CDK6 3 29 1.38629436111989 0.693147180559945 1.52168914111972 1.44179044332479 0.0798986977949292 0.735751564011008 1.5665062672111 0.0523834732893049 0.108594669319295 0.0510043907690043 0.959964827971307 NA NA 0.679038942672739 0.883767102776453 91.7220655365457 a1942 PTEN_mut 170 Shikonin unknown 6 24 2.77258872223978 NA -0.34505576213611 -0.38551896349944 0.0404632013633303 1.73707972265758 0.90677930954863 0.0367203237608809 0.0232938078981344 0.0446229870236802 0.960146482310728 NA NA 0.883641492975749 0.957856741996383 91.7220655365457 a1943 ARID1A_mut 304 SB52334 ALK5 3 26 2.99573227355399 NA 3.71675879914368 3.75143070878361 -0.0346719096399286 1.67580647183705 0.825965797029534 0.037836710030429 0.0206896859647049 0.0419774157291029 0.960181729228535 NA NA 0.233357346890743 0.974862188243202 91.7220655365457 a1944 PTEN_mut 1012 Vorinostat HDAC inhibitor Class I, IIa, IIb, IV 4 26 2.30258509299405 NA 0.00281262015943136 -0.0748998072974322 0.0777124274568635 0.337638344531175 0.678501602000709 0.119451053463742 0.230164697569438 0.114535363258851 0.960919964058498 NA NA 0.555035096005998 0.727630419243366 91.7220655365457 a1945 EP300_mut 6 PHA-665752 MET 5 22 0.693147180559945 NA 2.66306092093798 2.57226513962506 0.0907957813129183 0.510188379712718 0.737365750689233 0.128615511661059 0.177965208388408 0.123135338504737 0.960964165688434 NA NA 0.368040239705007 0.751220143260796 91.7220655365457 a1946 CREBBP_mut 279 BIX02189 MAP2K5 (MEK5) 6 23 2.99573227355399 NA 2.99952850705475 3.02792573841568 -0.0283972313609389 1.43324661423587 0.763255992843966 0.0307094031145184 0.0198132206131733 0.0372053827643436 0.961141939213655 NA NA 0.414348511083164 0.964229241850417 91.7220655365457 a1947 ARID1A_mut 261 TL-1-85 MAP3K7 (TAK1) 3 26 2.32630161961136 NA 1.54824093755251 1.54156679018301 0.00667414736950533 0.645389384459203 1.26964618891115 0.00540731911781411 0.0103412723081863 0.0052566986202897 0.9612559926389 NA NA 0.668020973982749 0.988811449040167 91.7220655365457 a1948 loss_cnaDLBC2 167 OSU-03012 PDPK1 (PDK1) 4 25 2.77258872223978 NA 1.31650557126168 1.34980696635216 -0.0333013950904795 0.27044401062391 0.596277405662333 0.058489406442408 0.123136005170363 0.0558488293774757 0.961658251367268 NA NA 0.155871669036617 0.857641060625582 91.7220655365457 a1949 CREBBP_mut 110 Roscovitine CDKs 7 21 2.77258872223978 NA 3.32435078074971 3.35245273539121 -0.0281019546414929 0.719945019080934 1.03682667815506 0.0288846008408593 0.0390334732468421 0.0271038113057603 0.963924712725635 NA NA 0.496095682742727 0.937756115766667 91.7973756306459 a1950 ARID1A_mut 274 PXD101, Belinostat HDAC 3 25 2.99573227355399 NA -1.48770823706876 -1.44439790468072 -0.0433103323880397 0.64360929985684 1.47017313543116 0.0304202988534329 0.0672928939927894 0.0294593414505142 0.964484477036353 NA NA 0.966674760439304 0.930641836505878 91.7973756306459 a1951 PTEN_mut 1017 Olaparib PARP1, PARP2 4 26 1.6094379124341 NA 3.14406525496349 2.98474165007484 0.159323604888653 1.37645946373491 0.805925827289633 0.180061435453768 0.11574885355239 0.197690158937413 0.965813126601675 NA NA 0.317843505249251 0.834667509560725 91.7973756306459 a1952 ARID1A_mut 1050 ZM-447439 AURKB 3 29 1.38629436111989 0.693147180559945 1.58529841180935 1.59977121430983 -0.0144728025004737 0.847106749571098 1.24551172860515 0.0118338934826438 0.0170849807392061 0.0116199648450374 0.966533670651368 NA NA 0.784111891578637 0.980346346628113 91.7973756306459 a1953 loss_cnaDLBC2 9 MG-132 Proteasome 3 24 0 NA -0.662335229811676 -0.569689872024151 -0.0926453577875254 0.72819515239646 1.1595252778305 0.0819081672505389 0.127226001824694 0.0798993860322452 0.967094774436818 NA NA 0.0825870360087561 0.858517118785509 91.7973756306459 a1954 ARID1A_mut 54 CGP-082996 CDK4 3 22 1.63315443905142 NA 2.06413027025325 2.16251879385928 -0.0983885236060367 0.813982082338412 1.06908672525907 0.0937597439630435 0.120873082762935 0.0920304417606478 0.967161113890974 NA NA 0.3190846477086 0.862476041653164 91.7973756306459 a1955 EP300_mut 226 GSK1070916 AURKB 6 19 0.940007258491471 2.32630161961136 0.56858035996172 0.407464447626354 0.161115912335365 2.51153713235108 2.63140600990474 0.0618293354815919 0.0641503206383187 0.0612280703657731 0.967167986473927 NA NA 0.346421597746362 0.895344066349536 91.7973756306459 a1956 MLL2_mut 41 S-Trityl-L-cysteine KIF11 8 17 1.63315443905142 NA 0.376354707451064 0.599969612068302 -0.223614904617239 1.05157044696786 1.40161394329254 0.171345037432184 0.212648525129266 0.15954101033837 0.967410309628264 NA NA 0.0278777476099201 0.662397120306084 91.7973756306459 a1957 PTEN_mut 91 KIN001-135 IKKE 4 23 1.6094379124341 NA 3.42921499815081 3.36222562684743 0.0669893713033836 0.73748521194958 0.613526131304587 0.106384518069003 0.0908348672189557 0.10918747855277 0.967784090015637 NA NA 0.586859278151461 0.87256651376072 91.7973756306459 a1958 EP300_mut 34 Imatinib ABL, KIT, PDGFR 5 22 0.693147180559945 NA 2.74542418797069 2.67972171811182 0.0657024698588748 0.465571846184641 0.540598079437389 0.124128759244126 0.14112208544676 0.121536632034011 0.96890142548473 NA NA 0.366183735754104 0.790797543713467 91.7973756306459 a1959 EP300_mut 91 KIN001-135 IKKE 5 22 1.6094379124341 NA 3.39534274759687 3.36687889418681 0.0284638534100563 0.739531856511134 0.606988231278266 0.0451755788341813 0.0384890159354856 0.0468935836698412 0.970505694567949 NA NA 0.586861366290798 0.93906217011718 91.7973756306459 a1960 CREBBP_mut 1047 Nutlin-3a MDM2 7 25 2.07944154167984 1.38629436111989 2.41080521780517 2.55462830544075 -0.143823087635576 1.42069923930414 1.12959926535129 0.12050401511979 0.101234014671551 0.127322221293097 0.970527051228516 NA NA 0.0710060788126678 0.811035968859977 91.7973756306459 a1961 ARID1A_mut 1008 Methotrexate Dihydrofolate reductase (DHFR) 3 27 -1.6094379124341 NA -2.44979806589484 -2.58281231773412 0.133014251839274 1.37123632858391 1.34641023184156 0.0986607191439115 0.0970031562514383 0.0987917714033879 0.97114222346734 NA NA 0.159744912467018 0.885361293892106 91.7973756306459 a1962 MLL2_mut 326 GSK690693 AKT 9 19 2.32630161961136 NA 0.89501857656282 0.920668116517801 -0.0256495399549806 2.5268994790598 2.59521745458999 0.00996334800966771 0.0101505976662452 0.00988338757880038 0.971257121013286 NA NA 0.952113163137218 0.980465095479278 91.7973756306459 a1963 PTEN_mut 176 IPA-3 PAK1, PAK2, PAK3 5 24 3.46573590279973 NA 3.10734791102098 2.79655535066516 0.310792560355821 1.8935377588778 1.18414406283846 0.236589029454617 0.16413327851461 0.262461781559612 0.97153047424783 NA NA 0.0571467052146086 0.739506404716109 91.7973756306459 a1964 EP300_mut 346 THZ-2-102-1 CDK7 6 23 0.916290731874155 2.99573227355399 -3.83557907090217 -3.74267639488567 -0.0929026760164926 0.792485844467447 1.54740493807607 0.064613262584311 0.117229445377568 0.0600377275078369 0.971539201437553 NA NA 0.380513565518447 0.841408960000586 91.7973756306459 a1965 MLL2_mut 1033 Vismodegib SMO 8 22 2.30258509299405 NA 3.78620620768842 3.80112661876095 -0.0149204110725289 0.653721740329221 0.72673053480802 0.0210388635145943 0.0228237951288187 0.0205308712898247 0.971574493452252 NA NA 0.598835386470763 0.958006423091841 91.7973756306459 a1966 TP53_mut 165 DMOG Prolyl-4-Hydroxylase 17 13 8.29404964010203 NA 5.181115830165 5.17729350615713 0.00382232400786986 1.62328483065888 1.63102757456185 0.00234987458630212 0.00235468473288105 0.00234350667486212 0.972900213718745 NA NA 0.908637355038214 0.994963336111656 91.7973756306459 a1967 loss_cnaDLBC2 175 PAC-1 CASP3 agonist 4 25 0.940007258491471 NA 1.14335021976712 1.1456938729507 -0.00234365318358254 0.816072334485174 1.08250725936708 0.00221889040632228 0.00287186942204217 0.00216502306409734 0.973385979737017 NA NA 0.789002909395523 0.99615264747764 91.7973756306459 a1968 TP53_mut 11 Paclitaxel Microtubules 15 10 -2.27886856637673 NA -3.52932067222341 -3.8717952745562 0.342474602332787 1.87337343657891 1.19082830733657 0.20876652024452 0.182811710492811 0.287593602052317 0.973390838675614 NA NA 0.0443179432182869 0.581782780221406 91.7973756306459 a1969 CREBBP_mut 89 Parthenolide NFKB1 7 20 1.6094379124341 NA 2.14302876192353 2.29900442737714 -0.155975665453613 1.58695156182122 1.18934401036488 0.120356845048752 0.098286342952152 0.131144281296512 0.973699742447051 NA NA 0.067221211637901 0.81773530423414 91.7973756306459 a1970 TP53_mut 167 OSU-03012 PDPK1 (PDK1) 16 13 2.77258872223978 NA 1.37568442511697 1.30771120322916 0.0679732218878115 0.552469378671443 0.587713825935054 0.119586225364594 0.123035274916541 0.115657006672705 0.973753687031143 NA NA 0.155881250153482 0.753003709048626 91.7973756306459 a1971 MLL2_mut 1043 JNK Inhibitor VIII JNK 9 23 2.30258509299405 NA 4.15327448102219 4.1821290419298 -0.0288545609076127 0.78289350794744 0.608588650548683 0.0437462540792627 0.0368563037178102 0.0474122560149593 0.973811442460334 NA NA 0.636584291318044 0.922435812842775 91.7973756306459 a1972 MLL2_mut 37 Crizotinib MET, ALK 8 18 0.693147180559945 NA 1.94844421506982 2.03046219018779 -0.0820179751179642 0.607080423460429 1.04499466260775 0.0873816927841625 0.135102322440991 0.0784865014652719 0.974494453221183 NA NA 0.378210212542103 0.804116385418587 91.8151773266726 a1973 CREBBP_mut 1030 KU-55933 ATM 7 25 2.30258509299405 NA 3.13676074236614 3.12168438273529 0.0150763596308563 0.932592124230142 0.903230646620455 0.0165823923634952 0.0161660807968992 0.0166915944307983 0.975463177256132 NA NA 0.617220524392961 0.970432658301014 91.8598667426706 a1974 TP53_mut 6 PHA-665752 MET 15 12 0.693147180559945 NA 2.6140746037238 2.55783488504868 0.0562397186751187 0.614921502479995 0.807788436609235 0.0796256637066692 0.0914583706185299 0.0696218417178513 0.977707518109903 NA NA 0.368056411413858 0.843982391750296 91.9536905536895 a1975 loss_cnaDLBC2 1003 Camptothecin TOP1 3 27 -2.30258509299405 NA -5.155219643156 -5.05468419000326 -0.100535453152738 1.37019467089626 1.59014934346826 0.0638135168159351 0.073373116454304 0.0632239063366598 0.97773138962285 NA NA 0.140403452891732 0.914084345441893 91.9536905536895 a1976 loss_cnaDLBC2 253 XMD14-99 EPHB3, CAMK1 4 25 2.32630161961136 NA 3.12691978491366 3.19398657447936 -0.0670667895657062 1.41158928600971 0.817330960898864 0.0742804859366195 0.047511546191521 0.0820558534720735 0.977944228768034 NA NA 0.320727367189337 0.931537438934956 91.9536905536895 a1977 ARID1A_mut 164 JQ12 HDAC 3 27 1.63315443905142 NA 0.444879033441741 0.540451113693206 -0.0955720802514645 0.80610110868163 1.62622737169643 0.0604193749141422 0.118560909074758 0.0587691991383509 0.979043594178296 NA NA 0.424472150788955 0.872672551504048 92.0104971625181 a1978 loss_cnaDLBC4_(CDKN2A) 272 AR-42 HDAC 6 22 1.63315443905142 NA -1.79352333611849 -1.81029154337681 0.0167682072583202 1.12659788516354 1.4054838586369 0.0123630824407394 0.0148839328381004 0.0119305584018466 0.981041197086178 NA NA 0.985969629594539 0.976248467694874 92.0166053114774 a1979 loss_cnaDLBC2 249 XL-184 VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL 4 25 1.63315443905142 NA 2.11141543565643 2.12376607568359 -0.0123506400271531 0.413016255037447 1.2175006405565 0.0106830471598276 0.0299035204462675 0.0101442575188362 0.981119650115412 NA NA 0.694217832148342 0.969696849064784 92.0166053114774 a1980 loss_cnaDLBC2 221 TAK-715 p38a 4 25 2.99573227355399 2.32630161961136 2.71665088729566 2.80316187757348 -0.0865109902778216 0.477865025100636 0.634558478122171 0.139734523838605 0.181036455345529 0.13633257337264 0.981782419992635 NA NA 0.0258052929019977 0.762374245262073 92.0166053114774 a1981 PTEN_mut 304 SB52334 ALK5 6 23 2.99573227355399 NA 3.83461522809716 3.72520797640096 0.1094072516962 1.10952077267128 0.8650599898589 0.119535501115198 0.098607664129434 0.126473600650569 0.981863993515508 NA NA 0.233374959247733 0.829160716630698 92.0166053114774 a1982 PTEN_mut 302 PI-103 PI3Ka, PRKDC (DNAPK) 6 22 2.32630161961136 NA -1.2737570348949 -1.39017291068525 0.116415875790352 2.68737629219945 1.93482841967535 0.0554204881082817 0.0433195292108024 0.060168578570851 0.982315595791128 NA NA 0.471537349707678 0.923883348098548 92.0166053114774 a1983 CREBBP_mut 304 SB52334 ALK5 6 23 2.99573227355399 NA 3.68454035333364 3.76435794373057 -0.0798175903969289 1.15849191061141 0.851056601890494 0.0871552928568699 0.0688978400848774 0.0937864652240829 0.982363987170761 NA NA 0.233375209771681 0.879262097947475 92.0166053114774 a1984 loss_cnaDLBC2 87 GW843682X PLK1 4 21 -1.36257783450257 NA -2.98193749277108 -2.7523642074091 -0.22957328536198 1.48606247203092 1.47426379489681 0.155557680585991 0.15448427618809 0.155720628938086 0.982575335986121 NA NA 0.0367530425548455 0.790174982975505 92.0166053114774 a1985 MLL2_mut 1021 Axitinib PDGFR, KIT, VEGFR 8 22 0.693147180559945 NA 1.70004143988114 1.69575335072864 0.00428808915249856 0.781064237276562 0.953840486140002 0.00469302982692126 0.00549005952116103 0.00449560404995136 0.983892165202351 NA NA 0.847555090157589 0.990186814771706 92.0787943316004 a1986 TP53_mut 245 UNC0638 G9a(EHMT2), GLP(EHMT1) 17 12 3.68887945411394 NA 1.8830662896121 1.86496525648235 0.018101033129752 0.661660810714614 0.778402722644851 0.0254392984398303 0.0273569672506405 0.023254072221444 0.984437090528121 NA NA 0.838459129619876 0.948345213966693 92.0787943316004 a1987 CREBBP_mut 1175 AG-014699 PARP1, PARP2 6 24 1.6094379124341 NA 3.27173749972154 3.30984422905716 -0.038106729335615 0.503176510674215 0.670027335781028 0.0592258537626686 0.0757323295647389 0.0568733950103622 0.985155823639374 NA NA 0.416077780050558 0.8803603567266 92.0787943316004 a1988 ARID1A_mut 271 VNLG/124 HDAC, RAR 3 26 1.63315443905142 NA 2.85873077945727 2.80517743736292 0.0535533420943457 1.10033684493494 0.916832990909431 0.0574812556921398 0.0486699526066605 0.058411229335481 0.985950273493767 NA NA 0.233337608433906 0.941789628877099 92.0787943316004 a1989 CREBBP_mut 205 BMS-708163 g-secretase 6 23 2.32630161961136 0.940007258491471 4.08104337000698 4.12528029789577 -0.0442369278887904 0.738582352219704 0.637626264567787 0.0672812760633805 0.0598943743454507 0.0693775183786952 0.986363385816939 NA NA 0.246242732867194 0.896953151766467 92.0787943316004 a1990 PTEN_mut 1494 SN-38 TOP1 5 26 -2.99573227355399 NA -4.56229883667688 -4.66600093834989 0.103702101673012 2.12991868502384 1.49405752677329 0.0649401552330019 0.0486882914367459 0.0694097113495867 0.986929947061765 NA NA 0.637751145210324 0.921342096045122 92.0787943316004 a1991 loss_cnaDLBC4_(CDKN2A) 17 Cyclopamine SMO 8 19 2.77258872223978 NA 4.00301679213939 4.06194623148632 -0.0589294393469348 1.11826735533783 1.05933031544992 0.0547590913470114 0.0526970934684328 0.0556289558483055 0.987611079004843 NA NA 0.544482629411626 0.900962474765679 92.0787943316004 a1992 ARID1A_mut 1006 Cytarabine DNA synthesis 3 27 0.693147180559945 NA -0.128622113020974 -0.195415581520585 0.0667934684996115 2.51384435059511 1.90033049171271 0.0342431751490654 0.0265702482668823 0.0351483432965455 0.987770561599415 NA NA 0.656633035086549 0.968038846871193 92.0787943316004 a1993 CREBBP_mut 1003 Camptothecin TOP1 7 23 -2.30258509299405 NA -5.17179020569064 -5.03215654868355 -0.139633657007094 1.54836761142872 1.58165354545537 0.0886799335133256 0.090181205016456 0.0882833395520208 0.988864540386979 NA NA 0.140407652872536 0.839452472926035 92.0787943316004 a1994 EP300_mut 104 Bortezomib Proteasome 5 23 -3.91202300542815 NA -5.92329437694202 -6.13928988746169 0.21599551051967 1.68096238307275 1.00555903535355 0.190151289589535 0.128495148192928 0.21480142182177 0.989275022749938 NA NA 0.0881681949145999 0.793861356542705 92.0787943316004 a1995 PTEN_mut 310 YM201636 FYV1 6 23 1.63315443905142 NA 0.884094699083787 0.885328343780406 -0.00123364469661869 0.583073625061979 0.995848527579371 0.00132182993624454 0.00211576144691428 0.0012387874887131 0.989773752655989 NA NA 0.937797955718991 0.996940228000894 92.0787943316004 a1996 MLL2_mut 1133 JNJ-26854165 MDM2 8 22 2.30258509299405 NA 2.62968517095914 2.65444952995176 -0.0247643589926194 0.964330382120624 0.873094484881393 0.0276149360907512 0.0256803679027109 0.02836389350917 0.990208178774196 NA NA 0.631492958685074 0.950266436049843 92.0787943316004 a1997 CREBBP_mut 204 Tipifarnib Farnesyl-transferase (FNTA) 7 22 2.77258872223978 NA 1.09006868160513 1.02830243012382 0.06176625148131 1.41998255120129 1.70123570073236 0.0375958388951265 0.043497894695295 0.0363066983926568 0.990740951295229 NA NA 0.634720864623073 0.925606775487171 92.0787943316004 a1998 CREBBP_mut 254 AC220 FLT3 6 23 0.0237165266173161 NA 1.6447361557945 1.67123482044596 -0.0264986646514611 0.647567966908136 0.750545412758287 0.0361722710726397 0.0409202832839016 0.0353058778336641 0.990834374384233 NA NA 0.52520568321912 0.933180236946795 92.0787943316004 a1999 CREBBP_mut 1036 PLX4720 BRAF 7 25 2.30258509299405 NA 3.37464877668617 3.34596141893591 0.028687357750262 0.759454332796487 0.826579600984845 0.0352598798259197 0.0377736441961276 0.0347061041865561 0.991359627914157 NA NA 0.503657604556325 0.932638144999189 92.0787943316004 a2000 loss_cnaDLBC4_(CDKN2A) 309 Y-39983 ROCK 7 22 2.99573227355399 NA 2.64057478301332 2.64820384282422 -0.00762905981089101 1.36165745753052 1.15019025442862 0.00635539608777797 0.00560277459554841 0.00663286772037634 0.991718693798007 NA NA 0.979327180702119 0.989618024241649 92.0787943316004 a2001 ARID1A_mut 152 CP466722 ATM 3 26 2.77258872223978 NA 1.49864043313037 1.5358960160541 -0.0372555829237324 2.2249234403285 0.940847465489205 0.0342051851523168 0.0167446583772033 0.0395978990115693 0.992169750118468 NA NA 0.627234864768527 0.979611763503453 92.0787943316004 a2002 loss_cnaDLBC4_(CDKN2A) 1057 NVP-BEZ235 PI3K (Class 1) and MTORC1/2 8 24 -1.38629436111989 0.693147180559945 -3.13127139164807 -3.16882853673718 0.0375571450891079 0.755859122799876 1.08111339222814 0.0370170559724392 0.0496880224849144 0.0347393209251658 0.992293565401719 NA NA 0.59585373697797 0.91494901574461 92.0787943316004 a2003 PTEN_mut 309 Y-39983 ROCK 6 23 2.99573227355399 NA 2.64471285349427 2.64679264792437 -0.00207979443010053 1.40224550011904 1.1496082834424 0.00173256845623165 0.00148318852149925 0.00180913312826242 0.992857708992734 NA NA 0.979327191883755 0.997421568844268 92.0787943316004 a2004 loss_cnaDLBC2 106 XMD8-85 MAP2K5 (ERK5) 3 24 2.07944154167984 NA 1.97184715506535 1.99726938348448 -0.0254222284191292 0.369339357289077 0.978948088740234 0.026908456772492 0.0688316257593734 0.0259689239005962 0.993259517779501 NA NA 0.731868654492579 0.933253144746631 92.0787943316004 a2005 EP300_mut 150 Bicalutamide ANDR (androgen receptor) 5 24 0.0237165266173161 NA 2.04295104487198 2.00082678072092 0.0421242641510648 0.617334249763645 0.489502451671268 0.0825214424069675 0.0682357477609459 0.0860552669496209 0.993728824195987 NA NA 0.467438612043101 0.891412853576409 92.0787943316004 a2006 CREBBP_mut 1009 ATRA Retinoic acid and retinoid X receptor agonist 7 23 2.30258509299405 NA 3.21012482964491 3.14547131704277 0.064653512602133 0.832897825742049 0.973451624073684 0.0684095895993148 0.0776247825410417 0.0664167699793567 0.99414226153611 NA NA 0.314153917316469 0.865964717164117 92.0787943316004 a2007 TP53_mut 151 QS11 ARFGAP 16 13 2.32630161961136 NA 2.43511114187501 2.3753886674726 0.0597224744024021 1.20052747123433 0.952433771830288 0.0544311572576179 0.0497468619697625 0.0627051204700917 0.99593604129739 NA NA 0.576161848288925 0.882370306403521 92.198975024728 a2008 loss_cnaDLBC4_(CDKN2A) 1054 PD-0332991 CDK4, CDK6 8 24 1.38629436111989 0.693147180559945 1.48027035358133 1.43895114379698 0.04131920978435 1.25586628507858 1.59836526448926 0.0270884695971069 0.032900962686298 0.0258509182489981 0.997501919710095 NA NA 0.679052245759138 0.94119792919964 92.2867516608492 a2009 CREBBP_mut 269 NSC-207895 MDM4 6 22 2.99573227355399 NA 2.96812983673775 3.05362094864209 -0.0854911119043411 1.20266389109779 1.3510891383093 0.0645781867333112 0.071084791467635 0.0632757006775449 0.998467652357016 NA NA 0.349852889367107 0.884011149538555 92.2867516608492 a2010 TP53_mut 60 BI-2536 PLK1, PLK2, PLK3 15 10 -1.36257783450257 NA -2.19189294555209 -2.45687717103408 0.264984225481992 1.55081932163552 0.777745025303242 0.20319581009423 0.170867245323288 0.340708351530342 0.998571651815447 NA NA 0.0372661162255308 0.578598139931086 92.2867516608492 a2011 EP300_mut 245 UNC0638 G9a(EHMT2), GLP(EHMT1) 6 23 3.68887945411394 NA 1.88588961913719 1.87288575158134 0.0130038675558573 0.32017408594361 0.773383421248369 0.018274709234164 0.0406149908026833 0.0168142569372212 0.998871021666954 NA NA 0.838460310797202 0.950646858133149 92.2867516608492 a2012 ARID1A_mut 295 NVP-BHG712 EPHB4 3 26 2.32630161961136 NA 1.21182730536262 1.30786398465839 -0.0960366792957643 2.38266773561353 1.45764799720914 0.0621485850789963 0.0403063666243984 0.0658846851089145 0.999657388981571 NA NA 0.280571705522789 0.951273272489579 92.3135006931152